Professor Scott Kanoski, PhD

Dr. Scott Kanoski, PhD - Professor and Principal Investigator at The Kanoski Lab for metabolic and behavioral neuroscience research at the University of Southern California

Research Expertise

Behavioral Neuroscience
Obesity
Learning and Memory

About

Dr. Scott Kanoski is a Professor of Biological Sciences at the University of Southern California who studies the neurobiology of food intake control and learning and memory function. His research is focused on discovering the underlying neural systems that regulate higher-order aspects of eating behavior (e.g., learned, cognitive, reward), and to understand how these neural systems are impacted by dietary and metabolic factors. Drawing on his broad training in psychology and behavioral neuroscience from the University of Illinois (B.S.), Purdue University (M.S.; PhD) and the University of Pennsylvania (postdoctoral fellow), Kanoski’s research applies multiple levels of analysis in rodent models, including behavioral, neuroanatomical, molecular, functional imaging, viral-based genetic, and neuropharmacological approaches. He has received several awards from the two premier scientific organizations focusing on obesity and ingestive behavior research [The Obesity Society and The Society for the Study of Ingestive Behavior (SSIB)], and has served in leadership roles on multiple committees in each of these organizations, including as the immediate past president of SSIB. Kanoski’s research program, continually funded by the National Institutes of Health for the past 15 years, has identified the hippocampus as a critical neural substrate responding to endocrine, neuropeptide, gut microbiome, and vagus nerve-mediated signals to regulate memory function and eating behavior. His work has further revealed mechanisms through which the hippocampus is highly vulnerable to consumption of an unhealthy “Western diet”, particularly when consumed during early life periods of development. Results from these ongoing research projects are advancing knowledge of the neurobiological connections between memory function, metabolism, eating behavior.

