Shailesh Advani

Epidemiologist HTA and Outcomes Research Evidence Generation (Pharma Biotech)

Research Expertise

Chronic Disease Epidemiology
Global Health
COVID-19
Health Disparities
Transplant Research

About

Experience clinical epidemiologist with over 8 years of experience in HTA, RWE and Outcomes research and evidence generation.

Publications

The Global Burden of Cardiovascular Diseases and Risks
Journal of the American College of Cardiology
2020
Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 2006 to 2016: A systematic analysis for the Global Burden of Disease study.
Journal of Clinical Oncology
2018
Review for "Global burden and attributable risk factors of acute lymphoblastic leukemia in 204 countries and territories in 1990–2019: Estimation based on Global Burden of Disease Study 2019"
Unknown Venue
2021
Trends and risk factors of mortality and disability adjusted life years for chronic respiratory diseases from 1990 to 2017: systematic analysis for the Global Burden of Disease Study 2017
BMJ
2020
Direct Healthy Life Expectancy Estimates from Life Tables with a Sullivan Extension. Bridging the Gap Between HALE and Eurostat Estimates
The Springer Series on Demographic Methods and Population Analysis
2020
Racial and Ethnic Disparities in COVID-19–Related Infections, Hospitalizations, and Deaths
Annals of Internal Medicine
2021
Global Burden of Alzheimer's disease and other dementias and Attributable to Risk factors, 1990–2019: An Analysis Based on the Global Burden of Disease Study 2019
Unknown Venue
2022
Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and initiation among young people in 204 countries and territories, 1990–2019
The Lancet Public Health
2021
Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
The Lancet Psychiatry
2022
Measurement matters: who and what counts on the road to universal health coverage
The Lancet Global Health
2020
Multisystem inflammatory syndrome in children: A systematic review
EClinicalMedicine
2020
The global, regional, and national burden of pancreatitis in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
BMC Medicine
2020
Global prevalence of mental health problems among healthcare workers during the Covid-19 pandemic: A systematic review and meta-analysis
International Journal of Nursing Studies
2021
The Global Burden of Childhood and Adolescent Leukemia and Attributable Risk Factors: An Analysis of the Global Burden of Disease Study 2019
Unknown Venue
2023
Classifying Colorectal Cancer by Tumor Location Rather than Sidedness Highlights a Continuum in Mutation Profiles and Consensus Molecular Subtypes
Clinical Cancer Research
2018
Epidemiology and outcomes of COVID-19 in HIV-infected individuals: a systematic review and meta-analysis
Scientific Reports
2021
Global, Regional, and National Burdens of Depressive Disorders in Adolescents and Young Adults Aged 10-24 Years from 1990 to 2021: A Systematic Analysis Based on the Global Burden of Disease Study 2021 via EMR Mining Methods
Unknown Venue
2024
Immuno-genomic landscape of osteosarcoma
Nature Communications
2020
The global burden of 29 cancer groups from 2010 to 2019: A systematic analysis for the Global Burden of Disease study 2019.
Journal of Clinical Oncology
2021
A Systematic Review of Smartphone Applications Available for Corona Virus Disease 2019 (COVID19) and the Assessment of their Quality Using the Mobile Application Rating Scale (MARS)
Journal of Medical Systems
2020
Global, regional, and national burden of chronic respiratory diseases and associated risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
Unknown Venue
2022
Measuring and ensuring routine childhood vaccination coverage
The Lancet
2021
Correction: Morbidity and mortality from road injuries: results from the global Burden of Disease Study 2017
Injury Prevention
2020
Use of non-steroidal anti-inflammatory drugs in US adults: changes over time and by demographic
Open Heart
2017
Global, Regional, and National Burden of Breast Cancer and Its Attributable Risk Factors Among Women, 1990–2017
Unknown Venue
2020
Pharmacological management of cachexia in adult cancer patients: a systematic review of clinical trials
BMC Cancer
2018
Mortality in hospitalized patients with cancer and coronavirus disease 2019: A systematic review and meta‐analysis of cohort studies
Cancer
2020
Mapping child growth failure across low- and middle-income countries
Nature
2020
Association of SMAD4 mutation with patient demographics, tumor characteristics, and clinical outcomes in colorectal cancer
PLOS ONE
2017
Gun violence incidence during the COVID-19 pandemic is higher than before the pandemic in the United States
Scientific Reports
2021
Clinical, Pathological, and Molecular Characteristics of CpG Island Methylator Phenotype in Colorectal Cancer: A Systematic Review and Meta-analysis
Translational Oncology
2018
Fatal police violence by race and state in the USA, 1980–2019: a network meta-regression
The Lancet
2021
Lung histopathological findings in COVID-19 disease – a systematic review
Infectious Agents and Cancer
2021
Calprotectin, an Emerging Biomarker of Interest in COVID-19: A Systematic Review and Meta-Analysis
Journal of Clinical Medicine
2021
Dementia as a mortality predictor among older adults with COVID-19: A systematic review and meta-analysis of observational study
Geriatric Nursing
