Vignesh Subramaniam

Postdoctoral Fellow at University of Florida

Research Expertise

soft matter physics
biomaterials
tissue engineering
soft robotics
bioinspiration

About

Multi-disciplinary researcher with a PhD in mechanical engineering from the University of Florida and over a decade of experience in bio-inspired robotics, tissue engineering, collective cell dynamics, and soft matter engineering. Ph.D. research thrusts include developing novel biomaterials, biofabricating 3D functional tissues, and exploring collective cell mechanics in bioprinted structures. Skilled in bioprinting, cell culture, confocal and multiphoton microscopy, rheology, image and big data analysis, particle-image velocimetry, product development, collaboration, and project management. Demonstrated ability in scientific communication, evidenced by high-impact publications and presentations, complemented by a strong record in collaborative research and project management. Passionate about applying engineering skills to solve real-world problems and advance the field of tissue engineering, regenerative medicine, and drug discovery.

Publications

Design and characterization of a hybrid soft gripper with active palm pose control
The International Journal of Robotics Research
2020
Ultra-fast escape maneuver of an octopus-inspired robot
Bioinspiration & Biomimetics
2015
Design of a bio-inspired whisker sensor for underwater applications
2012 IEEE Sensors
2012
Crocodile-inspired dome-shaped pressure receptors for passive hydrodynamic sensing
Bioinspiration & Biomimetics
2016
Performance analysis and characterization of bio-inspired whisker sensors for underwater applications
2013 IEEE/RSJ International Conference on Intelligent Robots and Systems
2013
Design and control of a field deployable batoid robot
2012 4th IEEE RAS & EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob)
2012
A Soft Gripper with Retractable Nails for Advanced Grasping and Manipulation
2020 IEEE International Conference on Robotics and Automation (ICRA)
2020
Cellular micromasonry: biofabrication with single cell precision
Soft Matter
2022
Biomimetic flow sensors for biomedical flow sensing in intravenous tubes
2016 IEEE SENSORS
2016
MEMS artificial neuromast arrays for hydrodynamic control of soft-robots
2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)
2016
Leveraging ultra-low interfacial tension and liquid–liquid phase separation in embedded 3D bioprinting
Biophysics Reviews
2022
Sensing on Robots Inspired by Nature
Biomimetic Microsensors Inspired by Marine Life
2016
A functional human liver tissue model: 3D bioprinted co-culture discoids
Biomaterials Advances
2025
Transitions between cooperative and crowding-dominated collective motion in non-jammed MDCK monolayers
Cells & Development
2025
Toward Bioactive Hydrogels: A Tunable Approach via Nucleic Acid-Collagen Complexation
Regenerative Engineering and Translational Medicine
2024
Determining Rates of Molecular Secretion from Supernatant Concentration Measurements in a 3D-Bioprinted Human Liver Tissue Model
ACS Biomaterials Science & Engineering
2024
Biopolymer networks packed with microgels combine strain stiffening and shape programmability
Giant
2024
IMMU-20. HYDROGEL-CXCL9 VACCINE RESULTS IN MRNA DELIVERY TO DENDRITIC CELLS AND POTENT ANTI-TUMOR RESPONSES IN GBM
Neuro-Oncology
2021
Crocodile-inspired dome shaped sensors for underwater object detection
2017 IEEE SENSORS
2017
Method and apparatus for gripping uniaxial fibrous composite materials
Composites
1985
Elastic modulus versus cell packing density in MDCK epithelial monolayers
Journal of Biomechanics
2025
CNSC-30. CD4 T CELLS MEDIATED UPREGULATION OF CCL4 CHEMOKINE DRIVES GLIOBLASTOMA TUMOR MICROENVIRONMENT REPROGRAMMING FOLLOWING TREATMENT WITH A NOVEL MRNA VACCINE
Neuro-Oncology
2023
DDDR-29. THE HYDROGEL-CXCL9-MRNA (HCM) VACCINE RESULTS IN SIGNIFICANT ANTI-TUMOR EFFICACY THROUGH RECRUITMENT OF NATURAL KILLER (NK) CELLS
Neuro-Oncology
2022
Thermo-Transitioning Core–Shell Microgels Combine Cohesive Reinforcement and Noncohesive Reconfigurability to Enable 3D Bioprinting and Stabilize Tissues During Incubation
ACS Biomaterials Science & Engineering
2026
1164 mRNA fusion-targeted vaccination elicits immune-mediated tumor killing
Regular and Young Investigator Award Abstracts
2025
TMIC-55. Tumor mRNA delivery via microgel-chemokine-mRNA (MCM) complex reprograms microglia and induces glioma regression through CCL4-CCR5 axis
Neuro-Oncology
2025
CNSC-17. UPREGULATION OF CCL4 AFTER TREATMENT WITH A NOVEL MRNA VACCINE SHIFTS THE PHENOTYPE OF CCR5-EXPRESSING MICROGLIA WITHIN TUMOR MICROENVIRONMENT
Neuro-Oncology
2024
Packing characteristics of jammed spheres with broad, power-law dispersity
APS March Meeting - Minneapolis, Minnesota, United States of America - March - 2024
2024
IMMU-33. CCL4 DRIVES GLIOBLASTOMA (GBM) TUMOR MICROENVIRONMENT (TME) REPROGRAMMING AFTER TREATMENT WITH A NOVEL MRNA VACCINE
Neuro-Oncology
2022
High-Fidelity Qubit Transfer Between Leaky Memory Blocks.
Proposed for presentation at the APS March Meeting 2022 in ,
2022
Elastic Modulus Versus Cell Packing Density in Mdck Epithelial Monolayers
Unknown Venue
2024
Evaporation-driven liquid flow in sessile droplets
Soft Matter
2022
Phase Behavior of Polymer-Grafted Nanoparticles.
Proposed for presentation at the 2021 APS March Meeting held March 15-19, 2021 in virtual.
2021
Transitions between Cooperative and Crowding-Dominated Collective Motion in Mdck Monolayers
Unknown Venue
2024

