Prof. Dr. med. Joachim Fluhr

Professor Charité Universitätsmedizin

Research Expertise

Allergology
Dermatology

Publications

pH Directly Regulates Epidermal Permeability Barrier Homeostasis, and Stratum Corneum Integrity/Cohesion
Journal of Investigative Dermatology
2003
Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: Changes in barrier function provide a sensitive indicator of disease activity
Journal of the American Academy of Dermatology
2002
Generation of Free Fatty Acids from Phospholipids Regulates Stratum Corneum Acidification and Integrity
Journal of Investigative Dermatology
2001
Short-Term Glucocorticoid Treatment Compromises Both Permeability Barrier Homeostasis and Stratum Corneum Integrity: Inhibition of Epidermal Lipid Synthesis Accounts for Functional Abnormalities
Journal of Investigative Dermatology
2003
Glycerol and the skin: holistic approach to its origin and functions
British Journal of Dermatology
2008
The tape stripping procedure – evaluation of some critical parameters
European Journal of Pharmaceutics and Biopharmaceutics
2009
Transepidermal water loss reflects permeability barrier status: validation in human and rodent in vivo and ex vivo models
Experimental Dermatology
2006
Beneficial Long-Term Effects of Combined Oral/Topical Antioxidant Treatment with the Carotenoids Lutein and Zeaxanthin on Human Skin: A Double-Blind, Placebo-Controlled Study
Skin Pharmacology and Physiology
2007
Glycerol Regulates Stratum Corneum Hydration in Sebaceous Gland Deficient (Asebia) Mice
Journal of Investigative Dermatology
2003
Non-invasive in vivo methods for investigation of the skin barrier physical properties
European Journal of Pharmaceutics and Biopharmaceutics
2009
Stratum corneum pH: Formation and Function of the ‘Acid Mantle’
Exogenous Dermatology
2002
Water Content
Bioengineering of the Skin
2004
Stratum Corneum Acidification Is Impaired in Moderately Aged Human and Murine Skin
Journal of Investigative Dermatology
2007
Liver X Receptor Activators Display Anti-Inflammatory Activity in Irritant and Allergic Contact Dermatitis Models: Liver-X-Receptor-Specific Inhibition of Inflammation and Primary Cytokine Production
Journal of Investigative Dermatology
2003
Functional skin adaptation in infancy – almost complete but not fully competent
Experimental Dermatology
2010
Definition of Sensitive Skin: An Expert Position Paper from the Special Interest Group on Sensitive Skin of the International Forum for the Study of Itch
Acta Dermato Venereologica
2017
Phenotypic and genotypic characterization of antibiotic-resistant Propionibacterium acnes isolated from acne patients attending dermatology clinics in Europe, the U.S.A., Japan and Australia
British Journal of Dermatology
2001
Infant epidermal skin physiology: adaptation after birth
British Journal of Dermatology
2012
Glycerol Accelerates Recovery of Barrier Function In Vivo
Acta Dermato-Venereologica
1999
Comparative study of five instruments measuring stratum corneum hydration (Corneometer CM 820 and CM 825, Skicon 200, Nova DPM 9003, DermaLab). Part I. In vitro
Skin Research and Technology
1999
Increased stratum corneum serine protease activity in acute eczematous atopic skin
British Journal of Dermatology
2009
The Objective Severity Assessment of Atopic Dermatitis Score
Archives of Dermatology
2003
Emollients, moisturizers, and keratolytic agents in psoriasis
Clinics in Dermatology
2008
Topical Peroxisome Proliferator Activated Receptor-α Activators Reduce Inflammation in Irritant and Allergic Contact Dermatitis Models
Journal of Investigative Dermatology
2002
Natural moisturizing factor components in the stratum corneum as biomarkers of filaggrin genotype: evaluation of minimally invasive methods
British Journal of Dermatology
2009
Acute barrier disruption by adhesive tapes is influenced by pressure, time and anatomical location: integrity and cohesion assessed by sequential tape stripping; a randomized, controlled study
British Journal of Dermatology
2007
Placebo-Controlled, Double-Blind, Randomized, Prospective Study of a Glycerol-Based Emollient on Eczematous Skin in Atopic Dermatitis: Biophysical and Clinical Evaluation
Skin Pharmacology and Physiology
2007
How to Approach Chronic Inducible Urticaria
The Journal of Allergy and Clinical Immunology: In Practice
2018
From seafood waste to active seafood packaging: An emerging opportunity of the circular economy
Journal of Cleaner Production
2019
Topical retinoids in acne – an evidence‐based overview
JDDG: Journal der Deutschen Dermatologischen Gesellschaft
2008
Full-Body Skin Mapping for Six Biophysical Parameters: Baseline Values at 16 Anatomical Sites in 125 Human Subjects
Skin Pharmacology and Physiology
2011
Skin Irritation and Sensitization: Mechanisms and New Approaches for Risk Assessment
Skin Pharmacology and Physiology
2008
