Christina Thornton

Assistant Professor, Division of Respirology, Department of Medicine with a cross-appointment in the Department of Microbiology Immunology and Infectious Diseases, University of Calgary

Research Expertise

Cystic Fibrosis
Bronchiectasis
Microbiome

About

Cystic fibrosis; polymicrobial interactions; molecular sequencing; 16S ribosomal RNA; microbiome and host interactions; lung microbiome and human health; antimicrobial resistance; virulence reservoirs in the microbiome; metagenomics; high-throughput sequencing.

Publications

Culture Enriched Molecular Profiling of the Cystic Fibrosis Airway Microbiome
PLoS ONE
2011
Characterization ofStreptococcus milleriGroup Isolates from Expectorated Sputum of Adult Patients with Cystic Fibrosis
Journal of Clinical Microbiology
2010
Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response
Frontiers in Immunology
2024
Microbial Epidemiology of the Cystic Fibrosis Airways: Past, Present, and Future
Seminars in Respiratory and Critical Care Medicine
2023
Exploring the Cystic Fibrosis Lung Microbiome: Making the Most of a Sticky Situation
Journal of the Pediatric Infectious Diseases Society
2022
The respiratory microbiome and nontuberculous mycobacteria: an emerging concern in human health
European Respiratory Review
2021
Prolonged SARS-CoV-2 infection following rituximab treatment: clinical course and response to therapeutic interventions correlated with quantitative viral cultures and cycle threshold values
Antimicrobial Resistance & Infection Control
2022
Effects of Wait Times on Treatment Adherence and Clinical Outcomes in Patients With Severe Sleep-Disordered Breathing
JAMA Network Open
2020
Macrolide and Clindamycin Resistance inStreptococcus milleriGroup Isolates from the Airways of Cystic Fibrosis Patients
Antimicrobial Agents and Chemotherapy
2010
Potential Contributions of Anaerobes in Cystic Fibrosis Airways
Journal of Clinical Microbiology
2021
Sputum microbiota in adults with CF associates with response to inhaled tobramycin
Thorax
2020
Epidemiological and genomic characterization of community-acquired Clostridium difficile infections
BMC Infectious Diseases
2018
Cough Aerosol Cultures of Mycobacterium tuberculosis: Insights on TST / IGRA Discordance and Transmission Dynamics
PLOS ONE
2015
Bromism in the Modern Day: Case Report and Canadian Review of Bromide Intoxication
Journal of General Internal Medicine
2020
Comparative Genomic Analyses of Streptococcus pseudopneumoniae Provide Insight into Virulence and Commensalism Dynamics
PLoS ONE
2013
Relation of Adolescents’ Physical Activity to After-School Recreation Environment
Journal of Physical Activity and Health
2017
Azithromycin and the microbiota of cystic fibrosis sputum
BMC Microbiology
2021
Prevalence and Clinical Impact of Respiratory Viral Infections from the STOP2 Study of Cystic Fibrosis Pulmonary Exacerbations
Annals of the American Thoracic Society
2024
Hodson and Geddes' Cystic Fibrosis
Unknown Venue
2023
Another Whipple’s triad? Pericardial, myocardial and valvular disease in an unusual case presentation from a Canadian perspective
BMC Cardiovascular Disorders
2019
Pulmonary Cryptococcus infections as a manifestation of idiopathic CD4 lymphocytopenia: case report and literature review
BMC Infectious Diseases
2019
Prevalence and impact of Streptococcus pneumoniae in adult cystic fibrosis patients: a retrospective chart review and capsular serotyping study
BMC Pulmonary Medicine
2015
Guideline-Concordant Therapy for Community-Acquired Pneumonia in the Hospitalized Population: A Systematic Review and Meta-analysis
Open Forum Infectious Diseases
2024
Porcine-derived pancreatic enzyme replacement therapy may be linked to chronic hepatitis E virus infection in cystic fibrosis lung transplant recipients
Gut
2024
Human papillomavirus (HPV) and cervical dysplasia in adult female cystic fibrosis (CF) lung transplant recipients
Thorax
2022
Clinical implications and characterization of Group A Streptoccoccus infections in adults with cystic fibrosis
BMC Pulmonary Medicine
2015
Antibiotic susceptibility and molecular mechanisms of macrolide resistance in streptococci isolated from adult cystic fibrosis patients
