Regan Hamel

Senior bioinformatics scientist, specializing in single cell omics in the context of cellular reprogramming and neuroinflammation

Cambridge

Research Expertise

single cell biology
transcriptomics
Cellular and Molecular Neuroscience
Cell Biology
Developmental Biology
Immunology
Immunology and Allergy
Drug Discovery
Pharmacology
Genetics
Molecular Biology
Molecular Medicine
History and Philosophy of Science

About

Regan Hamel has an MPhil and PhD in Clinical Neurosciences from University of Cambridge. She also has a Bachelor of Science in Neurosciences from McGill University. Her PhD with Stefano Pluchino and John Marioni focused on single cell transcriptomics in the context of neuroinflammation. Since 2021 she has worked as a Bioinformatics scientist at Mogrify Ltd, applying a multitude of computational biology techniques (including single cell omics, bulk RNAseq, and predictive modelling) in the context of cell reprogramming

Publications

Harnessing the Neural Stem Cell Secretome for Regenerative Neuroimmunology

Frontiers in Cellular Neuroscience / Nov 05, 2020

Willis, C. M., Nicaise, A. M., Hamel, R., Pappa, V., Peruzzotti-Jametti, L., & Pluchino, S. (2020). Harnessing the Neural Stem Cell Secretome for Regenerative Neuroimmunology. Frontiers in Cellular Neuroscience, 14. https://doi.org/10.3389/fncel.2020.590960

Stem Cell Therapies for Progressive Multiple Sclerosis

Frontiers in Cell and Developmental Biology / Jul 09, 2021

Smith, J. A., Nicaise, A. M., Ionescu, R.-B., Hamel, R., Peruzzotti-Jametti, L., & Pluchino, S. (2021). Stem Cell Therapies for Progressive Multiple Sclerosis. Frontiers in Cell and Developmental Biology, 9. https://doi.org/10.3389/fcell.2021.696434

Characterization of Human iPSC-derived Spinal Motor Neurons by Single-cell RNA Sequencing

Neuroscience / Dec 01, 2020

Thiry, L., Hamel, R., Pluchino, S., Durcan, T., & Stifani, S. (2020). Characterization of Human iPSC-derived Spinal Motor Neurons by Single-cell RNA Sequencing. Neuroscience, 450, 57–70. https://doi.org/10.1016/j.neuroscience.2020.04.041

Metabolic Control of Smoldering Neuroinflammation

Frontiers in Immunology / Jun 23, 2021

Peruzzotti-Jametti, L., Willis, C. M., Hamel, R., Krzak, G., & Pluchino, S. (2021). Metabolic Control of Smoldering Neuroinflammation. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.705920

Combination of In Situ Lcn2 pRNA-RNAi Nanotherapeutics and iNSC Transplantation Ameliorates Experimental SCI in Mice

Molecular Therapy / Dec 01, 2020

Braga, A., Bandiera, S., Verheyen, J., Hamel, R., Rutigliani, C., Edenhofer, F., Smith, J. A., & Pluchino, S. (2020). Combination of In Situ Lcn2 pRNA-RNAi Nanotherapeutics and iNSC Transplantation Ameliorates Experimental SCI in Mice. Molecular Therapy, 28(12), 2677–2690. https://doi.org/10.1016/j.ymthe.2020.08.001

Bioinformatics analysis identified apolipoprotein E as a hub gene regulating neuroinflammation in macrophages and microglia following spinal cord injury

Frontiers in Immunology / Aug 24, 2022

Yao, X.-Q., Chen, J.-Y., Yu, Z.-H., Huang, Z.-C., Hamel, R., Zeng, Y.-Q., Huang, Z.-P., Tu, K.-W., Liu, J.-H., Lu, Y.-M., Zhou, Z.-T., Pluchino, S., Zhu, Q.-A., & Chen, J.-T. (2022). Bioinformatics analysis identified apolipoprotein E as a hub gene regulating neuroinflammation in macrophages and microglia following spinal cord injury. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.964138

Time-resolved single-cell RNAseq profiling identifies a novel Fabp5-expressing subpopulation of inflammatory myeloid cells in chronic spinal cord injury

