A/Prof FOLEFAC AMINKENG
Associate Professor (Genomics, Pharmacogenomics, Precision Health and Health Disparities), Medical College of Wisconsin
Research Expertise
About
Publications
Pharmacogenomic strategies for the prevention of anthracycline-induced heart failure: A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer
Drug Metabolism and Pharmacokinetics / Jan 01, 2017
Ross, C. (2017). Pharmacogenomic strategies for the prevention of anthracycline-induced heart failure: A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer. Drug Metabolism and Pharmacokinetics, 32(1), S73–S74. https://doi.org/10.1016/j.dmpk.2016.10.292
Recommendations for genetic testing to reduce the incidence of anthracycline‐induced cardiotoxicity
British Journal of Clinical Pharmacology / Jun 30, 2016
Aminkeng, F., Ross, C. J. D., Rassekh, S. R., Hwang, S., Rieder, M. J., Bhavsar, A. P., Smith, A., Sanatani, S., Gelmon, K. A., Bernstein, D., Hayden, M. R., Amstutz, U., & Carleton, B. C. (2016). Recommendations for genetic testing to reduce the incidence of anthracycline‐induced cardiotoxicity. British Journal of Clinical Pharmacology, 82(3), 683–695. Portico. https://doi.org/10.1111/bcp.13008
The emerging era of pharmacogenomics: current successes, future potential, and challenges
Clinical Genetics / May 09, 2014
Lee, J. W., Aminkeng, F., Bhavsar, A. P., Shaw, K., Carleton, B. C., Hayden, M. R., & Ross, C. J. D. (2014). The emerging era of pharmacogenomics: current successes, future potential, and challenges. Clinical Genetics, 86(1), 21–28. Portico. https://doi.org/10.1111/cge.12392
Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects
Cell Reports / Feb 01, 2019
Ooi, J., Langley, S. R., Xu, X., Utami, K. H., Sim, B., Huang, Y., Harmston, N. P., Tay, Y. L., Ziaei, A., Zeng, R., Low, D., Aminkeng, F., Sobota, R. M., Ginhoux, F., Petretto, E., & Pouladi, M. A. (2019). Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects. Cell Reports, 26(9), 2494-2508.e7. https://doi.org/10.1016/j.celrep.2019.02.008
The molecular epidemiology of Huntington disease is related to intermediate allele frequency and haplotype in the general population
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics / Feb 20, 2018
Kay, C., Collins, J. A., Wright, G. E. B., Baine, F., Miedzybrodzka, Z., Aminkeng, F., Semaka, A. J., McDonald, C., Davidson, M., Madore, S. J., Gordon, E. S., Gerry, N. P., Cornejo‐Olivas, M., Squitieri, F., Tishkoff, S., Greenberg, J. L., Krause, A., & Hayden, M. R. (2018). The molecular epidemiology of Huntington disease is related to intermediate allele frequency and haplotype in the general population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 177(3), 346–357. Portico. https://doi.org/10.1002/ajmg.b.32618
Pharmacogenomics of Vincristine‐Induced Peripheral Neuropathy Implicates Pharmacokinetic and Inherited Neuropathy Genes
Clinical Pharmacology & Therapeutics / Aug 17, 2018
Wright, G. E. B., Amstutz, U., Drögemöller, B. I., Shih, J., Rassekh, S. R., Hayden, M. R., Carleton, B. C., & Ross, C. J. D. (2018). Pharmacogenomics of Vincristine‐Induced Peripheral Neuropathy Implicates Pharmacokinetic and Inherited Neuropathy Genes. Clinical Pharmacology & Therapeutics, 105(2), 402–410. Portico. https://doi.org/10.1002/cpt.1179
Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer
JAMA Oncology / Nov 01, 2017
Drögemöller, B. I., Monzon, J. G., Bhavsar, A. P., Borrie, A. E., Brooks, B., Wright, G. E. B., Liu, G., Renouf, D. J., Kollmannsberger, C. K., Bedard, P. L., Aminkeng, F., Amstutz, U., Hildebrand, C. A., Gunaretnam, E. P., Critchley, C., Chen, Z., Brunham, L. R., Hayden, M. R., Ross, C. J. D., … Carleton, B. C. (2017). Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer. JAMA Oncology, 3(11), 1558. https://doi.org/10.1001/jamaoncol.2017.0502
Association and clinical utility of NAT2 in the prediction of isoniazid-induced liver injury in Singaporean patients
PLOS ONE / Oct 16, 2017
Chan, S. L., Chua, A. P. G., Aminkeng, F., Chee, C. B. E., Jin, S., Loh, M., Gan, S. H., Wang, Y. T., & Brunham, L. R. (2017). Association and clinical utility of NAT2 in the prediction of isoniazid-induced liver injury in Singaporean patients. PLOS ONE, 12(10), e0186200. https://doi.org/10.1371/journal.pone.0186200
Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent
The Pharmacogenomics Journal / Apr 16, 2013
Aminkeng, F., Ross, C. J. D., Rassekh, S. R., Brunham, L. R., Sistonen, J., Dube, M.-P., Ibrahim, M., Nyambo, T. B., Omar, S. A., Froment, A., Bodo, J.-M., Tishkoff, S., Carleton, B. C., & Hayden, M. R. (2013). Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent. The Pharmacogenomics Journal, 14(2), 160–170. https://doi.org/10.1038/tpj.2013.13
Neutrophil-to-Lymphocyte Ratio Predicts Development of Immune-Related Adverse Events and Outcomes from Immune Checkpoint Blockade: A Case-Control Study
Cancers / Mar 15, 2021
Lee, P. Y., Oen, K. Q. X., Lim, G. R. S., Hartono, J. L., Muthiah, M., Huang, D. Q., Teo, F. S. W., Li, A. Y., Mak, A., Chandran, N. S., Tan, C. L., Yang, P., Tai, E. S., Ng, K. W. P., Vijayan, J., Chan, Y. C., Tan, L. L., Lee, M. B.-H., Chua, H. R., … Tay, S. H. (2021). Neutrophil-to-Lymphocyte Ratio Predicts Development of Immune-Related Adverse Events and Outcomes from Immune Checkpoint Blockade: A Case-Control Study. Cancers, 13(6), 1308. https://doi.org/10.3390/cancers13061308
Association between the TCF7L2 rs12255372 (G/T) gene polymorphism and type 2 diabetes mellitus in a Cameroonian population: a pilot study
Clinical and Translational Medicine / Apr 23, 2015
Nanfa, D., Sobngwi, E., Atogho‐Tiedeu, B., Noubiap, J. J. N., Donfack, O. S., Mofo, E. P. M., Guewo‐Fokeng, M., Nguimmo Metsadjio, A., Ndonwi Ngwa, E., Pokam Fosso, P., Djahmeni, E., Djokam‐Dadjeu, R., Evehe, M., Aminkeng, F., Mbacham, W. F., & Mbanya, J. C. (2015). Association between the TCF7L2 rs12255372 (G/T) gene polymorphism and type 2 diabetes mellitus in a Cameroonian population: a pilot study. Clinical and Translational Medicine, 4(1). Portico. https://doi.org/10.1186/s40169-015-0058-1
Contribution of the TCF7L2 rs7903146 (C/T) gene polymorphism to the susceptibility to type 2 diabetes mellitus in Cameroon
Journal of Diabetes & Metabolic Disorders / Apr 14, 2015
Guewo-Fokeng, M., Sobngwi, E., Atogho-Tiedeu, B., Donfack, O. S., Noubiap, J. J. N., Ngwa, E. N., Mato-Mofo, E. P., Fosso, P. P., Djahmeni, E., Djokam-Dadjeu, R., Evehe, M.-S., Aminkeng, F., Mbacham, W. F., & Mbanya, J. C. (2015). Contribution of the TCF7L2 rs7903146 (C/T) gene polymorphism to the susceptibility to type 2 diabetes mellitus in Cameroon. Journal of Diabetes & Metabolic Disorders, 14(1). https://doi.org/10.1186/s40200-015-0148-z
