severine margeridon

Molecular Diagnostics R&D leader

CASTRO VALLEY, California, United States of America

Research Expertise

Molecular diagnostics
NGS, qPCR, digital PCR
Infectious diseases
Women and reproductive health
Operational excellence
Project management
Molecular assay development
Oncology
NGS
Molecular Biology

About

An excellence driven Molecular Diagnostics leader, holding a Ph.D. in Virology and Molecular Biology, with nearly 20 years of combined professional experience as both a molecular assay development lead and a project manager professional. Extensive experience in developing cutting edge molecular biology assays utilizing NGS, qPCR, and digital PCR within the fields of oncology, infectious diseases, genetics, and women's reproductive health. Possesses advanced project and cross-functional management expertise, supported by a PMP certification. Successfully established international consortium, fostered external collaborations with clinical laboratories, and engaged scientific advisory boards effectively. Committed to providing answers to patients through innovation, integrity and inclusivity.

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Publications

Ultra‐Deep Pyrosequencing of Hepatitis B Virus Quasispecies from Nucleoside and Nucleotide Reverse‐Transcriptase Inhibitor (NRTI)–Treated Patients and NRTI‐Naive Patients
The Journal of Infectious Diseases
2009
Rolling Circle Amplification, a Powerful Tool for Genetic and Functional Studies of Complete Hepatitis B Virus Genomes from Low-Level Infections and for Directly Probing Covalently Closed Circular DNA
Antimicrobial Agents and Chemotherapy
2008
Comparison of the Mechanisms of Drug Resistance among HIV, Hepatitis B, and Hepatitis C
Viruses
2010
Hepatitis B virus reverse transcriptase sequence variant database for sequence analysis and mutation discovery
Antiviral Research
2010
Initiation of hepatitis B virus genome replication and production of infectious virus following delivery in HepG2 cells by novel recombinant baculovirus vector
Journal of General Virology
2008
A quasi-monoclonal anti-HBs response can lead to immune escape of ‘wild-type’ hepatitis B virus
Journal of General Virology
2005
Low-Level Persistence of Drug Resistance Mutations in Hepatitis B Virus-Infected Subjects with a Past History of Lamivudine Treatment
Antimicrobial Agents and Chemotherapy
2013
Similar Prevalence of Low-Abundance Drug-Resistant Variants in Treatment-Naive Patients with Genotype 1a and 1b Hepatitis C Virus Infections as Determined by Ultradeep Pyrosequencing
PLoS ONE
2014
A classification model for G-to-A hypermutation in hepatitis B virus ultra-deep pyrosequencing reads
Bioinformatics
2010
Detection of NS5B C316N—A resistant mutation to sofosbuvir in treatment-naïve genotype 1b HCV-infected patients using ultra-deep sequencing
Journal of Clinical Virology
2015
P626: A novel, iteratively designed and highly multiplexed droplet digital PCR assay for non-invasive prenatal screening
Genetics in Medicine Open
2023
What is really ongoing during occult HBV reactivation?†
Hepatology
2006
Efficient PCR Production of Single-Stranded DNA Sequencing Templates
PCR Sequencing Protocols
A method for generating user-defined circular single-stranded DNA from plasmid DNA using Golden Gate intramolecular ligation
Unknown Venue
2022
O.168 Rolling circle amplification technology for the study of HBV variants
Journal of Clinical Virology
2006
Chronic Hepatitis B Virus Persistence: Mechanisms and Insights
Cureus
2025
A statistical investigation of parameters associated with low cell-free fetal DNA fraction in maternal plasma for noninvasive prenatal testing
The Journal of Maternal-Fetal & Neonatal Medicine
2024
63. Effects of DNA Methylation on AAV Integration and Transgene Expression
Molecular Therapy
2010
European Space Agency
The Grants Register 2023
2022
Whole Genome Sequencing: A Considered Approach to Clinical Implementation
Current Protocols in Human Genetics
2013
Un matériau unique pour détecter le formaldéhyde et trouver ses sources d’émission
Photoniques
2016
Introduction. Produire de la connaissance scientifique pour la pratique du management
Le projet de th�se de DBA
2017
Analyses et enjeux sur la qualité de l’air intérieur
Pollution atmosphérique
2014
Reply to Menzo et al
The Journal of Infectious Diseases
2009
P0314 PERSISTENCE OF HEPATITIS B INFECTION DESPITE A HIGH LEVEL OF HBS ANTIBODIES
Journal of Pediatric Gastroenterology and Nutrition
2004
La persistance de l’infection par le virus GB-C est associée à un meilleur pronostic de l’infection par le VIH
Gastroentérologie Clinique et Biologique
2004

Education

Université Claude Bernard Lyon 1

Ph.D., Virology and molecular biology / September, 2006

Villeurbanne

Experience

Bio-Rad (United States)

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