severine margeridon
Molecular Diagnostics R&D leader
Research Expertise
About
Publications
Ultra‐Deep Pyrosequencing of Hepatitis B Virus Quasispecies from Nucleoside and Nucleotide Reverse‐Transcriptase Inhibitor (NRTI)–Treated Patients and NRTI‐Naive Patients
The Journal of Infectious Diseases / May 01, 2009
Margeridon‐Thermet, S., Shulman, N. S., Ahmed, A., Shahriar, R., Liu, T., Wang, C., Holmes, S. P., Babrzadeh, F., Gharizadeh, B., Hanczaruk, B., Simen, B. B., Egholm, M., & Shafer, R. W. (2009). Ultra‐Deep Pyrosequencing of Hepatitis B Virus Quasispecies from Nucleoside and Nucleotide Reverse‐Transcriptase Inhibitor (NRTI)–Treated Patients and NRTI‐Naive Patients. The Journal of Infectious Diseases, 199(9), 1275–1285. https://doi.org/10.1086/597808
Rolling Circle Amplification, a Powerful Tool for Genetic and Functional Studies of Complete Hepatitis B Virus Genomes from Low-Level Infections and for Directly Probing Covalently Closed Circular DNA
Antimicrobial Agents and Chemotherapy / Sep 01, 2008
Margeridon, S., Carrouée-Durantel, S., Chemin, I., Barraud, L., Zoulim, F., Trépo, C., & Kay, A. (2008). Rolling Circle Amplification, a Powerful Tool for Genetic and Functional Studies of Complete Hepatitis B Virus Genomes from Low-Level Infections and for Directly Probing Covalently Closed Circular DNA. Antimicrobial Agents and Chemotherapy, 52(9), 3068–3073. https://doi.org/10.1128/aac.01318-07
Comparison of the Mechanisms of Drug Resistance among HIV, Hepatitis B, and Hepatitis C
Viruses / Dec 14, 2010
Margeridon-Thermet, S., & Shafer, R. W. (2010). Comparison of the Mechanisms of Drug Resistance among HIV, Hepatitis B, and Hepatitis C. Viruses, 2(12), 2696–2739. https://doi.org/10.3390/v2122696
Hepatitis B virus reverse transcriptase sequence variant database for sequence analysis and mutation discovery
Antiviral Research / Dec 01, 2010
Rhee, S.-Y., Margeridon-Thermet, S., Nguyen, M. H., Liu, T. F., Kagan, R. M., Beggel, B., Verheyen, J., Kaiser, R., & Shafer, R. W. (2010). Hepatitis B virus reverse transcriptase sequence variant database for sequence analysis and mutation discovery. Antiviral Research, 88(3), 269–275. https://doi.org/10.1016/j.antiviral.2010.09.012
Initiation of hepatitis B virus genome replication and production of infectious virus following delivery in HepG2 cells by novel recombinant baculovirus vector
Journal of General Virology / Aug 01, 2008
Lucifora, J., Durantel, D., Belloni, L., Barraud, L., Villet, S., Vincent, I. E., Margeridon-Thermet, S., Hantz, O., Kay, A., Levrero, M., & Zoulim, F. (2008). Initiation of hepatitis B virus genome replication and production of infectious virus following delivery in HepG2 cells by novel recombinant baculovirus vector. Journal of General Virology, 89(8), 1819–1828. https://doi.org/10.1099/vir.0.83659-0
A quasi-monoclonal anti-HBs response can lead to immune escape of ‘wild-type’ hepatitis B virus
Journal of General Virology / Jun 01, 2005
Margeridon, S., Lachaux, A., Trepo, C., Zoulim, F., & Kay, A. (2005). A quasi-monoclonal anti-HBs response can lead to immune escape of ‘wild-type’ hepatitis B virus. Journal of General Virology, 86(6), 1687–1693. https://doi.org/10.1099/vir.0.80810-0
Low-Level Persistence of Drug Resistance Mutations in Hepatitis B Virus-Infected Subjects with a Past History of Lamivudine Treatment
Antimicrobial Agents and Chemotherapy / Jan 01, 2013
Margeridon-Thermet, S., Svarovskaia, E. S., Babrzadeh, F., Martin, R., Liu, T. F., Pacold, M., Reuman, E. C., Holmes, S. P., Borroto-Esoda, K., & Shafer, R. W. (2013). Low-Level Persistence of Drug Resistance Mutations in Hepatitis B Virus-Infected Subjects with a Past History of Lamivudine Treatment. Antimicrobial Agents and Chemotherapy, 57(1), 343–349. https://doi.org/10.1128/aac.01601-12