Cytokine Release Syndrome in Cancer Patients Receiving Immune Checkpoint Inhibitors: A Case Series of 25 Patients and Review of the Literature
Frontiers in Immunology / Jan 28, 2022
Tay, S. H., Toh, M. M. X., Thian, Y. L., Vellayappan, B. A., Fairhurst, A.-M., Chan, Y. H., Aminkeng, F., Bharwani, L. D., Huang, Y., Mak, A., & Wong, A. S. C. (2022). Cytokine Release Syndrome in Cancer Patients Receiving Immune Checkpoint Inhibitors: A Case Series of 25 Patients and Review of the Literature. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.807050
Common variation near IRF6 is associated with IFN-β-induced liver injury in multiple sclerosis
Nature Genetics / Jul 16, 2018
Kowalec, K., Wright, G. E. B., Drögemöller, B. I., Aminkeng, F., Bhavsar, A. P., Kingwell, E., Yoshida, E. M., Traboulsee, A., Marrie, R. A., Kremenchutzky, M., Campbell, T. L., Duquette, P., Chalasani, N., Wadelius, M., Hallberg, P., Xia, Z., De Jager, P. L., Denny, J. C., Davis, M. F., … Carleton, B. C. (2018). Common variation near IRF6 is associated with IFN-β-induced liver injury in multiple sclerosis. Nature Genetics, 50(8), 1081–1085. https://doi.org/10.1038/s41588-018-0168-y
IFIH1 gene polymorphisms in type 1 diabetes: Genetic association analysis and genotype–phenotype correlation in the Belgian population
Human Immunology / Sep 01, 2009
Aminkeng, F., Van Autreve, J. E., Weets, I., Quartier, E., Van Schravendijk, C., Gorus, F. K., & Van der Auwera, B. J. (2009). IFIH1 gene polymorphisms in type 1 diabetes: Genetic association analysis and genotype–phenotype correlation in the Belgian population. Human Immunology, 70(9), 706–710. https://doi.org/10.1016/j.humimm.2009.06.013
Risk factors for immune‐related adverse
events from anti‐PD ‐1 or
anti‐PD‐L1 treatment in an
Asian cohort of nonsmall cell lung cancer
patients
International Journal of Cancer / Oct 13, 2021
Huang, Y., Soon, Y. Y., Aminkeng, F., Tay, S. H., Ang, Y., Kee, A. C. L., Goh, B. C., Wong, A. S. C., & Soo, R. A. (2021). Risk factors for immune‐related adverse events from <scp>anti‐PD</scp>‐1 or anti‐<scp>PD‐L1</scp> treatment in an Asian cohort of nonsmall cell lung cancer patients. International Journal of Cancer, 150(4), 636–644. Portico. https://doi.org/10.1002/ijc.33822
Association of KIR2DL2 polymorphism rs2756923 with type 1 diabetes and preliminary evidence for lack of inhibition through HLA‐C1 ligand binding
Tissue Antigens / May 15, 2009
Ramos‐Lopez, E., Scholten, F., Aminkeng, F., Wild, C., Kalhes, H., Seidl, C., Tonn, T., Van der Auwera, B., & Badenhoop, K. (2009). Association of KIR2DL2 polymorphism rs2756923 with type 1 diabetes and preliminary evidence for lack of inhibition through HLA‐C1 ligand binding. Tissue Antigens, 73(6), 599–603. Portico. https://doi.org/10.1111/j.1399-0039.2009.01252.x
MICA is Associated with Type 1 Diabetes in the Belgian Population, Independent of HLA-DQ
Human Immunology / Jan 01, 2006
Van Autreve, J. E., Koeleman, B. P. C., Quartier, E., Aminkeng, F., Weets, I., Gorus, F. K., & Van der Auwera, B. J. R. (2006). MICA is Associated with Type 1 Diabetes in the Belgian Population, Independent of HLA-DQ. Human Immunology, 67(1–2), 94–101. https://doi.org/10.1016/j.humimm.2006.02.032
