Xiaolei Wang

R&D Scientist in biomedical imaging and surgical microscope development

Raleigh, North Carolina, United States of America

Research Expertise

Optical imaging system development
image analysis algorithm development
Atomic and Molecular Physics, and Optics
Mechanics of Materials
Mechanical Engineering
Biotechnology
Materials Chemistry
Bioengineering
Condensed Matter Physics
Instrumentation
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Metals and Alloys
Ceramics and Composites
Catalysis
Physical and Theoretical Chemistry
Electrical and Electronic Engineering
Industrial and Manufacturing Engineering
Molecular Biology
Developmental Biology

About

I am an R&D Optical Scientist and Expert specializing in Optical Imaging and Optical Microscope Development for biomedical and clinical applications. With a background in Physics and over 15 years of experience in optical science and imaging, I am passionate about pushing the boundaries of what light can achieve in the realm of medicine and healthcare. My journey in the world of optics has led me to become a leader in the research and development of next-generation optical imaging products that have a profound impact on surgical procedures and patient outcomes. My areas of expertise encompass optical physics, optical microscopy, optical metrology, photonics, and computational modeling and simulation. I've had the privilege of sharing my insights through multiple peer-reviewed publications in prestigious journals like ACS Nano, Optical Letter, and Advanced Materials. Additionally, I hold certifications in machine learning and deep learning for image analysis, allowing me to harness the power of cutting-edge technology in my work.

Publications

Optical Clearing Delivers Ultrasensitive Hyperspectral Dark-Field Imaging for Single-Cell Evaluation

ACS Nano / Feb 24, 2016

Cui, Y., Wang, X., Ren, W., Liu, J., & Irudayaraj, J. (2016). Optical Clearing Delivers Ultrasensitive Hyperspectral Dark-Field Imaging for Single-Cell Evaluation. ACS Nano, 10(3), 3132–3143. https://doi.org/10.1021/acsnano.6b00142

Single-Cell Quantification of Cytosine Modifications by Hyperspectral Dark-Field Imaging

ACS Nano / Nov 02, 2015

Wang, X., Cui, Y., & Irudayaraj, J. (2015). Single-Cell Quantification of Cytosine Modifications by Hyperspectral Dark-Field Imaging. ACS Nano, 9(12), 11924–11932. https://doi.org/10.1021/acsnano.5b04451

Optical bistability effect in plasmonic racetrack resonator with high extinction ratio

Optics Express / Sep 22, 2011

Wang, X., Jiang, H., Chen, J., Wang, P., Lu, Y., & Ming, H. (2011). Optical bistability effect in plasmonic racetrack resonator with high extinction ratio. Optics Express, 19(20), 19415. https://doi.org/10.1364/oe.19.019415

Optical bistability enhanced by highly localized bulk plasmon polariton modes in subwavelength metal-nonlinear dielectric multilayer structure

Applied Physics Letters / Feb 23, 2009

Chen, J., Wang, P., Wang, X., Lu, Y., Zheng, R., Ming, H., & Zhan, Q. (2009). Optical bistability enhanced by highly localized bulk plasmon polariton modes in subwavelength metal-nonlinear dielectric multilayer structure. Applied Physics Letters, 94(8). https://doi.org/10.1063/1.3079408

Oxygen Nanobubble Tracking by Light Scattering in Single Cells and Tissues

ACS Nano / Mar 13, 2017

Bhandari, P., Wang, X., & Irudayaraj, J. (2017). Oxygen Nanobubble Tracking by Light Scattering in Single Cells and Tissues. ACS Nano, 11(3), 2682–2688. https://doi.org/10.1021/acsnano.6b07478

Second-Stokes YVO_4/Nd:YVO_4/YVO_4self-frequency Raman laser

Optics Letters / May 29, 2012

Chen, W., Wei, Y., Huang, C., Wang, X., Shen, H., Zhai, S., Xu, S., Li, B., Chen, Z., & Zhang, G. (2012). Second-Stokes YVO_4/Nd:YVO_4/YVO_4self-frequency Raman laser. Optics Letters, 37(11), 1968. https://doi.org/10.1364/ol.37.001968

Superplastic Formation of Metal Nanostructure Arrays with Ultrafine Gaps

Advanced Materials / Aug 29, 2016

Hu, Y., Xuan, Y., Wang, X., Deng, B., Saei, M., Jin, S., Irudayaraj, J., & Cheng, G. J. (2016). Superplastic Formation of Metal Nanostructure Arrays with Ultrafine Gaps. Advanced Materials, 28(41), 9152–9162. Portico. https://doi.org/10.1002/adma.201602497

