Xander van Wijk, PhD, DABCC, FADLM

Strategic Leader in Clinical Diagnostics | Expert in Laboratory and Precision Medicine | Award-Winning Scientist & Author | CLIA Laboratory Director

Research Expertise

Clinical Chemistry
Cardiac Biomarkers
Analytical Toxicology
Pharmacogenomics
Blood Gas
Internal Medicine
Urology
Clinical Biochemistry
Cancer Research
Physiology
Molecular Biology
Biochemistry
Cell Biology
Nephrology
Immunology
Infectious Diseases
Parasitology
Microbiology
Genetics
Biotechnology
Virology
Molecular Medicine
Health (social science)
Health, Toxicology and Mutagenesis
Epidemiology
Health Information Management
Toxicology
Biochemistry (medical)
Environmental Chemistry
Chemical Health and Safety
Analytical Chemistry
Pharmacology
Pharmacology (medical)
Oncology
Neurology (clinical)
Neurology
Genetics (clinical)
Pediatrics, Perinatology and Child Health
Cardiology and Cardiovascular Medicine
Anesthesiology and Pain Medicine
Physiology (medical)

About

A leader in the field of laboratory and precision medicine, passionate about improving healthcare through innovative solutions. Well versed in working in regulated environments (CLIA, FDA). Holding multiple board and leadership positions. Strong track record of scientific contributions with 70+ peer-reviewed articles, book chapters, and (inter)national podium presentations. Received several recent major awards & recognitions.

