TANISHA SINGH

Research Scientist, University of Pittsburgh, School of Medicine

Research Expertise

Neurotoxicology

MicroRNAs

Neurodegenerative diseases

Stem Cells

Mitochondrial Biology

About

=Experienced scientist with 12+ Years of experience in areas of Cell and Molecular Biology, Neurotoxicology, Neurobiology and Stem cell Biology Research. =Successfully driving projects by planning, organizing and executing laboratory experiments. =Critically analyze data, interpret, review results and published manuscripts and grants. =Proven track record of independently and collaboratively working on different projects. =Expert in mammalian and primary cell culture along with IPSCs and their differentiated types, subtypes. =Skilled in animal handling and IN,IV,IP techniques =Proficient in designing and analyzing candidate as well as genome- wide expression assay (qPCR/qRT-PCR, Taqman assays and arrays) =Experienced in Molecular Biology and Biochemistry techniques =Mitochondrial biology and parameters =Mentored around 7 interns (undergraduate and Masters students) during doctoral and postdoctoral research.

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Publications

Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration

Journal of Clinical Investigation

2020

Critical role of the miR‐200 family in regulating differentiation and proliferation of neurons

Journal of Neurochemistry

2015

Regulation of miR-34 Family in Neuronal Development

Molecular Neurobiology

2017

Coordinated Action of miR-146a and Parkin Gene Regulate Rotenone-induced Neurodegeneration

Toxicological Sciences

2020

Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral sclerosis is developmentally regulated

Scientific Reports

2021

Role of microRNAs in neurodegeneration induced by environmental neurotoxicants and aging

Ageing Research Reviews

2020

Differentiation Induces Dramatic Changes in miRNA Profile, Where Loss of Dicer Diverts Differentiating SH-SY5Y Cells Toward Senescence

Molecular Neurobiology

2016

Transactivation of P53 by cypermethrin induced miR-200 and apoptosis in neuronal cells

Toxicology Research

2015

Expression of miR-145 and Its Target Proteins Are Regulated by miR-29b in Differentiated Neurons

Molecular Neurobiology

2018

Regulatory Triangle of Neurodegeneration, Adult Neurogenesis and MicroRNAs

CNS & Neurological Disorders - Drug Targets

2014

Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration

Journal of Clinical Investigation

2021

MicroRNAs are Emerging as Most Potential Molecular Biomarkers

Biochemistry & Analytical Biochemistry

2015

Neurodevelopmental disorders and neurotoxicity: MicroRNA in focus

Journal of Chemical Neuroanatomy

2022

Role of Stem Cells and Derived Exosomes as Novel Therapeutic Agents against Neuroinflammation and Stroke

Applications of Stem Cells and derived Exosomes in Neurodegenerative Disorders

2023

Ageing at Molecular Level: Role of MicroRNAs

Biochemistry and Cell Biology of Ageing: Part III Biomedical Science

2023

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