Dr. Kevin Pawlak, Ph.D.

Xavier University School of Medicine

Research Expertise

endocrinology
steroid
medical education
Cell Biology
Molecular Biology
Biochemistry
Clinical Biochemistry
Molecular Medicine
Endocrinology, Diabetes and Metabolism
Pharmacology
Biophysics

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Publications

Mitochondria-associated Endoplasmic Reticulum Membrane (MAM) Regulates Steroidogenic Activity via Steroidogenic Acute Regulatory Protein (StAR)-Voltage-dependent Anion Channel 2 (VDAC2) Interaction
Journal of Biological Chemistry
2015
Mitochondrial metabolic regulation by GRP78
Science Advances
2017
The role of progesterone metabolites in breast cancer: Potential for new diagnostics and therapeutics
The Journal of Steroid Biochemistry and Molecular Biology
2005
Inner Mitochondrial Translocase Tim50 Interacts with 3β-Hydroxysteroid Dehydrogenase Type 2 to Regulate Adrenal and Gonadal Steroidogenesis
Journal of Biological Chemistry
2011
Regulation of estrogen receptor (ER) levels in MCF-7 cells by progesterone metabolites
The Journal of Steroid Biochemistry and Molecular Biology
2007
Membrane 5α-pregnane-3,20-dione (5αP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5αP and down-regulated by the progesterone metabolites, 3α-dihydroprogesterone and 20α-dihydroprogesterone, with associated changes in cell proliferation and detachment
The Journal of Steroid Biochemistry and Molecular Biology
2005
An Outer Mitochondrial Translocase, Tom22, Is Crucial for Inner Mitochondrial Steroidogenic Regulation in Adrenal and Gonadal Tissues
Molecular and Cellular Biology
2016
Mechanism of action of the breast cancer-promoter hormone, 5α-dihydroprogesterone (5αP), involves plasma membrane-associated receptors and MAPK activation
The Journal of Steroid Biochemistry and Molecular Biology
2016
Decreased CytochromecOxidase IV Expression Reduces Steroidogenesis
Journal of Pharmacology and Experimental Therapeutics
2011
Plasma Membrane Receptors for the Cancer-Regulating Progesterone Metabolites, 5α-Pregnane-3,20-dione and 3α-Hydroxy-4-pregnen-20-one in MCF-7 Breast Cancer Cells
Biochemical and Biophysical Research Communications
2000

Education

University of Western Ontario

PhD, Biology (Physiology) / October, 2008

London, Ontario, Canada

Experience

Xavier University School of Medicine

Associate Professor of Physiology / April, 2017Present

Dean of Pre-Health Sciences / July, 2019Present

Zirve University School of Medicine

Assistant Professor / September, 2014June, 2016

Mercer University School of Medicine

Post Doctoral Fellow / August, 2008June, 2014

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