Pharmacogenomic screening for anthracycline‐induced cardiotoxicity in childhood cancer
British Journal of Clinical Pharmacology / Mar 19, 2017
Aminkeng, F., Ross, C. J. D., Rassekh, S. R., Rieder, M. J., Bhavsar, A. P., Sanatani, S., Bernstein, D., Hayden, M. R., Amstutz, U., & Carleton, B. C. (2017). Pharmacogenomic screening for anthracycline‐induced cardiotoxicity in childhood cancer. British Journal of Clinical Pharmacology, 83(5), 1143–1145. Portico. https://doi.org/10.1111/bcp.13218
Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: Relation to autoantibody status and comparison with Belgian patients
Diabetes Research and Clinical Practice / Jan 01, 2014
Asanghanwa, M., Gorus, F. K., Weets, I., der Auwera, B. V., Aminkeng, F., Mbunwe, E., Goubert, P., Verhaeghen, K., Sobngwi, E., Wenzlau, J. M., Hutton, J. C., Pipeleers, D. G., Keymeulen, B., Mbanya, J.-C. N., & van Schravendijk, C. (2014). Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: Relation to autoantibody status and comparison with Belgian patients. Diabetes Research and Clinical Practice, 103(1), 97–105. https://doi.org/10.1016/j.diabres.2013.11.013
Neither an intronic CA repeat within the CD48 gene nor the HERV‐K18 polymorphisms are associated with type 1 diabetes
Tissue Antigens / Jul 06, 2006
Ramos‐Lopez, E., Ghebru, S., Van Autreve, J., Aminkeng, F., Herwig, J., Seifried, E., Seidl, C., Van der Auwera, B., & Badenhoop, K. (2006). Neither an intronic CA repeat within the CD48 gene nor the HERV‐K18 polymorphisms are associated with type 1 diabetes. Tissue Antigens, 68(2), 147–152. Portico. https://doi.org/10.1111/j.1399-0039.2006.00637.x
Pharmacogenomic diversity in Singaporean populations and Europeans
The Pharmacogenomics Journal / May 27, 2014
Brunham, L. R., Chan, S. L., Li, R., Aminkeng, F., Liu, X., Saw, W. Y., Ong, R. T. H., Pillai, E. N., Carleton, B. C., Toh, D., Tan, S. H., Koo, S. H., Lee, E. J. D., Chia, K. S., Ross, C. J. D., Hayden, M. R., Sung, C., & Teo, Y. Y. (2014). Pharmacogenomic diversity in Singaporean populations and Europeans. The Pharmacogenomics Journal, 14(6), 555–563. https://doi.org/10.1038/tpj.2014.22
HINT1 mutations define a
novel disease entity – autosomal recessive
axonal neuropathy with neuromyotonia
Clinical Genetics / Jan 01, 2013
Aminkeng, F. (2013). <scp>HINT1</scp> mutations define a novel disease entity – autosomal recessive axonal neuropathy with neuromyotonia. Clinical Genetics, 83(1), 31–32. Portico. https://doi.org/10.1111/cge.12030
Association of IL-2RA/CD25 with type 1 diabetes in the Belgian population
Human Immunology / Dec 01, 2010
Aminkeng, F., Weets, I., Van Autreve, J. E., Koeleman, B. P. C., Quartier, E., Van Schravendijk, C., Gorus, F. K., & Van der Auwera, B. J. R. (2010). Association of IL-2RA/CD25 with type 1 diabetes in the Belgian population. Human Immunology, 71(12), 1233–1237. https://doi.org/10.1016/j.humimm.2010.09.006
Real‐world experience of consolidation
durvalumab after concurrent
chemoradiotherapy in stage
III non‐small cell lung cancer
Thoracic Cancer / Sep 30, 2022
Huang, Y., Zhao, J. J., Soon, Y. Y., Wong, A., Aminkeng, F., Ang, Y., Asokumaran, Y., Low, J. L., Lee, M., Choo, J. R. E., Chan, G., Kee, A., Tay, S. H., Goh, B. C., & Soo, R. A. (2022). Real‐world experience of consolidation durvalumab after concurrent chemoradiotherapy in stage <scp>III</scp> non‐small cell lung cancer. Thoracic Cancer, 13(22), 3152–3161. Portico. https://doi.org/10.1111/1759-7714.14667