2021
Association of Breast Density With Breast Cancer Risk Among Women Aged 65 Years or Older by Age Group and Body Mass Index
JAMA Network Open
2021
Prognostic Implications of Mucinous Differentiation in Metastatic Colorectal Carcinoma Can Be Explained by Distinct Molecular and Clinicopathologic Characteristics
Clinical Colorectal Cancer
2018
Red Flag Signs and Symptoms for Patients With Early-Onset Colorectal Cancer
JAMA Network Open
2024
Smoking cessation interventions for potential use in the lung cancer screening setting: A systematic review and meta-analysis
Lung Cancer
2019
A proposed staging system and stage-specific interventions for familial adenomatous polyposis
Gastrointestinal Endoscopy
2016
ARID1A Mutation May Define an Immunologically Active Subgroup in Patients with Microsatellite Stable Colorectal Cancer
Clinical Cancer Research
2021
Association of primary (1°) site and molecular features with progression-free survival (PFS) and overall survival (OS) of metastatic colorectal cancer (mCRC) after anti-epidermal growth factor receptor (αEGFR) therapy.
Journal of Clinical Oncology
2016
The cumulative United States experience in living donor organ transplantation
Living Donor Organ Transplantation
2024
Mobile Technologies and Cervical Cancer Screening in Low- and Middle-Income Countries: A Systematic Review
JCO Global Oncology
2020
Regional lymph node involvement and outcomes in appendiceal neuroendocrine tumors: a SEER database analysis
Oncotarget
2017
Modelling the Anatomic Distribution of Neurologic Events in Patients with COVID-19: A Systematic Review of MRI Findings
American Journal of Neuroradiology
2021
Endogenous and exogenous testosterone and prostate cancer: decreased-, increased- or null-risk?
Translational Andrology and Urology
2017
MicroRNA panels as diagnostic biomarkers for colorectal cancer: A systematic review and meta-analysis
Frontiers in Medicine
2022
Frailty as a mortality predictor in older adults with COVID-19: A systematic review and meta-analysis of cohort studies
Geriatric Nursing
2021
Epidemiology and Molecular-Pathologic Characteristics of CpG Island Methylator Phenotype (CIMP) in Colorectal Cancer
Clinical Colorectal Cancer
2021
Screening Mammography Outcomes: Risk of Breast Cancer and Mortality by Comorbidity Score and Age
JNCI: Journal of the National Cancer Institute
2019
Advances in microfabrication technologies in tissue engineering and regenerative medicine
Artificial Organs
2022
Low‐dose CT lung cancer screening uptake: A rural–urban comparison
The Journal of Rural Health
2021
Global differences in the prevalence of the CpG island methylator phenotype of colorectal cancer
BMC Cancer
2019
Trends and Patterns of Testosterone Therapy among U.S. Male Medicare Beneficiaries, 1999 to 2014
Journal of Urology
2020
Disparities in H1N1 Vaccination Rates: a Systematic Review and Evidence Synthesis to Inform COVID-19 Vaccination Efforts
Journal of General Internal Medicine
2021
Ongoing and future directions in the management of metastatic colorectal cancer: Update on clinical trials
Journal of Surgical Oncology
2019
Racial/ethnic disparities in use of surveillance mammogram among breast cancer survivors: a systematic review
Journal of Cancer Survivorship
2021
Serum Magnesium Levels in Hospitalized Patients with SARS-CoV-2
Journal of Investigative Medicine
2022
Cost-Effectiveness of Screening Mammography Beyond Age 75 Years
Annals of Internal Medicine
2022
Prevalence and mortality of Lung Comorbidities Among Patients with COVID-19: A systematic review and meta-analysis
Unknown Venue
2020
Technology-based health solutions for cancer caregivers to better shoulder the impact of COVID-19: a systematic review protocol
Systematic Reviews
2021
Association between Body Mass Index and Immune-Related Adverse Events (irAEs) among Advanced-Stage Cancer Patients Receiving Immune Checkpoint Inhibitors: A Pan-Cancer Analysis
Cancers
2021
Comorbidity Profiles and Lung Cancer Screening among Older Adults: U.S. Behavioral Risk Factor Surveillance System 2017–2019
Annals of the American Thoracic Society
2021
Risk and Predictors of Variceal Bleeding in Cirrhosis Patients Receiving Primary Prophylaxis With Non-Selective Beta-Blockers
American Journal of Gastroenterology
2016
Addressing Vaccine Hesitancy to Reduce Racial and Ethnic Disparities in COVID-19 Vaccination Uptake Across the UK and US
Frontiers in Public Health
2021
Optimizing selection of candidates for lung cancer screening: role of comorbidity, frailty and life expectancy
Translational Lung Cancer Research
2019
Screening adherence and cancer risk perceptions in colorectal cancer survivors with Lynch‐like syndrome
Clinical Genetics
2015
Concomitant infections in patients with cancer and COVID-19: A COVID-19 and Cancer Consortium (CCC19) study.
Journal of Clinical Oncology
2021
Toolkit for detecting misused epidemiological methods
Environmental Health
2021
Vaccines for All: Challenges and Potential Solutions for Equitable COVID-19 Vaccine Distribution (Preprint)
Unknown Venue
2021
Double trouble: Co‐occurrence of testosterone deficiency and body fatness associated with all‐cause mortality in US men
Clinical Endocrinology
2017
Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study
BMJ
2022
Factors Associated with Health Inequalities in Infectious Disease Pandemics Predating COVID-19 in the United States: A Systematic Review