Plasmonic racetrack resonator with high extinction ratio under critical coupling condition

Journal of Applied Physics / Jun 15, 2010

Wang, X., Wang, P., Chen, C., Chen, J., Lu, Y., Ming, H., & Zhan, Q. (2010). Plasmonic racetrack resonator with high extinction ratio under critical coupling condition. Journal of Applied Physics, 107(12). https://doi.org/10.1063/1.3437639

Theoretical and experimental studies of surface plasmons excited at metal-uniaxial dielectric interface

Applied Physics Letters / Jan 10, 2011

Wang, X., Wang, P., Chen, J., Lu, Y., Ming, H., & Zhan, Q. (2011). Theoretical and experimental studies of surface plasmons excited at metal-uniaxial dielectric interface. Applied Physics Letters, 98(2). https://doi.org/10.1063/1.3541653

Snapshot multifocal light field microscopy

Optics Express / Apr 08, 2020

He, K., Wang, X., Wang, Z. W., Yi, H., Scherer, N. F., Katsaggelos, A. K., & Cossairt, O. (2020). Snapshot multifocal light field microscopy. Optics Express, 28(8), 12108. https://doi.org/10.1364/oe.390719

Computational multifocal microscopy

Biomedical Optics Express / Nov 28, 2018

He, K., Wang, Z., Huang, X., Wang, X., Yoo, S., Ruiz, P., Gdor, I., Selewa, A., Ferrier, N. J., Scherer, N., Hereld, M., Katsaggelos, A. K., & Cossairt, O. (2018). Computational multifocal microscopy. Biomedical Optics Express, 9(12), 6477. https://doi.org/10.1364/boe.9.006477

A plasmonic nano-antenna with controllable resonance frequency: Cu1.94S–ZnS dimeric nanoheterostructure synthesized in solution

Journal of Materials Chemistry / Jan 01, 2012

Huang, F., Wang, X., Xu, J., Chen, D., & Wang, Y. (2012). A plasmonic nano-antenna with controllable resonance frequency: Cu1.94S–ZnS dimeric nanoheterostructure synthesized in solution. Journal of Materials Chemistry, 22(42), 22614. https://doi.org/10.1039/c2jm34239a

Nanoscale Resolution 3D Snapshot Particle Tracking by Multifocal Microscopy

Nano Letters / Sep 06, 2019

Wang, X., Yi, H., Gdor, I., Hereld, M., & Scherer, N. F. (2019). Nanoscale Resolution 3D Snapshot Particle Tracking by Multifocal Microscopy. Nano Letters, 19(10), 6781–6787. https://doi.org/10.1021/acs.nanolett.9b01734

A compact efficient deep ultraviolet laser at 266 nm

Laser Physics Letters / Feb 08, 2013

Zhai, S. Y., Wang, X. L., Wei, Y., Chen, W. D., Zhuang, F. J., Xu, S., Li, B. X., Fu, J. J., Chen, Z. Q., Wang, H. W., Huang, C. H., & Zhang, G. (2013). A compact efficient deep ultraviolet laser at 266 nm. Laser Physics Letters, 10(4), 045402. https://doi.org/10.1088/1612-2011/10/4/045402

Kinase phosphorylation monitoring with i-motif DNA cross-linked SERS probes

Chemical Communications / Jan 01, 2016

Ren, W., Damayanti, N. P., Wang, X., & Irudayaraj, J. M. K. (2016). Kinase phosphorylation monitoring with i-motif DNA cross-linked SERS probes. Chemical Communications, 52(2), 410–413. https://doi.org/10.1039/c5cc06566f

Sensitivity enhanced all-optical switching using prism-grating coupled surface plasmon modes

Optics Communications / Jan 01, 2010

Chen, J., Wang, P., Wang, X., Hu, J., Chen, C., Lu, Y., Ming, H., & Zhan, Q. (2010). Sensitivity enhanced all-optical switching using prism-grating coupled surface plasmon modes. Optics Communications, 283(1), 151–154. https://doi.org/10.1016/j.optcom.2009.09.060

6.2 W diode-end-pumped 1313 nm Nd:YLF laser

Laser Physics / May 11, 2012

Wei, Y., Xu, S., Huang, C. H., Zhuang, F. J., Chen, W. D., Huang, L. X., Wang, X. L., & Zhang, G. (2012). 6.2 W diode-end-pumped 1313 nm Nd:YLF laser. Laser Physics, 22(6), 1029–1032. https://doi.org/10.1134/s1054660x12060163

