Changquan Calvin Sun

Professor in Pharmaceutical Materials Science and Engineering at Purdue University

Research Expertise

Materials Science and Engineering
Physical Pharmacy
Powder Technology
Crystal engineering
Formulation

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Publications

Polymorphs, Salts, and Cocrystals: What’s in a Name?
Crystal Growth & Design
2012
Characterization of thermal behavior of deep eutectic solvents and their potential as drug solubilization vehicles
International Journal of Pharmaceutics
2009
Evaluation of the effects of tableting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction
Journal of Pharmaceutical Sciences
2005
Improving Mechanical Properties of Caffeine and Methyl Gallate Crystals by Cocrystallization
Crystal Growth & Design
2008
Decoding Powder Tabletability: Roles of Particle Adhesion and Plasticity
Journal of Adhesion Science and Technology
2011
Influence of Crystal Structure on the Tableting Properties of Sulfamerazine Polymorphs
Pharmaceutical Research
2001
Mechanical properties and peculiarities of molecular crystals
Chemical Society Reviews
2023
Materials Science Tetrahedron—A Useful Tool for Pharmaceutical Research and Development
Journal of Pharmaceutical Sciences
2009
True Density of Microcrystalline Cellulose
Journal of Pharmaceutical Sciences
2005
Mechanism of moisture induced variations in true density and compaction properties of microcrystalline cellulose
International Journal of Pharmaceutics
2008
Cocrystallization for successful drug delivery
Expert Opinion on Drug Delivery
2012
Reduced tabletability of roller compacted granules as a result of granule size enlargement
Journal of Pharmaceutical Sciences
2006
Simultaneously Improving the Mechanical Properties, Dissolution Performance, and Hygroscopicity of Ibuprofen and Flurbiprofen by Cocrystallization with Nicotinamide
Pharmaceutical Research
2012
Quantifying Effects of Particulate Properties on Powder Flow Properties Using a Ring Shear Tester
Journal of Pharmaceutical Sciences
2008
Understanding the relationship between crystal structure, plasticity and compaction behaviour of theophylline, methyl gallate, and their 1 : 1 co-crystal
CrystEngComm
2010
Setting the bar for powder flow properties in successful high speed tableting
Powder Technology
2010
Influence of Elastic Deformation of Particles on Heckel Analysis
Pharmaceutical Development and Technology
2001
Development of a high drug load tablet formulation based on assessment of powder manufacturability: Moving towards quality by design
Journal of Pharmaceutical Sciences
2009
Resveratrol cocrystals with enhanced solubility and tabletability
International Journal of Pharmaceutics
2016
Effects of initial particle size on the tableting properties of l-lysine monohydrochloride dihydrate powder
International Journal of Pharmaceutics
2001
Validation and applications of an expedited tablet friability method
International Journal of Pharmaceutics
2015
Mini review: Mechanisms to the loss of tabletability by dry granulation
European Journal of Pharmaceutics and Biopharmaceutics
2016
A Novel Method for Deriving True Density of Pharmaceutical Solids Including Hydrates and Water-Containing Powders
Journal of Pharmaceutical Sciences
2004
Improved Tableting Properties of p-Hydroxybenzoic Acid by Water of Crystallization: A Molecular Insight
Pharmaceutical Research
2004
Profoundly improving flow properties of a cohesive cellulose powder by surface coating with nano‐silica through comilling
Journal of Pharmaceutical Sciences
2011
Correlation Among Crystal Structure, Mechanical Behavior, and Tabletability in the Co-Crystals of Vanillin Isomers
Crystal Growth & Design
2015
Exceptionally Elastic Single-Component Pharmaceutical Crystals
Chemistry of Materials
2019
Crystal and Particle Engineering Strategies for Improving Powder Compression and Flow Properties to Enable Continuous Tablet Manufacturing by Direct Compression
Journal of Pharmaceutical Sciences
2018
A critical Examination of the Phenomenon of Bonding Area - Bonding Strength Interplay in Powder Tableting
Pharmaceutical Research
2016
Influence of Crystal Shape on the Tableting Performance of L‐Lysine Monohydrochloride Dihydrate
Journal of Pharmaceutical Sciences
2001
The relationship among tensile strength, Young's modulus, and indentation hardness of pharmaceutical compacts
Powder Technology
2018
The landscape of mechanical properties of molecular crystals
CrystEngComm
2020
Direct correlation among crystal structure, mechanical behaviour and tabletability in a trimorphic molecular compound
