Xander van Wijk, PhD, DABCC, FADLM
Strategic Leader in Clinical Diagnostics | Expert in Laboratory and Precision Medicine | Award-Winning Scientist & Author | CLIA Laboratory Director
Research Expertise
About
Publications
Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type
Scientific Reports / Aug 21, 2017
Ihse, E., Yamakado, H., van Wijk, X. M., Lawrence, R., Esko, J. D., & Masliah, E. (2017). Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. Scientific Reports, 7(1). https://doi.org/10.1038/s41598-017-08720-5
Adverse Effects From Counterfeit Alprazolam Tablets
JAMA Internal Medicine / Oct 01, 2016
Arens, A. M., van Wijk, X. M. R., Vo, K. T., Lynch, K. L., Wu, A. H. B., & Smollin, C. G. (2016). Adverse Effects From Counterfeit Alprazolam Tablets. JAMA Internal Medicine, 176(10), 1554. https://doi.org/10.1001/jamainternmed.2016.4306
The Distribution and Function of Chondroitin Sulfate and Other Sulfated Glycosaminoglycans in the Human Bladder and Their Contribution to the Protective Bladder Barrier
Journal of Urology / Jan 01, 2013
Janssen, D. A. W., van Wijk, X. M. R., Jansen, K. C. F. J., van Kuppevelt, T. H., Heesakkers, J. P. F. A., & Schalken, J. A. (2013). The Distribution and Function of Chondroitin Sulfate and Other Sulfated Glycosaminoglycans in the Human Bladder and Their Contribution to the Protective Bladder Barrier. Journal of Urology, 189(1), 336–342. https://doi.org/10.1016/j.juro.2012.09.022
Heparan sulfate in angiogenesis: a target for therapy
Angiogenesis / Oct 22, 2013
van Wijk, X. M. R., & van Kuppevelt, T. H. (2013). Heparan sulfate in angiogenesis: a target for therapy. Angiogenesis. https://doi.org/10.1007/s10456-013-9401-6
The Polybasic Insertion in Autotaxin α Confers Specific Binding to Heparin and Cell Surface Heparan Sulfate Proteoglycans
Journal of Biological Chemistry / Jan 01, 2013
Houben, A. J. S., van Wijk, X. M. R., van Meeteren, L. A., van Zeijl, L., van de Westerlo, E. M. A., Hausmann, J., Fish, A., Perrakis, A., van Kuppevelt, T. H., & Moolenaar, W. H. (2013). The Polybasic Insertion in Autotaxin α Confers Specific Binding to Heparin and Cell Surface Heparan Sulfate Proteoglycans. Journal of Biological Chemistry, 288(1), 510–519. https://doi.org/10.1074/jbc.m112.358416
Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis
Kidney International / Nov 01, 2014
LWMM Rops, A., Loeven, M. A., van Gemst, J. J., Eversen, I., Van Wijk, X. M., Dijkman, H. B., van Kuppevelt, T. H., Berden, J. H. M., Rabelink, T. J., Esko, J. D., & van der Vlag, J. (2014). Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis. Kidney International, 86(5), 932–942. https://doi.org/10.1038/ki.2014.115
Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity
Infection and Immunity / Sep 01, 2015
Xu, D., Olson, J., Cole, J. N., van Wijk, X. M., Brinkmann, V., Zychlinsky, A., Nizet, V., Esko, J. D., & Chang, Y.-C. (2015). Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity. Infection and Immunity, 83(9), 3648–3656. https://doi.org/10.1128/iai.00545-15
Role of von Willebrand Factor in COVID-19 Associated Coagulopathy
The Journal of Applied Laboratory Medicine / Jun 13, 2021
Mei, Z. W., van Wijk, X. M. R., Pham, H. P., & Marin, M. J. (2021). Role of von Willebrand Factor in COVID-19 Associated Coagulopathy. The Journal of Applied Laboratory Medicine, 6(5), 1305–1315. https://doi.org/10.1093/jalm/jfab042
A common sugar‐nucleotide‐mediated mechanism of inhibition of (glycosamino)glycan biosynthesis, as evidenced by 6F‐GalNAc (Ac 3 )