金属-非线性介质-金属结构对表面等离子体的动态调控

Chinese Optics Letters / Jan 01, 2010

Wang, X., Wang, P., Chen, C., Chen, J., Lu, Y., Ming, H., & Zhan, Q. (2010). 金属-非线性介质-金属结构对表面等离子体的动态调控. Chinese Optics Letters, 8(6), 584. https://doi.org/10.3788/col20100806.0584

Design and simulation of a snapshot multi-focal interferometric microscope

Optics Express / Oct 05, 2018

He, K., Huang, X., Wang, X., Yoo, S., Ruiz, P., Gdor, I., Ferrier, N. J., Scherer, N., Hereld, M., Katsaggelos, A. K., & Cossairt, O. (2018). Design and simulation of a snapshot multi-focal interferometric microscope. Optics Express, 26(21), 27381. https://doi.org/10.1364/oe.26.027381

Plasmon mode characteristics of metallic nanowire in uniaxial anisotropic dielectric

Optics Letters / Jul 03, 2014

Chen, J., & Wang, X. (2014). Plasmon mode characteristics of metallic nanowire in uniaxial anisotropic dielectric. Optics Letters, 39(14), 4088. https://doi.org/10.1364/ol.39.004088

Investigation on performance of all optical buffer with large dynamical delay time based on cascaded double loop optical buffers

Chinese Physics B / Sep 01, 2010

Yong-Jun, W., Chong-Qing, W., Xiang-Jun, X., Kuang-Lu, Y., & Xiao-Lei, Z. (2010). Investigation on performance of all optical buffer with large dynamical delay time based on cascaded double loop optical buffers. Chinese Physics B, 19(9), 094210. https://doi.org/10.1088/1674-1056/19/9/094210

Modulation of Splitting Beam Angle with Metal–Nonlinear Optical Material–Metal (M-NL-M) Array Structure

Chinese Physics Letters / Dec 01, 2008

Xiao-Lei, W., Pei, W., Chang-Jun, M., Jun-Xue, C., Yong-Hua, L., & Hai, M. (2008). Modulation of Splitting Beam Angle with Metal–Nonlinear Optical Material–Metal (M-NL-M) Array Structure. Chinese Physics Letters, 25(12), 4375–4377. https://doi.org/10.1088/0256-307x/25/12/053

DeepProjection: specific and robust projection of curved 2D tissue sheets from 3D microscopy using deep learning

Development / Nov 01, 2022

Haertter, D., Wang, X., Fogerson, S. M., Ramkumar, N., Crawford, J. M., Poss, K. D., Di Talia, S., Kiehart, D. P., & Schmidt, C. F. (2022). DeepProjection: specific and robust projection of curved 2D tissue sheets from 3D microscopy using deep learning. Development, 149(21). https://doi.org/10.1242/dev.200621

Particle tracking by repetitive phase-shift interferometric super resolution microscopy

Optics Letters / Jun 07, 2018

Gdor, I., Wang, X., Daddysman, M., Yifat, Y., Wilton, R., Hereld, M., Noirot-Gros, M.-F., & Scherer, N. F. (2018). Particle tracking by repetitive phase-shift interferometric super resolution microscopy. Optics Letters, 43(12), 2819. https://doi.org/10.1364/ol.43.002819

Snapshot 3D tracking of insulin granules in live cells

Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXV / Feb 23, 2018

Haunold, T., Gdor, I., Scherer, N., Wang, X., Daddysman, M., Huang, X., Selewa, A., Hereld, M., & Yi, H. (2018). Snapshot 3D tracking of insulin granules in live cells. In T. G. Brown, C. J. Cogswell, & T. Wilson (Eds.), Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXV. SPIE. https://doi.org/10.1117/12.2285530

A continuous-wave, widely tunable, intra-cavity, singly resonant, magnesium-doped, periodically poled lithium niobate optical parametric oscillator

Laser Physics / Apr 10, 2013

Li, Z. P., Duan, Y. M., Wu, K. R., Zhang, G., Zhu, H. Y., Wang, X. L., Chen, Y. H., Xue, Z. Q., Lin, Q., Song, G. C., & Su, H. (2013). A continuous-wave, widely tunable, intra-cavity, singly resonant, magnesium-doped, periodically poled lithium niobate optical parametric oscillator. Laser Physics, 23(5), 055006. https://doi.org/10.1088/1054-660x/23/5/055006

