Jonathan Moore

Genome edit designer

Norwich

Research Expertise

Data science
Genome editing
Bioinformatics
Evolution
Biodiversity
Cell Biology
Plant Science
Physiology (medical)
Physiology
Endocrinology, Diabetes and Metabolism
Virology
Genetics
Molecular Biology
Immunology
Microbiology
Parasitology
Developmental Biology
Molecular Medicine
Biotechnology
Biomedical Engineering
Applied Microbiology and Biotechnology
Bioengineering
Nutrition and Dietetics
Genetics (clinical)
Ecology, Evolution, Behavior and Systematics
Agronomy and Crop Science
Computational Mathematics
Computational Theory and Mathematics
Computer Science Applications
Statistics and Probability
Applied Mathematics
Structural Biology
Infectious Diseases

Legacy Map

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Publications

Evidence for Network Evolution in an Arabidopsis Interactome Map
Science
2011
High-Resolution Temporal Profiling of Transcripts during Arabidopsis Leaf Senescence Reveals a Distinct Chronology of Processes and Regulation    
The Plant Cell
2011
Independently Evolved Virulence Effectors Converge onto Hubs in a Plant Immune System Network
Science
2011
Transcriptome and methylome profiling reveals relics of genome dominance in the mesopolyploid Brassica oleracea
Genome Biology
2014
Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice
American Journal of Physiology-Endocrinology and Metabolism
2014
Arabidopsis Defense against Botrytis cinerea: Chronology and Regulation Deciphered by High-Resolution Temporal Transcriptomic Analysis    
The Plant Cell
2012
A Virulent Strain of Deformed Wing Virus (DWV) of Honeybees (Apis mellifera) Prevails after Varroa destructor-Mediated, or In Vitro, Transmission
PLoS Pathogens
2014
Uterine Selection of Human Embryos at Implantation
Scientific Reports
2014
A local regulatory network around three NAC transcription factors in stress responses and senescence in Arabidopsis leaves
The Plant Journal
2013
Loss of Endometrial Plasticity in Recurrent Pregnancy Loss
Stem Cells
2015
The dynamic architecture of the metabolic switch in Streptomyces coelicolor
BMC Genomics
2010
Tracing the ancestry of modern bread wheats
Nature Genetics
2019
Recombinants between Deformed wing virus and Varroa destructor virus-1 may prevail in Varroa destructor-infested honeybee colonies
Journal of General Virology
2010
Transcriptional Dynamics Driving MAMP-Triggered Immunity and Pathogen Effector-Mediated Immunosuppression in Arabidopsis Leaves Following Infection with Pseudomonas syringae pv tomato DC3000
The Plant Cell
2015
The CACTA transposon Bot1 played a major role in Brassica genome divergence and gene proliferation
The Plant Journal
2008
Metabolic Switches and Adaptations Deduced from the Proteomes of Streptomyces coelicolor Wild Type and phoP Mutant Grown in Batch Culture
Molecular & Cellular Proteomics
2012
Developing genetic resources for pre-breeding in Brassica oleracea L.: an overview of the UK perspective
Journal of Plant Biotechnology
2012
CWRIS: an information management system to aid crop wild relative conservation and sustainable use.
Crop wild relative conservation and use
2007
Enhancing Data Integration with Text Analysis to Find Proteins Implicated in Plant Stress Response
Journal of Integrative Bioinformatics
2010
Biotechnology and Genomics: Exploiting the Potential of CWR
Crop Wild Relatives and Climate Change
2015
Genomics and biochemical analyses reveal a metabolon key to β-L-ODAP biosynthesis in Lathyrus sativus
Nature Communications
2023
Evolutionarily related Sacbrood virus and Deformed wing virus evoke different transcriptional responses in the honeybee which may facilitate horizontal or vertical transmission of these viruses
Unknown Venue
2015
Field cancerisation in colorectal cancer: Characterisation of the gene expression profile of the mucosal field around colorectal cancers and polyps
International Journal of Surgery
2016
PWE-254 Is the macroscopically normal mucosa (MNM) around colorectal cancer really ‘normal’?: Abstract PWE-254 Table 1
Gut
2015
Vitamin B12 deficiency alters adipogenesis and associated microRNA's in human adipocytes
Endocrine Abstracts
2015
Vitamin B12 and folate imbalance induces cholesterol synthesis and endoplasmic reticulum stress in human adipocytes
Endocrine Abstracts
2013
Unified establishment and epigenetic inheritance of DNA methylation through cooperative MET1 activity
Unknown Venue
2022
Generated Randomly and Selected Functionally? The Nature of Enterovirus Recombination
Viruses
2022
The Evolutionary History of Wild, Domesticated, and FeralBrassica oleracea(Brassicaceae)
Unknown Venue
2021
Epigenetic inheritance mediates phenotypic diversity in natural populations
Unknown Venue
2021
Identification of microbial signatures linked to oilseed rape yield decline at the landscape scale
Microbiome
2021
The Evolutionary History of Wild, Domesticated, and Feral Brassica oleracea (Brassicaceae)
Molecular Biology and Evolution
2021
Time‐series transcriptomics reveals a BBX32‐directed control of acclimation to high light in mature Arabidopsis leaves
The Plant Journal
2021
Time series transcriptomics reveals aBBX32-directed control of dynamic acclimation to high light in matureArabidopsisleaves