An Introductory Tutorial on Cardiovascular Pharmacogenetics for Healthcare Providers
Clinical Pharmacology & Therapeutics / Jun 12, 2023
Oni‐Orisan, A., Tuteja, S., Hoffecker, G., Smith, D. M., Castrichini, M., Crews, K. R., Murphy, W. A., Nguyen, N. H. K., Huang, Y., Lteif, C., Friede, K. A., Tantisira, K., Aminkeng, F., Voora, D., Cavallari, L. H., Whirl‐Carrillo, M., Duarte, J. D., & Luzum, J. A. (2023). An Introductory Tutorial on Cardiovascular Pharmacogenetics for Healthcare Providers. Clinical Pharmacology & Therapeutics, 114(2), 275–287. Portico. https://doi.org/10.1002/cpt.2957
Genome-wide Scan Identifies Association Between an Interferon Regulatory Factor Variant and Interferon-beta Induced Liver Injury in Multiple Sclerosis Patients
Journal of Pharmacological and Toxicological Methods / Nov 01, 2017
Kowalec, K., Wright, G. E. B., Drögemöller, B. I., Aminkeng, F., Bhavsar, A. P., Kingwell, E., Yoshida, E. M., Traboulsee, A., Marrie, R. A., Kremenchutzky, M., Campbell, T. L., Duquette, P., Chalasani, N., Wadelius, M., Hallberg, P., Xia, Z., De Jager, P., Ross, C., Tremlett, H., & Carleton, B. (2017). Genome-wide Scan Identifies Association Between an Interferon Regulatory Factor Variant and Interferon-beta Induced Liver Injury in Multiple Sclerosis Patients. Journal of Pharmacological and Toxicological Methods, 88, 173. https://doi.org/10.1016/j.vascn.2017.09.019
P2.05-05 Genomic Variants Associated with Response to Immune Checkpoint Inhibitors Amongst Asian Patients with Advanced NSCLC
Journal of Thoracic Oncology / Nov 01, 2023
Huang, Y., Aminkeng, F., Zhao, J. J., Soon, Y. Y., Kee, A., Ang, Y., Low, J. L., Tay, S. H., Wong, A., Bharwani, L. D., Goh, B. C., & Soo, R. A. (2023). P2.05-05 Genomic Variants Associated with Response to Immune Checkpoint Inhibitors Amongst Asian Patients with Advanced NSCLC. Journal of Thoracic Oncology, 18(11), S309–S310. https://doi.org/10.1016/j.jtho.2023.09.532
A Non-Coding Variant in LOC105371512 Confers Susceptibility to Bleomycin-Induced Lung Injury
Blood / Nov 15, 2022
Lee, J., Tabatabaeian, H., Poon, M. L., Somasundaram, N., Xin, L., Yuen, Y. C., Teoh, C. M., Yan, B., Chan, E. H. L., Chee, Y. L., De Mel, S., Zhang, B., Chew, X. H., Tang, T., Khor, C. C., Ngeow, J. Y. Y., Ong, C. K., Lim, S. T., Chng, W. J., … Aminkeng, F. (2022). A Non-Coding Variant in LOC105371512 Confers Susceptibility to Bleomycin-Induced Lung Injury. Blood, 140(Supplement 1), 4542–4544. https://doi.org/10.1182/blood-2022-169416
EP08.01-101 Factors Predictive of Primary Resistance to Immune Checkpoint Inhibitors in Asian Patients with Advanced NSCLC
Journal of Thoracic Oncology / Sep 01, 2022
Huang, Y., Zhao, J. J., Soon, Y. Y., Kee, A., Tay, S. H., Aminkeng, F., Ang, Y., Wong, A., Goh, B. C., & Soo, R. (2022). EP08.01-101 Factors Predictive of Primary Resistance to Immune Checkpoint Inhibitors in Asian Patients with Advanced NSCLC. Journal of Thoracic Oncology, 17(9), S391. https://doi.org/10.1016/j.jtho.2022.07.673
Pharmacogenomic prediction of immune-related adverse events from immune checkpoint inhibitors among Asian patients.
