Dr. Shallini Jain

Assistant Professor, University of South Florida

New Port Richey, Florida, United States of America

Research Expertise

Nutrition
Metabolism
Aging
Cancer
Alzheimer

About

**Dr\. Shalini Jain – Co\-Founder\, MusB Research \| Scientific Leader in Translational Microbiome and Clinical Innovation** Dr. Shalini Jain is a distinguished scientist, entrepreneur, and co-founder of MusB Research, where she leads strategic initiatives in clinical and translational research for dietary supplements, natural products, and microbiome-based health solutions. With extensive experience across academic and industry settings, Dr. Jain specializes in bridging early-stage scientific discoveries into clinically validated, market-ready products. Her work focuses on designing and executing rigorous preclinical and clinical studies that generate high-quality, regulatory-aligned evidence. She has led multiple projects spanning gut health, metabolic disorders, women’s health, and longevity, with a strong emphasis on microbiome modulation, biomarker development, and functional health outcomes. Dr. Jain brings deep expertise in study design, operational execution, and cross-functional collaboration, ensuring that research programs are both scientifically robust and commercially relevant. At MusB Research, she plays a central role in building partnerships with industry sponsors, academic investigators, and global collaborators. She is also actively involved in advancing innovative platforms such as decentralized clinical trials and multi-site global research networks, enabling faster and more cost-efficient product validation. Dr. Jain is committed to helping partners substantiate their products with credible science, differentiate in competitive markets, and accelerate their path to commercialization. She is recognized for her collaborative approach, attention to scientific rigor, and ability to align research outcomes with business and regulatory goals. **For industry partners**, Dr. Jain offers a trusted pathway to transform promising concepts into clinically validated solutions with strong scientific and market positioning.

