Ariel Aptekmann
Bioinformatician at Hackensack Meridian Hospital Center for Discovery and Innovation
Research Expertise
About
Publications
Molecular link between auxin and ROS-mediated polar growth
Proceedings of the National Academy of Sciences / May 01, 2017
Mangano, S., Denita-Juarez, S. P., Choi, H.-S., Marzol, E., Hwang, Y., Ranocha, P., Velasquez, S. M., Borassi, C., Barberini, M. L., Aptekmann, A. A., Muschietti, J. P., Nadra, A. D., Dunand, C., Cho, H.-T., & Estevez, J. M. (2017). Molecular link between auxin and ROS-mediated polar growth. Proceedings of the National Academy of Sciences, 114(20), 5289–5294. https://doi.org/10.1073/pnas.1701536114
Quantifying structural relationships of metal-binding sites suggests origins of biological electron transfer
Science Advances / Jan 14, 2022
Bromberg, Y., Aptekmann, A. A., Mahlich, Y., Cook, L., Senn, S., Miller, M., Nanda, V., Ferreiro, D. U., & Falkowski, P. G. (2022). Quantifying structural relationships of metal-binding sites suggests origins of biological electron transfer. Science Advances, 8(2). https://doi.org/10.1126/sciadv.abj3984
Apoplastic class III peroxidases PRX62 and PRX69 promote Arabidopsis root hair growth at low temperature
Nature Communications / Mar 14, 2022
Pacheco, J. M., Ranocha, P., Kasulin, L., Fusari, C. M., Servi, L., Aptekmann, Ariel. A., Gabarain, V. B., Peralta, J. M., Borassi, C., Marzol, E., Rodríguez-Garcia, D. R., del Carmen Rondón Guerrero, Y., Sardoy, M. C., Ferrero, L., Botto, J. F., Meneses, C., Ariel, F., Nadra, A. D., Petrillo, E., … Estevez, J. M. (2022). Apoplastic class III peroxidases PRX62 and PRX69 promote Arabidopsis root hair growth at low temperature. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-28833-4
Deep learning of a bacterial and archaeal universal language of life enables transfer learning and illuminates microbial dark matter
Nature Communications / May 11, 2022
Hoarfrost, A., Aptekmann, A., Farfañuk, G., & Bromberg, Y. (2022). Deep learning of a bacterial and archaeal universal language of life enables transfer learning and illuminates microbial dark matter. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-30070-8
Decoding the effects of synonymous variants
Nucleic Acids Research / Nov 30, 2021
Zeng, Z., Aptekmann, A. A., & Bromberg, Y. (2021). Decoding the effects of synonymous variants. Nucleic Acids Research, 49(22), 12673–12691. https://doi.org/10.1093/nar/gkab1159
Core promoter information content correlates with optimal growth temperature
Scientific Reports / Jan 22, 2018
Aptekmann, A. A., & Nadra, A. D. (2018). Core promoter information content correlates with optimal growth temperature. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-19495-8
Ecology theory disentangles microbial dichotomies
Environmental Microbiology / Sep 05, 2023
Couso, L. L., Soler‐Bistué, A., Aptekmann, A. A., & Sánchez, I. E. (2023). Ecology theory disentangles microbial dichotomies. Environmental Microbiology. Portico. https://doi.org/10.1111/1462-2920.16495
A finely tuned interplay between calcium binding, ionic strength and pH modulates conformational and oligomerization equilibria in the Respiratory Syncytial Virus Matrix (M) protein
Archives of Biochemistry and Biophysics / Nov 01, 2022
Esperante, S. A., Alvarez-Paggi, D., Salgueiro, M., Desimone, M. F., de Oliveira, G. A. P., Arán, M., García-Pardo, J., Aptekmann, A. A., Ventura, S., Alonso, L. G., & de Prat-Gay, G. (2022). A finely tuned interplay between calcium binding, ionic strength and pH modulates conformational and oligomerization equilibria in the Respiratory Syncytial Virus Matrix (M) protein. Archives of Biochemistry and Biophysics, 731, 109424. https://doi.org/10.1016/j.abb.2022.109424