Oct 21, 2020

Hamel, R., Peruzzotti-Jametti, L., Ridley, K., Testa, V., Yu, B., Rowitch, D., Marioni, J. C., & Pluchino, S. (2020). Time-resolved single-cell RNAseq profiling identifies a novel Fabp5-expressing subpopulation of inflammatory myeloid cells in chronic spinal cord injury. https://doi.org/10.1101/2020.10.21.346635

Single cell biology—a Keystone Symposia report

Annals of the New York Academy of Sciences / Oct 03, 2021

Cable, J., Elowitz, M. B., Domingos, A. I., Habib, N., Itzkovitz, S., Hamidzada, H., Balzer, M. S., Yanai, I., Liberali, P., Whited, J., Streets, A., Cai, L., Stergachis, A. B., Hong, C. K. Y., Keren, L., Guilliams, M., Alon, U., Shalek, A. K., Hamel, R., … Romeike, M. (2021). Single cell biology—a Keystone Symposia report. Annals of the New York Academy of Sciences, 1506(1), 74–97. Portico. https://doi.org/10.1111/nyas.14692

The therapeutic potential of exogenous adult stem cells for the injured central nervous system

Handbook of Innovations in Central Nervous System Regenerative Medicine / Jan 01, 2020

Smith, J. A., Braga, A., Hamel, R., Rutigliani, C., Yu, B., Peruzzotti-Jametti, L., & Pluchino, S. (2020). The therapeutic potential of exogenous adult stem cells for the injured central nervous system. Handbook of Innovations in Central Nervous System Regenerative Medicine, 147–258. https://doi.org/10.1016/b978-0-12-818084-6.00006-4

Integrative multi-omics analysis reveals molecular landscape associated with chronic lipid accumulation following contusive spinal cord injury

Jan 04, 2023

Yao, X.-Q., Chen, J.-Y., Yu, Z.-H., Huang, Z.-C., Hamel, R., Liu, J.-H., Shen, X., Wang, Y.-E., Zeng, Y.-Q., Huang, Z.-P., Lu, Y.-M., Zhou, Z.-T., Liu, C.-T., Shi, J.-M., Peruzzotti-Jametti, L., Pluchino, S., Zhu, Q.-A., & Chen, J.-T. (2023). Integrative multi-omics analysis reveals molecular landscape associated with chronic lipid accumulation following contusive spinal cord injury. https://doi.org/10.21203/rs.3.rs-2437316/v1

Multiple sclerosis and neuromyelitis optica spectrum disorders

Neurobiology of Brain Disorders / Jan 01, 2023

Ionescu, R.-B., Willis, C., Nicaise, A. M., Krzak, G., Hamel, R., Peruzzotti-Jametti, L., & Pluchino, S. (2023). Multiple sclerosis and neuromyelitis optica spectrum disorders. Neurobiology of Brain Disorders, 575–608. https://doi.org/10.1016/b978-0-323-85654-6.00051-4

Time-resolved single-cell RNAseq profiling identifies a novel Fabp5+ subpopulation of inflammatory myeloid cells with delayed cytotoxic profile in chronic spinal cord injury

Heliyon / Aug 01, 2023

Hamel, R., Peruzzotti-Jametti, L., Ridley, K., Testa, V., Yu, B., Rowitch, D., Marioni, J. C., & Pluchino, S. (2023). Time-resolved single-cell RNAseq profiling identifies a novel Fabp5+ subpopulation of inflammatory myeloid cells with delayed cytotoxic profile in chronic spinal cord injury. Heliyon, 9(8), e18339. https://doi.org/10.1016/j.heliyon.2023.e18339

Education

University of Cambridge

PhD, Clinical Neurosciences / September, 2021

Cambridge

University of Cambridge

MPhil, Clinical Neurosciences / September, 2018

Cambridge

McGill University

Bachelor of Science, Neurosciences / June, 2017

Montreal

Experience

Mogrify Ltd

Bioinformatics scientist / August, 2021June, 2023

Senior Bioinformatics Scientist / July, 2023Present

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