Michael Cukan

Bioconjugates, Analytical biochemistry method development

Research Expertise

Immunology
Antibodies
Antibody drug conjugates
Applied Microbiology and Biotechnology
Biomedical Engineering
Molecular Medicine
Biotechnology
Bioengineering
Immunology and Allergy
Molecular Biology
Cell Biology
Biochemistry
Hematology

About

Michael Cukan is a highly experienced and educated scientist with a background in chemistry, cell biology, and biochemistry. He earned his PhD in Chemistry from Dartmouth College in 2019, his M.S. in Cell Biology from Yale University, and his A.B. in Biochemistry from Cornell University.

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Publications

Optimization of humanized IgGs in glycoengineered Pichia pastoris
Nature Biotechnology
2006
Production of monoclonal antibodies by glycoengineered Pichia pastoris
Journal of Biotechnology
2009
IgG2m4, an engineered antibody isotype with reduced Fc function
mAbs
2009
Glycoengineered Pichia produced anti-HER2 is comparable to trastuzumab in preclinical study
mAbs
2011
Recombinant human lactoferrin expressed in glycoengineered Pichia pastoris: effect of terminal N-acetylneuraminic acid on in vitro secondary humoral immune response
Glycoconjugate Journal
2008
Purification process development of a recombinant monoclonal antibody expressed in glycoengineered Pichia pastoris
Protein Expression and Purification
2011
Characterization of N-Linked Glycosylation on Recombinant Glycoproteins Produced in Pichia pastoris Using ESI-MS and MALDI-TOF
Glycomics
2008
KPMW135, a Biosuperior CD3 Bispecific Version of Rituximab Created By a Novel Chemical Conjugation Technology Demonstrates Increased Anti-Tumor Activity By Adding T Cell-Mediated Cytotoxicity Activity to the Existing Mechanisms of Rituximab
Blood
2020
635 A novel site-directed chemical conjugation technology confers antitumor activity via native Fc receptor to plasma immunoglobulin by attaching tumor binders
Regular and young investigator award abstracts
2020
Binding of DC-SIGN to glycoproteins expressed in glycoengineered Pichia pastoris
Journal of Immunological Methods
2012
A high-throughput purification of monoclonal antibodies from glycoengineered Pichia pastoris
Protein Expression and Purification
2010

Education

Dartmouth College

PhD, Chemistry / January, 2019

Hanover, New Hampshire, United States of America

Yale University

M.S., Cell Biology / August, 2002

New Haven

Cornell University

A.B., Biochemistry / May, 1996

Ithaca

Experience

Olympus Biotech

2011August, 2013

Glycofi Inc

Research Biologist / August, 2004December, 2010

Agilix Corp

20022004

Cornell University

19961997

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