CrystEngComm
2012
Theophylline monohydrate
Acta Crystallographica Section E Structure Reports Online
2002
Dependence of ejection force on tableting speed—A compaction simulation study
Powder Technology
2015
Cocrystal engineering of pharmaceutical solids: therapeutic potential and challenges
CrystEngComm
2021
Microstructure of Tablet—Pharmaceutical Significance, Assessment, and Engineering
Pharmaceutical Research
2016
Enhancing Bioavailability of Dihydromyricetin through Inhibiting Precipitation of Soluble Cocrystals by a Crystallization Inhibitor
Crystal Growth & Design
2016
Superior Plasticity and Tabletability of Theophylline Monohydrate
Molecular Pharmaceutics
2017
Twistable Pharmaceutical Crystal Exhibiting Exceptional Plasticity and Tabletability
Chemistry of Materials
2019
Development of highly stabilized curcumin nanoparticles by flash nanoprecipitation and lyophilization
European Journal of Pharmaceutics and Biopharmaceutics
2015
Overcoming Poor Tabletability of Pharmaceutical Crystals by Surface Modification
Pharmaceutical Research
2011
On the Identification of Slip Planes in Organic Crystals Based on Attachment Energy Calculation
Journal of Pharmaceutical Sciences
2008
Origin of Deteriorated Crystal Plasticity and Compaction Properties of a 1:1 Cocrystal between Piroxicam and Saccharin
Crystal Growth & Design
2014
Quantifying effects of moisture content on flow properties of microcrystalline cellulose using a ring shear tester
Powder Technology
2016
Tablets of multi-unit pellet system for controlled drug delivery
Journal of Controlled Release
2017
Impact of Crystal Habit on Biopharmaceutical Performance of Celecoxib
Crystal Growth & Design
2013
Kinetic Entrapment of a Hidden Curcumin Cocrystal with Phloroglucinol
Crystal Growth & Design
2014
Insensitivity of Compaction Properties of Brittle Granules to Size Enlargement by Roller Compaction
Journal of Pharmaceutical Sciences
2007
Systematic evaluation of common lubricants for optimal use in tablet formulation
European Journal of Pharmaceutical Sciences
2018
Gaining insight into tablet capping tendency from compaction simulation
International Journal of Pharmaceutics
2017
Improving solid-state properties of berberine chloride through forming a salt cocrystal with citric acid
International Journal of Pharmaceutics
2019
Mechanism and Kinetics of Punch Sticking of Pharmaceuticals
Journal of Pharmaceutical Sciences
2017
The suitability of common compressibility equations for characterizing plasticity of diverse powders
International Journal of Pharmaceutics
2017
The development of carbamazepine-succinic acid cocrystal tablet formulations with improved in vitro and in vivo performance
Drug Development and Industrial Pharmacy
2015
Direct Compression Tablet Containing 99% Active Ingredient—A Tale of Spherical Crystallization
Journal of Pharmaceutical Sciences
2019
Identifying Slip Planes in Organic Polymorphs by Combined Energy Framework Calculations and Topology Analysis
Crystal Growth & Design
2018
Powder properties and compaction parameters that influence punch sticking propensity of pharmaceuticals
International Journal of Pharmaceutics
2017
Dapagliflozin-citric acid cocrystal showing better solid state properties than dapagliflozin
European Journal of Pharmaceutical Sciences
2017
A new tablet brittleness index
European Journal of Pharmaceutics and Biopharmaceutics
2015
Ionized form of acetaminophen with improved compaction properties
CrystEngComm
2012
Sweet Berberine
Crystal Growth & Design
2016
Origin of profound changes in powder properties during wetting and nucleation stages of high-shear wet granulation of microcrystalline cellulose
Powder Technology
2011
Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter
International Journal of Pharmaceutics: X
2021
Near-infrared chemical imaging (NIR-CI) as a process monitoring solution for a production line of roll compaction and tableting
European Journal of Pharmaceutics and Biopharmaceutics
2015
Designing Micellar Nanocarriers with Improved Drug Loading and Stability Based on Solubility Parameter
Molecular Pharmaceutics
2015
Initial moisture content in raw material can profoundly influence high shear wet granulation process
International Journal of Pharmaceutics
2011
Dependence of Friability on Tablet Mechanical Properties and a Predictive Approach for Binary Mixtures
Pharmaceutical Research
2017
Relationships among Crystal Structures, Mechanical Properties, and Tableting Performance Probed Using Four Salts of Diphenhydramine
Crystal Growth & Design
2017
