David Stevens, PhD, PMP

Drug delivery, nanotechnology, formulations, consulting

Research Expertise

Nanotechnology based drug delivery

About

Experienced pharmaceutical scientist with a demonstrated history of R&D, innovation, consulting, and project management. Expertise in nanoparticle- and polymer-based drug delivery formulations for small molecule drugs, oligonucleotides, peptides, and proteins, as well as expertise in topical/transdermal drug delivery applications.

Publications

Nanosponge Formation from Organocatalytically Synthesized Poly(carbonate) Copolymers

ACS Macro Letters

2012

Dual drug delivery of tamoxifen and quercetin: Regulated metabolism for anticancer treatment with nanosponges

Journal of Controlled Release

2015

Combined MEK Inhibition and BMP2 Treatment Promotes Osteoblast Differentiation and Bone Healing in Nf1Osx−/− Mice

Journal of Bone and Mineral Research

2014

When Is It Important to Measure Unbound Drug in Evaluating Nanomedicine Pharmacokinetics?

Drug Metabolism and Disposition

2016

One-pot polyglycidol nanogels via liposome master templates for dual drug delivery

Journal of Controlled Release

2016

Nanomedicine Reformulation of Chloroquine and Hydroxychloroquine

Molecules

2020

Semibranched polyglycidols as “fillers” in polycarbonate hydrogels to tune hydrophobic drug release

Polymer Chemistry

2015

Practical polymerization of functionalized lactones and carbonates with Sn(OTf)2 in metal catalysed ring-opening polymerization methods

Polymer Chemistry

2013

An assessment of nanosponges for intravenous and oral drug delivery of BCS class IV drugs: Drug delivery kinetics and solubilization

Polymer Chemistry

2014

Application of a Scavenger Receptor A1-Targeted Polymeric Prodrug Platform for Lymphatic Drug Delivery in HIV

Molecular Pharmaceutics

2020

The Synthesis of Curved and Linear Structures from a Minimal Set of Monomers

Unknown Venue

Total drug quantification in prodrugs using an automated elemental analyzer

Drug Delivery and Translational Research

2019

Combined MEK Inhibition and BMP2 Treatment Promotes Osteoblast Differentiation and Bone Healing in Nf1Osx–/– Mice

Journal of Bone and Mineral Research

2015

Factors Controlling Drug Release in Cross-linked Poly(valerolactone) Based Matrices

Unknown Venue

Pelvic Floor Physical Therapy is Self-Reported as a Minimally Effective, and Sometimes Harmful, Treatment for Pudendal Neuralgia: A Cross-Sectional Study

International Journal of Sexual Health

2024

(133) SELF-REPORTED EFFICACY OF PELVIC FLOOR PHYSICAL THERAPY AS A TREATMENT FOR PUDENDAL NEURALGIA: A CROSS-SECTIONAL STUDY

The Journal of Sexual Medicine

2024

Hard flaccid syndrome symptoms, comorbidities, and self-reported efficacy and satisfaction of treatments: a cross-sectional survey

International Journal of Impotence Research

2024

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Journal of Visualized Experiments

2016

Three-Dimensional Lymphatics-on-a-Chip Reveals Distinct Size-Dependent Nanoparticle Transport Mechanisms in Lymphatic Drug Delivery

Unknown Venue

Precise Microscale Polymeric Networks through Piezoelectronic Inkjet Printing

ACS Biomaterials Science & Engineering

2016

Controlled branching of polyglycidol and formation of protein–glycidol bioconjugates via a graft-from approach with “PEG-like” arms

Chemical Communications

2013

Abstract 1960: Nanosponges as suitable platforms for targeted chemotherapy

Cancer Research

2012

Education

Vanderbilt University

Ph.D., Pharmacology / May, 2014

Nashville, Tennessee, United States of America

Experience

GlycosBio

Senior Scientist / October, 2020 — Present

• Developing synthetic lipids enhanced nutrition, personal care products, cosmetics, and topical/transdermal drug delivery applications • Leading pre-clinical and clinical drug delivery projects

Freelance

Scientific Consultant / December, 2014 — Present

• Providing subject matter expertise to startup/pharma companies in the following areas: o Pre-clinical development and characterization of nanoparticle/microparticle drug formulations o Synthesis and characterization of functionalized polymers o Anti-fouling coatings for medical devices o Planning and developing R&D projects

Leidos Biomedical Research, Inc.

Scientist II / August, 2014 — September, 2020

• Evaluated data and scientific merits of clients’ nanomedicine candidates, and provided feedback and guidance to academic, biotech, and government managers • Led formulation development efforts for small molecule drugs, peptides, and proteins including experimental design, execution, and pre-clinical testing • Performed characterization of formulations including physicochemical properties, drug release, cytotoxicity, and stability studies • Coordinated and assisted with pharmacokinetics, toxicology, and efficacy studies in pre-clinical animal models

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