The FASEB Journal / Apr 13, 2015
Wijk, X. M., Lawrence, R., Thijssen, V. L., Broek, S. A., Troost, R., Scherpenzeel, M., Naidu, N., Oosterhof, A., Griffioen, A. W., Lefeber, D. J., Delft, F. L., & Kuppevelt, T. H. (2015). A common sugar‐nucleotide‐mediated mechanism of inhibition of (glycosamino)glycan biosynthesis, as evidenced by 6F‐GalNAc (Ac 3 ). The FASEB Journal, 29(7), 2993–3002. Portico. https://doi.org/10.1096/fj.14-264226
Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin α2 as a Host Factor for Bacterial Invasion
mBio / Mar 08, 2017
van Wijk, X. M., Döhrmann, S., Hallström, B. M., Li, S., Voldborg, B. G., Meng, B. X., McKee, K. K., van Kuppevelt, T. H., Yurchenco, P. D., Palsson, B. O., Lewis, N. E., Nizet, V., & Esko, J. D. (2017). Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin α2 as a Host Factor for Bacterial Invasion. MBio, 8(1). https://doi.org/10.1128/mbio.02128-16
Interfering with UDP-GlcNAc Metabolism and Heparan Sulfate Expression Using a Sugar Analogue Reduces Angiogenesis
ACS Chemical Biology / Sep 03, 2013
van Wijk, X. M., Thijssen, V. L., Lawrence, R., van den Broek, S. A., Dona, M., Naidu, N., Oosterhof, A., van de Westerlo, E. M., Kusters, L. J., Khaled, Y., Jokela, T. A., Nowak-Sliwinska, P., Kremer, H., Stringer, S. E., Griffioen, A. W., van Wijk, E., van Delft, F. L., & van Kuppevelt, T. H. (2013). Interfering with UDP-GlcNAc Metabolism and Heparan Sulfate Expression Using a Sugar Analogue Reduces Angiogenesis. ACS Chemical Biology, 8(10), 2331–2338. https://doi.org/10.1021/cb4004332
Analytical and Clinical Evaluation of the Automated Elecsys Anti–SARS-CoV-2 Antibody Assay on the Roche cobas e602 Analyzer
American Journal of Clinical Pathology / Aug 20, 2020
Chan, C. W., Parker, K., Tesic, V., Baldwin, A., Tang, N. Y., van Wijk, X. M. R., & Yeo, K.-T. J. (2020). Analytical and Clinical Evaluation of the Automated Elecsys Anti–SARS-CoV-2 Antibody Assay on the Roche cobas e602 Analyzer. American Journal of Clinical Pathology, 154(5), 620–626. https://doi.org/10.1093/ajcp/aqaa155
Counterfeit Norco Poisoning Outbreak — San Francisco Bay Area, California, March 25–April 5, 2016
MMWR. Morbidity and Mortality Weekly Report / Apr 29, 2016
Vo, K. T., van Wijk, X. M. R., Lynch, K. L., Wu, A. H. B., & Smollin, C. G. (2016). Counterfeit Norco Poisoning Outbreak — San Francisco Bay Area, California, March 25–April 5, 2016. MMWR. Morbidity and Mortality Weekly Report, 65(16), 420–423. https://doi.org/10.15585/mmwr.mm6516e1
Synthetic agents off the darknet: a case of U-47700 and phenazepam abuse
Clinical Toxicology / Oct 13, 2016
Vo, K. T., van Wijk, X. M. R., Wu, A. H. B., Lynch, K. L., & Ho, R. Y. (2016). Synthetic agents off the darknet: a case of U-47700 and phenazepam abuse. Clinical Toxicology, 55(1), 71–72. https://doi.org/10.1080/15563650.2016.1240806
A 4-deoxy analogue of N-acetyl-d-glucosamine inhibits heparan sulphate expression and growth factor binding in vitro
Experimental Cell Research / Sep 01, 2010
van Wijk, X. M. R., Oosterhof, A., van den Broek, S. A. M. W., Griffioen, A. W., ten Dam, G. B., Rutjes, F. P. J. T., van Delft, F. L., & van Kuppevelt, T. H. (2010). A 4-deoxy analogue of N-acetyl-d-glucosamine inhibits heparan sulphate expression and growth factor binding in vitro. Experimental Cell Research, 316(15), 2504–2512. https://doi.org/10.1016/j.yexcr.2010.04.025