Unknown Venue
2020
Generated randomly and selected functionally? The nature of enterovirus recombination
Unknown Venue
2020
A draft genome of grass pea (Lathyrus sativus), a resilient diploid legume
Unknown Venue
2020
DNA Methylation and Histone H1 Jointly Repress Transposable Elements and Aberrant Intragenic Transcripts
Molecular Cell
2020
DNA methylation and histone H1 cooperatively repress transposable elements and aberrant intragenic transcripts
Unknown Venue
2019
Differential expression of Lp-PLA2 in obesity and type 2 diabetes and the influence of lipids
Diabetologia
2018
Changes in Gene Expression in Space and Time Orchestrate Environmentally Mediated Shaping of Root Architecture
The Plant Cell
2017
The transcription factor Maf-S regulates metabolic resistance to insecticides in the malaria vector Anopheles gambiae
BMC Genomics
2017
The ‘known’ genetic potential for microbial communities to degrade organic phosphorus is reduced in low‐pH soils
MicrobiologyOpen
2017
Identification of extracellular glycerophosphodiesterases in Pseudomonas and their role in soil organic phosphorus remineralisation
Scientific Reports
2017
BTB-BACK Domain Protein POB1 Suppresses Immune Cell Death by Targeting Ubiquitin E3 ligase PUB17 for Degradation
PLOS Genetics
2017
Towards new sources of resistance to the currant-lettuce aphid (Nasonovia ribisnigri)
Molecular Breeding
2017
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis
Nature Communications
2016
Comparative genomic, proteomic and exoproteomic analyses of three Pseudomonas strains reveals novel insights into the phosphorus scavenging capabilities of soil bacteria
Environmental Microbiology
2016
The Iflaviruses Sacbrood virus and Deformed wing virus evoke different transcriptional responses in the honeybee which may facilitate their horizontal or vertical transmission
PeerJ
2016
Prediction of human population responses to toxic compounds by a collaborative competition
Nature Biotechnology
2015
A Randomized Trial of Progesterone in Women with Recurrent Miscarriages
New England Journal of Medicine
2015
The clock protein period 2 synchronizes mitotic expansion and decidual transformation of human endometrial stromal cells
The FASEB Journal
2015
Time-Series Transcriptomics Reveals That AGAMOUS-LIKE22 Affects Primary Metabolism and Developmental Processes in Drought-Stressed Arabidopsis
The Plant Cell
2016
Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes
Clinical Epigenetics
2015
Decidualization Induces a Secretome Switch in Perivascular Niche Cells of the Human Endometrium
Endocrinology
2014
MosaicSolver: a tool for determining recombinants of viral genomes from pileup data
Nucleic Acids Research
2014
Assessment of myometrial transcriptome changes associated with spontaneous human labour by high‐throughput RNA‐seq
Experimental Physiology
2014
Dissecting the organ specificity of insecticide resistance candidate genes in Anopheles gambiae: known and novel candidate genes
BMC Genomics
2014
BAI3, CDX2 and VIL1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas
Histopathology
2013
Multiple copies of eukaryotic translation initiation factors in Brassica rapa facilitate redundancy, enabling diversification through variation in splicing and broad‐spectrum virus resistance
The Plant Journal
2013
Genetic regulation of glucoraphanin accumulation in Beneforté® broccoli
New Phytologist
2013
MEME-LaB: motif analysis in clusters
Bioinformatics
2013
Making open data work for plant scientists
Journal of Experimental Botany
2013
Archaeogenomic Evidence of Punctuated Genome Evolution in Gossypium
Molecular Biology and Evolution
2012
Conserved Noncoding Sequences Highlight Shared Components of Regulatory Networks in Dicotyledonous Plants
The Plant Cell
2012
MCMC-ODPR: Primer design optimization using Markov Chain Monte Carlo sampling
BMC Bioinformatics
2012
Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor
BMC Genomics
2010
Archaeogenetic Evidence of Ancient Nubian Barley Evolution from Six to Two-Row Indicates Local Adaptation
PLoS ONE
2009
CWRML: representing crop wild relative conservation and use data in XML
BMC Bioinformatics
2008
TreeMos: a high-throughput phylogenomic approach to find and visualize phylogenetic mosaicism
Bioinformatics
2008
The Genomic Organization of Retrotransposons in Brassica oleracea
Plant Molecular Biology
2005

Education

University of Warwick

PhD Bioinformatics, Wellesbourne / June, 2007

Coventry

University of Birmingham

MSc Conservation and Utilisation of Plant Genetic Resources, Biology / June, 2003

Birmingham

Sheffield Hallam University Sheffield Business School

PGCert Enterprise and Network Management / June, 1996

Sheffield

University of Sheffield

B.eng Electronic and Electrical Engineering, Engineering / June, 1985

Sheffield

Experience

Tropic Biosciences

Bioinformatician / July, 2021Present

John Innes Centre

Research Bioinformatics Specialist / September, 2017June, 2021

Earlham Institute

Bioinformatics Manager / November, 2015August, 2017

University of Warwick

Senior Research Fellow in Bioinformatics / March, 2008October, 2015

PDRA Ancient DNA Bioinformatics / 2006March, 2008

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