Dr. Lindsey Kuehm, Ph.D.
PhD immunologist specializing in cancer immunotherapy
Research Expertise
About
Publications
Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells
Immunity / Nov 01, 2016
Jones, A., Bourque, J., Kuehm, L., Opejin, A., Teague, R. M., Gross, C., & Hawiger, D. (2016). Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells. Immunity, 45(5), 1066–1077. https://doi.org/10.1016/j.immuni.2016.10.008
Fructose Promotes Cytoprotection in Melanoma Tumors and Resistance to Immunotherapy
Cancer Immunology Research / Feb 01, 2021
Kuehm, L. M., Khojandi, N., Piening, A., Klevorn, L. E., Geraud, S. C., McLaughlin, N. R., Griffett, K., Burris, T. P., Pyles, K. D., Nelson, A. M., Preuss, M. L., Bockerstett, K. A., Donlin, M. J., McCommis, K. S., DiPaolo, R. J., & Teague, R. M. (2021). Fructose Promotes Cytoprotection in Melanoma Tumors and Resistance to Immunotherapy. Cancer Immunology Research, 9(2), 227–238. https://doi.org/10.1158/2326-6066.cir-20-0396
Oxidized Lipoproteins Promote Resistance to Cancer Immunotherapy Independent of Patient Obesity
Cancer Immunology Research / Feb 01, 2021
Khojandi, N., Kuehm, L. M., Piening, A., Donlin, M. J., Hsueh, E. C., Schwartz, T. L., Farrell, K., Richart, J. M., Geerling, E., Pinto, A. K., George, S. L., Albert, C. J., Ford, D. A., Chen, X., Kline, J., & Teague, R. M. (2021). Oxidized Lipoproteins Promote Resistance to Cancer Immunotherapy Independent of Patient Obesity. Cancer Immunology Research, 9(2), 214–226. https://doi.org/10.1158/2326-6066.cir-20-0358
Rescue of Tolerant CD8+ T Cells during Cancer Immunotherapy with IL2:Antibody Complexes
Cancer Immunology Research / Nov 30, 2016
Klevorn, L. E., Berrien-Elliott, M. M., Yuan, J., Kuehm, L. M., Felock, G. D., Crowe, S. A., & Teague, R. M. (2016). Rescue of Tolerant CD8+ T Cells during Cancer Immunotherapy with IL2:Antibody Complexes. Cancer Immunology Research, 4(12), 1016–1026. https://doi.org/10.1158/2326-6066.cir-16-0159
Interleukin 27 Protects From Gastric Atrophy and Metaplasia During Chronic Autoimmune Gastritis
Cellular and Molecular Gastroenterology and Hepatology / Jan 01, 2020
Bockerstett, K. A., Petersen, C. P., Noto, C. N., Kuehm, L. M., Wong, C. F., Ford, E. L., Teague, R. M., Mills, J. C., Goldenring, J. R., & DiPaolo, R. J. (2020). Interleukin 27 Protects From Gastric Atrophy and Metaplasia During Chronic Autoimmune Gastritis. Cellular and Molecular Gastroenterology and Hepatology, 10(3), 561–579. https://doi.org/10.1016/j.jcmgh.2020.04.014
Checkpoint blockade immunotherapy enhances the frequency and effector function of murine tumor-infiltrating T cells but does not alter TCRβ diversity
Cancer Immunology, Immunotherapy / May 18, 2019
Kuehm, L. M., Wolf, K., Zahour, J., DiPaolo, R. J., & Teague, R. M. (2019). Checkpoint blockade immunotherapy enhances the frequency and effector function of murine tumor-infiltrating T cells but does not alter TCRβ diversity. Cancer Immunology, Immunotherapy, 68(7), 1095–1106. https://doi.org/10.1007/s00262-019-02346-4
Obesity-related T cell dysfunction impairs immunosurveillance and increases cancer risk
Nature Communications / Apr 02, 2024
Piening, A., Ebert, E., Gottlieb, C., Khojandi, N., Kuehm, L. M., Hoft, S. G., Pyles, K. D., McCommis, K. S., DiPaolo, R. J., Ferris, S. T., Alspach, E., & Teague, R. M. (2024). Obesity-related T cell dysfunction impairs immunosurveillance and increases cancer risk. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-47359-5
High-Dimensional Analyses Reveal IL15 Enhances Activation of Sipuleucel-T Lymphocyte Subsets and Reverses Immunoresistance
Cancer Immunology Research / Feb 26, 2024
Saeed, M. A., Peng, B., Kim, K., Rawat, K., Kuehm, L. M., Siegel, Z. R., Borkowski, A., Habib, N., Van Tine, B., Sheikh, N., Tuyen, V., Thorek, D. L. J., Fehniger, T. A., & Pachynski, R. K. (2024). High-Dimensional Analyses Reveal IL15 Enhances Activation of Sipuleucel-T Lymphocyte Subsets and Reverses Immunoresistance. Cancer Immunology Research, 12(5), 559–574. https://doi.org/10.1158/2326-6066.cir-23-0652
Editorial: Teaching old CAR-T cells new tricks
Journal of Leukocyte Biology / Aug 01, 2017
Kuehm, L. M., & Teague, R. M. (2017). Editorial: Teaching old CAR-T cells new tricks. Journal of Leukocyte Biology, 102(2), 188–190. https://doi.org/10.1189/jlb.5ce0816-369r
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells
Nature Communications / Apr 21, 2023
Herrejon Chavez, F., Luo, H., Cifani, P., Pine, A., Chu, K. L., Joshi, S., Barin, E., Schurer, A., Chan, M., Chang, K., Han, G. Y. Q., Pierson, A. J., Xiao, M., Yang, X., Kuehm, L. M., Hong, Y., Nguyen, D. T. T., Chiosis, G., Kentsis, A., … Kharas, M. G. (2023). RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-38001-x
Education
Saint Louis University
PhD, Molecular Microbiology and Immunology / April, 2020
University of North Texas Health Science Center
MS, Microbiology and Immunology / August, 2014
University of North Texas
BS, Biology / December, 2008
Experience
Washington University School of Medicine in St. Louis
Postdoctoral Research Scholar / October, 2023 — Present
Cell Microsystems
Field Application Scientist / February, 2022 — February, 2023
TCR Cure Biopharma
Research Scientist / June, 2020 — January, 2022
Bristol-Myers Squibb
Quality Control Microbiologist / June, 2014 — June, 2015
Neos Therapeutics
Quality Control Microbiologist / August, 2012 — June, 2014
Links & Social Media
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