Mass spectrometry in emergency toxicology: Current state and future applications
Critical Reviews in Clinical Laboratory Sciences / Apr 01, 2019
Van Wijk, X. M. R., Goodnough, R., & Colby, J. M. (2019). Mass spectrometry in emergency toxicology: Current state and future applications. Critical Reviews in Clinical Laboratory Sciences, 56(4), 225–238. https://doi.org/10.1080/10408363.2019.1585415
A Liquid-Chromatography High-Resolution Mass Spectrometry Method for Non-FDA Approved Benzodiazepines
Journal of Analytical Toxicology / Nov 14, 2018
van Wijk, X. M. R., Yun, C., Hooshfar, S., Arens, A. M., Lung, D., Wu, A. H. B., & Lynch, K. L. (2018). A Liquid-Chromatography High-Resolution Mass Spectrometry Method for Non-FDA Approved Benzodiazepines. Journal of Analytical Toxicology, 43(4), 316–320. https://doi.org/10.1093/jat/bky092
The ImPreSS Trial:
Implementation of Point‐of‐Care
Pharmacogenomic Decision Support in
Perioperative Care
Clinical Pharmacology & Therapeutics / Aug 21, 2019
Truong, T. M., Apfelbaum, J., Shahul, S., Anitescu, M., Danahey, K., Knoebel, R. W., Liebovitz, D., Karrison, T., van Wijk, X. M. R., Yeo, K. J., Meltzer, D., Ratain, M. J., & O’Donnell, P. H. (2019). The ImPre<scp>SS</scp> Trial: Implementation of Point‐of‐Care Pharmacogenomic Decision Support in Perioperative Care. Clinical Pharmacology & Therapeutics, 106(6), 1179–1183. Portico. https://doi.org/10.1002/cpt.1567
Impact of CYP2D6 Pharmacogenomic
Status on Pain Control Among
Opioid-Treated Oncology
Patients
The Oncologist / Sep 19, 2021
Reizine, N., Danahey, K., Schierer, E., Liu, P., Middlestadt, M., Ludwig, J., Truong, T. M., Wijk, X. M. R., Yeo, K.-T. J., Malec, M., Ratain, M. J., & O’Donnell, P. H. (2021). Impact of CYP2D6 Pharmacogenomic Status on Pain Control Among <scp>Opioid-Treated</scp> Oncology Patients. The Oncologist, 26(11), e2042–e2052. https://doi.org/10.1002/onco.13953
Release of cardiac troponin using a high sensitivity assay after exercise: Type 2 acute myocardial infarction?
Clinica Chimica Acta / Jun 01, 2015
Aw, T. C., van Wijk, X. M. R., Wu, A. H. B., & Jaffe, A. S. (2015). Release of cardiac troponin using a high sensitivity assay after exercise: Type 2 acute myocardial infarction? Clinica Chimica Acta, 446, 6–8. https://doi.org/10.1016/j.cca.2015.04.002
Implementation of pharmacogenomic testing in oncology care (PhOCus): study protocol of a pragmatic, randomized clinical trial
Therapeutic Advances in Medical Oncology / Jan 01, 2020
Reizine, N., Vokes, E. E., Liu, P., Truong, T. M., Nanda, R., Fleming, G. F., Catenacci, D. V. T., Pearson, A. T., Parsad, S., Danahey, K., van Wijk, X. M. R., Yeo, K.-T. J., Ratain, M. J., & O’Donnell, P. H. (2020). Implementation of pharmacogenomic testing in oncology care (PhOCus): study protocol of a pragmatic, randomized clinical trial. Therapeutic Advances in Medical Oncology, 12, 175883592097411. https://doi.org/10.1177/1758835920974118
Cardiac troponin I is present in plasma of type 1 myocardial infarction patients and patients with troponin I elevations due to other etiologies as complex with little free I
Clinical Biochemistry / Nov 01, 2019
van Wijk, X. M. R., Claassen, S., Enea, N. S., Li, P., Yang, S., Brouwer, M. A., Cramer, G. E., Zuk, R., Lynch, K. L., & Wu, A. H. B. (2019). Cardiac troponin I is present in plasma of type 1 myocardial infarction patients and patients with troponin I elevations due to other etiologies as complex with little free I. Clinical Biochemistry, 73, 35–43. https://doi.org/10.1016/j.clinbiochem.2019.06.012