Publications

Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats
Nutrition
2007
Probiotics, their health benefits and applications for developing healthier foods: a review
FEMS Microbiology Letters
2012
Cholesterol-Lowering Probiotics as Potential Biotherapeutics for Metabolic Diseases
Experimental Diabetes Research
2012
Medicinal and biological potential of pumpkin: an updated review
Nutrition Research Reviews
2010
Bioactive peptides derived from milk proteins and their health beneficial potentials: an update
Food Funct.
2011
Cancer-preventing attributes of probiotics: an update
International Journal of Food Sciences and Nutrition
2010
Oral administration of dahi containing probioticLactobacillus acidophilusandLactobacillus caseidelayed the progression of streptozotocin-induced diabetes in rats
Journal of Dairy Research
2008
Exotic fruits as therapeutic complements for diabetes, obesity and metabolic syndrome
Food Research International
2011
A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut
Gut
2023
Effect of camel milk on glycemic control and insulin requirement in patients with type 1 diabetes: 2-years randomized controlled trial
European Journal of Clinical Nutrition
2011
A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis
JCI Insight
2020
Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice
GeroScience
2019
Obesity-Linked Gut Microbiome Dysbiosis Associated with Derangements in Gut Permeability and Intestinal Cellular Homeostasis Independent of Diet
Journal of Diabetes Research
2018
Novel designer receptors to probe GPCR signaling and physiology
Trends in Pharmacological Sciences
2013
Molecular approaches for identification and characterization of lactic acid bacteria
Journal of Digestive Diseases
2008
Biological and Medicinal Properties of Grapes and Their Bioactive Constituents: An Update
Journal of Medicinal Food
2009
Putative bacterial volatile-mediated growth in soybean (Glycine max L. Merrill) and expression of induced proteins under salt stress
Journal of Applied Microbiology
2015
Production of free fatty acids and conjugated linoleic acid in probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei during fermentation and storage
International Dairy Journal
2007
Milk, Milk Products, and Disease Free Health: An Updated Overview
Critical Reviews in Food Science and Nutrition
2012
Metformin Reduces Aging-Related Leaky Gut and Improves Cognitive Function by Beneficially Modulating Gut Microbiome/Goblet Cell/Mucin Axis
The Journals of Gerontology: Series A
2020
Chronic activation of a designer Gq-coupled receptor improves β cell function
Journal of Clinical Investigation
2013
Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake
Nature Communications
2016
Noninvasive Method for Glucose Level Estimation by Saliva
Journal of Diabetes & Metabolism
2013
IR2V EC
ACM Transactions on Architecture and Code Optimization
2020
Heuristic design of pressure swing adsorption: a preliminary study
Separation and Purification Technology
2003
Hexagonal fuzzy number and its distinctive representation, ranking, defuzzification technique and application in production inventory management problem
Granular Computing
2020
Complementary and Comparative Study on Hypoglycemic and Antihyperglycemic Activity of Various Extracts of Eugenia jambolana Seed, Momordica charantia Fruits, Gymnema sylvestre, and Trigonella foenum graecum Seeds in Rats
Applied Biochemistry and Biotechnology
2009
Gut–Brain Axis as a Pathological and Therapeutic Target for Neurodegenerative Disorders
International Journal of Molecular Sciences
2022
Cross-Talk Between Gluten, Intestinal Microbiota and Intestinal Mucosa in Celiac Disease: Recent Advances and Basis of Autoimmunity
Frontiers in Microbiology
2018
Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
Nature Communications
2018
Probiotics and Prebiotics for Promoting Health
Probiotics, Prebiotics, and Synbiotics
2016
Effect of Lifestyle Modification Measures on Lipid Profile In Type -2 Diabetic Patients
International Academic Journal of Applied Bio-Medical Sciences
2021
A Novel Experimental Strategy to Assess the Metabolic Effects of Selective Activation of a Gq-Coupled Receptor in Hepatocytes In Vivo
Endocrinology
2013
Hypothermia in mouse is caused by adenosine A1 and A3 receptor agonists and AMP via three distinct mechanisms
Neuropharmacology
2017
Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer
Cancer Research
2015
Primary Intraspinal Primitive Neuroectodermal Tumor (PNET): A Rare Occurrence
MOJ Clinical & Medical Case Reports
2017
Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis
Nature Communications
2019
Antimicrobial Property of a Herbal Preparation Containing Dalbergia Sissoo and Datura Stramonium with Cow Urine against Pathogenic Bacteria
International Journal of Immunopathology and Pharmacology
2008
Evaluation of changes during storage of probiotic dahi at 7°C
International Journal of Dairy Technology
2007
Effect of Skim Milk and Dahi (Yogurt) on Blood Glucose, Insulin, and Lipid Profile in Rats Fed with High Fructose Diet
Journal of Medicinal Food
2006
Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function
JCI Insight
2024
Dahi Containing Probiotic Lactobacillus Acidophilus and Lactobacillus Casei Has a Protective Effect against Salmonella Enteritidis Infection in Mice
International Journal of Immunopathology and Pharmacology
2008
Protection of Alzheimer’s disease progression by a human-origin probiotics cocktail
Scientific Reports
2025
Evaluation of Micronuclei Induction Capacity and Mutagenicity of Organochlorine and Organophosphate Pesticides
Drug Metabolism Letters
2013
Probiotic Dahi Containing Lactobacillus casei Protects Against Salmonella enteritidis Infection and Modulates Immune Response in Mice
Journal of Medicinal Food
2009
Effect of an isoflavones-containing red clover preparation and alkaline supplementation on bone metabolism in ovariectomized rats
Clinical Interventions in Aging
2009
Effect of Dahi ContainingLactococcus lactison the Progression of Diabetes Induced by a High-Fructose Diet in Rats
Bioscience, Biotechnology, and Biochemistry
2006
Potential Anti-Diabetic Effect of Camel Milk
Practice, Progress, and Proficiency in Sustainability
2020
Antioxidant and cholesterol assimilation activities of selected lactobacilli and lactococci cultures
Journal of Dairy Research
2009
Microbiome and Postbiotics in Skin Health
Biomedicines
2025
The Effect of Probiotic Dahi Containing Lactobacillus acidophilus and Lactobacillus casei on Gastropathic Consequences in Diabetic Rats