Education

University of Florida

Ph.D., Mechanical Engineering / May, 2025

Gainesville, Florida, United States of America

University of Florida

Master of Science, Mechanical Engineering / December, 2020

Gainesville, Florida, United States of America

Experience

University of Florida

Postdoctoral Fellow / May, 2025Present

Built a bioprinting platform for spatially resolved ATP sensing in organoid culture microenvironments. Engineered a custom extrusion bioprinter using Festo actuation and Python control to deposit cell structures and ATP solutions with 10 μm precision for controlled spatial perturbation experiments. Established quantitative workflows including calibration curves, controls, imaging, and analysis to map spatiotemporal ATP profiles in 3D printed structures, linking geometry, diffusion/release, and measured signal. Led suborbital flight payload development of microbes in microgels for space biomanufacturing. Developed protocols to inoculate and encapsulate bacteria in microgels, initially with E. coli and with planned expansion to Vibrio fischeri and other hosts. Executed freeze-thaw viability studies and designed vacuum/low-temperature exposure experiments with controls, recovery steps, and post-exposure viability and gene expression readouts.

University of Florida

Graduate Research Assistant / April, 2019May, 2025

Engineered shape-programmable collagen-microgel biomaterials resisting compaction for vascularized bioprinted tissues; bioprinted tubular constructs; quantified mechanics/remodeling by rheology/microscopy; tuned low-ECM formulations for print fidelity, robustness, and cell compatibility; leveraged fibroblast contractility to laminate tissues. Developed and patented (PCT/US2022/077536) bioprinted liver tissues integrating iPSC-derived/primary hepatocytes plus endothelial, fibroblast, and Kupffer cells; optimized workflows for albumin/urea, metabolite-responsive CYP activity, ADME expression, drug-screening/PK scalability, dose-response analysis. Led tumor-immune cocultures, epithelial mechanics, micromasonry, patented silicone AM (PCT/US2024/035383), spinal-cord injury testbeds, PILP-mineralized collagen-microgel biocomposites, and PEG microgels for mRNA vaccine delivery; managed confocal/multiphoton microscopes, rheometers, bioprinters; trained researchers; maintained BSL-2 compliance.

Singapore University of Technology and Design

Research Associate / November, 2017July, 2018

• Designed, manufactured, and patented (PCT/SG2021/050096) high-payload soft robotic grippers ◦ integrated with industrial robotic arms (KUKA IIWA 14, Universal Robot UR10e) ◦ validated pick and place and manipulation of gearbox components and consumer products ◦ developed novel repeatable fabrication/testing workflows for vacuum-actuated soft robotic systems ◦ enhancing safety, payload handling, and adaptability in precision manufacturing applications

Singapore-MIT Alliance for Research and Technology

Senior Research Engineer / August, 2011July, 2018

Developed octopus- and stingray-inspired robots and seal-whisker- and blind cave fish-inspired flow sensors. Led design and fabrication of novel propulsion systems and integrated bio-inspired sensors and actuators. Validated performance through hydrodynamic measurements (PIV) and field trials, improving underwater maneuverability and sensing. Directed high-fidelity prototyping and test platforms for marine robotics research by commissioning and managing 3D printers, a PIV towing tank, and a high-precision gantry. Coordinated sea trials of autonomous surface vehicles with bio-inspired sensors and mentored interdisciplinary teams on design, integration, and field deployment. Served as Co-PI on a saucer-shaped multi-domain drone capable of water-air transition; secured SG$48,000 grant and led concept design, prototype fabrication, and field testing for rapid oceanographic sampling and profiling.

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