Smain CHEMAT

Research Centre in Chemical and Physical Analysis (CRAPC)

Jacksonville, Florida, United States of America

Research Expertise

Extraction and Separation Techniques
biorefinery
bioactive compounds
process development
medicinal herbs
Method development and validation

About

Experienced Chemical Process Scientist with project management experience in process development, biobased chemicals and environmental engineering. Leadership and product development experience with problem solving skills and a strong knowledge of FDA, ICH and EPA guidelines.

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Publications

Comparison of conventional and ultrasound‐assisted extraction of carvone and limonene from caraway seeds
Flavour and Fragrance Journal
2004
Microwave-assisted extraction kinetics of terpenes from caraway seeds
Chemical Engineering and Processing: Process Intensification
2005
Rapid Extraction of Volatile Compounds Using a New Simultaneous Microwave Distillation: Solvent Extraction Device
Chromatographia
2007
Ultrasound induced intensification and selective extraction of essential oil from Carum carvi L. seeds
Chemical Engineering and Processing: Process Intensification
2012
Antimalarial-agent artemisinin and derivatives portray more potent binding to Lys353 and Lys31-binding hotspots of SARS-CoV-2 spike protein than hydroxychloroquine: potential repurposing of artenimol for COVID-19
Journal of Biomolecular Structure and Dynamics
2020
Sono-oxidation treatment of humic substances in drinking water
Ultrasonics Sonochemistry
2001
Screening of new solvents for artemisininextraction process using ab initio methodology
Green Chem.
2010
Development of HPLC analytical protocols for quantification of artemisinin in biomass and extracts
Journal of Pharmaceutical and Biomedical Analysis
2009
Ultrasound assisted microwave digestion
Ultrasonics Sonochemistry
2004
Microwave - ultrasound combined reactor suitable for atmospheric sample preparation procedure of biological and chemical products
Analusis
1999
Extraction mechanism of ultrasound assisted extraction and its effect on higher yielding and purity of artemisinin crystals from Artemisia annua L. leaves
Ultrasonics Sonochemistry
2017
Limonene as Green Solvent for Extraction of Natural Products
Green Solvents I
2012
Conventional extraction
Food Waste Recovery
2021
Ultrasound-Assisted Aromatisation with Condiments as an Enabling Technique for Olive Oil Flavouring and Shelf Life Enhancement
Food Analytical Methods
2015
Efficient Solvent Selection Approach for High Solubility of Active Phytochemicals: Application for the Extraction of an Antimalarial Compound from Medicinal Plants
ACS Sustainable Chemistry & Engineering
2017
Composition and microbial activity of thyme (Thymus algeriensis genuinus) essential oil
Journal of Essential Oil Research
2012
An Original Microwave-Ultra Violet Combined Reactor Suitable for Organic Synthesis and Degradation
Journal of Microwave Power and Electromagnetic Energy
1999
Membrane-Interactive Compounds From Pistacia lentiscus L. Thwart Pseudomonas aeruginosa Virulence
Frontiers in Microbiology
2020
Edible Oils
Unknown Venue
2017
Contribution of microwaves or ultrasonics on carvone and limonene recovery from dill fruits (Anethum graveolens L.)
Innovative Food Science & Emerging Technologies
2013
The effect of O-methylated flavonoids and other co-metabolites on the crystallization and purification of artemisinin
Journal of Biotechnology
2014
Integrating medicinal plants extraction into a high-value biorefinery: An example of Artemisia annua L.
Comptes Rendus. Chimie
2014
Assessment of artemisinin and antioxidant activities of three wild Artemisia species of Algeria
Natural Product Research
2022
Isolation of berberine tannate using a chromatography activity-guided fractionation from root bark of Berberis hispanica Boiss. & Reut.
Journal of Liquid Chromatography & Related Technologies
2017
Vegetable Oils and Fats: Extraction, Composition and Applications
Green Chemistry and Sustainable Technology
2019
Leishmanicidal and Cytotoxic Activity of Algerian Medicinal Plants on Leishmania major and Leishmania infantum
Journal of Medical Microbiology and Infectious Diseases
2019
Identification of alkylsalicylic acids in Lentisk oil (Pistacia lentiscusL.) and cytotoxicity on Human Normal Dermal Fibroblasts
Unknown Venue
2020
Study of the degradation in aqueous solution of a refractory organic compound: avermectin type used as pesticide in agriculture
Water Science and Technology
2017
Promising Algerian essential oils as natural acaricides against the honey bee mite Varroa destructor (Acari: Varroidae)
Experimental and Applied Acarology
2023
Biosynthesis of spathulenol and camphor stand as a competitive route to artemisinin production as revealed by a new chemometric convergence approach based on nine locations’ field-grown Artemesia annua L.
Industrial Crops and Products
2019
Procédés de chauffage par micro-ondes : approches expérimentales et numériques des interactions avec les produits alimentaires
Science et technologie des aliments
2019
Bioassay-guided fractionation of Calamintha baborensis Batt. herbal extracts reveals disaccharide glucuronide as a potent antistaphylococcal compound
South African Journal of Botany
2022
Assessment of L-DOPA, bioactive molecules and antioxidant activities of the local Algerian legume Tadelaght (Vigna mungo L.Hepper) extract
Food Bioscience
2024
Optimization of silybin production fromSilybum marianumtissue cell cultures using different elicitor solutions
Journal of Food Processing and Preservation
2022
Octabenzone Isolated from Saharan Myrtle Leaves (Myrtus nivellei)
The Natural Products Journal
2021
Green Solvents for Edible Oils Extraction
Edible Oils
2017
Utilisation de l’Energie Solaire dans le Traitement des Eaux : Dégradation Photocatalytique de Micropolluants Organiques en Solution Aqueuse
Journal of Renewable Energies
1998