Random Population Model for Self Pulsation in Single-Section Quantum-Dot Lasers

IEEE Photonics Technology Letters / Feb 01, 2013

Wang, Y., Mao, Y., Chen, Y., Wang, X., & Su, H. (2013). Random Population Model for Self Pulsation in Single-Section Quantum-Dot Lasers. IEEE Photonics Technology Letters, 25(4), 389–392. https://doi.org/10.1109/lpt.2013.2238918

DeepProjection: Rapid and structure-specific projections of tissue sheets embedded in 3D microscopy stacks using deep learning

Nov 19, 2021

Haertter, D., Wang, X., Fogerson, S. M., Ramkumar, N., Crawford, J. M., Poss, K. D., Di Talia, S., Kiehart, D. P., & Schmidt, C. F. (2021). DeepProjection: Rapid and structure-specific projections of tissue sheets embedded in 3D microscopy stacks using deep learning. https://doi.org/10.1101/2021.11.17.468809

Bayesian Approach for Automatic Joint Parameter Estimation in 3D Image Reconstruction from Multi-Focus Microscope

2018 25th IEEE International Conference on Image Processing (ICIP) / Oct 01, 2018

Yoo, S., Ruiz, P., Huang, X., He, K., Wang, X., Gdor, I., Selewa, A., Daddysman, M., Ferrier, N. J., Hereld, M., Scherer, N., Cossairt, O., & Katsaggelos, A. K. (2018, October). Bayesian Approach for Automatic Joint Parameter Estimation in 3D Image Reconstruction from Multi-Focus Microscope. 2018 25th IEEE International Conference on Image Processing (ICIP). https://doi.org/10.1109/icip.2018.8451309

Analytical Investigation of Transmission Properties of Metallic Gratings

Chinese Physics Letters / Dec 01, 2008

Jun-Xue, C., Pei, W., Xiao-Lei, W., Yong-Hua, L., Rong-Sheng, Z., & Hai, M. (2008). Analytical Investigation of Transmission Properties of Metallic Gratings. Chinese Physics Letters, 25(12), 4385–4387. https://doi.org/10.1088/0256-307x/25/12/056

Integrated Dynamic 3D Imaging of Microbial Processes and Communities in Rhizosphere Environments: The Argonne Small Worlds Project

Microscopy and Microanalysis / Jul 01, 2017

Kemner, K. M., Hereld, M., Scherer, N., Selewa, A., Wang, X., Gdor, I., Daddysman, M., Jureller, J., Huynh, T., Cossairt, O., Katsaggelos, A., He, K., Yoo, S., Matsuda, N., Glick, B., Riviere, P. L., Austin, J., Day, K., Chandler, T., … Noirot, M. F. (2017). Integrated Dynamic 3D Imaging of Microbial Processes and Communities in Rhizosphere Environments: The Argonne Small Worlds Project. Microscopy and Microanalysis, 23(S1), 340–341. https://doi.org/10.1017/s1431927617002380

Efficient end-pumped multi-wavelength laser operation of disordered Nd:LiGd(WO4)2crystal

Laser Physics / Aug 19, 2013

Xu, S., Huang, X., Li, B., Wei, Y., Wang, X., Huang, C., Zhuang, F., Chen, W., Zhai, S., & Zhang, G. (2013). Efficient end-pumped multi-wavelength laser operation of disordered Nd:LiGd(WO4)2crystal. Laser Physics, 23(9), 095807. https://doi.org/10.1088/1054-660x/23/9/095807

Observation of antiphase dynamics and harmonic resonance in a modulated dual-wavelength laser

Chinese Optics Letters / Jan 01, 2016

Huibin Chen, H. C., Ge Zhang, G. Z., Wenbin Liao, W. L., Bingxuan Li, B. L., Xiaolei Wang, X. W., & and Zhenqiang Chen, and Z. C. (2016). Observation of antiphase dynamics and harmonic resonance in a modulated dual-wavelength laser. Chinese Optics Letters, 14(1), 011403–011407. https://doi.org/10.3788/col201614.011403

Education

University of Science and Technology of China

Ph.D., Optics / June, 2011

Hefei

Anhui Normal University

Bachelor, Physics / July, 2006

Wuhu

Experience

Duke University

Research Scientist/Manager / June, 2019May, 2022

University of Chicago

Research Professional / April, 2016May, 2019

True Digital Surgery

Principal R&D Scientist / July, 2022January, 2024

Links & Social Media

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