Olivier Saulnier

The Hospital for Sick Children

Research Expertise

Neurology (clinical)
Cancer Research
Oncology
Genetics
Cell Biology
Molecular Biology
Molecular Medicine

Publications

Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes
Neurology
2014
Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution
Cell Reports
2020
EPEN-52. METABOLIC REGULATION OF THE EPIGENOME DRIVES LETHAL INFANTILE EPENDYMOMA
Neuro-Oncology
2020
scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy
Nature Communications
2019
TCF12 is mutated in anaplastic oligodendroglioma
Nature Communications
2015
Unified rhombic lip origins of group 3 and group 4 medulloblastoma
Nature
2022
A neurodevelopmental epigenetic programme mediated by SMARCD3–DAB1–Reelin signalling is hijacked to promote medulloblastoma metastasis
Nature Cell Biology
2023
Hedgehog target genes regulate lipid metabolism to drive basal cell carcinoma and medulloblastoma
Unknown Venue
2023
MDB-21. THE OTX2-REGULATED ALTERNATIVE SPLICING LANDSCAPE CONTROLS DIFFERENTIATION AND RECONSTITUTES THE DEVELOPMENTAL ORIGINS OF GROUP 3 MEDULLOBLASTOMA
Neuro-Oncology
2023
BIOL-23. LOSS OF MICRORNAS COOPERATES WITH TUMOR SUPPRESSORS TO INITIATE MYC-DEPENDENT METASTATIC MEDULLOBLASTOMA
Neuro-Oncology
2023
Abstract IA009: Oncogenic transcription factors drive highly tumor-specific LincRNA
Clinical Cancer Research
2022
The LIN28B–let‐7–PBK pathway is essential for group 3 medulloblastoma tumor growth and survival
Molecular Oncology
2023
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma
Cancer Discovery
2023
Author Correction: Failure of human rhombic lip differentiation underlies medulloblastoma formation
Nature
2022
Failure of human rhombic lip differentiation underlies medulloblastoma formation
Nature
2022
Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression
Communications Biology
2022
Enhancement of mitochondrial function fosters B cell immune memory
Unknown Venue
2022
Author Correction: scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy
Nature Communications
2022
Oncogenic chimeric transcription factors drive tumor-specific transcription, processing, and translation of silent genomic regions
Molecular Cell
2022
Hijacking a neurodevelopmental epigenomic program in metastatic dissemination of medulloblastoma
Unknown Venue
2022
ERG transcription factors have a splicing regulatory function involving RBFOX2 that is altered in the EWS-FLI1 oncogenic fusion
Nucleic Acids Research
2021
An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate
Nature Communications
2020
Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma
Cell
2020
ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin
Nucleic Acids Research
2020
Transcriptional programs define intratumoral heterogeneity of Ewing sarcoma at single cell resolution
Unknown Venue
2019

Experience

Hospital for Sick Children

Postdoctoral fellow / 2019Present

Institut Curie

PhD student / 20152019

Institute of Cancer Research

Internship / 20142015

Institut du cerveau et de la moelle épinière

Internship / 20122013

Links & Social Media

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