Similar Prevalence of Low-Abundance Drug-Resistant Variants in Treatment-Naive Patients with Genotype 1a and 1b Hepatitis C Virus Infections as Determined by Ultradeep Pyrosequencing
PLoS ONE / Aug 20, 2014
Margeridon-Thermet, S., Le Pogam, S., Li, L., Liu, T. F., Shulman, N., Shafer, R. W., & Najera, I. (2014). Similar Prevalence of Low-Abundance Drug-Resistant Variants in Treatment-Naive Patients with Genotype 1a and 1b Hepatitis C Virus Infections as Determined by Ultradeep Pyrosequencing. PLoS ONE, 9(8), e105569. https://doi.org/10.1371/journal.pone.0105569
A classification model for G-to-A hypermutation in hepatitis B virus ultra-deep pyrosequencing reads
Bioinformatics / Oct 11, 2010
Reuman, E. C., Margeridon-Thermet, S., Caudill, H. B., Liu, T., Borroto-Esoda, K., Svarovskaia, E. S., Holmes, S. P., & Shafer, R. W. (2010). A classification model for G-to-A hypermutation in hepatitis B virus ultra-deep pyrosequencing reads. Bioinformatics, 26(23), 2929–2932. https://doi.org/10.1093/bioinformatics/btq570
Detection of NS5B C316N—A resistant mutation to sofosbuvir in treatment-naïve genotype 1b HCV-infected patients using ultra-deep sequencing
Journal of Clinical Virology / Aug 01, 2015
Wang, Y., Rao, H., & Wei, L. (2015). Detection of NS5B C316N—A resistant mutation to sofosbuvir in treatment-naïve genotype 1b HCV-infected patients using ultra-deep sequencing. Journal of Clinical Virology, 69, 234. https://doi.org/10.1016/j.jcv.2015.06.039
P626: A novel, iteratively designed and highly multiplexed droplet digital PCR assay for non-invasive prenatal screening
Genetics in Medicine Open / Jan 01, 2023
Ramesh, M., Warczak, T., Dzvova, N., Abayan, R., Gencoglu, M., Riel, T., Henriquez, A., Markose, P., Loomis, K., Mikhaylichenko, O., Hendel, N., Hall, E., Dannebaum, R., Margeridon, S., & Herrera, M. (2023). P626: A novel, iteratively designed and highly multiplexed droplet digital PCR assay for non-invasive prenatal screening. Genetics in Medicine Open, 1(1), 100682. https://doi.org/10.1016/j.gimo.2023.100682
What is really ongoing during occult HBV reactivation?†
Hepatology / Jan 01, 2006
Chemin, I., Alain, S., Margeridon, S., Mrani, S., Kay, A., & Trépo, C. (2006). What is really ongoing during occult HBV reactivation?†. Hepatology, 43(1), 195. https://doi.org/10.1002/hep.21008
Efficient PCR Production of Single-Stranded DNA Sequencing Templates
PCR Sequencing Protocols
Kaltenboeck, B., & Kousoulas, K. G. (n.d.). Efficient PCR Production of Single-Stranded DNA Sequencing Templates. In PCR Sequencing Protocols (pp. 149–154). Humana Press. https://doi.org/10.1385/0-89603-344-9:149
A method for generating user-defined circular single-stranded DNA from plasmid DNA using Golden Gate intramolecular ligation
Nov 22, 2022
Strawn, I. K., Steiner, P. J., Newton, M. S., & Whitehead, T. A. (2022). A method for generating user-defined circular single-stranded DNA from plasmid DNA using Golden Gate intramolecular ligation. https://doi.org/10.1101/2022.11.21.517425
O.168 Rolling circle amplification technology for the study of HBV variants
Journal of Clinical Virology / Jan 01, 2006
Margeridon, S., Durantel, S., Chemin, I., Barraud, L., Zoulim, F., Trépo, C., & Kay, A. (2006). O.168 Rolling circle amplification technology for the study of HBV variants. Journal of Clinical Virology, 36, S51–S52. https://doi.org/10.1016/s1386-6532(06)80158-7
Chronic Hepatitis B Virus Persistence: Mechanisms and Insights
Cureus / Feb 13, 2025
Naidu, S., & Margeridon, S. (2025). Chronic Hepatitis B Virus Persistence: Mechanisms and Insights. Cureus. https://doi.org/10.7759/cureus.78944