Journal of Clinical Oncology / Jun 01, 2022
Huang, Y., Aminkeng, F., Wong, A. S. C., Tay, S. H., Zhao, J. J., Ang, Y., Soo, R. A., & Goh, B. C. (2022). Pharmacogenomic prediction of immune-related adverse events from immune checkpoint inhibitors among Asian patients. Journal of Clinical Oncology, 40(16_suppl), 2547–2547. https://doi.org/10.1200/jco.2022.40.16_suppl.2547
P75.10 Risk Factors for Immune-Related Adverse Events from Anti-PD-1/PD-L1 Treatment in an Asian Cohort of NSCLC Patients
Journal of Thoracic Oncology / Mar 01, 2021
Huang, Y., Soon, Y. Y., Aminkeng, F., Tay, S. H., Ang, Y., Goh, B. C., Wong, A., & Soo, R. A. (2021). P75.10 Risk Factors for Immune-Related Adverse Events from Anti-PD-1/PD-L1 Treatment in an Asian Cohort of NSCLC Patients. Journal of Thoracic Oncology, 16(3), S577. https://doi.org/10.1016/j.jtho.2021.01.1044
Pharmacogenomic Prediction of Bleomycin-Induced Pneumonitis in South East Asian Hodgkin Lymphoma Patients
Blood / Nov 29, 2018
Lee, J. S. X., Poon, L. M., Liu, X., Yuen, Y. C., Somasundaram, N., Chin, S. T., Teoh, C. M., Yan, B., Chan, H. L. E. H. L., Chee, Y.-L., Tang, T., Farzana, N., Aw, C. H. T., Khor, C. C., Ngeow, J. Y. Y., Ong, C. K., Tai, E. S., Chng, W. J., Goh, B. C., … Aminkeng, F. (2018). Pharmacogenomic Prediction of Bleomycin-Induced Pneumonitis in South East Asian Hodgkin Lymphoma Patients. Blood, 132(Supplement 1), 4111–4111. https://doi.org/10.1182/blood-2018-99-113952
Pharmacogenomic Prediction of Cisplatin-Induced Nephrotoxicity in Patients Treated for Childhood Cancer
Journal of Pharmacological and Toxicological Methods / Nov 01, 2017
Medeiros, M., Aminkeng, F., Jimenez-Triana, C., Rivas-Ruiz, R., Juarez, L., Palomo, M., Clark, P., Castañeda-Hernandez, G., Ross, C., & Carleton, B. (2017). Pharmacogenomic Prediction of Cisplatin-Induced Nephrotoxicity in Patients Treated for Childhood Cancer. Journal of Pharmacological and Toxicological Methods, 88, 173–174. https://doi.org/10.1016/j.vascn.2017.09.021
Pharmacogenomic Prediction of Ribavirin-Induced Hemolytic Anemia in Patients Treated for Hepatitis C Infection
Journal of Pharmacological and Toxicological Methods / Nov 01, 2017
Abel, S., Aminkeng, F., Kowalec, K., Drogemoller, B., Wright, G., Bader, R., Stortz, J., Yoshida, E., Lee, S., Al-Judaibi, B., Kim, R., Tam, E., Ramji, A., Ross, C., & Carleton, B. (2017). Pharmacogenomic Prediction of Ribavirin-Induced Hemolytic Anemia in Patients Treated for Hepatitis C Infection. Journal of Pharmacological and Toxicological Methods, 88, 167. https://doi.org/10.1016/j.vascn.2017.09.002
Genetic Variation in SLC16A5 Confers Protection from Cisplatin-Induced Ototoxicity in Adult Testicular Cancer Patients
Journal of Pharmacological and Toxicological Methods / Nov 01, 2017
Drogemoller, B., Monzon, J., Bhavsar, A., Borrie, A., Brooks, B., Wright, G., Liu, G., Fadhel, E., Renouf, D., Kollmannsberger, C., Bedard, P., Aminkeng, F., Hildebrand, C., Gunaretnam, E., Critchley, C., Chen, Z., Brunham, L., Hayden, M., Ross, C., … Carleton, B. (2017). Genetic Variation in SLC16A5 Confers Protection from Cisplatin-Induced Ototoxicity in Adult Testicular Cancer Patients. Journal of Pharmacological and Toxicological Methods, 88, 169–170. https://doi.org/10.1016/j.vascn.2017.09.010
Multifactorial Prediction of Anthracycline-Induced Cardiotoxicity in Childhood Cancer: 10 Years of Active Surveillance and Pharmacogenomics Studies at the Canadian Pharmacogenomics Network for Drug Safety
Journal of Pharmacological and Toxicological Methods / Nov 01, 2017
