Dushani L. Palliyaguru, Ph.D.
Toxicologist | Aging, Nutrition and Metabolism Research Scientist | Systems Biologist
Research Expertise
About
Publications
Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane
Seminars in Oncology / Feb 01, 2016
Yang, L., Palliyaguru, D. L., & Kensler, T. W. (2016). Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane. Seminars in Oncology, 43(1), 146–153. https://doi.org/10.1053/j.seminoncol.2015.09.013
Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling
Molecular and Cellular Biology / Feb 15, 2014
Wakabayashi, N., Skoko, J. J., Chartoumpekis, D. V., Kimura, S., Slocum, S. L., Noda, K., Palliyaguru, D. L., Fujimuro, M., Boley, P. A., Tanaka, Y., Shigemura, N., Biswal, S., Yamamoto, M., & Kensler, T. W. (2014). Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling. Molecular and Cellular Biology, 34(4), 653–663. https://doi.org/10.1128/mcb.01408-13
Isothiocyanates: Translating the Power of Plants to People
Molecular Nutrition & Food Research / Mar 26, 2018
Palliyaguru, D. L., Yuan, J.-M., Kensler, T. W., & Fahey, J. W. (2018). Isothiocyanates: Translating the Power of Plants to People. Molecular Nutrition & Food Research, 62(18), 1700965. Portico. https://doi.org/10.1002/mnfr.201700965
Withania somnifera : From prevention to treatment of cancer
Molecular Nutrition & Food Research / Jan 29, 2016
Palliyaguru, D. L., Singh, S. V., & Kensler, T. W. (2016). Withania somnifera : From prevention to treatment of cancer. Molecular Nutrition & Food Research, 60(6), 1342–1353. Portico. https://doi.org/10.1002/mnfr.201500756
Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms
Free Radical Biology and Medicine / Dec 01, 2016
Palliyaguru, D. L., Chartoumpekis, D. V., Wakabayashi, N., Skoko, J. J., Yagishita, Y., Singh, S. V., & Kensler, T. W. (2016). Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms. Free Radical Biology and Medicine, 101, 116–128. https://doi.org/10.1016/j.freeradbiomed.2016.10.003
Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions
Mechanisms of Ageing and Development / Jun 01, 2019
Palliyaguru, D. L., Moats, J. M., Di Germanio, C., Bernier, M., & de Cabo, R. (2019). Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions. Mechanisms of Ageing and Development, 180, 42–48. https://doi.org/10.1016/j.mad.2019.03.005
Global geographical overlap of aflatoxin and hepatitis C: controlling risk factors for liver cancer worldwide
Food Additives & Contaminants: Part A / Mar 01, 2013
Palliyaguru, D. L., & Wu, F. (2013). Global geographical overlap of aflatoxin and hepatitis C: controlling risk factors for liver cancer worldwide. Food Additives & Contaminants: Part A, 30(3), 534–540. https://doi.org/10.1080/19440049.2012.751630
Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice
American Journal of Physiology-Endocrinology and Metabolism / Aug 01, 2018
Chartoumpekis, D. V., Palliyaguru, D. L., Wakabayashi, N., Fazzari, M., Khoo, N. K. H., Schopfer, F. J., Sipula, I., Yagishita, Y., Michalopoulos, G. K., O’Doherty, R. M., & Kensler, T. W. (2018). Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice. American Journal of Physiology-Endocrinology and Metabolism, 315(2), E180–E195. https://doi.org/10.1152/ajpendo.00311.2017
Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice
Molecular Metabolism / Jul 01, 2015
Chartoumpekis, D. V., Palliyaguru, D. L., Wakabayashi, N., Khoo, N. K. H., Schoiswohl, G., O’Doherty, R. M., & Kensler, T. W. (2015). Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice. Molecular Metabolism, 4(7), 543–550. https://doi.org/10.1016/j.molmet.2015.04.004
Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice
JCI Insight / Mar 08, 2018
Chartoumpekis, D. V., Yagishita, Y., Fazzari, M., Palliyaguru, D. L., Rao, U. N. M., Zaravinos, A., Khoo, N. K. H., Schopfer, F. J., Weiss, K. R., Michalopoulos, G. K., Sipula, I., O’Doherty, R. M., Kensler, T. W., & Wakabayashi, N. (2018). Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice. JCI Insight, 3(5). https://doi.org/10.1172/jci.insight.97735
