Michael W Harman

Distinguished Subject Matter Expert & Leader in Medical Technologies.

East Greenwich, RI, Rhode Island, United States of America

Research Expertise

Bacteria & Cell Bio-Physics
Biomechanics
Infectious Diseases
Immunology
Microbiology
Parasitology
Biophysics
Cell Biology
Molecular Biology
Biochemistry
Cancer Research
Genetics
Oncology
Biotechnology

About

Highly skilled, energetic, and motivated professional empowered by over a decade of cross-disciplinary engineering and scientific applications experience. Presenting elegant solutions to prevalent biomedical challenges. Motivated by driving deliverable outcomes from complex research studies through effective leadership, active consulting work, and innovative problem-solving techniques. Seeking to make an immediate impact in a fast-paced biotechnology environment capitalizing on my advanced comprehension, continued professional growth, strategic product development expertise, and active network of personal connections across all areas of science, engineering, medicine, manufacturing and healthcare.

Publications

The Hybrid Histidine Kinase Hk1 Is Part of a Two-Component System That Is Essential for Survival of Borrelia burgdorferi in Feeding Ixodes scapularis Ticks

Infection and Immunity / Aug 01, 2011

Caimano, M. J., Kenedy, M. R., Kairu, T., Desrosiers, D. C., Harman, M., Dunham-Ems, S., Akins, D. R., Pal, U., & Radolf, J. D. (2011). The Hybrid Histidine Kinase Hk1 Is Part of a Two-Component System That Is Essential for Survival of Borrelia burgdorferi in Feeding Ixodes scapularis Ticks. Infection and Immunity, 79(8), 3117–3130. https://doi.org/10.1128/iai.05136-11

The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue

Proceedings of the National Academy of Sciences / Feb 06, 2012

Harman, M. W., Dunham-Ems, S. M., Caimano, M. J., Belperron, A. A., Bockenstedt, L. K., Fu, H. C., Radolf, J. D., & Wolgemuth, C. W. (2012). The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue. Proceedings of the National Academy of Sciences, 109(8), 3059–3064. https://doi.org/10.1073/pnas.1114362109

Viscous Dynamics of Lyme Disease and Syphilis Spirochetes Reveal Flagellar Torque and Drag

Biophysical Journal / Nov 01, 2013

Harman, M., Vig, D. K., Radolf, J. D., & Wolgemuth, C. W. (2013). Viscous Dynamics of Lyme Disease and Syphilis Spirochetes Reveal Flagellar Torque and Drag. Biophysical Journal, 105(10), 2273–2280. https://doi.org/10.1016/j.bpj.2013.10.004

Measuring DNA content in live cells by fluorescence microscopy

Cell Division / Sep 04, 2018

Gomes, C. J., Harman, M. W., Centuori, S. M., Wolgemuth, C. W., & Martinez, J. D. (2018). Measuring DNA content in live cells by fluorescence microscopy. Cell Division, 13(1). https://doi.org/10.1186/s13008-018-0039-z

Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning

Cell Reports / Jun 01, 2021

Watson, A. W., Grant, A. D., Parker, S. S., Hill, S., Whalen, M. B., Chakrabarti, J., Harman, M. W., Roman, M. R., Forte, B. L., Gowan, C. C., Castro-Portuguez, R., Stolze, L. K., Franck, C., Cusanovich, D. A., Zavros, Y., Padi, M., Romanoski, C. E., & Mouneimne, G. (2021). Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning. Cell Reports, 35(13), 109293. https://doi.org/10.1016/j.celrep.2021.109293

Context-Dependent Role of Vinculin in Neutrophil Adhesion, Motility and Trafficking

Scientific Reports / Feb 07, 2020

Wilson, Z. S., Witt, H., Hazlett, L., Harman, M., Neumann, B. M., Whitman, A., Patel, M., Ross, R. S., Franck, C., Reichner, J. S., & Lefort, C. T. (2020). Context-Dependent Role of Vinculin in Neutrophil Adhesion, Motility and Trafficking. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-58882-y

Vancomycin Reduces Cell Wall Stiffness and Slows Swim Speed of the Lyme Disease Bacterium

Biophysical Journal / Feb 01, 2017

Harman, M. W., Hamby, A. E., Boltyanskiy, R., Belperron, A. A., Bockenstedt, L. K., Kress, H., Dufresne, E. R., & Wolgemuth, C. W. (2017). Vancomycin Reduces Cell Wall Stiffness and Slows Swim Speed of the Lyme Disease Bacterium. Biophysical Journal, 112(4), 746–754. https://doi.org/10.1016/j.bpj.2016.12.039

The induction of endoreduplication and polyploidy by elevated expression of 14-3-3γ

Genes & Cancer / Dec 24, 2017

Gomes, C. J., Centuori, S. M., Harman, M. W., Putnam, C. W., Wolgemuth, C. W., & Martinez, J. D. (2017). The induction of endoreduplication and polyploidy by elevated expression of 14-3-3γ. Genes & Cancer, 8(11–12), 771–783. https://doi.org/10.18632/genesandcancer.161