Health Equity
2022
Analysis of HSP27 and the Autophagy Marker LC3B+ Puncta Following Preoperative Chemotherapy Identifies High-Risk Osteosarcoma Patients
Molecular Cancer Therapeutics
2018
Patients Recently Treated for B-lymphoid Malignancies Show Increased Risk of Severe COVID-19
Blood Cancer Discovery
2022
A Systematic Review of Dermatologic Manifestations Among Adult Patients with COVID-19 Diagnosis
Skin Health and Disease
2021
Impartially Validated Multiple Deep-Chain Models to Detect COVID-19 in Chest X-ray Using Latent Space Radiomics
Journal of Clinical Medicine
2021
Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: a systematic analysis for the Global Burden of Disease Study 2019
The Lancet
2020
Association of Urinary Phthalate Metabolites With Erectile Dysfunction in Racial and Ethnic Groups in the National Health and Nutrition Examination Survey 2001-2004
American Journal of Men's Health
2016
Cancer screening behaviors and risk perceptions among family members of colorectal cancer patients with unexplained mismatch repair deficiency
Familial Cancer
2016
Local Control Modality and Outcome for Ewing Sarcoma of the Femur: A Report From the Children’s Oncology Group
Annals of Surgical Oncology
2016
Findings of living donation experiences shared on a digital storytelling platform: A thematic analysis
PEC Innovation
2022
Mammography use in relation to comorbidities and functional limitations among older breast cancer survivors
Journal of Cancer Survivorship
2020
Technology-Based Interventions for Nursing Home Residents: Implications for Nursing Home Practice Amid and Beyond the Influence of COVID-19: A Systematic Review Protocol
Unknown Venue
2020
Impact of healthcare access and HIV testing on utilisation of cervical cancer screening among US women at high risk of HIV infection: cross-sectional analysis of 2016 BRFSS data
BMJ Open
2020
Sleep Disorders in the Athlete
Psychiatric Clinics of North America
2021
Impact of Underlying Comorbidities on Mortality in SARS-COV-2 Infected Cancer Patients: A Systematic Review and Meta-Analysis
Asian Pacific Journal of Cancer Prevention
2021
Informal Providers—Ground Realities in South Asian Association for Regional Cooperation Nations: Toward Better Cancer Primary Care: A Narrative Review
JCO Global Oncology
2022
Association of Childhood Socioeconomic Status with Leukocyte Telomere Length Among African Americans and the Mediating Role of Behavioral and Psychosocial Factors: Results from the GENE-FORECAST Study
Journal of Racial and Ethnic Health Disparities
2021
CEA as a blood-based biomarker in anal cancer
Oncotarget
2021
Celecoxib Colorectal Bioavailability and Chemopreventive Response in Patients with Familial Adenomatous Polyposis
Cancer Prevention Research
2021
Engaging Patients with Late-Stage Non-Small Cell Lung Cancer in Shared Decision Making about Treatment
Journal of Personalized Medicine
2021
Technology-based interventions for nursing home residents: a systematic review protocol
BMJ Open
2021
Is Socioeconomic Advantage Associated With Positive Health Behaviors and Health Outcomes Among Asian Indians?
Health Services Research and Managerial Epidemiology
2019
Association of Prediagnosis Obesity and Postdiagnosis Aspirin With Survival From Stage IV Colorectal Cancer
JAMA Network Open
2022
Coinfections in Patients With Cancer and COVID-19: A COVID-19 and Cancer Consortium (CCC19) Study
Open Forum Infectious Diseases
2022
Global and regional disparities in the burden of disease and risk factors between pancreatitis and pancreatic cancer: a systematic analysis for the global burden of disease study
BMC Gastroenterology
2026
Hyperammonemia in lung transplant patients and its management: a review
Indian Journal of Thoracic and Cardiovascular Surgery
2022
Mammography adherence in relation to function-related indicators in older women
Preventive Medicine
2022
67 Breast biopsy patterns and findings among older women undergoing screening mammography: what is the impact of age and comorbidity?
Oral Presentations
2019
Association of White Matter Hyperintensity Markers on MRI and Long-term Risk of Mortality and Ischemic Stroke
Neurology
2021
Function-related Indicators and Outcomes of Screening Mammography in Older Women: Evidence from the Breast Cancer Surveillance Consortium Cohort
Cancer Epidemiology, Biomarkers & Prevention
2021
The Effects of Martial Arts on Cancer-Related Fatigue and Quality of Life in Cancer Patients: An Up-to-Date Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
International Journal of Environmental Research and Public Health
2021
Immuno-genomic landscape of osteosarcoma
immuneACCESS
Patient-reported Symptom Outcomes and Microsatellite Instability in Patients With Metastatic Colorectal Cancer
Clinical Colorectal Cancer
2020
Correction: Association of SMAD4 mutation with patient demographics, tumor characteristics, and clinical outcomes in colorectal cancer
PLOS ONE
2017
Data from Classifying Colorectal Cancer by Tumor Location Rather than Sidedness Highlights a Continuum in Mutation Profiles and Consensus Molecular Subtypes
Unknown Venue
2023
Health-Related Quality of Life and Survival Outcomes of Pediatric Patients With Nonmetastatic Osteosarcoma Treated in Countries With Different Resources
Journal of Global Oncology
2018