Education

University of Sciences and Technology Houari Boumediene

PhD, Chemical Engineering

Algiers

Experience

Johnson & Johnson Med

Scientist / August, 2024Present

• Managing studies in analytical development and method validation for raw ingredients and impurities under GMP guidelines. Supporting pilot scale lines in process optimization with data review and validation • Drafted, reviewed and signed off technical reports. Collect and interpretation of research data for the analysis of leachable and extractables from polymer mix • Presenting project progress’ outcomes during meetings

Awakened Energy

Scientific Affairs Manager / September, 2023May, 2024

Multi-tasking with R&D, IP/patent review, formula development and manufacturing of dietary supplements • Set scientific rationale, sourced and formulated dietary supplements as capsules (PEA, Ketones as BHB salts, micronutrients, mushroom extracts, botanicals) and tinctures (cannabinoids & botanical extracts) • Managed accelerated stability studies and slug testing to optimize composition and formula stability • Reviewed analytical chemistry data for compliance of raw and finished OTC products at FDA registered labs. Reviewed compliance of CoAs, MSDS and analytical chemistry data (potency, residual solvents, heavy metals, pesticides, mycotoxins, microbiology)

Research Center in Analytical Chemistry

Principal Scientist / Group Leader / January, 2010August, 2023

• Built and lead a team of scientists in projects in process development and validation, extraction & separation science from biosources and cell culture, structure characterization and stability testing of biobased chemicals • Experienced at extraction and downstream processing technologies: pressurized reactors, bed filtration, ultrafiltration, ion exchange, disk stack centrifuge, crystallization, and chromatography • Developed and validated for industry clients bioprocessing SOPs and PFDs. Selected machinery for extraction and purification of polysaccharides (800 MT/y) from herbs and biopolymers from algae (2000 MT/y) *Trained staff and performed risk assessment to identify & mitigate hazards in the use of chemicals and skids • Evaluated project proposals seeking grants at the Latvian Council of Science and research foundations

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