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Publications

Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity
Physiology & Behavior
2011
Gut to Brain Dysbiosis: Mechanisms Linking Western Diet Consumption, the Microbiome, and Cognitive Impairment
Frontiers in Behavioral Neuroscience
2017
Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1 Receptor Agonists, Liraglutide and Exendin-4
Endocrinology
2011
The Effects of a High-Energy Diet on Hippocampal Function and Blood-Brain Barrier Integrity in the Rat
Journal of Alzheimer's Disease
2010
GLP-1 and weight loss: unraveling the diverse neural circuitry
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
2016
The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide
Neuropharmacology
2012
The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat
Behavioural Brain Research
2007
Functions of Interoception: From Energy Regulation to Experience of the Self
Trends in Neurosciences
2021
Hippocampus Contributions to Food Intake Control: Mnemonic, Neuroanatomical, and Endocrine Mechanisms
Biological Psychiatry
2017
Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation
Cell Metabolism
2011
Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats
Hippocampus
2014
Different patterns of memory impairments accompany short- and longer-term maintenance on a high-energy diet.
Journal of Experimental Psychology: Animal Behavior Processes
2010
Ghrelin Signaling in the Ventral Hippocampus Stimulates Learned and Motivational Aspects of Feeding via PI3K-Akt Signaling
Biological Psychiatry
2013
Memory inhibition and energy regulation
Physiology & Behavior
2005
A potential role for the hippocampus in energy intake and body weight regulation
Current Opinion in Pharmacology
2007
Role of the glucagon-like-peptide-1 receptor in the control of energy balance
Physiology & Behavior
2010
Gut vagal sensory signaling regulates hippocampus function through multi-order pathways
Nature Communications
2018
Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia
Frontiers in Aging Neuroscience
2014
Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation
Hippocampus
2008
Hippocampal GLP-1 Receptors Influence Food Intake, Meal Size, and Effort-Based Responding for Food through Volume Transmission
Neuropsychopharmacology
2014
Hippocampal Leptin Signaling Reduces Food Intake and Modulates Food-Related Memory Processing
Neuropsychopharmacology
2011
The physiological control of eating: signals, neurons, and networks
Physiological Reviews
2022
Astrocytes Regulate GLP-1 Receptor-Mediated Effects on Energy Balance
The Journal of Neuroscience
2016
Homeostatic and non-homeostatic controls of feeding behavior: Distinct vs. common neural systems
Physiology & Behavior
2018
Comparative Effects of the Long‐Acting GLP‐1 Receptor Ligands, Liraglutide and Exendin‐4, on Food Intake and Body Weight Suppression in Rats
Obesity
2011
Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways
eLife
2015
Hippocampal lesions impair retention of discriminative responding based on energy state cues.
Behavioral Neuroscience
2010
Early-Life Sugar Consumption Affects the Rat Microbiome Independently of Obesity
The Journal of Nutrition
2017
Lateral hypothalamic GLP-1 receptors are critical for the control of food reinforcement, ingestive behavior and body weight
Molecular Psychiatry
2017
Prenatal and early life exposure to air pollution induced hippocampal vascular leakage and impaired neurogenesis in association with behavioral deficits
Translational Psychiatry
2018
Control of Feeding Behavior by Cerebral Ventricular Volume Transmission of Melanin-Concentrating Hormone
Cell Metabolism
2018
A hippocampus to prefrontal cortex neural pathway inhibits food motivation through glucagon-like peptide-1 signaling
Molecular Psychiatry
2017
The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
2011
Incretins and Amylin: Neuroendocrine Communication Between the Gut, Pancreas, and Brain in Control of Food Intake and Blood Glucose
Annual Review of Nutrition
2014
Hindbrain leptin and glucagon-like-peptide-1 receptor signaling interact to suppress food intake in an additive manner
International Journal of Obesity
2012
Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity
Molecular Metabolism
2018
Early life exposure to obesogenic diets and learning and memory dysfunction
Current Opinion in Behavioral Sciences
2016
Cognitive and neuronal systems underlying obesity
Physiology & Behavior
2012
Hypothalamus-hippocampus circuitry regulates impulsivity via melanin-concentrating hormone
Nature Communications
2019
Ghrelin Signaling Affects Feeding Behavior, Metabolism, and Memory through the Vagus Nerve
Current Biology
2020
Early-life sugar consumption has long-term negative effects on memory function in male rats
Nutritional Neuroscience
2017
Gut microbial taxa elevated by dietary sugar disrupt memory function
Translational Psychiatry
2021
Western Diet Consumption During Development: Setting the Stage for Neurocognitive Dysfunction
Frontiers in Neuroscience
2021
Ghrelin: A link between memory and ingestive behavior
Physiology & Behavior
2016
Ghrelin and Orexin Interact to Increase Meal Size Through a Descending Hippocampus to Hindbrain Signaling Pathway
Biological Psychiatry
2020
Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
2011
Leptin Signaling in the Medial Nucleus Tractus Solitarius Reduces Food Seeking and Willingness to Work for Food
Neuropsychopharmacology
2013
Protein-tyrosine Phosphatase 1B (PTP1B) Is a Novel Regulator of Central Brain-derived Neurotrophic Factor and Tropomyosin Receptor Kinase B (TrkB) Signaling
Journal of Biological Chemistry
2014
The interoceptive cue properties of ghrelin generalize to cues produced by food deprivation
Peptides
2005
Regulation of Memory Function by Feeding-Relevant Biological Systems: Following the Breadcrumbs to the Hippocampus
Frontiers in Molecular Neuroscience
2019
Glucagon-Like Peptide-1 Receptor Signaling in the Lateral Dorsal Tegmental Nucleus Regulates Energy Balance
Neuropsychopharmacology
2017
Phasic dopamine responses to a food-predictive cue are suppressed by the glucagon-like peptide-1 receptor agonist Exendin-4
