VIJAYASSHEKAR MANUKONDA

Biotechnologist with core competence in biochemistry/cell-biology/molecular biology

Research Expertise

Alzheimer
Type I and Type II Diabetes
Cancer
Neurobiology
Structural Biology
Cell Biology
Biochemistry
Molecular Biology
Drug Discovery
Clinical Biochemistry
Molecular Medicine
Pharmaceutical Science
Organic Chemistry
Pharmacology
Immunology and Allergy
Immunology

About

At UNC, I worked on type 1 diabetes, particularly the regulatory role of AIM2, a DNA sensor inflammasome molecule associated with autoimmune disorders. NOD mice deficient in AIM2 do not develop diabetes, indicating a potential beyond host defense. My research involves mapping AIM2's functional binding partners using various methods. During my time at FIU, I worked on characterizing glycan structures in ovarian cancer and developing a peptide and glycan array for identifying potential biomarkers. At BIIR in Dallas, I researched nuclear hormonal transcription factors implicated in autoimmune disorders and cancers, utilizing various methods. Additionally, my work at UTMB in Galveston involved studying cell adhesion molecules linked to neurological disorders, using biochemical and biophysical techniques. My academic background includes extensive knowledge of molecular and biochemical techniques gained at Jawaharlal Nehru Technological University in Hyderabad, India.

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Publications

Calsyntenin-3 Molecular Architecture and Interaction with Neurexin 1α
Journal of Biological Chemistry
2014
Molecular Architecture of Contactin-associated Protein-like 2 (CNTNAP2) and Its Interaction with Contactin 2 (CNTN2)
Journal of Biological Chemistry
2016
Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors
Bioorganic & Medicinal Chemistry Letters
2013
X-Ray Structure of PTP1B in Complex with a New PTP1B Inhibitor
Protein & Peptide Letters
2013
Structural Plasticity of Neurexin 1α: Implications for its Role as Synaptic Organizer
Journal of Molecular Biology
2018
Diphenylether Derivative as Selective Inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B) Over T-cell Protein Tyrosine Phosphatase (TCPTP) Identified through Virtual Screening
Mini-Reviews in Medicinal Chemistry
2013
Design and Synthesis of Novel 2- Substituted Benzothiazole Compounds as PTP1B Inhibitors
Letters in Drug Design & Discovery
2014
New Developments in Autism Treatment
Autism-Open Access
2018
Radiolabeled Small Molecule Inhibitors of VEGFR - Recent Advances
Current Pharmaceutical Design
2012
The regulation of self-tolerance and the role of inflammasome molecules
Frontiers in Immunology
2023
The clinical role of glycobiology on ovarian cancer progression
Advances in Cancer Research
2023
Meeting and Course Announcements
Glycobiology
2017
Co-Occurring Disorders and Treatment
Journal of Addiction Research & Therapy
2018
ChemInform Abstract: L‐Proline‐Catalyzed Synthesis of Novel 5‐(1H‐Indol‐3‐yl‐methylene)‐thiazolidine‐2,4‐dione Derivatives as Potential Antihyperglycemic Agents.
ChemInform
2012
Biophysical Rationale for the Selective Inhibition of PTP1B over TCPTP by Nonpolar Terpenoids
Unknown Venue

Education

Jawaharlal Nehru Technological University, Hyderabad

BIOTECHNOLOGY / February, 2014

Hyderabad

Experience

UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

Links & Social Media

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