William A. Muller, MD, PhD

Janardan K. Reddy Endowed Professor of Pathology, Northwestern University Feinberg School of Medicine; expert in inflammation and inflammatory disease.

Research Expertise

inflammation
immunology
vascular biology

Publications

Endocytosis and the recycling of plasma membrane.
The Journal of cell biology
1983
PECAM-1 is required for transendothelial migration of leukocytes.
The Journal of experimental medicine
1993
PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily
Science
1990
Leukocyte–endothelial-cell interactions in leukocyte transmigration and the inflammatory response
Trends in Immunology
2003
Differentiation of Phagocytic Monocytes into Lymph Node Dendritic Cells In Vivo
Immunity
1999
Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
Science
1998
Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule.
The Journal of cell biology
1991
Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs
Proceedings of the National Academy of Sciences
2004
The Abundant NK Cells in Human Secondary Lymphoid Tissues Require Activation to Express Killer Cell Ig-Like Receptors and Become Cytolytic
The Journal of Immunology
2004
Mechanisms of Leukocyte Transendothelial Migration
Annual Review of Pathology: Mechanisms of Disease
2011
CD99 plays a major role in the migration of monocytes through endothelial junctions
Nature Immunology
2002
The Leukotriene C4 Transporter MRP1 Regulates CCL19 (MIP-3β, ELC)–Dependent Mobilization of Dendritic Cells to Lymph Nodes
Cell
2000
Locomotion of monocytes on endothelium is a critical step during extravasation
Nature Immunology
2004
Getting Leukocytes to the Site of Inflammation
Veterinary Pathology
2013
Genetic Evidence for Functional Redundancy of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1): CD31-Deficient Mice Reveal PECAM-1-Dependent and PECAM-1-Independent Functions
The Journal of Immunology
1999
A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions.
The Journal of experimental medicine
1989
Leukocyte-Endothelial Cell Interactions in the Inflammatory Response
Laboratory Investigation
2002
Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis
Nature
2003
Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo.
The Journal of experimental medicine
1994
Mechanisms of Transendothelial Migration of Leukocytes
Circulation Research
2009
Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability
Blood
2001
The Role of Phosphatidylinositol 3-Kinase in Vascular Endothelial Growth Factor Signaling
Journal of Biological Chemistry
1999
A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels
Proceedings of the National Academy of Sciences
1998
The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infection
Journal of Leukocyte Biology
2003
Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1.
The Journal of experimental medicine
1995
Migration of leukocytes across endothelium and beyond: molecules involved in the transmigration and fate of monocytes
Journal of Leukocyte Biology
1999
PECAM-1/CDS31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes
Nature Medicine
1997
The role of PECAM-1 (CD31) in leukocyte emigration: studies in vitro and in vivo
Journal of Leukocyte Biology
1995
Soluble Domain 1 of Platelet–Endothelial Cell Adhesion Molecule (PECAM) Is Sufficient to Block Transendothelial Migration In Vitro and In Vivo
The Journal of Experimental Medicine
1997
Monocytes Induce Reversible Focal Changes in Vascular Endothelial Cadherin Complex during Transendothelial Migration under Flow
The Journal of Cell Biology
2000
Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) in natural killer cell transendothelial migration and beta 2 integrin activation.
The Journal of Immunology
1996
Platelet/endothelial cell adhesion molecule-1 (CD31)-mediated cellular aggregation involves cell surface glycosaminoglycans
Journal of Biological Chemistry
1993
Transcellular migration of leukocytes is mediated by the endothelial lateral border recycling compartment
Journal of Experimental Medicine
2009
Ligation of platelet/endothelial cell adhesion molecule 1 (PECAM-1/CD31) on monocytes and neutrophils increases binding capacity of leukocyte CR3 (CD11b/CD18).
The Journal of Immunology
1995
NK cells of human secondary lymphoid tissues enhance T cell polarization via IFN‐γ secretion
European Journal of Immunology
