Michael Matthias, PhD

Senior Research Scientist

Research Expertise

Leptospirosis
Leptospira pathogenesis
Microbial Ecology
Evolution
Microbiology
Infectious Diseases
Virology
Parasitology
Public Health, Environmental and Occupational Health
Microbiology (medical)
Immunology
Molecular Biology
Immunology and Allergy
Cancer Research
Oncology
Genetics
Ecology, Evolution, Behavior and Systematics
Biotechnology
Biochemistry

Publications

Leptospirosis: a zoonotic disease of global importance
The Lancet Infectious Diseases
2003
Fecal Markers of Intestinal Inflammation and Permeability Associated with the Subsequent Acquisition of Linear Growth Deficits in Infants
The American Journal of Tropical Medicine and Hygiene
2013
What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira
PLOS Neglected Tropical Diseases
2016
Clinical Spectrum of Pulmonary Involvement in Leptospirosis in a Region of Endemicity, with Quantification of Leptospiral Burden
Clinical Infectious Diseases
2005
Determining Risk for Severe Leptospirosis by Molecular Analysis of Environmental Surface Waters for Pathogenic Leptospira
PLoS Medicine
2006
Human Leptospirosis Caused by a New, Antigenically Unique Leptospira Associated with a Rattus Species Reservoir in the Peruvian Amazon
PLoS Neglected Tropical Diseases
2008
Asymptomatic Renal Colonization of Humans in the Peruvian Amazon by Leptospira
PLoS Neglected Tropical Diseases
2010
Toll-Like Receptor 4 Protects against LethalLeptospira interrogansSerovar Icterohaemorrhagiae Infection and Contributes to In Vivo Control of Leptospiral Burden
Infection and Immunity
2006
Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri Lanka
Clinical Infectious Diseases
2012
Leptospiral Pathogenomics
Pathogens
2014
DIVERSITY OF BAT-ASSOCIATED LEPTOSPIRA IN THE PERUVIAN AMAZON INFERRED BY BAYESIAN PHYLOGENETIC ANALYSIS OF 16S RIBOSOMAL DNA SEQUENCES
The American Journal of Tropical Medicine and Hygiene
2005
Leptospira interrogansActivation of Human Peripheral Blood Mononuclear Cells: Preferential Expansion of TCRγδ+ T Cells vs TCRαβ+ T Cells
The Journal of Immunology
2003
Whole Genome Analysis of Leptospira licerasiae Provides Insight into Leptospiral Evolution and Pathogenicity
PLoS Neglected Tropical Diseases
2012
Real-Time PCR Reveals Rapid Dissemination of Leptospira interrogans after Intraperitoneal and Conjunctival Inoculation of Hamsters
Infection and Immunity
2016
Regional Differences of Leptospirosis in Sri Lanka: Observations from a Flood-Associated Outbreak in 2011
PLoS Neglected Tropical Diseases
2014
Keloids: Current Therapies in Barbados
West Indian Medical Journal
2016
Pathogenomic Inference of Virulence-Associated Genes in Leptospira interrogans
PLoS Neglected Tropical Diseases
2013
Comparative analysis of lipopolysaccharides of pathogenic and intermediately pathogenic Leptospira species
BMC Microbiology
2015
Utility and Limitations of Direct Multi-Locus Sequence Typing on qPCR-Positive Blood to Determine Infecting Leptospira Strain
The American Journal of Tropical Medicine and Hygiene
2013
Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer
BMC Cancer
2017
Proteomic Analysis of Urine Exosomes Reveals Renal Tubule Response to Leptospiral Colonization in Experimentally Infected Rats
PLOS Neglected Tropical Diseases
2015
Expression of sialic acids and other nonulosonic acids in Leptospira
BMC Microbiology
2012
12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka
PLOS Neglected Tropical Diseases
2021
A Foodborne Outbreak of Brucellosis at a Police Station Cafeteria, Lima, Peru
The American Journal of Tropical Medicine and Hygiene
2013
High Degree of Plasmodium vivax Diversity in the Peruvian Amazon Demonstrated by Tandem Repeat Polymorphism Analysis
The American Journal of Tropical Medicine and Hygiene