Study of Longitudinal Aging in Mice: Presentation of Experimental Techniques
The Journals of Gerontology: Series A / Dec 18, 2020
Palliyaguru, D. L., Vieira Ligo Teixeira, C., Duregon, E., di Germanio, C., Alfaras, I., Mitchell, S. J., Navas-Enamorado, I., Shiroma, E. J., Studenski, S., Bernier, M., Camandola, S., Price, N. L., Ferrucci, L., & de Cabo, R. (2020). Study of Longitudinal Aging in Mice: Presentation of Experimental Techniques. The Journals of Gerontology: Series A, 76(4), 552–560. https://doi.org/10.1093/gerona/glaa285
Fasting blood glucose as a predictor of mortality: Lost in translation
Cell Metabolism / Nov 01, 2021
Palliyaguru, D. L., Shiroma, E. J., Nam, J. K., Duregon, E., Vieira Ligo Teixeira, C., Price, N. L., Bernier, M., Camandola, S., Vaughan, K. L., Colman, R. J., Deighan, A., Korstanje, R., Peters, L. L., Dickinson, S. L., Ejima, K., Simonsick, E. M., Launer, L. J., Chia, C. W., Egan, J., … de Cabo, R. (2021). Fasting blood glucose as a predictor of mortality: Lost in translation. Cell Metabolism, 33(11), 2189-2200.e3. https://doi.org/10.1016/j.cmet.2021.08.013
Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet
The Journals of Gerontology: Series A / Jun 18, 2020
Palliyaguru, D. L., Minor, R. K., Mitchell, S. J., Palacios, H. H., Licata, J. J., Ward, T. M., Abulwerdi, G., Elliott, P., Westphal, C., Ellis, J. L., Sinclair, D. A., Price, N. L., Bernier, M., & de Cabo, R. (2020). Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet. The Journals of Gerontology: Series A, 75(11), 2037–2041. https://doi.org/10.1093/gerona/glaa148
Perinatal diet influences health and survival in a mouse model of leukemia
GeroScience / May 11, 2020
Palliyaguru, D. L., Rudderow, A. L., Sossong, A. M., Lewis, K. N., Younts, C., Pearson, K. J., Bernier, M., & de Cabo, R. (2020). Perinatal diet influences health and survival in a mouse model of leukemia. GeroScience, 42(4), 1147–1155. https://doi.org/10.1007/s11357-020-00199-9
Evaluation of 2-Thiothiazolidine-4-Carboxylic Acid, a Common Metabolite of Isothiocyanates, as a Potential Biomarker of Cruciferous Vegetable Intake
Molecular Nutrition & Food Research / Nov 22, 2018
Palliyaguru, D. L., Salvatore, S. R., Schopfer, F. J., Cheng, X., Zhou, J., Kensler, T. W., & Wendell, S. G. (2018). Evaluation of 2-Thiothiazolidine-4-Carboxylic Acid, a Common Metabolite of Isothiocyanates, as a Potential Biomarker of Cruciferous Vegetable Intake. Molecular Nutrition & Food Research, 63(3), 1801029. Portico. https://doi.org/10.1002/mnfr.201801029
Sulforaphane Diminishes the Formation of Mammary Tumors in Rats Exposed to 17β-Estradiol
Nutrients / Jul 30, 2020
Palliyaguru, D. L., Yang, L., Chartoumpekis, D. V., Wendell, S. G., Fazzari, M., Skoko, J. J., Liao, Y., Oesterreich, S., Michalopoulos, G. K., & Kensler, T. W. (2020). Sulforaphane Diminishes the Formation of Mammary Tumors in Rats Exposed to 17β-Estradiol. Nutrients, 12(8), 2282. https://doi.org/10.3390/nu12082282
Spontaneous chordoma: a case report on a female UM-HET3 mouse from the SLAM study
Aging Pathobiology and Therapeutics / Dec 31, 2020
Duregon, E., Ligo Teixeira, C. V., & de Cabo, R. (2020). Spontaneous chordoma: a case report on a female UM-HET3 mouse from the SLAM study. Aging Pathobiology and Therapeutics, 2(4), 219–222. https://doi.org/10.31491/apt.2020.12.043
Longitudinal Fasting Blood Glucose Trends and Mortality Risk in Mice Differs From That of Non-Human Primates and Humans
Innovation in Aging / Dec 01, 2020
de Cabo, R., Palliyaguru, D., Shiroma, E., Nam, J., & Ferrucci, L. (2020). Longitudinal Fasting Blood Glucose Trends and Mortality Risk in Mice Differs From That of Non-Human Primates and Humans. Innovation in Aging, 4(Supplement_1), 737–738. https://doi.org/10.1093/geroni/igaa057.2625
Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans
Innovation in Aging / Dec 01, 2020
Palliyaguru, D., Shiroma, E., Nam, J., Ferrucci, L., & de Cabo, R. (2020). Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans. Innovation in Aging, 4(Supplement_1), 518–518. https://doi.org/10.1093/geroni/igaa057.1672
