Akash Gupta

University of Arizona

Research Expertise

Cancer biology

Publications

Endothelial HIF-2α Contributes to Severe Pulmonary Hypertension by Inducing Endothelial-to-Mesenchymal Transition
American Journal of Physiology-Lung Cellular and Molecular Physiology
2017
RANKL expression in normal and malignant breast tissue responds to progesterone and is up-regulated during the luteal phase
Breast Cancer Research and Treatment
2014
Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α
American Journal of Respiratory Cell and Molecular Biology
2020
Crosstalk between the vitamin D receptor (VDR) and miR-214 in regulating SuFu, a hedgehog pathway inhibitor in breast cancer cells
Experimental Cell Research
2016
Glyceollins Trigger Anti-Proliferative Effects in Hormone-Dependent Aromatase-Inhibitor-Resistant Breast Cancer Cells through the Induction of Apoptosis
International Journal of Molecular Sciences
2022
A novel and cost-effective ex vivo orthotopic model for the study of human breast cancer in mouse mammary gland organ culture
Biology Open
2020
The eNAMPT/TLR4 inflammatory cascade drives the severity of intra-amniotic inflammation in pregnancy and predicts infant outcomes
Frontiers in Physiology
2023
GALNT1-mediated O-GalNAc Glycosylation Is a Novel Mediator of Pulmonary Arterial Hypertension
D18. MOLECULAR TRAFFIC HUBS IN PULMONARY VASCULAR DISEASE
2023
Abstract 2051: MDN1, a novel potential early biomarker for endocrine resistant breast cancer
Cancer Research
2023
GALNT1/13 as Novel Mediators of Pulmonary Arterial Hypertension
TP85. TP085 A HARD DAY?S NIGHT - NOVEL MOLECULAR MECHANISMS AND TREATMENT OPTIONS IN PAH AND BEYOND: FROM PULMONARY VASCULATURE TO RV
2021
Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Hypertension
B5. B005 HERE COMES THE SUN - BASIC AND TRANSLATIONAL ADVANCES IN PULMONARY HYPERTENSION: LESSONS FROM BEST ABSTRACTS
2021
First person – Akash Gupta
Biology Open
2020
Sa1148 GENERATION AND CHARACTERIZATION OF HUMAN PANCREATIC NEUROENDOCRINE TUMOR ORGANOID: A CONFOCAL AND QPCR ANALYSIS.
Gastroenterology
2020
354 INTERFERON ALPHA MEDIATES SCHLAFIN4+-MDSC POLARIZATION DURING HELICOBACTER-INDUCED SPASMOLYTIC POLYPEPTIDE-EXPRESSING METAPLASIA
Gastroenterology
2020
Faculty Opinions recommendation of Whole-exome sequencing reveals TopBP1 as a novel gene in idiopathic pulmonary arterial hypertension.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
2014
Ligand-Independent EGFR Activation In The Development Pulmonary Hypertension
C62. EXPERIMENTAL MODELS IN PULMONARY HYPERTENSION II
2012
Pulmonary Thromboembolism
Pulmonary and Critical Care Medicine: Respiratory Critical Care
2017
Abstract 3275: Development of a new ex-vivo orthotopic model-Human breast cancer cells in mouse mammary gland organ culture
Cancer Research
2012
Abstract P2-09-10: Antiprogestin CDB4124 suppressed progesterone receptor-mediated DNA binding activity, proliferation and gene expression in T47D cancer cells and normal human breast microstructures
Cancer Research
2013
Abstract 3812: Deguelin as a novel therapeutic agent for Herceptin resistant breast cancers
Cancer Research
2012
Abstract 3829: Inhibition of breast cancer metastasis by deguelin in an experimental model
Cancer Research
2012
Characterising an aromatase inhibitor resistant breast cancer cell line
BMC Proceedings
2012
P2-17-05: Antiprogestin Proellex Suppresses Proliferation of Aromatase Overexpressing and Letrozole Resistant T47D Breast Cancer Cells.
Cancer Research
2011
Abstract 5691: Significance of combination treatment of antiprogestin and aromatase inhibitors in aromatase overexpressing T47D breast cancer cells
Cancer Research
2010
Abstract 2118: Targeting telomerase in HER2 positive breast cancer: role of cancer stem cells.
Cancer Research
2013
Announcement
Chemico-Biological Interactions
2006
Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension
Circulation
2024
Extracellular Nicotinamide Phosphoribosyltransferase Is a Therapeutic Target in Experimental Necrotizing Enterocolitis
Biomedicines
2024
IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias
Blood
2021
Endothelial Targets of SOX17 in Pulmonary Arterial Hypertension: A Quantitative Proteomic Approach
D54. TO LIVE AND LET DIE: THE ENDOTHELIUM IN PAH
2019
Mo1730 – Butyrate-Treated Colon Organoids from Fap Subjects Supresses Key Cancer Pathways When Zbp-89 (ZNF148) Deleted
Gastroenterology
2019
Imaging assessment of cardioprotection mediated by a dodecafluoropentane oxygen-carrier administered during myocardial infarction
Nuclear Medicine and Biology
2019
Associations of Prolonged QTc in Sickle Cell Disease
PLOS ONE
2016
Genome-Wide Analysis Identifies IL-18 and FUCA2 as Novel Genes Associated with Diastolic Function in African Americans with Sickle Cell Disease
PLOS ONE
2016
Progesterone receptor blockade in human breast cancer cells decreases cell cycle progression through G2/M by repressing G2/M genes
BMC Cancer
2016
Comment on “Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast”
Science Translational Medicine
2013
Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells
Clinical & Experimental Metastasis
2013
Efficacy and mechanism of action of Proellex, an antiprogestin in aromatase overexpressing and Letrozole resistant T47D breast cancer cells
The Journal of Steroid Biochemistry and Molecular Biology
2013

Education

Illinois Institute of Technology

Ph.D. Biology , Biology

Chicago, Illinois, United States of America

University of Madras

M.Sc. Biotechnology

Chennai

University of Madras

B.S. Microbiology

Chennai

Experience

University of Arizona

Research associate / 2014Present

Robert H. Lurie Comprehensive Cancer Center

Post doctoral fellow / 20122014

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