Pharmacogenomic‐Based Decision Support to Predict Adherence to Medications
Clinical Pharmacology & Therapeutics / May 25, 2020
Christian, C., Borden, B. A., Danahey, K., Yeo, K. J., van Wijk, X. M. R., Ratain, M. J., & O’Donnell, P. H. (2020). Pharmacogenomic‐Based Decision Support to Predict Adherence to Medications. Clinical Pharmacology & Therapeutics, 108(2), 368–376. Portico. https://doi.org/10.1002/cpt.1838
Polymorphisms in CACNA1E and Camk2d are associated with seizure susceptibility of Sprague–Dawley rats
Epilepsy Research / Sep 01, 2010
Rijkers, K., Mescheriakova, J., Majoie, M., Lemmens, E., van Wijk, X., Philippens, M., Van Kranen-Mastenbroek, V., Schijns, O., Vles, J., & Hoogland, G. (2010). Polymorphisms in CACNA1E and Camk2d are associated with seizure susceptibility of Sprague–Dawley rats. Epilepsy Research, 91(1), 28–34. https://doi.org/10.1016/j.eplepsyres.2010.06.006
Evaluation of Biomarkers in Sepsis: High Dimethylarginine (ADMA and SDMA) Concentrations Are Associated with Mortality
The Journal of Applied Laboratory Medicine / Dec 31, 2020
van Wijk, X. M. R., Yun, C., & Lynch, K. L. (2020). Evaluation of Biomarkers in Sepsis: High Dimethylarginine (ADMA and SDMA) Concentrations Are Associated with Mortality. The Journal of Applied Laboratory Medicine, 6(3), 592–605. https://doi.org/10.1093/jalm/jfaa156
Two cases of severe opiate toxicity after ingestion of poppy seed tea
Toxicology Communications / Jan 01, 2018
Spyres, M. B., van Wijk, X. M. R., Lapoint, J., & Levine, M. (2018). Two cases of severe opiate toxicity after ingestion of poppy seed tea. Toxicology Communications, 2(1), 102–104. https://doi.org/10.1080/24734306.2018.1540178
A comparison of methods for evaluation of a case of suspected macro-aspartate aminotransferase
Clinica Chimica Acta / Dec 01, 2016
van Wijk, X. M. R., Magee, C. A., Wu, A. H. B., Tana, M. M., & Lynch, K. L. (2016). A comparison of methods for evaluation of a case of suspected macro-aspartate aminotransferase. Clinica Chimica Acta, 463, 1–3. https://doi.org/10.1016/j.cca.2016.10.011
Extraction and structural analysis of glycosaminoglycans from formalin-fixed, paraffin-embedded tissues
Glycobiology / Aug 02, 2012
van Wijk, X. M. R., Vallen, M. J., van de Westerlo, E. M., Oosterhof, A., Hao, W., Versteeg, E. M., Raben, J., Wismans, R. G., Smetsers, T. F. C. M., Dijkman, H. B. P. M., Schalkwijk, J., & van Kuppevelt, T. H. (2012). Extraction and structural analysis of glycosaminoglycans from formalin-fixed, paraffin-embedded tissues. Glycobiology, 22(12), 1666–1672. https://doi.org/10.1093/glycob/cws119
Clinically actionable genotypes for anticancer prescribing among >1500 patients with pharmacogenomic testing
Cancer / Jan 28, 2022
Reizine, N. M., Danahey, K., Truong, T. M., George, D., House, L. K., Karrison, T. G., van Wijk, X. M. R., Yeo, K. J., Ratain, M. J., & O’Donnell, P. H. (2022). Clinically actionable genotypes for anticancer prescribing among >1500 patients with pharmacogenomic testing. Cancer, 128(8), 1649–1657. Portico. https://doi.org/10.1002/cncr.34104
Evaluation of a New Generation Automated Assay for 25-Hydroxy Vitamin D Based on Competitive Protein Binding
The Journal of Applied Laboratory Medicine / Sep 01, 2019
Asif, M., Groboske, S. E., Leung, E. K. Y., Yeo, K.-T. J., & van Wijk, X. M. R. (2019). Evaluation of a New Generation Automated Assay for 25-Hydroxy Vitamin D Based on Competitive Protein Binding. The Journal of Applied Laboratory Medicine, 4(2), 247–253. https://doi.org/10.1373/jalm.2018.028415
