John M Baust, Ph.D

Proven success in delivering best-in-class services across scientific, commercial and education environments.

Ithaca, New York, United States of America

Research Expertise

Cell Biology
Biotechnology
Biomedical Engineering
Transplantation
Surgery
Management of Technology and Innovation
Bioengineering
Oncology
Cancer Research
Urology
Developmental Biology
Hematology
Internal Medicine
Pharmacology (medical)
Physiology (medical)
Physiology
Materials Chemistry

About

***Proven success in delivering best-in-class services across highly regulated scientific and commercial environments.*** * Resourceful, dynamic, and future-focused professional; equipped with strategic leadership, business, research, and academic expertise with career excellence in conducting in-depth research, leading multi-faceted R&D projects, and developing new products and treatments. * Dedicated, driven self-starter focused on developing innovative life changing technologies and procedures advancing the areas of cancer treatment, regenerative medicine and cell therapy.   * Substantial experience in providing oversight for medical device development, pre-clinical studies, cancer therapy, stem cell preservation, cell therapy, tissue engineering, and organ transplantation, etc. * Astute at establishing solid relationships with stakeholders and industry leaders to drive innovative ideas and lead collaborative efforts in pursuit of accomplishing long-term milestones. * Successful in delivering interactive academic instruction across higher education settings offering captivating lectures on Biology and Entrepreneurship courses in accordance with the organizational mission. * Accredited with authoring, managing, and executing multi-million dollar grants, corporate contracts * Accomplished author of numerous patents and high profile publications to disseminate essential research findings.