2006
CD99 Is a Key Mediator of the Transendothelial Migration of Neutrophils
The Journal of Immunology
2007
A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31).
The Journal of experimental medicine
1992
The membrane proteins of the vacuolar system. II. Bidirectional flow between secondary lysosomes and plasma membrane.
The Journal of cell biology
1980
Cloning of a human alpha(1,3)-fucosyltransferase gene that encodes ELFT but does not confer ELAM-1 recognition on Chinese hamster ovary cell transfectants.
Journal of Biological Chemistry
1991
Platelet Endothelial Cell Adhesion Molecule Deficiency or Blockade Significantly Reduces Leukocyte Emigration in a Majority of Mouse Strains
The Journal of Immunology
2004
Role of Tissue Factor in Adhesion of Mononuclear Phagocytes to and Trafficking Through Endothelium In Vitro
Blood
1998
MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury
Circulation Research
2017
Monocyte-selective transendothelial migration: dissection of the binding and transmigration phases by an in vitro assay.
The Journal of experimental medicine
1992
How Endothelial Cells Regulate Transmigration of Leukocytes in the Inflammatory Response
The American Journal of Pathology
2014
PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation
Frontiers in Immunology
2019
Transendothelial migration: unifying principles from the endothelial perspective
Immunological Reviews
2016
Tonsilar NK Cells Restrict B Cell Transformation by the Epstein-Barr Virus via IFN-γ
PLoS Pathogens
2008
Endothelial Cell Calcium Signaling during Barrier Function and Inflammation
The American Journal of Pathology
2020
New Mechanisms and Pathways for Monocyte Recruitment
The Journal of Experimental Medicine
2001
Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells
Blood
2002
Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity
Journal of Cell Science
2011
Neutrophil platelet endothelial cell adhesion molecule-1 participates in neutrophil recruitment at inflammatory sites and is down-regulated after leukocyte extravasation.
The Journal of Immunology
1997
Leukocyte transmigration requires kinesin-mediated microtubule-dependent membrane trafficking from the lateral border recycling compartment
The Journal of Experimental Medicine
2008
ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer
Nature Communications
2021
Interleukin 2 receptors are expressed by alveolar macrophages during pulmonary sarcoidosis and are inducible by lymphokine treatment of normal human lung macrophages, blood monocytes, and monocyte cell lines.
The Journal of Immunology
1987
Plasmalemmal proteins of cultured vascular endothelial cells exhibit apical-basal polarity: analysis by surface-selective iodination.
The Journal of cell biology
1986
TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response
Journal of Experimental Medicine
2015
Migration of Leukocytes across Endothelial Junctions: Some Concepts and Controversies
Microcirculation
2001
The membrane proteins of the vacuolar system I. Analysis of a novel method of intralysosomal iodination.
The Journal of cell biology
1980
ICAM-1–activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration
Blood
2012
Rapid Remodeling of Tight Junctions during Paracellular Diapedesis in a Human Model of the Blood–Brain Barrier
The Journal of Immunology
2014
Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule 1.
Proceedings of the National Academy of Sciences
1993
Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration
Journal of Experimental Medicine
2015
Transendothelial Migration of Monocytes: The Underlying Molecular Mechanisms and Consequences of HIV-1 Infection
Current HIV Research
2005
Vascular Endothelial Cadherin (VE‐Cadherin): Cloning and Role in Endothelial Cell‐Cell Adhesion
Microcirculation
1997
Putting the brakes on innate immunity: a regulatory role for CD200?
Nature Immunology
2001
The regulation of transendothelial migration: new knowledge and new questions
Cardiovascular Research
2015
Leukocyte trans-endothelial migration: JAMs add new pieces to the puzzle
Thrombosis and Haemostasis
2003
CD99 Is Essential for Leukocyte Diapedesis In Vivo
Cell Communication & Adhesion
2008
Membrane proteins of the vacuolar system. III. Further studies on the composition and recycling of endocytic vacuole membrane in cultured macrophages