Oncology
Self-Assessment Q&A in Clinical Laboratory Science, III / Jan 01, 2021
Marin, M. J., & van Wijk, X. M. R. (2021). Oncology. In Self-Assessment Q&A in Clinical Laboratory Science, III (pp. 37–47). Elsevier. https://doi.org/10.1016/b978-0-12-822093-1.00004-1
Validation of a Large Custom-Designed Pharmacogenomics Panel on an Array Genotyping Platform
The Journal of Applied Laboratory Medicine / Jul 15, 2021
Tang, N. Y., Pei, X., George, D., House, L., Danahey, K., Lipschultz, E., Ratain, M. J., O’Donnell, P. H., Yeo, K.-T. J., & van Wijk, X. M. R. (2021). Validation of a Large Custom-Designed Pharmacogenomics Panel on an Array Genotyping Platform. The Journal of Applied Laboratory Medicine, 6(6), 1505–1516. https://doi.org/10.1093/jalm/jfab056
Cardiac Troponin Composition Characterization after Non ST-Elevation Myocardial Infarction: Relation with Culprit Artery, Ischemic Time Window, and Severity of Injury
Clinical Chemistry / Nov 22, 2020
Damen, S. A. J., Cramer, G. E., Dieker, H.-J., Gehlmann, H., Ophuis, T. J. M. O., Aengevaeren, W. R. M., Fokkert, M., Verheugt, F. W. A., Suryapranata, H., Wu, A. H., van Wijk, X. M. R., & Brouwer, M. A. (2020). Cardiac Troponin Composition Characterization after Non ST-Elevation Myocardial Infarction: Relation with Culprit Artery, Ischemic Time Window, and Severity of Injury. Clinical Chemistry, 67(1), 227–236. https://doi.org/10.1093/clinchem/hvaa231
Cocaine use is associated with a higher prevalence of elevated ST2 concentrations
Clinical Biochemistry / Sep 01, 2017
van Wijk, X. M. R., Vittinghoff, E., Wu, A. H. B., Lynch, K. L., & Riley, E. D. (2017). Cocaine use is associated with a higher prevalence of elevated ST2 concentrations. Clinical Biochemistry, 50(13–14), 791–793. https://doi.org/10.1016/j.clinbiochem.2017.04.015
Implementation of pharmacogenomics into inpatient general medicine
Pharmacogenetics and Genomics / Dec 09, 2022
Chen, T., O’Donnell, P. H., Middlestadt, M., Ruhnke, G. W., Danahey, K., van Wijk, X. M. R., Choksi, A., Knoebel, R., Hartman, S., Yeo, K.-T. J., Friedman, P. N., Ratain, M. J., Nutescu, E. A., O’Leary, K. J., Perera, M. A., & Meltzer, D. O. (2022). Implementation of pharmacogenomics into inpatient general medicine. Pharmacogenetics and Genomics, 33(2), 19–23. https://doi.org/10.1097/fpc.0000000000000487
Stability of Whole Blood Electrolyte Specimens at Room Temperature vs. Slushed Ice Conditions
The Journal of Applied Laboratory Medicine / Aug 27, 2021
Zavorsky, G. S., van Wijk, X. M. R., Gasparyan, S., Stollenwerk, N. S., & Brooks, R. A. (2021). Stability of Whole Blood Electrolyte Specimens at Room Temperature vs. Slushed Ice Conditions. The Journal of Applied Laboratory Medicine, 7(2), 541–554. https://doi.org/10.1093/jalm/jfab089
Anticholinergic toxicity associated with ingestion of water containing lupini bean extract
Clinical Toxicology / Apr 26, 2017
Li, K., van Wijk, X. M. R., Hayashi, S., Lynch, K. L., Wu, A. H. B., & Smollin, C. G. (2017). Anticholinergic toxicity associated with ingestion of water containing lupini bean extract. Clinical Toxicology, 55(7), 687–688. https://doi.org/10.1080/15563650.2017.1315821
‘Immunosequencing’ of heparan sulfate from human cell lines and rat kidney: the (GlcNS6S-IdoA2S)3 motif, recognized by antibody NS4F5, is located towards the non-reducing end