Massing in high shear wet granulation can simultaneously improve powder flow and deteriorate powder compaction: A double-edged sword
European Journal of Pharmaceutical Sciences
2011
Assessment of the relative performance of a confined impinging jets mixer and a multi-inlet vortex mixer for curcumin nanoparticle production
European Journal of Pharmaceutics and Biopharmaceutics
2014
Transforming Powder Mechanical Properties by Core/Shell Structure: Compressible Sand
Journal of Pharmaceutical Sciences
2010
Computational Techniques for Predicting Mechanical Properties of Organic Crystals: A Systematic Evaluation
Molecular Pharmaceutics
2019
Effect of Crystal Habit on Intrinsic Dissolution Behavior of Celecoxib Due to Differential Wettability
Crystal Growth & Design
2014
Structural Origins of Elastic and 2D Plastic Flexibility of Molecular Crystals Investigated with Two Polymorphs of Conformationally Rigid Coumarin
Chemistry of Materials
2021
Recent Advances in Co-processed APIs and Proposals for Enabling Commercialization of These Transformative Technologies
Molecular Pharmaceutics
2020
Improved solid-state stability of salts by cocrystallization between conjugate acid–base pairs
CrystEngComm
2013
A material-sparing method for simultaneous determination of true density and powder compaction properties—Aspartame as an example
International Journal of Pharmaceutics
2006
Lubrication with magnesium stearate increases tablet brittleness
Powder Technology
2017
Understanding Size Enlargement and Hardening of Granules on Tabletability of Unlubricated Granules Prepared by Dry Granulation
Journal of Pharmaceutical Sciences
2011
Roles of Granule Size in Over-Granulation During High Shear Wet Granulation
Journal of Pharmaceutical Sciences
2010
Polymer Nanocoating of Amorphous Drugs for Improving Stability, Dissolution, Powder Flow, and Tabletability: The Case of Chitosan-Coated Indomethacin
Molecular Pharmaceutics
2019
Solid-state characterization of optically pure (+)Dihydromyricetin extracted from Ampelopsis grossedentata leaves
International Journal of Pharmaceutics
2016
Improving manufacturability of an ibuprofen powder blend by surface coating with silica nanoparticles
Powder Technology
2013
Tableting performance of various mannitol and lactose grades assessed by compaction simulation and chemometrical analysis
International Journal of Pharmaceutics
2019
Preparation, Characterization, and Formulation Development of Drug–Drug Protic Ionic Liquids of Diphenhydramine with Ibuprofen and Naproxen
Molecular Pharmaceutics
2018
Influence of crystal structure on the tableting properties of n‐alkyl 4‐hydroxybenzoate esters (parabens)
Journal of Pharmaceutical Sciences
2007
Quantifying Errors in Tableting Data Analysis Using the Ryshkewitch Equation Due to Inaccurate True Density
Journal of Pharmaceutical Sciences
2005
A systematic evaluation of dual functionality of sodium lauryl sulfate as a tablet lubricant and wetting enhancer
International Journal of Pharmaceutics
2018
Improving Dissolution Rate of Carbamazepine-Glutaric Acid Cocrystal Through Solubilization by Excess Coformer
Pharmaceutical Research
2017
Conformation Directed Interaction Anisotropy Leading to Distinct Bending Behaviors of Two ROY Polymorphs
Crystal Growth & Design
2020
Comparative analyses of flow and compaction properties of diverse mannitol and lactose grades
International Journal of Pharmaceutics
2018
Thermal Expansion of Organic Crystals and Precision of Calculated Crystal Density: A Survey of Cambridge Crystal Database
Journal of Pharmaceutical Sciences
2007
Extended Release of Highly Water Soluble Isoniazid Attained through Cocrystallization with Curcumin
Crystal Growth & Design
2020
Cocrystal Engineering of Itraconazole with Suberic Acid via Rotary Evaporation and Spray Drying
Crystal Growth & Design
2019
Reproducibility of flow properties of microcrystalline cellulose — Avicel PH102
Powder Technology
2011
Preparation and Characterization of Surface-Engineered Coarse Microcrystalline Cellulose Through Dry Coating with Silica Nanoparticles
Journal of Pharmaceutical Sciences
2012
Enabling Tablet Product Development of 5-Fluorocytosine Through Integrated Crystal and Particle Engineering
Journal of Pharmaceutical Sciences
2014
Expedited development of a high dose orally disintegrating metformin tablet enabled by sweet salt formation with acesulfame
International Journal of Pharmaceutics
2017
Crystal Growth of Celecoxib from Amorphous State: Polymorphism, Growth Mechanism, and Kinetics
Crystal Growth & Design
2019
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