Education

University of Texas Health Science Center Houston

PhD Epidemiology / 2017

Western Kentucky University

MPH Public Health / 2011

University of Seychelles American Institute of Medicine

MD / 2008

Experience

Evidence Center Texas AM University ICA Global

Freelance Research Consultant / May, 2023May, 2025

Lead systematic reviews and meta-analyses supporting FDA and WHO decision-making; translate evidence into regulatory-ready reports and executive summaries. Provided evidence synthesis and clinical literature evaluation for pharma FDA and CMS-facing projects including rare diseases and medical devices. Worked with HTA team at ICA in developing study protocols manuscripts and working with critical stakeholders.

Roswell Park Comprehensive Cancer Center

Research Scientist / May, 2023May, 2024

Conducted oncology outcomes and RWE analyses informing screening and treatment effectiveness; co-authored peer-reviewed manuscripts and supported grant-funded research.

Bridge Medical Consulting

Consultant / January, 2022April, 2023

Working with pharmaceutical clients on performing evidence based systematic reviews preparing slide decks for medical advisory board systematic literature reviews targeted reviews and medical writing for scientific manuscripts as well as study design and creating statistical analysis plans.

NIH (NHGRI) Georgetown University

Postdoctoral Fellow / January, 2018December, 2020

Conducted population-based epidemiologic studies and contributed to NIH grant proposals and multidisciplinary research initiatives. Worked as a data manager for ongoing R01 study. Manuscript writing grant writing and scientific data management with cross-disciplinary stakeholders.

MD Anderson Cancer Center

Graduate Research Assistant / January, 2012December, 2017

Worked as a GRA across departments (GI Medical Oncology Pediatric Oncology Cancer Education and Training Program) and responsibilities included primary and secondary data management and analysis clinical trial patient recruitment and data management manuscript preparation.

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