Biochemical Journal / Jul 10, 2014
van Wijk, X. M. R., Oosterhof, A., Versteeg, E. M. M., van de Westerlo, E. M. A., & van Kuppevelt, T. H. (2014). ‘Immunosequencing’ of heparan sulfate from human cell lines and rat kidney: the (GlcNS6S-IdoA2S)3 motif, recognized by antibody NS4F5, is located towards the non-reducing end. Biochemical Journal, 461(3), 461–468. https://doi.org/10.1042/bj20140355
Machine Learning in Healthcare: Mapping a Path to Title 21
Clinical Chemistry / Mar 30, 2022
Marin, M. J., Van Wijk, X. M. R., & Durant, T. J. S. (2022). Machine Learning in Healthcare: Mapping a Path to Title 21. Clinical Chemistry, 68(4), 609–610. https://doi.org/10.1093/clinchem/hvab285
Large inter-assay difference of serum creatinine in pediatric population: a threat to accurate staging of chronic kidney disease
Pediatric Nephrology / Nov 10, 2021
Lao, K., Sykes, E., van Wijk, X. M. R., Li, J., Williams, J., Gherasim, C., & Sun, Q. (2021). Large inter-assay difference of serum creatinine in pediatric population: a threat to accurate staging of chronic kidney disease. Pediatric Nephrology, 37(3), 677–681. https://doi.org/10.1007/s00467-021-05335-x
A retrospective analysis of high sensitivity cardiac troponin-T ranges in non-myocardial infarction emergency department visits
BMC Cardiovascular Disorders / Jun 07, 2021
Kong, N., Chua, R. F. M., Besser, S. A., Heelan, L., Nathan, S., Spiegel, T. F., van Wijk, X. M. R., & Tabit, C. E. (2021). A retrospective analysis of high sensitivity cardiac troponin-T ranges in non-myocardial infarction emergency department visits. BMC Cardiovascular Disorders, 21(1). https://doi.org/10.1186/s12872-021-02089-0
Evaluation of interference effects from hemolysis, icterus and lipemia on the Roche Elecsys® Anti-SARS-CoV-2 assay
Clinica Chimica Acta / Oct 01, 2020
Tang, N.-Y., Yeo, K.-T. J., & van Wijk, X. M. R. (2020). Evaluation of interference effects from hemolysis, icterus and lipemia on the Roche Elecsys® Anti-SARS-CoV-2 assay. Clinica Chimica Acta, 509, 293–294. https://doi.org/10.1016/j.cca.2020.06.041
Pilot Findings of Pharmacogenomics in Perioperative Care: Initial Results From the First Phase of the ImPreSS Trial
Anesthesia & Analgesia / Feb 25, 2022
Truong, T. M., Apfelbaum, J. L., Danahey, K., Schierer, E., Ludwig, J., George, D., House, L., Karrison, T., Shahul, S., Anitescu, M., Choksi, A., Hartman, S., Knoebel, R. W., van Wijk, X. M. R., Yeo, K.-T. J., Meltzer, D. O., Ratain, M. J., & O’Donnell, P. H. (2022). Pilot Findings of Pharmacogenomics in Perioperative Care: Initial Results From the First Phase of the ImPreSS Trial. Anesthesia & Analgesia, 135(5), 929–940. https://doi.org/10.1213/ane.0000000000005951
Applicability of Pharmacogenomically Guided Medication Treatment during Hospitalization of At-Risk Minority Patients
Journal of Personalized Medicine / Dec 10, 2021
Saulsberry, L., Danahey, K., Middlestadt, M., O’Leary, K. J., Nutescu, E. A., Chen, T., Lee, J. C., Ruhnke, G. W., George, D., House, L., van Wijk, X. M. R., Yeo, K.-T. J., Choksi, A., Hartman, S. W., Knoebel, R. W., Friedman, P. N., Rasmussen, L. V., Ratain, M. J., Perera, M. A., … O’Donnell, P. H. (2021). Applicability of Pharmacogenomically Guided Medication Treatment during Hospitalization of At-Risk Minority Patients. Journal of Personalized Medicine, 11(12), 1343. https://doi.org/10.3390/jpm11121343
False-Positive Hepatitis B Surface Antibody Results: An Example of Reagent Carryover