Physiology & Behavior
2020
Amylin Acts in the Lateral Dorsal Tegmental Nucleus to Regulate Energy Balance Through Gamma-Aminobutyric Acid Signaling
Biological Psychiatry
2017
Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals
American Journal of Physiology-Endocrinology and Metabolism
2012
Hippocampus ghrelin receptor signaling promotes socially-mediated learned food preference
Neuropharmacology
2018
Correction: Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE
Molecular Psychiatry
2023
Food cue reactivity: Neurobiological and behavioral underpinnings
Reviews in Endocrine and Metabolic Disorders
2022
Ghrelin's control of food reward and body weight in the lateral hypothalamic area is sexually dimorphic
Physiology & Behavior
2017
TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin
American Journal of Physiology-Endocrinology and Metabolism
2012
The gut-brain axis and cognitive control: A role for the vagus nerve
Seminars in Cell & Developmental Biology
2024
Memory and eating: A bidirectional relationship implicated in obesity
Neuroscience & Biobehavioral Reviews
2022
Interoceptive “satiety” signals produced by leptin and CCK
Peptides
2007
Oxytocin and Food Intake Control: Neural, Behavioral, and Signaling Mechanisms
International Journal of Molecular Sciences
2021
Liraglutide, leptin and their combined effects on feeding: additive intake reduction through common intracellular signalling mechanisms
Diabetes, Obesity and Metabolism
2015
Ghrelin and Glucagon-Like Peptide-1: A Gut-Brain Axis Battle for Food Reward
Nutrients
2021
Nucleus accumbens melanin-concentrating hormone signaling promotes feeding in a sex-specific manner
Neuropharmacology
2020
Sex Differences and Estrous Influences on Oxytocin Control of Food Intake
Neuroscience
2020
Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency
American Journal of Physiology-Endocrinology and Metabolism
2012
Melanin-concentrating hormone and food intake control: Sites of action, peptide interactions, and appetition
Peptides
2021
Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure
American Journal of Physiology-Endocrinology and Metabolism
2011
Hypothalamic melanin-concentrating hormone neurons integrate food-motivated appetitive and consummatory processes in rats
Nature Communications
2023
Hindbrain GLP-1 receptor mediation of cisplatin-induced anorexia and nausea
Physiology & Behavior
2016
Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling
Brain, Behavior, and Immunity
2024
Early-life low-calorie sweetener consumption disrupts glucose regulation, sugar-motivated behavior, and memory function in rats
JCI Insight
2022
Ventral hippocampus-lateral septum circuitry promotes foraging-related memory
Cell Reports
2022
Central oxytocin signaling inhibits food reward-motivated behaviors and VTA dopamine responses to food-predictive cues in male rats
Hormones and Behavior
2020
Early life Western diet-induced memory impairments and gut microbiome changes in female rats are long-lasting despite healthy dietary intervention
Nutritional Neuroscience
2021
Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats
Nature Communications
2022
Stable potassium isotopes (41K/39K) track transcellular and paracellular potassium transport in biological systems
Frontiers in Physiology
2022
Amylin Modulates a Ventral Tegmental Area–to–Medial Prefrontal Cortex Circuit to Suppress Food Intake and Impulsive Food-Directed Behavior
Biological Psychiatry
2024
Neurokinin B-Expressing Neurons of the Central Extended Amygdala Mediate Inhibitory Synaptic Input onto Melanin-Concentrating Hormone Neuron Subpopulations
The Journal of Neuroscience
2021
Obesity, Western Diet Intake, and Cognitive Impairment
Omega-3 Fatty Acids in Brain and Neurological Health
2014
Early-life influences of low-calorie sweetener consumption on sugar taste
Physiology & Behavior
2023
Early Life Low-Calorie Sweetener Consumption Impacts Energy Balance during Adulthood
Nutrients
2022
Hippocampus Oxytocin Signaling Promotes Prosocial Eating in Rats
Biological Psychiatry
2025
Western Diet and Cognitive Impairment
Diet and Nutrition in Dementia and Cognitive Decline
2015
Separate orexigenic hippocampal ensembles shape dietary choice by enhancing contextual memory and motivation
Nature Metabolism
2025
Early- but not late-adolescent Western diet consumption programs for long-lasting memory impairments in male but not female rats
Appetite
2024
ATLAS: a rationally designed anterograde transsynaptic tracer
Nature Methods
2025
Proceedings from the Albert Charitable Trust Inaugural Workshop on ‘Understanding the Acute Effects of Exercise on the Brain’
Brain Plasticity
2022
Food Hedonics
Neuroendocrinology of Appetite
2016
Oxytocin neurons in the paraventricular and supraoptic hypothalamic nuclei bidirectionally modulate food intake
Molecular Metabolism
2025
Ventral hippocampus neurons encode meal-related memory
Nature Communications
2025
Early life consumption of a "processed" diet high in advanced glycation end products impairs memory function and alters the gut microbiome in rats
Physiology
2024
Lasting effects of low-calorie sweeteners on glucose regulation, sugar intake, and memory
Unknown Venue
2021
Vagal afferent nerve ghrelin signaling influences energy balance and episodic memory
The FASEB Journal
2020
Glucagon-like peptide-1 receptor (GLP-1R) signaling in the ventral hippocampus reduces feeding via monosynaptic communication to the medial prefrontal cortex (mPFC)
Molecular Psychiatry
2018
Early life food insecurity in male rats impairs memory function during adulthood
Appetite
2025
The vagus nerve promotes memory via septo-hippocampal acetylcholine: Implications for obesity-induced cognitive dysfunction
Unknown Venue
2025

Education

University of Illinois at Urbana-Champaign

B.S. in Psychology, Psychology / 2000

Purdue University

M.S. in Psychology, Psychology / 2006

Purdue University

Ph.D. in Psychology, Psychology / 2009

University of Pennsylvania

Postdoctoral Fellow, Psychology / 2012

Experience

University of Southern California

Professor / January, 2013Present

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