Stratum Corneum Acidification in Neonatal Skin: Secretory Phospholipase A2 and the Sodium/Hydrogen Antiporter-1 Acidify Neonatal Rat Stratum Corneum
Journal of Investigative Dermatology
2004
Positive Effect of HPA Lanolin versus Expressed Breastmilk on Painful and Damaged Nipples during Lactation
Skin Pharmacology and Physiology
2010
Filaggrin Deficiency Leads to Impaired Lipid Profile and Altered Acidification Pathways in a 3D Skin Construct
Journal of Investigative Dermatology
2014
Direct Comparison of Skin Physiology in Children and Adults with Bioengineering Methods
Pediatric Dermatology
2000
Testing for irritation with a multifactorial approach: comparison of eight non-invasive measuring techniques on five different irritation types
British Journal of Dermatology
2001
Risk assessment of the application of a plasma jet in dermatology
Journal of Biomedical Optics
2009
Impact of anatomical location on barrier recovery, surface pH and stratum corneum hydration after acute barrier disruption
British Journal of Dermatology
2002
In vivo skin treatment with tissue‐tolerable plasma influences skin physiology and antioxidant profile in human stratum corneum
Experimental Dermatology
2011
H1 histamine receptor mediates inflammatory responses in human keratinocytes
Journal of Allergy and Clinical Immunology
2004
Influence of skin type, race, sex, and anatomic location on epidermal barrier function
Clinics in Dermatology
2012
Acute Acidification of Stratum Corneum Membrane Domains Using Polyhydroxyl Acids Improves Lipid Processing and Inhibits Degradation of Corneodesmosomes
Journal of Investigative Dermatology
2010
Tolerance Profile of Retinol, Retinaldehyde and Retinoic Acid under Maximized and Long-Term Clinical Conditions
Dermatology
1999
Optical coherence tomography for presurgical margin assessment of non‐melanoma skin cancer – a practical approach
Experimental Dermatology
2013
Topical retinoids in the management of photodamaged skin: from theory to evidence-based practical approach
British Journal of Dermatology
2010
Atopic dermatitis as a systemic disease
Clinics in Dermatology
2014
Bioengineering of the Skin
Unknown Venue
2004
In vivoRaman spectroscopy detects increased epidermal antioxidative potential with topically applied carotenoids
Laser Physics Letters
2009
German S2k guidelines for the therapy of pathological scars (hypertrophic scars and keloids)
JDDG: Journal der Deutschen Dermatologischen Gesellschaft
2012
Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid
JDDG: Journal der Deutschen Dermatologischen Gesellschaft
2006
Functional Consequences of a Neutral pH in Neonatal Rat Stratum Corneum
Journal of Investigative Dermatology
2004
In vivo distribution of carotenoids in different anatomical locations of human skin: comparative assessment with two different Raman spectroscopy methods
Experimental Dermatology
2009
Morphological skin ageing criteria by multiphoton laser scanning tomography: non‐invasive in vivo scoring of the dermal fibre network
Experimental Dermatology
2008
Effects of Prolonged Occlusion on Stratum corneum Barrier Function and Water Holding Capacity<sup>1</sup>
Skin Pharmacology and Physiology
1999
Topical beta‐carotene protects against infra‐red‐light–induced free radicals
Experimental Dermatology
2011
Acute irritant threshold correlates with barrier function, skin hydration and contact hypersensitivity in atopic dermatitis and rosacea
Experimental Dermatology
2013
Structural and Functional Consequences of Loricrin Mutations in Human Loricrin Keratoderma (Vohwinkel Syndrome with Ichthyosis)
Journal of Investigative Dermatology
2004
Additive impairment of the barrier function by mechanical irritation, occlusion and sodium lauryl sulphate in vivo
British Journal of Dermatology
2005
Photodynamic therapy in dermatology: past, present, and future
Journal of Biomedical Optics
2012
Skin Irritation and Sensitization: Mechanisms and New Approaches for Risk Assessment
Skin Pharmacology and Physiology
2008
The Skin Acid Mantle: An Update on Skin pH
Journal of Investigative Dermatology
2025
In vivo study for the discrimination of cancerous and normal skin using fibre probe‐based Raman spectroscopy
Experimental Dermatology
2015
Functional assessment of a washing emulsion for sensitive skin: mild impairment of stratum corneum hydration, pH, barrier function, lipid content, integrity and cohesion in a controlled washing test
Skin Research and Technology
2005
Recalcitrant hand and foot warts successfully treated with photodynamic therapy with topical 5-aminolaevulinic acid: a pilot study
Clinical and Experimental Dermatology
1999
Pathophysiology and management of sensitive skin: position paper from the special interest group on sensitive skin of the International Forum for the Study of Itch (IFSI)
Journal of the European Academy of Dermatology and Venereology
2019