The Journal of Applied Laboratory Medicine / Mar 01, 2020
Tang, N.-Y., Groboske, S. E., Baldwin, A. D., Yeo, K.-T. J., & van Wijk, X. M. R. (2020). False-Positive Hepatitis B Surface Antibody Results: An Example of Reagent Carryover. The Journal of Applied Laboratory Medicine, 5(2), 429–431. https://doi.org/10.1093/jalm/jfz015
A new ultra-high sensitivity troponin I assay for chest pain patients with no evidence of troponin I using a conventional assay
Clinical Biochemistry / Mar 01, 2015
Wu, A. H. B., & van Wijk, X. M. R. (2015). A new ultra-high sensitivity troponin I assay for chest pain patients with no evidence of troponin I using a conventional assay. Clinical Biochemistry, 48(4–5), 358–359. https://doi.org/10.1016/j.clinbiochem.2014.11.018
The stability of blood gases and CO-oximetry under slushed ice and room temperature conditions
Clinical Chemistry and Laboratory Medicine (CCLM) / Apr 06, 2023
Zavorsky, G. S., & van Wijk, X. M. R. (2023). The stability of blood gases and CO-oximetry under slushed ice and room temperature conditions. Clinical Chemistry and Laboratory Medicine (CCLM), 61(10), 1750–1759. https://doi.org/10.1515/cclm-2022-1085
Reducing Specimen Rejection Rates Using Concentration-Dependent Hemolysis Rejection Thresholds
The Journal of Applied Laboratory Medicine / Jan 02, 2023
Tang, N. Y., Mitchell, K. R., Groboske, S. E., Baldwin, A. D., Lenza, M., Yeo, K.-T. J., & van Wijk, X. M. R. (2023). Reducing Specimen Rejection Rates Using Concentration-Dependent Hemolysis Rejection Thresholds. The Journal of Applied Laboratory Medicine, 8(2), 285–295. https://doi.org/10.1093/jalm/jfac095
Abstract 13919: Race and Gender Specific High Sensitivity Troponin-t Cutoff Values Improve Detection in Patients’ With Ischemic Heart Disease
Circulation / Nov 17, 2020
Kong, N., Chua, R., Besser, S., Heelan, L., Nathan, S., Spiegel, T., van Wijk, X., & Tabit, C. E. (2020). Abstract 13919: Race and Gender Specific High Sensitivity Troponin-t Cutoff Values Improve Detection in Patients’ With Ischemic Heart Disease. Circulation, 142(Suppl_3). https://doi.org/10.1161/circ.142.suppl_3.13919
A comparison of venous blood gas analysis with paired specimens collected in syringes and evacuated blood collection tubes
Clinica Chimica Acta / Nov 01, 2020
Tang, N.-Y., Leanse, J. H., Tesic, V., & van Wijk, X. M. R. (2020). A comparison of venous blood gas analysis with paired specimens collected in syringes and evacuated blood collection tubes. Clinica Chimica Acta, 510, 671–674. https://doi.org/10.1016/j.cca.2020.08.023
A root cause analysis of ‘falsely elevated’ oxygen saturation: investigation of pneumatic tube transport and differences between estimated and measured saturation in a critical patient population
Clinical Chemistry and Laboratory Medicine (CCLM) / Sep 17, 2019
van Wijk, X. M. R., Leanse, J. H., Poinier, A., Uriel, N., O’Connor, M. F., Weber, S. G., Tesic, V., & Staneva, I. (2019). A root cause analysis of ‘falsely elevated’ oxygen saturation: investigation of pneumatic tube transport and differences between estimated and measured saturation in a critical patient population. Clinical Chemistry and Laboratory Medicine (CCLM), 58(3), e72–e74. https://doi.org/10.1515/cclm-2019-0776
Development of an LC-MS/MS Method for Measurement of Irinotecan and Its Major Metabolites in Plasma: Technical Considerations
Laboratory Medicine / Aug 05, 2021