Aminkeng, F., Rassekh, S., Bhavsar, A., Luo, H., Wright, G., Drögemöller, B., Rieder, M., Hayden, M., Ross, C., & Carleton, B. (2017). Multifactorial Prediction of Anthracycline-Induced Cardiotoxicity in Childhood Cancer: 10 Years of Active Surveillance and Pharmacogenomics Studies at the Canadian Pharmacogenomics Network for Drug Safety. Journal of Pharmacological and Toxicological Methods, 88, 168. https://doi.org/10.1016/j.vascn.2017.09.005
OP13 Association entre le polymorphisme rs7903146(C/T) du gène TCF7L2 et l'obésité dans une population Camerounaise
Diabetes Research and Clinical Practice / Feb 01, 2014
Metsadjio, A. N., Sobngwi, E., Sontsa, O. D., Dongwi, E. N., Mato, E. P. M., Fokeng, M. G., Pokam, P. F., Djahmeni, E., Tiedeu, B. A., Evehe, M. S., Djokam-Dadjeu, R., Aminkeng, F., Mbacham, W. F., & Mbanya, J. C. (2014). OP13 Association entre le polymorphisme rs7903146(C/T) du gène TCF7L2 et l’obésité dans une population Camerounaise. Diabetes Research and Clinical Practice, 103, S12. https://doi.org/10.1016/s0168-8227(14)70040-3
Factors Predictive of Primary Resistance to Immune Checkpoint Inhibitors in Patients with Advanced Non-Small Cell Lung Cancer
Cancers / May 12, 2023
Huang, Y., Zhao, J. J., Soon, Y. Y., Kee, A., Tay, S. H., Aminkeng, F., Ang, Y., Wong, A. S. C., Bharwani, L. D., Goh, B. C., & Soo, R. A. (2023). Factors Predictive of Primary Resistance to Immune Checkpoint Inhibitors in Patients with Advanced Non-Small Cell Lung Cancer. Cancers, 15(10), 2733. https://doi.org/10.3390/cancers15102733
An initial health economic evaluation of pharmacogenomic testing in patients treated for childhood cancer with anthracyclines
Pediatric Blood & Cancer / Dec 22, 2017
Dionne, F., Aminkeng, F., Bhavsar, A. P., Groeneweg, G., Smith, A., Visscher, H., Rassekh, S. R., Ross, C., & Carleton, B. (2017). An initial health economic evaluation of pharmacogenomic testing in patients treated for childhood cancer with anthracyclines. Pediatric Blood & Cancer, 65(3). Portico. https://doi.org/10.1002/pbc.26887
DLL4 loss‐of‐function heterozygous mutations cause Adams–Oliver syndrome
Clinical Genetics / Oct 16, 2015
Aminkeng, F. (2015). DLL4 loss‐of‐function heterozygous mutations cause Adams–Oliver syndrome. Clinical Genetics, 88(6), 532–532. Portico. https://doi.org/10.1111/cge.12681
PDGFRB mutation causes
autosomal‐dominant Penttinen syndrome
Clinical Genetics / Oct 27, 2015
Aminkeng, F. (2015). <scp>PDGFRB</scp> mutation causes autosomal‐dominant Penttinen syndrome. Clinical Genetics, 88(6), 531–531. Portico. https://doi.org/10.1111/cge.12680
A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer
Nature Genetics / Aug 03, 2015
Aminkeng, F., Bhavsar, A. P., Visscher, H., Rassekh, S. R., Li, Y., Lee, J. W., Brunham, L. R., Caron, H. N., van Dalen, E. C., Kremer, L. C., van der Pal, H. J., Amstutz, U., Rieder, M. J., Bernstein, D., Carleton, B. C., Hayden, M. R., Ross, C. J. D., Hayden, M. R., … Carleton, B. C. (2015). A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer. Nature Genetics, 47(9), 1079–1084. https://doi.org/10.1038/ng.3374
Association between the rs12255372 variant of the TCF7L2 gene and obesity in a Cameroonian population
BMC Research Notes / Nov 25, 2015
Ngwa, E. N., Sobngwi, E., Atogho-Tiedeu, B., Noubiap, J. J. N., Donfack, O. S., Guewo-Fokeng, M., Mofo, E. P. M., Fosso, P. P., Djahmeni, E., Djokam-Dadjeu, R., Evehe, M.-S., Aminkeng, F., Mbacham, W. F., & Mbanya, J. C. (2015). Association between the rs12255372 variant of the TCF7L2 gene and obesity in a Cameroonian population. BMC Research Notes, 8(1). https://doi.org/10.1186/s13104-015-1661-3
EIF2AK4 genetic
mutations cause a recessive form of rare
and deadly lung disease, pulmonary
veno‐occlusive disease