Legacy Map

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Publications

Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type
Scientific Reports
2017
Adverse Effects From Counterfeit Alprazolam Tablets
JAMA Internal Medicine
2016
The Distribution and Function of Chondroitin Sulfate and Other Sulfated Glycosaminoglycans in the Human Bladder and Their Contribution to the Protective Bladder Barrier
Journal of Urology
2013
Heparan sulfate in angiogenesis: a target for therapy
Angiogenesis
2013
The Polybasic Insertion in Autotaxin α Confers Specific Binding to Heparin and Cell Surface Heparan Sulfate Proteoglycans
Journal of Biological Chemistry
2013
Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis
Kidney International
2014
Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity
Infection and Immunity
2015
Role of von Willebrand Factor in COVID-19 Associated Coagulopathy
The Journal of Applied Laboratory Medicine
2021
A common sugar‐nucleotide‐mediated mechanism of inhibition of (glycosamino)glycan biosynthesis, as evidenced by 6F‐GalNAc (Ac 3 )
The FASEB Journal
2015
Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin α2 as a Host Factor for Bacterial Invasion
mBio
2017
Interfering with UDP-GlcNAc Metabolism and Heparan Sulfate Expression Using a Sugar Analogue Reduces Angiogenesis
ACS Chemical Biology
2013
Analytical and Clinical Evaluation of the Automated Elecsys Anti–SARS-CoV-2 Antibody Assay on the Roche cobas e602 Analyzer
American Journal of Clinical Pathology
2020
Counterfeit Norco Poisoning Outbreak — San Francisco Bay Area, California, March 25–April 5, 2016
MMWR. Morbidity and Mortality Weekly Report
2016
Synthetic agents off the darknet: a case of U-47700 and phenazepam abuse
Clinical Toxicology
2016
A 4-deoxy analogue of N-acetyl-d-glucosamine inhibits heparan sulphate expression and growth factor binding in vitro
Experimental Cell Research
2010
Mass spectrometry in emergency toxicology: Current state and future applications
Critical Reviews in Clinical Laboratory Sciences
2019
A Liquid-Chromatography High-Resolution Mass Spectrometry Method for Non-FDA Approved Benzodiazepines
Journal of Analytical Toxicology
2018
The ImPreSS Trial: Implementation of Point‐of‐Care Pharmacogenomic Decision Support in Perioperative Care
Clinical Pharmacology & Therapeutics
2019
Impact of CYP2D6 Pharmacogenomic Status on Pain Control Among Opioid-Treated Oncology Patients
The Oncologist
2021
Release of cardiac troponin using a high sensitivity assay after exercise: Type 2 acute myocardial infarction?
Clinica Chimica Acta
2015
Implementation of pharmacogenomic testing in oncology care (PhOCus): study protocol of a pragmatic, randomized clinical trial
Therapeutic Advances in Medical Oncology
2020
Cardiac troponin I is present in plasma of type 1 myocardial infarction patients and patients with troponin I elevations due to other etiologies as complex with little free I
Clinical Biochemistry
2019
Pharmacogenomic‐Based Decision Support to Predict Adherence to Medications
Clinical Pharmacology & Therapeutics
2020
Polymorphisms in CACNA1E and Camk2d are associated with seizure susceptibility of Sprague–Dawley rats
Epilepsy Research
2010
Evaluation of Biomarkers in Sepsis: High Dimethylarginine (ADMA and SDMA) Concentrations Are Associated with Mortality
The Journal of Applied Laboratory Medicine
2020
Two cases of severe opiate toxicity after ingestion of poppy seed tea
Toxicology Communications
2018
A comparison of methods for evaluation of a case of suspected macro-aspartate aminotransferase
Clinica Chimica Acta
2016
Extraction and structural analysis of glycosaminoglycans from formalin-fixed, paraffin-embedded tissues
Glycobiology
2012
Clinically actionable genotypes for anticancer prescribing among >1500 patients with pharmacogenomic testing
Cancer
2022
Evaluation of a New Generation Automated Assay for 25-Hydroxy Vitamin D Based on Competitive Protein Binding
The Journal of Applied Laboratory Medicine
2019
Oncology
Self-Assessment Q&A in Clinical Laboratory Science, III
2021
Validation of a Large Custom-Designed Pharmacogenomics Panel on an Array Genotyping Platform
The Journal of Applied Laboratory Medicine
2021
Cardiac Troponin Composition Characterization after Non ST-Elevation Myocardial Infarction: Relation with Culprit Artery, Ischemic Time Window, and Severity of Injury
Clinical Chemistry
2020
Cocaine use is associated with a higher prevalence of elevated ST2 concentrations
Clinical Biochemistry
2017
Implementation of pharmacogenomics into inpatient general medicine
Pharmacogenetics and Genomics
2022
Stability of Whole Blood Electrolyte Specimens at Room Temperature vs. Slushed Ice Conditions
The Journal of Applied Laboratory Medicine
2021
Anticholinergic toxicity associated with ingestion of water containing lupini bean extract
Clinical Toxicology
2017
‘Immunosequencing’ of heparan sulfate from human cell lines and rat kidney: the (GlcNS6S-IdoA2S)3 motif, recognized by antibody NS4F5, is located towards the non-reducing end
Biochemical Journal
2014
Machine Learning in Healthcare: Mapping a Path to Title 21
Clinical Chemistry
2022
Large inter-assay difference of serum creatinine in pediatric population: a threat to accurate staging of chronic kidney disease
Pediatric Nephrology
2021
A retrospective analysis of high sensitivity cardiac troponin-T ranges in non-myocardial infarction emergency department visits
BMC Cardiovascular Disorders
2021
Evaluation of interference effects from hemolysis, icterus and lipemia on the Roche Elecsys® Anti-SARS-CoV-2 assay
Clinica Chimica Acta
2020
Pilot Findings of Pharmacogenomics in Perioperative Care: Initial Results From the First Phase of the ImPreSS Trial
Anesthesia & Analgesia
2022
Applicability of Pharmacogenomically Guided Medication Treatment during Hospitalization of At-Risk Minority Patients
Journal of Personalized Medicine
2021
False-Positive Hepatitis B Surface Antibody Results: An Example of Reagent Carryover
The Journal of Applied Laboratory Medicine
2020
A new ultra-high sensitivity troponin I assay for chest pain patients with no evidence of troponin I using a conventional assay
Clinical Biochemistry
2015
The stability of blood gases and CO-oximetry under slushed ice and room temperature conditions
Clinical Chemistry and Laboratory Medicine (CCLM)
2023
Reducing Specimen Rejection Rates Using Concentration-Dependent Hemolysis Rejection Thresholds
The Journal of Applied Laboratory Medicine
2023
Abstract 13919: Race and Gender Specific High Sensitivity Troponin-t Cutoff Values Improve Detection in Patients’ With Ischemic Heart Disease
Circulation
2020
A comparison of venous blood gas analysis with paired specimens collected in syringes and evacuated blood collection tubes
Clinica Chimica Acta
2020
A root cause analysis of ‘falsely elevated’ oxygen saturation: investigation of pneumatic tube transport and differences between estimated and measured saturation in a critical patient population
Clinical Chemistry and Laboratory Medicine (CCLM)
2019
Development of an LC-MS/MS Method for Measurement of Irinotecan and Its Major Metabolites in Plasma: Technical Considerations
Laboratory Medicine
2021
Short-term analytical imprecision for a fifth generation cardiac troponin T assay does not exceed rule-in and rule-out thresholds of the ESC 0/1-h algorithm
Clinica Chimica Acta
2021
Intraoperative Fine Needle Aspiration Parathyroid Hormone Assay Can Be Used as an Alternative to Frozen Section Analysis for the Identification of Parathyroid Tissue
American Journal of Clinical Pathology
2020
Can We Improve Current Cancer Screening Programs?
Clinical Chemistry
2020
Sensitive immunoassay testing platforms
Biomarkers for Traumatic Brain Injury
2020
P4503A multi-site coronary vein sampling study on cardiac troponin T degradation in non-ST-elevation myocardial infarction
European Heart Journal
2019
Losing sight of the Forest for the trees: Why clinical laboratories need to perform their own interference studies
Clinica Chimica Acta
2018
Inactivation of heparan sulfate 2‐O‐sulfotransferase reduce neutrophil bactericidal activity and endothelial integrity to exacerbate host survival upon Group B Streptococcus infection (607.14)
The FASEB Journal
2014

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