PhISCO: a simple method to infer phenotypes from protein sequences
Oct 23, 2022
Berthet, A. S. H., Aptekmann, A. A., Tejero, J., Sánchez, I. E., Noguera, M. E., & Roman, E. A. (2022). PhISCO: a simple method to infer phenotypes from protein sequences. https://doi.org/10.1101/2022.10.23.511734
Illuminating the Microbial Dark Matter Driving Energy Transformations in the Environment with a Universal Language of Life
Goldschmidt2021 abstracts / Jan 01, 2021
Hoarfrost, A., Aptekmann, A., Farfañuk, G., Falkowski, P., & Bromberg, Y. (2021). Illuminating the Microbial Dark Matter Driving Energy Transformations in the Environment with a Universal Language of Life. Goldschmidt2021 Abstracts. https://doi.org/10.7185/gold2021.4886
Dark Matter of the Transcription Factor Binding Site Motif Universe
Feb 16, 2021
Aptekmann, A. A., Bulavka, D., Nadra, A. D., & Sánchez, I. E. (2021). Dark Matter of the Transcription Factor Binding Site Motif Universe. https://doi.org/10.21203/rs.3.rs-199537/v1
ANÁLISIS DE LOS FLUJOS EXTREMOS DE ELECTRONES ENERGÉTICOS EN EL CINTURÓN DE RADIACIÓN EXTERIOR Y EN LA ANOMALÍA MAGNÉTICA DEL ATLÁNTICO SUR
Meteorologica / Jun 01, 2021
Lanabere, V., & Dasso, S. (2021). ANÁLISIS DE LOS FLUJOS EXTREMOS DE ELECTRONES ENERGÉTICOS EN EL CINTURÓN DE RADIACIÓN EXTERIOR Y EN LA ANOMALÍA MAGNÉTICA DEL ATLÁNTICO SUR. Meteorologica, 46(2), e006–e006. https://doi.org/10.24215/1850468xe006
NAC1 directs CEP1-CEP3 peptidase expression and modulates root hair growth in Arabidopsis
Mar 17, 2023
Rodríguez-García, D. R., Guerrero, Y. del C. R., Ferrero, L., Rossi, A. H., Miglietta, E. A., Aptekmann, A. A., Marzol, E., Pacheco, J. M., Carignani, M., Gabarain, V. B., Lopez, L. E., Dominguez, G. D., Borassi, C., Sánchez-Serrano, J. J., Xu, L., Nadra, A. D., Rojo, E., Ariel, F., & Estevez, J. M. (2023). NAC1 directs CEP1-CEP3 peptidase expression and modulates root hair growth in Arabidopsis. https://doi.org/10.1101/2023.03.15.532802
mebipred: identifying metal-binding potential in protein sequence
Bioinformatics / May 27, 2022
Aptekmann, A. A., Buongiorno, J., Giovannelli, D., Glamoclija, M., Ferreiro, D. U., & Bromberg, Y. (2022). mebipred: identifying metal-binding potential in protein sequence. Bioinformatics, 38(14), 3532–3540. https://doi.org/10.1093/bioinformatics/btac358
Class III Peroxidases PRX01, PRX44, and PRX73 Control Root Hair Growth in Arabidopsis thaliana
International Journal of Molecular Sciences / May 11, 2022
Marzol, E., Borassi, C., Carignani Sardoy, M., Ranocha, P., Aptekmann, A. A., Bringas, M., Pennington, J., Paez-Valencia, J., Martínez Pacheco, J., Rodríguez-Garcia, D. R., Rondón Guerrero, Y. del C., Peralta, J. M., Fleming, M., Mishler-Elmore, J. W., Mangano, S., Blanco-Herrera, F., Bedinger, P. A., Dunand, C., Capece, L., … Estevez, J. M. (2022). Class III Peroxidases PRX01, PRX44, and PRX73 Control Root Hair Growth in Arabidopsis thaliana. International Journal of Molecular Sciences, 23(10), 5375. https://doi.org/10.3390/ijms23105375
Transcription factor specificity limits the number of DNA-binding motifs
PLOS ONE / Jan 28, 2022
Aptekmann, A. A., Bulavka, D., Nadra, A. D., & Sánchez, I. E. (2022). Transcription factor specificity limits the number of DNA-binding motifs. PLOS ONE, 17(1), e0263307. https://doi.org/10.1371/journal.pone.0263307
mebipred: identifying metal-binding potential in protein sequences.
