Zichong Li

Gladstone Institutes, University of California, San Francisco

Research Expertise

genetics
chromatin
gene regulation
biochemistry
HIV

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Publications

The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation
Nucleic Acids Research
2012
AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation
Proceedings of the National Academy of Sciences
2013
The Ubiquitin Ligase Siah1 Controls ELL2 Stability and Formation of Super Elongation Complexes to Modulate Gene Transcription
Molecular Cell
2012
Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription
Nucleic Acids Research
2015
Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency
PLOS Pathogens
2019
The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency
PLOS Pathogens
2018
Viral–Host Interactions That Control HIV-1 Transcriptional Elongation
Chemical Reviews
2013
Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription
Nature Communications
2017
A Minor Subset of Super Elongation Complexes Plays a Predominant Role in Reversing HIV-1 Latency
Molecular and Cellular Biology
2016
Analysis of white spot syndrome virus envelope protein complexome by two-dimensional blue native/SDS PAGE combined with mass spectrometry
Archives of Virology
2011
Identification of unrecognized host factors promoting HIV-1 latency
PLOS Pathogens
2020
Comprehensive synergy mapping links a BAF- and NSL-containing “supercomplex” to the transcriptional silencing of HIV-1
Cell Reports
2023
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