Journal of Medicinal Food
2008
Formation of oligosaccharides in skim milk fermented with mixed dahi cultures, Lactococcus lactis ssp diacetylactis and probiotic strains of lactobacilli
Journal of Dairy Research
2007
Hyperdense artery sign, symptomatic infarct swelling and effect of alteplase in acute ischaemic stroke
Stroke and Vascular Neurology
2020
Needle-based fluorescence endomicroscopy via structured illumination with a plastic, achromatic objective
Journal of Biomedical Optics
2013
Optimization of Conversion of High Free Fatty Acid Jatropha curcas Oil to Biodiesel Using Response Surface Methodology
ISRN Chemical Engineering
2012
Classification of Diabetic Retinopathy using Pre-Trained Deep Learning Models
Advances in Machine Learning & Artificial Intelligence
2024
Infection of Early and Young Callus Tissues of Indica Rice BPT 5204 Enhances Regeneration and Transformation Efficiency
Rice Science
2013
Fermentation Technology in the Development of Functional Foods for Human Health: Where We Should Head
Fermentation Technology
2012
Anti-allergic effects of probiotic Dahi through modulation of the gut immune system
The Turkish Journal of Gastroenterology
2010
The effects of prebiotics on gastrointestinal side effects of metformin in youth: A pilot randomized control trial in youth-onset type 2 diabetes
Frontiers in Endocrinology
2023
Cardioprotective Effect of a Biofermented Nutraceutical on Endothelial Function in Healthy Middle-Aged Subjects
Rejuvenation Research
2012
Preventive Effect of Diabegon, a Polyherbal Preparation, During Progression of Diabetes Induced by High-Fructose Feeding in Rats
Journal of Pharmacological Sciences
2007
Regulating Redox Balance Gene Expression in Healthy Individuals by Nutraceuticals: A Pilot Study
Rejuvenation Research
2010
Stimulation of Innate Immunity by Oral Administration of Dahi Containing Probiotic Lactobacillus casei in Mice
Journal of Medicinal Food
2008
The Oral–Gut Microbiome–Brain Axis in Cognition
Microorganisms
2025
POSET-RL: Phase ordering for Optimizing Size and Execution Time using Reinforcement Learning
2022 IEEE International Symposium on Performance Analysis of Systems and Software (ISPASS)
2022
Minireview: Novel Aspects of M3 Muscarinic Receptor Signaling in Pancreatic β-Cells
Molecular Endocrinology
2013
Protective effect of a phytocompound on oxidative stress and DNA fragmentation against paracetamol-induced liver damage
Annals of Hepatology
2009
Unique trans-kingdom microbiome structural and functional signatures predict cognitive decline in older adults
GeroScience
2023
Critical metabolic roles of β-cell M3 muscarinic acetylcholine receptors
Life Sciences
2012
Personal protective equipments and occupational stress in covid-19 era
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
2021
The Triple Alliance: Microbiome, Mitochondria, and Metabolites in the Context of Age-Related Cognitive Decline and Alzheimer’s Disease
The Journals of Gerontology: Series A
2023
Increased fecal viral content associated with obesity in mice
World Journal of Diabetes
2016
Epigenomic derangement of hepatic glucose metabolism by feeding of high fructose diet and its prevention by Rosiglitazone in rats
Digestive and Liver Disease
2009
Adipose Tissue Transferrin and Insulin Resistance
The Journal of Clinical Endocrinology & Metabolism
2018
A Cascade of Microbiota-Leaky Gut-Inflammation- Is it a Key Player in Metabolic Disorders?
Current Obesity Reports
2025
Activation of Microbiota Sensing – Free Fatty Acid Receptor 2 Signaling Ameliorates Amyloid-β Induced Neurotoxicity by Modulating Proteolysis-Senescence Axis
Frontiers in Aging Neuroscience
2021
Conjugated linoleic acid: a multifunctional nutraceutical from the rumen
Current Research Topics in Applied Microbiology and Microbial Biotechnology
2009
Metal nanoparticles and medicinal plants: Present status and future prospects in cancer therapy
Materials Today: Proceedings
2020
Identification and expression analysis of pathogenicity-related genes in Tilletia indica inciting Karnal bunt of wheat
Australasian Plant Pathology
2020
Whole Grains in Amelioration of Metabolic Derangements
Journal of Nutritional Health & Food Science
2016
Gut Microbiome Derived Metabolites to Regulate Energy Homeostasis: How Microbiome Talks to Host
Journal of Postgenomics Drug & Biomarker Development
2016
Activities of Glycolytic Enzymes in Leaves and Roots of Contrasting Cultivars of Sorghum During Flooding
Biologia plantarum
2003
Anomalous Information Reception by Research Mediums Demonstrated Using a Novel Triple-Blind Protocol
EXPLORE
2007
Intermittent fasting with ketogenic diet: A combination approach for management of chronic diseases
Clinical Nutrition ESPEN
2023
Sleep deprivation in obesogenic setting alters lipidome and microbiome toward suboptimal inflammation in acute heart failure
The FASEB Journal
2023
Impact of obesity and diabetes on arthritis: An update
Health
2013
Poor Oral Health Linked with Higher Risk of Alzheimer’s Disease
Brain Sciences
2023
Diet-microbiome-gut-brain nexus in acute and chronic brain injury
Frontiers in Neuroscience
2022
Activation of adenosine A2A or A2B receptors causes hypothermia in mice
Neuropharmacology
2018
Characterization and anti-microbial susceptibility of bacterial isolates: Experience from a tertiary care cancer center in Delhi
Indian Journal of Cancer
2014
Dichloroacetate improves systemic energy balance and feeding behavior during sepsis
JCI Insight
2022
Complementary Hypoglycemic and Anti-Hyperglycemic Activity of Various Extracts of Fenugreek Seeds in Rats
Asian Journal of Biochemistry
2008
Abnormalities in gut virome signatures linked with cognitive impairment in older adults
Gut Microbes
2024
Bacterial Asparaginase: A Potential Antineoplastic Agent for Treatment of Acute Lymphoblastic Leukemia
Bacteria and Cancer
2011
Novel Insights: Differentially Expressed tsRNAs Modulate the Advance of Early-Stage Diabetic Nephropathy in Mice
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
2022
Modulation of cytokine gene expression in spleen and Peyer's patches by feeding dahi containing probiotic Lactobacillus casei in mice
Journal of Digestive Diseases
2009
Age-Related Cognitive Decline and Dementia: Interface of Microbiome–Immune–Neuronal Interactions
The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences
2025

Education

Ph.D., Biochemistry (Nutritional Immunology and Probiotics) / April, 2007

Karnal
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