Aoullay, Z., Van Wijk, X. M. R., Yanhui, M., Meddah, B., Lynch, K. L., Cherrah, Y., & Wu, A. H. B. (2021). Development of an LC-MS/MS Method for Measurement of Irinotecan and Its Major Metabolites in Plasma: Technical Considerations. Laboratory Medicine, 53(1), 47–52. https://doi.org/10.1093/labmed/lmab059
Short-term analytical imprecision for a fifth generation cardiac troponin T assay does not exceed rule-in and rule-out thresholds of the ESC 0/1-h algorithm
Clinica Chimica Acta / Aug 01, 2021
Tang, N. Y., Datoru, A. D., & van Wijk, X. M. R. (2021). Short-term analytical imprecision for a fifth generation cardiac troponin T assay does not exceed rule-in and rule-out thresholds of the ESC 0/1-h algorithm. Clinica Chimica Acta, 519, 204–205. https://doi.org/10.1016/j.cca.2021.05.005
Intraoperative Fine Needle Aspiration Parathyroid Hormone Assay Can Be Used as an Alternative to Frozen Section Analysis for the Identification of Parathyroid Tissue
American Journal of Clinical Pathology / Oct 01, 2020
Olivas, A. D., van Wijk, X. M., & Angelos, P. (2020). Intraoperative Fine Needle Aspiration Parathyroid Hormone Assay Can Be Used as an Alternative to Frozen Section Analysis for the Identification of Parathyroid Tissue. American Journal of Clinical Pathology, 154(Supplement_1), S43–S44. https://doi.org/10.1093/ajcp/aqaa161.092
Can We Improve Current Cancer Screening Programs?
Clinical Chemistry / Apr 30, 2020
Marin, M. J., & van Wijk, X. M. R. (2020). Can We Improve Current Cancer Screening Programs? Clinical Chemistry, 66(5), 746–746. https://doi.org/10.1093/clinchem/hvaa078
Sensitive immunoassay testing platforms
Biomarkers for Traumatic Brain Injury / Jan 01, 2020
Marin, M. J., & van Wijk, X. M. R. (2020). Sensitive immunoassay testing platforms. In Biomarkers for Traumatic Brain Injury (pp. 243–264). Elsevier. https://doi.org/10.1016/b978-0-12-816346-7.00018-x
P4503A multi-site coronary vein sampling study on cardiac troponin T degradation in non-ST-elevation myocardial infarction
European Heart Journal / Oct 01, 2019
Cramer, G. E., Damen, S. A. J., Vroemen, W. H. M., Mezger, S. T. P., Suryapranata, H., Van Royen, N., Bekers, O., Meex, S. J. R., Wodzig, W. K. W. H., Verheugt, F. W. A., De Boer, D., Brouwer, M. A., & Mingels, A. M. A. (2019). P4503A multi-site coronary vein sampling study on cardiac troponin T degradation in non-ST-elevation myocardial infarction. European Heart Journal, 40(Supplement_1). https://doi.org/10.1093/eurheartj/ehz745.0896
Losing sight of the Forest for the trees: Why clinical laboratories need to perform their own interference studies
Clinica Chimica Acta / Aug 01, 2018
Marin, M. J., van Wijk, X. M. R., & Yeo, K.-T. J. (2018). Losing sight of the Forest for the trees: Why clinical laboratories need to perform their own interference studies. Clinica Chimica Acta, 483, 239–240. https://doi.org/10.1016/j.cca.2018.05.008
Inactivation of heparan sulfate 2‐O‐sulfotransferase reduce neutrophil bactericidal activity and endothelial integrity to exacerbate host survival upon Group B Streptococcus infection (607.14)
The FASEB Journal / Apr 01, 2014
Chang, Y., Xu, D., van Wijk, X., Esko, J., & Nizet, V. (2014). Inactivation of heparan sulfate 2‐O‐sulfotransferase reduce neutrophil bactericidal activity and endothelial integrity to exacerbate host survival upon Group B Streptococcus infection (607.14). The FASEB Journal, 28(S1). Portico. https://doi.org/10.1096/fasebj.28.1_supplement.607.14
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