Breast tumor stiffness instructs bone metastasis via mechanical memory

Nov 20, 2019

Watson, A. W., Grant, A., Parker, S. S., Harman, M. W., Roman, M. R., Forte, B. L., Gowan, C. C., Castro-Portuguez, R., Franck, C., Cusanovich, D., Padi, M., Romanoski, C., & Mouneimne, G. (2019). Breast tumor stiffness instructs bone metastasis via mechanical memory. https://doi.org/10.1101/847699

Vinculin in Neutrophil Adhesion, Motility and Trafficking

The FASEB Journal / Apr 01, 2018

Wilson, Z., Harman, M., Hazlett, L., Odzer, J., Witt, H., Franck, C., Reichner, J., & Lefort, C. (2018). Vinculin in Neutrophil Adhesion, Motility and Trafficking. The FASEB Journal, 32(S1). Portico. https://doi.org/10.1096/fasebj.2018.32.1_supplement.280.11

Four Dimensional Traction Measurements of Chemotactic Neutrophils in Hydrogels

Biophysical Journal / Feb 01, 2018

Harman, M. W., Franck, C., & Reichner, J. (2018). Four Dimensional Traction Measurements of Chemotactic Neutrophils in Hydrogels. Biophysical Journal, 114(3), 324a. https://doi.org/10.1016/j.bpj.2017.11.1819

Context-dependent role of vinculin in neutrophil adhesion, motility and trafficking

Nov 20, 2019

Wilson, Z. S., Witt, H., Hazlett, L., Harman, M., Neumann, B. M., Whitman, A., Patel, M., Ross, R. S., Franck, C., Reichner, J. S., & Lefort, C. T. (2019). Context-dependent role of vinculin in neutrophil adhesion, motility and trafficking. https://doi.org/10.1101/847780

Abstract 3591: Expression of 14-3-3 gamma stabilizes polyploidization in NSCLC cells

Cancer Research / Jul 15, 2016

Gomes, C. J., Harman, M., Centuori, S., Wolgemuth, C., & Martinez, J. (2016). Abstract 3591: Expression of 14-3-3 gamma stabilizes polyploidization in NSCLC cells. Cancer Research, 76(14_Supplement), 3591–3591. https://doi.org/10.1158/1538-7445.am2016-3591

Abstract 2066: Aberrant upregulation of 14-3-3 gamma promotes mononucleated polyploidization in human lung cancers

Cancer Research / Aug 01, 2015

Gomes, C. J., Harman, M., Martinez, J., & Centuori, S. (2015). Abstract 2066: Aberrant upregulation of 14-3-3 gamma promotes mononucleated polyploidization in human lung cancers. Cancer Research, 75(15_Supplement), 2066–2066. https://doi.org/10.1158/1538-7445.am2015-2066

The Computational Analysis of Spirochete Motility in Viscous Fluids: Mimicking Host Reservoir Micro-Environments

Biophysical Journal / Jan 01, 2013

Harman, M. W., Vig, D. K., Radolf, J. D., & Wolgemuth, C. W. (2013). The Computational Analysis of Spirochete Motility in Viscous Fluids: Mimicking Host Reservoir Micro-Environments. Biophysical Journal, 104(2), 638a–639a. https://doi.org/10.1016/j.bpj.2012.11.3526

Education

University of Connecticut

BS, Biomedical Engineering, Biofluid Mechanics Track / May, 2008

Storrs, Connecticut, United States of America

University of Connecticut

MS, Biomedical Engineering, Biomechanics Concentration / December, 2009

Storrs, Connecticut, United States of America

University of Arizona

Ph.D, Biochemistry, Molecular and Cellular Biology / December, 2015

Tucson, Arizona, United States of America

Experience

Brown University

Postdoctoral Research Fellow / May, 2016August, 2018

Critical lead asset driving preclinical collaborative cell biomechanics study managing 30 personnel between immunology, pathobiology, and experimental soft matter mechanics laboratories.

Rhode Island Hospital

Postdoctoral Research Fellow / May, 2016August, 2018

Critical lead asset driving preclinical collaborative cell biomechanics study managing 30 personnel between immunology, pathobiology, and experimental soft matter mechanics laboratories.

Ximedica

Research & Development Engineer / September, 2018October, 2019

Provided technical subject matter expertise to enhance the clinical performance of novel medical products being designed.

Research & Development Engineering Manager / October, 2019July, 2020

Grew a team of Research & Development Engineers out of our traditional designer, mechanical, and electrical engineering departments to form a novel team within the organization and supported each of their individual professional development needs.

Veranex Solutions (formerly Ximedica)

Director of Research & Development, Technology, and Innovation / July, 2020July, 2022

As a director, served in a tactical leader role on product development teams that are executing functional design efforts on cutting-edge medical products, including complex capital equipment, as well as, high-volume disposable components across all sectors of the business (medtech, diagnostics, drug delivery, and cell therapies).

BioVentrix

Director of Research & Development, and Engineering / January, 2023Present

Independently organize, manage, and execute the relocation of all company operations from San Ramon, CA to their new office in Mansfield, MA

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