Evaluation of 2-thiothiazolidine-4-carboxylic Acid, a Common Metabolite of Isothiocyanates as a Potential Biomarker of Cruciferous Vegetable Intake (P06-017-19)
Current Developments in Nutrition / Jun 01, 2019
Palliyaguru, D., Salvatore, S., Schopfer, F., Cheng, X., Zhou, J., & Wendell, S. (2019). Evaluation of 2-thiothiazolidine-4-carboxylic Acid, a Common Metabolite of Isothiocyanates as a Potential Biomarker of Cruciferous Vegetable Intake (P06-017-19). Current Developments in Nutrition, 3(Supplement_1). https://doi.org/10.1093/cdn/nzz031.p06-017-19
Education
University of Pittsburgh
Ph.D., Environmental and Occupational Health (Toxicology) / May, 2016
Clark University
B.A., Biochemistry and Molecular Biology, Mathematics / May, 2009
Experience
National Institute on Aging Intramural Research Program, Translational Gerontology Branch
IRTA Postdoctoral Fellow, K99/R00 Grant Recipient / September, 2018 — Present
-Leading, managing and coordinating large population longitudinal studies within US Federal Government and Industry partnerships - Successfully writing, submitting, and managing grants and manuscripts to ensure continuity of research initiatives -Hiring, mentoring, and supervising research fellows and technicians -Applying epidemiological, machine learning and data science methods to multi-omics data to characterize biomarkers of aging and aging-related diseases -Testing nutritional and pharmacological compounds for lifespan extension, and prevention of chronic diseases (eg. Alzheimer’s)
University of Pittsburgh, Department of Pharmacology and Chemical Biology
Postdoctoral Fellow / May, 2016 — September, 2018
Identified a novel urinary biomarker of cruciferous vegetable intake in cancer prevention clinical trials using liquid chromatography mass spectrometry -Led and managed project that showed broccoli-derived sulforaphane prevented breast cancer through altering gene expression and lipidomics profiles
Healthcare Ready
Health Policy Fellow / January, 2017 — January, 2018
-Synthesized data, mined literature and wrote Toolkits/ Issue Brief on “Pharmacy and Emergency Preparedness: A Landscape Analysis”
University of Pittsburgh, Department of Environmental and Occupational Health
Graduate Student Researcher / August, 2010 — May, 2016
-Identified gene and protein expression profiles and pharmacodynamic properties of novel chemopreventive compounds -Studied the global geographical overlap of liver cancer risk factors - aflatoxin exposure and hepatitis viruses with public health data -Evaluated the molecular basis of organ toxicity induced by acetaminophen, diquat and high fat diet and tested how interventions can prevent or minimize these toxicities
UMASS Medical School, Department of Pathology
Research Technician / May, 2009 — May, 2010
-Investigated the role of the immunoproteasome in antigen presentation in the adaptive immune system
UMASS Medical School, Department of Cancer Biology
Research Intern / May, 2007 — May, 2009
-Studied the role of insulin receptor substrate (IRS) in breast cancer metastasis in cell lines and tumors using bioinformatics software
Join Dushani on NotedSource!
Join Now
At NotedSource, we believe that professors, post-docs, scientists and other researchers have deep, untapped knowledge and expertise that can be leveraged to drive innovation within companies. NotedSource is committed to bridging the gap between academia and industry by providing a platform for collaboration with industry and networking with other researchers.
For industry, NotedSource identifies the right academic experts in 24 hours to help organizations build and grow. With a platform of thousands of knowledgeable PhDs, scientists, and industry experts, NotedSource makes connecting and collaborating easy.
For academic researchers such as professors, post-docs, and Ph.D.s, NotedSource provides tools to discover and connect to your colleagues with messaging and news feeds, in addition to the opportunity to be paid for your collaboration with vetted partners.
Expert Institutions
Proudly trusted by