Aug 13, 2021
Aptekmann, A. A., Buongiorno, J., Giovannelli, D., Glamoclija, M., Ferreiro, D. U., & Bromberg, Y. (2021). mebipred: identifying metal-binding potential in protein sequences. https://doi.org/10.1101/2021.08.12.456141
Transcriptomic analysis and molecular docking reveal genes involved in the response of Aedes aegypti larvae to an essential oil extracted from Eucalyptus
PLOS Neglected Tropical Diseases / Jul 16, 2021
Sierra, I., Latorre-Estivalis, J. M., Traverso, L., Gonzalez, P. V., Aptekmann, A., Nadra, A. D., Masuh, H., & Ons, S. (2021). Transcriptomic analysis and molecular docking reveal genes involved in the response of Aedes aegypti larvae to an essential oil extracted from Eucalyptus. PLOS Neglected Tropical Diseases, 15(7), e0009587. https://doi.org/10.1371/journal.pntd.0009587
Decoding the effects of synonymous variants
May 22, 2021
Zeng, Z., Aptekmann, A. A., & Bromberg, Y. (2021). Decoding the effects of synonymous variants. https://doi.org/10.1101/2021.05.20.445019
Thousands of protein linear motif classes may still be undiscovered
PLOS ONE / May 03, 2021
Bulavka, D., Aptekmann, A. A., Méndez, N. A., Krick, T., & Sánchez, I. E. (2021). Thousands of protein linear motif classes may still be undiscovered. PLOS ONE, 16(5), e0248841. https://doi.org/10.1371/journal.pone.0248841
Shedding Light on Microbial Dark Matter with A Universal Language of Life
Dec 24, 2020
Hoarfrost, A., Aptekmann, A., Farfañuk, G., & Bromberg, Y. (2020). Shedding Light on Microbial Dark Matter with A Universal Language of Life. https://doi.org/10.1101/2020.12.23.424215
Computational Approaches for Unraveling the Effects of Variation in the Human Genome and Microbiome
Annual Review of Biomedical Data Science / Jul 20, 2020
Zhu, C., Miller, M., Zeng, Z., Wang, Y., Mahlich, Y., Aptekmann, A., & Bromberg, Y. (2020). Computational Approaches for Unraveling the Effects of Variation in the Human Genome and Microbiome. Annual Review of Biomedical Data Science, 3(1), 411–432. https://doi.org/10.1146/annurev-biodatasci-030320-041014
The molecular link between auxin and ROS-Mediated polar root hair growth
Mar 14, 2017
Mangano, S., Denita-Juarez, S. P., Choi, H.-S., Marzol, E., Hwang, Y., Ranocha, P., Velasquez, S. M., Borassi, C., Barberini, M. L., Aptekmann, A. A., Muschietti, J. P., Nadra, A. D., Dunand, C., Cho, H.-T., & Estevez, J. M. (2017). The molecular link between auxin and ROS-Mediated polar root hair growth. https://doi.org/10.1101/116517
Education
University of Buenos Aires
PhD, Biological Chemistry, Bioinformatics / February, 2018
Rutgers, The State University of New Jersey
Postdoc, Computational Biology / March, 2021
Experience
Hackensack Meridian Hospital Center for Discovery and Innovation
Bioinformatician / March, 2021 — Present
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