Xiaolei Wang

R&D Scientist in biomedical imaging and surgical microscope development

Raleigh, North Carolina, United States of America

Research Expertise

Optical imaging system development
image analysis algorithm development
Atomic and Molecular Physics, and Optics
Mechanics of Materials
Mechanical Engineering
Biotechnology
Materials Chemistry
Bioengineering
Condensed Matter Physics
Instrumentation
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Metals and Alloys
Ceramics and Composites
Catalysis
Physical and Theoretical Chemistry
Electrical and Electronic Engineering
Industrial and Manufacturing Engineering
Molecular Biology
Developmental Biology

About

I am an R&D Optical Scientist and Expert specializing in Optical Imaging and Optical Microscope Development for biomedical and clinical applications. With a background in Physics and over 15 years of experience in optical science and imaging, I am passionate about pushing the boundaries of what light can achieve in the realm of medicine and healthcare. My journey in the world of optics has led me to become a leader in the research and development of next-generation optical imaging products that have a profound impact on surgical procedures and patient outcomes. My areas of expertise encompass optical physics, optical microscopy, optical metrology, photonics, and computational modeling and simulation. I've had the privilege of sharing my insights through multiple peer-reviewed publications in prestigious journals like ACS Nano, Optical Letter, and Advanced Materials. Additionally, I hold certifications in machine learning and deep learning for image analysis, allowing me to harness the power of cutting-edge technology in my work.

Legacy Map

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Publications

Optical Clearing Delivers Ultrasensitive Hyperspectral Dark-Field Imaging for Single-Cell Evaluation
ACS Nano
2016
Single-Cell Quantification of Cytosine Modifications by Hyperspectral Dark-Field Imaging
ACS Nano
2015
Optical bistability effect in plasmonic racetrack resonator with high extinction ratio
Optics Express
2011
Optical bistability enhanced by highly localized bulk plasmon polariton modes in subwavelength metal-nonlinear dielectric multilayer structure
Applied Physics Letters
2009
Oxygen Nanobubble Tracking by Light Scattering in Single Cells and Tissues
ACS Nano
2017
Second-Stokes YVO_4/Nd:YVO_4/YVO_4self-frequency Raman laser
Optics Letters
2012
Superplastic Formation of Metal Nanostructure Arrays with Ultrafine Gaps
Advanced Materials
2016
Plasmonic racetrack resonator with high extinction ratio under critical coupling condition
Journal of Applied Physics
2010
Theoretical and experimental studies of surface plasmons excited at metal-uniaxial dielectric interface
Applied Physics Letters
2011
Snapshot multifocal light field microscopy
Optics Express
2020
Computational multifocal microscopy
Biomedical Optics Express
2018
A plasmonic nano-antenna with controllable resonance frequency: Cu1.94S–ZnS dimeric nanoheterostructure synthesized in solution
Journal of Materials Chemistry
2012
Nanoscale Resolution 3D Snapshot Particle Tracking by Multifocal Microscopy
Nano Letters
2019
A compact efficient deep ultraviolet laser at 266 nm
Laser Physics Letters
2013
Kinase phosphorylation monitoring with i-motif DNA cross-linked SERS probes
Chemical Communications
2016
Sensitivity enhanced all-optical switching using prism-grating coupled surface plasmon modes
Optics Communications
2010
6.2 W diode-end-pumped 1313 nm Nd:YLF laser
Laser Physics
2012
金属-非线性介质-金属结构对表面等离子体的动态调控
Chinese Optics Letters
2010
Design and simulation of a snapshot multi-focal interferometric microscope
Optics Express
2018
Plasmon mode characteristics of metallic nanowire in uniaxial anisotropic dielectric
Optics Letters
2014
Investigation on performance of all optical buffer with large dynamical delay time based on cascaded double loop optical buffers
Chinese Physics B
2010
Modulation of Splitting Beam Angle with Metal–Nonlinear Optical Material–Metal (M-NL-M) Array Structure
Chinese Physics Letters
2008
DeepProjection: specific and robust projection of curved 2D tissue sheets from 3D microscopy using deep learning
Development
2022
Particle tracking by repetitive phase-shift interferometric super resolution microscopy
Optics Letters
2018
Snapshot 3D tracking of insulin granules in live cells
Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXV
2018
A continuous-wave, widely tunable, intra-cavity, singly resonant, magnesium-doped, periodically poled lithium niobate optical parametric oscillator
Laser Physics
2013
Random Population Model for Self Pulsation in Single-Section Quantum-Dot Lasers
IEEE Photonics Technology Letters
2013
DeepProjection: Rapid and structure-specific projections of tissue sheets embedded in 3D microscopy stacks using deep learning
Unknown Venue
2021
Bayesian Approach for Automatic Joint Parameter Estimation in 3D Image Reconstruction from Multi-Focus Microscope
2018 25th IEEE International Conference on Image Processing (ICIP)
2018
Analytical Investigation of Transmission Properties of Metallic Gratings
Chinese Physics Letters
2008
Integrated Dynamic 3D Imaging of Microbial Processes and Communities in Rhizosphere Environments: The Argonne Small Worlds Project
Microscopy and Microanalysis
2017
Efficient end-pumped multi-wavelength laser operation of disordered Nd:LiGd(WO4)2crystal
Laser Physics
2013
Observation of antiphase dynamics and harmonic resonance in a modulated dual-wavelength laser
Chinese Optics Letters
2016

Education

University of Science and Technology of China

Ph.D., Optics / June, 2011

Hefei

Anhui Normal University

Bachelor, Physics / July, 2006

Wuhu

Experience

Duke University

Research Scientist/Manager / June, 2019May, 2022

University of Chicago

Research Professional / April, 2016May, 2019

True Digital Surgery

Principal R&D Scientist / July, 2022January, 2024

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