Clinical Genetics / Jul 21, 2014
Aminkeng, F. (2014). <scp>EIF2AK4</scp> genetic mutations cause a recessive form of rare and deadly lung disease, pulmonary veno‐occlusive disease. Clinical Genetics, 86(3), 218–219. Portico. https://doi.org/10.1111/cge.12446
GFI1B mutation causes
autosomal dominant gray platelet syndrome
Clinical Genetics / Apr 09, 2014
Aminkeng, F. (2014). <scp>GFI1B</scp> mutation causes autosomal dominant gray platelet syndrome. Clinical Genetics, 85(6), 534–535. Portico. https://doi.org/10.1111/cge.12380
Using pharmacogenetics in real time to guide therapy: the warfarin example
Clinical Genetics / Apr 09, 2014
Aminkeng, F. (2014). Using pharmacogenetics in real time to guide therapy: the warfarin example. Clinical Genetics, 85(6), 533–534. Portico. https://doi.org/10.1111/cge.12378
WDR45 mutations define a
novel disease entity—Static Encephalopathy
of Childhood with Neurodegeneration in
Adulthood
Clinical Genetics / May 29, 2013
Aminkeng, F. (2013). <scp>WDR45</scp> mutations define a novel disease entity—Static Encephalopathy of Childhood with Neurodegeneration in Adulthood. Clinical Genetics, 84(3), 209–209. Portico. https://doi.org/10.1111/cge.12183
KCNT1 mutations in
ADNFLE and MMPSI : a
new driver in the etiology and
pathophysiology of early‐onset epileptic
syndromes
Clinical Genetics / Apr 01, 2013
Aminkeng, F. (2013). <scp>KCNT1</scp> mutations in <scp>ADNFLE</scp> and <scp>MMPSI</scp>: a new driver in the etiology and pathophysiology of early‐onset epileptic syndromes. Clinical Genetics, 83(4), 319–320. Portico. https://doi.org/10.1111/cge.12082
Mutations in
ATP1A3 cause alternating
hemiplegia of childhood
Clinical Genetics / Jan 01, 2013
Aminkeng, F. (2013). Mutations in <scp>ATP1A3</scp> cause alternating hemiplegia of childhood. Clinical Genetics, 83(1), 32–33. Portico. https://doi.org/10.1111/cge.12031
TNFa microsatellite polymorphism modulates the risk of type 1 diabetes in the Belgian population, independent of HLA-DQ
Human Immunology / Aug 01, 2007
Aminkeng, F., Van Autreve, J. E., Koeleman, B. P. C., Quartier, E., Van Schravendijk, C., Gorus, F. K., & Van der Auwera, B. J. R. (2007). TNFa microsatellite polymorphism modulates the risk of type 1 diabetes in the Belgian population, independent of HLA-DQ. Human Immunology, 68(8), 690–697. https://doi.org/10.1016/j.humimm.2007.05.001
Education
Vrije Universiteit Brussel
Doctor in Medical Sciences, Medical Biochemistry and Diabetes Research Centre / September, 2010
Vrije Universiteit Brussel
Master Degree in Medical and Pharmaceutical Research, Medical Biochemsitry and Diabetes Research Centre / June, 2005
University of Buea
Bachelor of Medical Laboratory Science, Medical Laboratory Science / August, 2001
Experience
Medical College of Wisconsin
Associate Professor / March, 2024 — Present
Principal Investigator / March, 2024 — Present
National University of Singapore
Faculty / August, 2021 — February, 2024
Assistant Professor / April, 2020 — February, 2024
Adjunct Assistant Professor / July, 2018 — December, 2019
Adjunct Assistant Professor / January, 2018 — December, 2019
National University Health System
Faculty / April, 2020 — February, 2024
Agency for Science, Technology and Research
Head - Pharmacogenomics and Personalized Medicine Program / February, 2017 — December, 2019
Assistant Principal Investigator / February, 2017 — December, 2019
University of British Columbia
Research Associate / April, 2016 — January, 2017
Postdoctoral Fellow / February, 2011 — March, 2016
University of Ottawa
Postdoctoral Fellow / December, 2010 — February, 2011
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