Legacy Map

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Publications

An In Vitro Investigation into Cryoablation and Adjunctive Cryoablation/Chemotherapy Combination Therapy for the Treatment of Pancreatic Cancer Using the PANC-1 Cell Line
Biomedicines
2022
Assessment of the Impact of Post-Thaw Stress Pathway Modulation on Cell Recovery following Cryopreservation in a Hematopoietic Progenitor Cell Model
Cells
2022
Improved cryopreservation outcome is facilitated by an intracellular-type medium and inhibition of apoptosis
Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.99CH37015)
Cryopreservation of an Engineered Skin Equivalent: The Apoptosis Paradigm
Advances in Heat and Mass Transfer in Biotechnology
1999
Chemo-Cryo Combination Therapy: An Adjunctive Model for the Treatment of Prostate Cancer
Cryobiology
2001
Molecular Mechanisms of Cellular Demise Associated with Cryopreservation Failure
Cell Preservation Technology
2002
Gene Activation of the Apoptotic Caspase Cascade Following Cryogenic Storage
Cell Preservation Technology
2002
Modulation of the cryopreservation cap: elevated survival with reduced dimethyl sulfoxide concentration
Cryobiology
2002
The effect of cell culture substrate on cell tolerance to desiccation
Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology
Cryosurgery—a putative approach to molecular-based optimization
Cryobiology
2004
Transplantation Diagnostics: A Preliminary Analysis Using Protein Microarray to Determine Kidney Status Prior To and Following Implantation
Cell Preservation Technology
2004
Long-Term Function of Cryopreserved Rat Hepatocytes in a Coculture System
Cell Transplantation
2004
Biological Packaging for the Global Cell and Tissue Therapy Markets
BioProcessing Journal
2004
Addition of anticancer agents enhances freezing-induced prostate cancer cell death: implications of mitochondrial involvement
Cryobiology
2004
Cellular Components of the Coronary Vasculature Exhibit Differential Sensitivity to Low Temperature Insult
Cell Preservation Technology
2002
Effect of Cell Substrate Interactions on the Desiccation Behavior of Human Fibroblasts
Cell Preservation Technology
2004
Cell Preservation in Reparative and Regenerative Medicine: Evolution of Individualized Solution Composition
Tissue Engineering
2004
Cryopreservation of Isolated Primary Rat Hepatocytes
Annals of Surgery
2005
Enhanced Hypothermic Storage of Neonatal Cardiomyocytes
Cell Preservation Technology
2005
A Paradigm Shift in Cryopreservation: Molecular-Based Advances to Improve Outcome
Cryogenic Engineering
Involvement of the Cysteine Protease Calpain Family in Cell Death After Cryopreservation
Cell Preservation Technology
2006
Bioprocessing
Genetic Engineering & Biotechnology News
2013
Issues Critical to the Successful Application of Cryosurgical Ablation of the Prostate
Technology in Cancer Research & Treatment
2007
Cryoablation of Renal Cancer: Variables Involved in Freezing-Induced Cell Death
Technology in Cancer Research & Treatment
2007
Development of a Tissue Engineered Human Prostate Tumor Equivalent for Use in the Evaluation of Cryoablative Techniques
Technology in Cancer Research & Treatment
2007
Cardiomyocyte Responses to Thermal Excursions: Implications for Electrophysiological Cardiac Mapping
Cell Preservation Technology
2007
Cryosurgical technique: Assessment of the fundamental variables using human prostate cancer model systems
Cryobiology
2007
Activation of Mitochondrial-Associated Apoptosis Contributes to Cryopreservation Failure
Cell Preservation Technology
2007
Preliminary Report: Evaluation of Storage Conditions and Cryococktails during Peripheral Blood Mononuclear Cell Cryopreservation
Cell Preservation Technology
2007
Cryoablative response of prostate cancer cells is influenced by androgen receptor expression
BJU International
2008
The pathophysiology of thermoablation: optimizing cryoablation
Current Opinion in Urology
2009
Changing Paradigms in Biopreservation
Biopreservation and Biobanking
2009
Cryopreservation
Organogenesis
2009
In VitroAssessment of Apoptosis and Necrosis Following Cold Storage in a Human Airway Cell Model
Biopreservation and Biobanking
2009
Experimental cryosurgery investigations in vivo
Cryobiology
2009
Integrin involvement in freeze resistance of androgen-insensitive prostate cancer
Prostate Cancer and Prostatic Diseases
2010
How Much Will the Biobanking Industry Come to Rely on Private Companies?
Biopreservation and Biobanking
2010
Morphology of hypoxia following cryoablation in a prostate cancer murine model: Its relationship to necrosis, apoptosis and, microvessel density
Cryobiology
2010
Role of Vitamin D3 as a Sensitizer to Cryoablation in a Murine Prostate Cancer Model: Preliminary In Vivo Study
Urology
2010
Mechanisms of Cryoablation
Cryoablation of Cardiac Arrhythmias
2011
Use of 1,25α dihydroxyvitamin D3 as a cryosensitizing agent in a murine prostate cancer model
Prostate Cancer and Prostatic Diseases
2011
The unfolded protein response in human corneal endothelial cells following hypothermic storage: Implications of a novel stress pathway
Cryobiology
2011
Vitamin D3 cryosensitization increases prostate cancer susceptibility to cryoablation via mitochondrial‐mediated apoptosis and necrosis
BJU International
2011
Implications of Differential Stress Response Activation Following Non-Frozen Hepatocellular Storage
Biopreservation and Biobanking
2013
Temperature-dependent activation of differential apoptotic pathways during cryoablation in a human prostate cancer model
Prostate Cancer and Prostatic Diseases
2012
Characterization and modulation of human mesenchymal stem cell stress pathway response following hypothermic storage
Cryobiology
2014
Mechanisms of cryoablation: Clinical consequences on malignant tumors
Cryobiology
2014
Re-purposing cryoablation: a combinatorial ‘therapy’ for the destruction of tissue
Prostate Cancer and Prostatic Diseases
2015
Development and Assessment of a Novel Device for the Controlled, Dry Thawing of Cryopreserved Cell Products
BioProcessing Journal
2016
Characterization of Pancreatic Cancer Cell Thermal Response to Heat Ablation or Cryoablation
Technology in Cancer Research & Treatment
2016
Investigation of the Impact of Cell Cycle Stage on Freeze Response Sensitivity of Androgen-Insensitive Prostate Cancer
Technology in Cancer Research & Treatment
2016
Assessment of Cryosurgical Device Performance Using a 3D Tissue-Engineered Cancer Model
Technology in Cancer Research & Treatment
2017
Dual thermal ablation of pancreatic cancer cells as an improved combinatorial treatment strategy
Liver and Pancreatic Sciences
2017
Integrating Molecular Control to Improve Cryopreservation Outcome
Biopreservation and Biobanking
2017
Best practices in cell culture: an overview
In Vitro Cellular & Developmental Biology - Animal
2017
Best practices for cryopreserving, thawing, recovering, and assessing cells
In Vitro Cellular & Developmental Biology - Animal
2017
Dose Escalation of Vitamin D3 Yields Similar Cryosurgical Outcome to Single Dose Exposure in a Prostate Cancer Model
Cancer Control
2018
Evaluation of a new epicardial cryoablation system for the treatment of Cardiac Tachyarrhythmias
Trends in Medicine
2018
Defeating Cancers’ Adaptive Defensive Strategies Using Thermal Therapies: Examining Cancer’s Therapeutic Resistance, Ablative, and Computational Modeling Strategies as a means for Improving Therapeutic Outcome
Technology in Cancer Research & Treatment
2018
Biobanking Expands into Research Services
Genetic Engineering & Biotechnology News
2018
Assessment of a novel cryoablation device for the endovascular treatment of cardiac tachyarrhythmias
SAGE Open Medicine
2018
Cryoablation: physical and molecular basis with putative immunological consequences
International Journal of Hyperthermia
2019
Investigation of Bladder Cancer Cell Response to Cryoablation and Adjunctive Cisplatin Based Cryo/Chemotherapy
Clinical Research: Open Access
2020
Characterization of mastocytoma cancer cell response to cryosensitization therapy
Cryobiology
2011
Cryoablation of Prostate- Improving Efficacy and Safety
Medical Research Archives
2020
Evaluation of a Novel Cystoscopic Compatible Cryocatheter for the Treatment of Bladder Cancer
Bladder Cancer
2020
Breast Cancer Cryoablation: Assessment of the Impact of Fundamental Procedural Variables in an In Vitro Human Breast Cancer Model
Breast Cancer: Basic and Clinical Research
2020
In Vitro Investigation of Renal Cell Carcinoma Response to Combination Sorafenib and Cryoablation Treatment
Clinical Oncology and Research
2022

Education

Harvard Medical School

Post Doc

Boston, Massachusetts, United States of America

Binghamton University

Ph.D.

Binghamton, New York, United States of America

Cornell University

BS

Ithaca, New York, United States of America

Experience

Cell Preservation Services (United States)

President

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