Zackary Cope

Seasoned behavioral neuroscientist and in vivo pharmacologist with university and industry experience

Research Expertise

Cross-Species Behavioral Neuroscience
Circadian Mechanisms in Psychiatric Illness
Chemicogenetics
Aging
Cognitive Neuroscience
Pharmacology
Psychiatry and Mental health
Genetics
Behavioral Neuroscience
Neurology
Developmental Neuroscience
Experimental and Cognitive Psychology
Cellular and Molecular Neuroscience
Clinical Biochemistry
Toxicology
Biochemistry
Biological Psychiatry
Neurology (clinical)
Geriatrics and Gerontology
Health Policy
Epidemiology
Physiology

Legacy Map

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Publications

Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study
Frontiers in Aging Neuroscience
2021
Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse
The Journal of Neuroscience
2018
Mice with reduced DAT levels recreate seasonal-induced switching between states in bipolar disorder
Neuropsychopharmacology
2018
Premature responses in the five-choice serial reaction time task reflect rodents’ temporal strategies: evidence from no-light and pharmacological challenges
Psychopharmacology
2016
Modeling neurodevelopmental cognitive deficits in tasks with cross‐species translational validity
Genes, Brain and Behavior
2016
Schizophrenia and Substance Abuse Comorbidity: Nicotine Addiction and the Neonatal Quinpirole Model
Developmental Neuroscience
2012
DREADD-mediated modulation of locus coeruleus inputs to mPFC improves strategy set-shifting
Neurobiology of Learning and Memory
2019
Chronic methamphetamine self-administration alters cognitive flexibility in male rats
Psychopharmacology
2016
Amphetamine increases activity but not exploration in humans and mice
Psychopharmacology
2015
Modafinil improves attentional performance in healthy, non-sleep deprived humans at doses not inducing hyperarousal across species
Neuropharmacology
2017
Oxytocin improves probabilistic reversal learning but not effortful motivation in Brown Norway rats
Neuropharmacology
2019
The Five‐Choice Continuous Performance Task (5C‐CPT): A Cross‐Species Relevant Paradigm for Assessment of Vigilance and Response Inhibition in Rodents
Current Protocols in Neuroscience
2017
Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H
Frontiers in Aging Neuroscience
2021
Dopamine transporter knockdown mice in the behavioral pattern monitor: A robust, reproducible model for mania-relevant behaviors
Pharmacology Biochemistry and Behavior
2019
Neonatal quinpirole treatment enhances locomotor activation and dopamine release in the nucleus accumbens core in response to amphetamine treatment in adulthood
Synapse
2009
Nicotine sensitization in adult male and female rats quinpirole-primed as neonates
Psychopharmacology
2008
Sex differences in nicotine sensitization and conditioned hyperactivity in adolescent rats neonatally treated with quinpirole: Role of D2 and D3 receptor subtypes.
Behavioral Neuroscience
2009
Converging evidence that short-active photoperiod increases acetylcholine signaling in the hippocampus
Cognitive, Affective, & Behavioral Neuroscience
2020
Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL‐AD preclinical testing core study
Alzheimer's & Dementia: Translational Research & Clinical Interventions
2022
Prophylactic evaluation of verubecestat on disease‐ and symptom‐modifying effects in 5XFAD mice
Alzheimer's & Dementia: Translational Research & Clinical Interventions
2022
Cognitive Phenotypes for Biomarker Identification in Mental Illness: Forward and Reverse Translation
Biomarkers in Psychiatry
2018
Evidence for light-entrainment-induced switching between depression- & mania-relevant behaviors in mice
Neuropsychopharmacology
2019
Emerging Electroencephalographic Biomarkers to Improve Preclinical to Clinical Translation in Alzheimer’s Disease
Frontiers in Aging Neuroscience
2022
Chronic antipsychotic treatment exerts limited effects on the mania-like behavior of dopamine transporter knockdown mice
Behavioural Brain Research
2021
A multi-discipline phenotyping platform for late-onset Alzheimer’s disease employed on a novel, humanized APOEε4.Trem2*R47H mouse model
Unknown Venue
2021
Short-active photoperiod gestation induces psychiatry-relevant behavior in healthy mice but a resiliency to such effects are seen in mice with reduced dopamine transporter expression
Scientific Reports
2020
Histologic validation of locus coeruleus MRI contrast in post-mortem tissue
NeuroImage
2015
Corrigendum: Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H
Frontiers in Aging Neuroscience
2022
APOEe4.Trem2*R47H Mice Show Changes in Alzheimer’s Disease-Relevant Processes in the Absence of Amyloid Plaques
Unknown Venue
2021
Pharmacokinetic, pharmacodynamic and transcriptomic analyses of verubecestat treatment in 5XFAD mice
Alzheimer's & Dementia
2020
498. Acetylcholinergic Mechanisms of Depressive-Like Behaviors Induced by Seasonally Relevant Reductions in Active Photoperiod
Biological Psychiatry
2017
F38. WINTER-LIKE PHOTOPERIOD GESTATION DELETERIOUSLY AFFECT EXPERIENTIAL- BUT NOT EXPRESSIVE-RELATED BEHAVIORS, WHILE ADULT PHENCYCLIDINE TREATMENT INCREASES EXPERIENTIAL BEHAVIORS: RELEVANCE TO SCHIZOPHRENIA
Schizophrenia Bulletin
2018
M113. Modafinil Improves Continuous Task Performance in Healthy, Non-Sleep Deprived Humans at Doses Not Inducing Hyperarousal Across Species
Schizophrenia Bulletin
2017
Unilateral electrical stimulation of rat locus coeruleus elicits bilateral response of norepinephrine neurons and sustained activation of medial prefrontal cortex
Journal of Neurophysiology
2014
Physical exercise in Parkinson disease: Moving toward more robust evidence?
Movement Disorders
2013
Depressive-Like Behavior in Adolescents after Maternal Separation: Sex Differences, Controllability, and GABA
Developmental Neuroscience
2012

Education

B.S., Psychology and Biology / May, 2005

Johnson City, Tennessee, United States of America

East Tennessee State University

M.A., Experimental Psychology / April, 2008

Johnson City, Tennessee, United States of America

Medical University of South Carolina

Ph.D., Neuroscience / December, 2014

Charleston, South Carolina, United States of America

University of California, San Diego

Postdoctorate, Translational Psychiatry / July, 2019

San Diego, California, United States of America

Experience

Sage Therapeutics

Scientist II / September, 2021September, 2023

Early Discovery Researcher, Experiment Management and Overshight, Cross-function Communication

University of Pittsburgh

Project Research Scientist / July, 2019September, 2021

Early Project Launch, Method Validation, Protocol Development

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