A statistical investigation of parameters associated with low cell-free fetal DNA fraction in maternal plasma for noninvasive prenatal testing
The Journal of Maternal-Fetal & Neonatal Medicine / Jan 02, 2024
Pan, Y., Pan, X., Zhuang, D., Zhou, Y., Xue, J., Wu, S., Chen, C., & Li, H. (2024). A statistical investigation of parameters associated with low cell-free fetal DNA fraction in maternal plasma for noninvasive prenatal testing. The Journal of Maternal-Fetal & Neonatal Medicine, 37(1). https://doi.org/10.1080/14767058.2024.2338440
63. Effects of DNA Methylation on AAV Integration and Transgene Expression
Molecular Therapy / May 01, 2010
63. Effects of DNA Methylation on AAV Integration and Transgene Expression. (2010). Molecular Therapy, 18, S25–S26. https://doi.org/10.1016/s1525-0016(16)37504-9
European Space Agency
The Grants Register 2023 / Jan 01, 2022
European Space Agency. (2022). In The Grants Register 2023 (pp. 456–456). Palgrave Macmillan UK. https://doi.org/10.1057/978-1-349-96053-8_4236
Whole Genome Sequencing: A Considered Approach to Clinical Implementation
Current Protocols in Human Genetics / Apr 01, 2013
Dimmock, D. (2013). Whole Genome Sequencing: A Considered Approach to Clinical Implementation. Current Protocols in Human Genetics, 77(1). Portico. https://doi.org/10.1002/0471142905.hg0922s77
Un matériau unique pour détecter le formaldéhyde et trouver ses sources d’émission
Photoniques / Sep 01, 2016
Tran-Thi, T.-H., Le Chevallier, G., Rivron, C., Mugherli, L., Margeridon-Thermet, S., Abedini, F., François, R., & Hammel, F. (2016). Un matériau unique pour détecter le formaldéhyde et trouver ses sources d’émission. Photoniques, 83, 28–33. https://doi.org/10.1051/photon/20168328
Introduction. Produire de la connaissance scientifique pour la pratique du management
Le projet de th�se de DBA / Jan 01, 2017
Beaulieu, P. (2017). Introduction. Produire de la connaissance scientifique pour la pratique du management. In Le projet de th�se de DBA (p. 8). EMS Editions. https://doi.org/10.3917/ems.beaul.2017.01.0008
Analyses et enjeux sur la qualité de l’air intérieur
Pollution atmosphérique / Jun 01, 2014
Derbez, M. (2014). Analyses et enjeux sur la qualité de l’air intérieur: La qualité de l’air intérieur : un enjeu pour les bâtiments performants en énergie ? Pollution Atmosphérique, NS 7, 8–10. https://doi.org/10.54563/pollution-atmospherique.7742
Reply to Menzo et al
The Journal of Infectious Diseases / Dec 01, 2009
Margeridon‐Thermet, S., Rhee, S., & Shafer, R. W. (2009). Reply to Menzo et al. The Journal of Infectious Diseases, 200(11), 1799–1800. https://doi.org/10.1086/647992
P0314 PERSISTENCE OF HEPATITIS B INFECTION DESPITE A HIGH LEVEL OF HBS ANTIBODIES
Journal of Pediatric Gastroenterology and Nutrition / Jun 01, 2004
Margeridon, S., Lachaux, A., Trepo, C., Zoulim, F., & Kay, A. (2004). P0314 PERSISTENCE OF HEPATITIS B INFECTION DESPITE A HIGH LEVEL OF HBS ANTIBODIES. Journal of Pediatric Gastroenterology and Nutrition, 39(Supplement 1), S176. https://doi.org/10.1097/00005176-200406001-00438
La persistance de l’infection par le virus GB-C est associée à un meilleur pronostic de l’infection par le VIH
Gastroentérologie Clinique et Biologique / Nov 01, 2004
Roger, P.-M. (2004). La persistance de l’infection par le virus GB-C est associée à un meilleur pronostic de l’infection par le VIH. Gastroentérologie Clinique et Biologique, 28(11), 1194–1196. https://doi.org/10.1016/s0399-8320(04)95211-6
Education
Université Claude Bernard Lyon 1
Ph.D., Virology and molecular biology / September, 2006
Experience
Bio-Rad (United States)
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