Optical Coherence Tomography–Based Optimization of Mohs Micrographic Surgery of Basal Cell Carcinoma: A Pilot Study
Dermatologic Surgery
2013
Epidermal barrier function in dry, flaky and sensitive skin: A narrative review
Journal of the European Academy of Dermatology and Venereology
2023
Melanosome Morphologies in Murine Models of Hermansky–Pudlak Syndrome Reflect Blocks in Organelle Development
Journal of Investigative Dermatology
2002
Scavenger Receptor Class B Type I Is Expressed in Cultured Keratinocytes and Epidermis
Journal of Biological Chemistry
2002
Practical Aspects of Cosmetic Testing
Unknown Venue
2020
Towards drug quantification in human skin with confocal Raman microscopy
European Journal of Pharmaceutics and Biopharmaceutics
2013
Antifungal and antibacterial properties of a silver‐loaded cellulosic fiber
Journal of Biomedical Materials Research Part B: Applied Biomaterials
2005
Encapsulated curcumin results in prolonged curcumin activity in vitro and radical scavenging activity ex vivo on skin after UVB-irradiation
European Journal of Pharmaceutics and Biopharmaceutics
2012
The Objective Severity Assessment of Atopic Dermatitis (OSAAD) score: validity, reliability and sensitivity in adult patients with atopic dermatitis
British Journal of Dermatology
2005
Is the Filaggrin–Histidine–Urocanic Acid Pathway Essential for Stratum Corneum Acidification?
Journal of Investigative Dermatology
2010
On the course of the irritant reaction after irritation with sodium lauryl sulphate
Skin Research and Technology
2004
Lysophosphatidic Acid Induces Chemotaxis, Oxygen Radical Production, CD11b Up-Regulation, Ca2+ Mobilization, and Actin Reorganization in Human Eosinophils via Pertussis Toxin-Sensitive G Proteins
The Journal of Immunology
2004
Dermal carotenoid level and kinetics after topical and systemic administration of antioxidants: Enrichment strategies in a controlled in vivo study
Journal of Dermatological Science
2011
The Multifaceted Roles of Mast Cells in Immune Homeostasis, Infections and Cancers
International Journal of Molecular Sciences
2022
The Diagnostic Workup in Chronic Spontaneous Urticaria—What to Test and Why
The Journal of Allergy and Clinical Immunology: In Practice
2021
Role of IL‐17 in atopy—A systematic review
Clinical and Translational Allergy
2021
Sensitive Skin Syndrome
Unknown Venue
2006
Opposing Effects of Glycerol on the Protective Function of the Horny Layer against Irritants and on the Penetration of Hexyl Nicotinate
Dermatology
1998
Silver‐loaded seaweed‐based cellulosic fiber improves epidermal skin physiology in atopic dermatitis: safety assessment, mode of action and controlled, randomized single‐blinded exploratory in vivo study
Experimental Dermatology
2010
EEMCO Guidance for the in vivo Assessment of Biomechanical Properties of the Human Skin and Its Annexes: Revisiting Instrumentation and Test Modes
Skin Pharmacology and Physiology
2019
Skin barrier disruptions in tape stripped and allergic dermatitis models have no effect on dermal penetration and systemic distribution of AHAPS-functionalized silica nanoparticles
Nanomedicine: Nanotechnology, Biology and Medicine
2014
S2k – Guideline on the Therapy of Acne
JDDG: Journal der Deutschen Dermatologischen Gesellschaft
2010
Evaluation of optical coherence tomography as a non‐invasive diagnostic tool in cutaneous wound healing
Skin Research and Technology
2013
In vivo methods for the analysis of the penetration of topically applied substances in and through the skin barrier
International Journal of Cosmetic Science
2012
Role of Peroxisome Proliferator-Activated Receptor α in Epidermal Development in Utero
Journal of Investigative Dermatology
2002
Glycerol — Just a Moisturizer? Biological and Biophysical Effects
Dry Skin and Moisturizers
2005
Disease modification in chronic spontaneous urticaria
Allergy
2024
Dermatologische Externatherapie
Unknown Venue
2000
Clinical study on the effects of a cosmetic product on dermal extracellular matrix components using a high-resolution multiphoton tomograph
Skin Research and Technology
2010
Skin Ceramide Alterations in First-Episode Schizophrenia Indicate Abnormal Sphingolipid Metabolism
Schizophrenia Bulletin
2012
Increased sensitivity of patch testing by standardized tape stripping beforehand: a multicentre diagnostic accuracy study
Contact Dermatitis
2010
Assessment of a scoring system for Basal Cell Carcinoma with multi‐beam optical coherence tomography
Journal of the European Academy of Dermatology and Venereology
2015
Percutaneous Penetration of Topically Applied Melatonin in a Cream and an Alcoholic Solution
Skin Pharmacology and Physiology
2004
Standardized Tape Stripping: A Practical and Reproducible Protocol to Uniformly Reduce the Stratum Corneum
Skin Pharmacology and Physiology
2010
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