2012
Optimizing the microscopic agglutination test (MAT) panel for the diagnosis of Leptospirosis in a low resource, hyper-endemic setting with varied microgeographic variation in reactivity
PLOS Neglected Tropical Diseases
2021
Current trends in translational research in leptospirosis
Current Opinion in Infectious Diseases
2013
Suburban Leptospirosis: Atypical Lymphocytosis and  -  T Cell Response
Clinical Infectious Diseases
2006
Whole Genome Shotgun Sequencing Shows Selection on Leptospira Regulatory Proteins During in vitro Culture Attenuation
The American Journal of Tropical Medicine and Hygiene
2016
Diagnostic method-based underestimation of leptospirosis in clinical and research settings; an experience from a large prospective study in a high endemic setting
PLOS Neglected Tropical Diseases
2022
Pathogenic Leptospira Evolved a Unique Gene Family Comprised of Ricin B-Like Lectin Domain-Containing Cytotoxins
Frontiers in Microbiology
2022
Complete Genome Sequence of Leptospira interrogans Strains FMAS_KW1, FMAS_KW2 and FMAS_AW1 Isolated from Leptospirosis Patients from Karawanalla and Awissawella, Sri Lanka
Journal of Genomics
2020
Serological and molecular epidemiology of leptospirosis and the role of dogs as sentinel for human infection in Nigeria
Heliyon
2022
Culture-Independent Detection and Identification of Leptospira Serovars
Unknown Venue
2022
Complete genome sequences of twelve strains of Leptospira interrogans isolated from humans in Sri Lanka
Infection, Genetics and Evolution
2023
Demographic, exposure, clinical, biochemical and diagnostic data of febrile patients recruited for the largest field study on leptospirosis in Sri Lanka
Data in Brief
2022
Experimental Infection of Rattus norvegicus by the Group II Intermediate Pathogen, Leptospira licerasiae
The American Journal of Tropical Medicine and Hygiene
2018
Correction: Proteomic Analysis of Urine Exosomes Reveals Renal Tubule Response to Leptospiral Colonization in Experimentally Infected Rats
PLOS Neglected Tropical Diseases
2015
Clinical spectrum of endemic leptospirosis in relation to cytokine response
PLOS ONE
2021
Differentiation of Leptospira species and serovars by PCR-restriction endonuclease analysis, arbitrarily primed PCR and low-stringency PCR
Journal of Medical Microbiology
1997
Whole genome sequencing data of Leptospira weilii and Leptospira kirschneri isolated from human subjects of Sri Lanka
Data in Brief
2024
Novel R-type Lectin Domain-Containing Cytotoxins Comprise a Family of Virulence-Modifying Proteins in PathogenicLeptospira
Unknown Venue
2020
Clinical Case Report of Suspected Fulminating Leptospirosis In A 4‐Months Old Caucasian Dog And Molecular Detection of Pathogenic Leptospira In Canine In Northwestern Nigeria: Public Health Significance And Ramifications
The FASEB Journal
2018
A High Resolution Melting Point Analysis Based Simplex PCR Assay Enables Reliable Identification of Clinically Relevant Candida Species
Unknown Venue
2018
Microgeographical Differences of Plasmodium vivax Relapse and Re-Infection in the Peruvian Amazon
The American Journal of Tropical Medicine and Hygiene
2013
Quantification of Pathogenic Leptospira in Surface Waters Explains Urban Predominance of Severe Human Leptospirosis in the Peruvian Amazon
Journal of Investigative Medicine
2006
Correction: Correction: Proteomic Analysis of Urine Exosomes Reveals Renal Tubule Response to Leptospiral Colonization in Experimentally Infected Rats
PLOS Neglected Tropical Diseases
2015
Albendazole versus Praziquantel in the Treatment of Neurocysticercosis: A Meta-analysis of Comparative Trials
PLoS Neglected Tropical Diseases
2008

Education

University of the West Indies

PhD, Biomedical Sciences / May, 2003

Cave Hill
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