The Journal of Cell Biology
1983
Chapter 9 Assays of Transendothelial Migration In Vitro
Methods in Enzymology
2008
Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro
Fluids and Barriers of the CNS
2020
Poliovirus Receptor (CD155) Regulates a Step in Transendothelial Migration between PECAM and CD99
The American Journal of Pathology
2013
Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils
The Journal of Experimental Medicine
2005
Ligation of CD31/PECAM-1 modulates the function of lymphocytes, monocytes and neutrophils
European Journal of Immunology
1998
Neutrophil and monocyte recruitment by PECAM, CD99, and other molecules via the LBRC
Seminars in Immunopathology
2013
A Novel and Critical Role for Tyrosine 663 in Platelet Endothelial Cell Adhesion Molecule-1 Trafficking and Transendothelial Migration
The Journal of Immunology
2009
Isolation and longterm culture of human intestinal microvascular endothelial cells.
Gut
1995
Localized signals that regulate transendothelial migration
Current Opinion in Immunology
2016
Monocytes from HIV-infected individuals show impaired cholesterol efflux and increased foam cell formation after transendothelial migration
AIDS
2015
A Postmortem Portrait of the Coronavirus Disease 2019 (COVID-19) Pandemic: A Large Multi-institutional Autopsy Survey Study
Archives of Pathology & Laboratory Medicine
2021
The Murine CD99-Related Molecule CD99-Like 2 (CD99L2) Is an Adhesion Molecule Involved in the Inflammatory Response
Cell Communication & Adhesion
2007
In situ induction of dendritic cell–based T cell tolerance in humanized mice and nonhuman primates
Journal of Experimental Medicine
2011
Inhibition of Antigen-Specific T Cell Trafficking into the Central Nervous System via Blocking PECAM1/CD31 Molecule
Journal of Neuropathology & Experimental Neurology
2001
Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation
Immunity
2021
Endothelial cell activation promotes foam cell formation by monocytes following transendothelial migration in an in vitro model
Experimental and Molecular Pathology
2012
Effects of HIV-1 infection in vitro on transendothelial migration by monocytes and monocyte-derived macrophages
Journal of Leukocyte Biology
2009
Transgenic Mice Expressing Different Levels of Soluble Platelet/Endothelial Cell Adhesion Molecule-IgG Display Distinct Inflammatory Phenotypes
The Journal of Immunology
1999
Different susceptibilities of PECAM-deficient mouse strains to spontaneous idiopathic pneumonitis
Experimental and Molecular Pathology
2006
Cell Surface Glycosaminoglycans Do Not Serve as Ligands for PECAM-1
Journal of Biological Chemistry
1998
Kaposi’s Sarcoma-Associated Herpesvirus K3 and K5 Proteins Block Distinct Steps in Transendothelial Migration of Effector Memory CD4+ T Cells by Targeting Different Endothelial Proteins
The Journal of Immunology
2010
Binding of Plasmodium falciparum-infected erythrocytes to soluble platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): frequent recognition by clinical isolates.
The American Journal of Tropical Medicine and Hygiene
2001
Migration of leukocytes across the vascular intima molecules and mechanisms
Trends in Cardiovascular Medicine
1995
Endothelial Src kinase regulates membrane recycling from the lateral border recycling compartment during leukocyte transendothelial migration
European Journal of Immunology
2008
Longitudinal deep-brain imaging in mouse using visible-light optical coherence tomography through chronic microprism cranial window
Biomedical Optics Express
2019
PECAM: Regulating the start of diapedesis
Adhesion Molecules: Function and Inhibition
2007
Attenuation of Leukocyte Sequestration by Selective Blockade of PECAM-1 or VCAM-1 in Murine Endotoxemia
European Surgical Research
2004
Blocking platelet/endothelial cell adhesion molecule 1 (PECAM) inhibits disease progression and prevents joint erosion in established collagen antibody-induced arthritis
Experimental and Molecular Pathology
2010
4D intravital microscopy uncovers critical strain differences for the roles of PECAM and CD99 in leukocyte diapedesis
American Journal of Physiology-Heart and Circulatory Physiology
2016
PECAM-Independent Thioglycollate Peritonitis Is Associated With a Locus on Murine Chromosome 2
PLoS ONE
2009

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