Journal of Medical Microbiology
2015
Rigid bronchoscopy and balloon dilation for removal of aspirated thumbtacks: Case series and literature review
International Journal of Pediatric Otorhinolaryngology
2015
Airway bacterial community composition in persons with advanced cystic fibrosis lung disease
Journal of Cystic Fibrosis
2023
Stenotrophomonas maltophilia natural history and evolution in the airways of adults with cystic fibrosis
Frontiers in Microbiology
2023
Upfront riociguat and ambrisentan combination therapy for newly diagnosed pulmonary arterial hypertension: A prospective open-label trial
The Journal of Heart and Lung Transplantation
2022
Group B streptococcus (GBS) is an important pathogen in human disease- but what about in cystic fibrosis?
BMC Infectious Diseases
2017
Quantifying variation in home spirometry in people with cystic fibrosis during baseline health, and associations with clinical outcomes
Journal of Cystic Fibrosis
2024
Cystic fibrosis and the cardiovascular system: the unexpected heartache
European Respiratory Journal
2023
Impact of Digital Health on Patient-Provider Relationships in Respiratory Secondary Care Based on Qualitative and Quantitative Evidence: Systematic Review
Journal of Medical Internet Research
2025
Impact of wait times for treatment on clinical outcomes in patients with obstructive sleep apnoea: protocol for a randomised controlled trial
ERJ Open Research
2022
Investigating the Swimming of Microbial Pathogens Using Digital Holography
Advances in Experimental Medicine and Biology
2016
Coming Up for Air: The Role of Anaerobes in Cystic Fibrosis
Annals of the American Thoracic Society
2022
Severe skin disease in lupus associated with hemophagocytic lymphohistiocytosis: case reports and review of the literature
BMC Rheumatology
2019
Disparities in pedestrian streetscape environments by income and race/ethnicity
SSM - Population Health
2016
Sex and gender in rhinosinusitis: a review
Future Microbiology
2024
The airway microbiome of persons with cystic fibrosis correlates with acquisition and microbiological outcomes of incident Stenotrophomonas maltophilia infection
Frontiers in Microbiology
2024
A Prescription that Addresses the Decline of Basic Science Education in Medical School
Clinical and Investigative Medicine
2014
Global, Regional, and National Levels and Trends in Maternal Mortality, Progress Towards the Sustainable Development Goals, and Mortality From COVID-19 Infection in Pregnant Women, 1990-2023: A Systematic Analysis for the Global Burden of Disease Study 2023
Unknown Venue
2026
Assessment of factors and interventions towards therapeutic adherence among persons with non-cystic fibrosis bronchiectasis
ERJ Open Research
2022
ACR Appropriateness Criteria® Chronic Dyspnea-Noncardiovascular Origin: 2024 Update
Journal of the American College of Radiology
2025
Genes take the lead: genetic testing becomes the gold standard for diagnosing primary ciliary dyskinesia
European Respiratory Journal
2024
Impact of day-to-day variation in FEV1 on measures of change: A conceptual description
Journal of Cystic Fibrosis
2024
Anaphylaxis and anaphylactoid reactions associated with the insertion of peripherally inserted central catheters: A multiyear comparative retrospective cohort study
Infection Control & Hospital Epidemiology
2019
The Worldwide Puzzle of Bronchiectasis Etiology in Adults
Archivos de Bronconeumología
2025
Viewpoint: a white paper for a greener design, conduct and reporting of clinical trials in respiratory medicine
European Respiratory Journal
2025
STOP Using Corticosteroids in Cystic Fibrosis Pulmonary Exacerbations
Annals of the American Thoracic Society
2024
Bronchiectasis and COVID-19: For Better or for Worse?
Annals of the American Thoracic Society
2024
Endoscopic Removal of Pulmonary Aspergilloma in a Nonsurgical Candidate
Annals of the American Thoracic Society
2023
Characteristics and Outcomes of Children With Cystic Fibrosis Hospitalized With Cirrhosis in the United States
American Journal of Gastroenterology
2021
Early Echocardiographic Improvements with Upfront Riociguat and Ambrisentan Combination Therapy for Incident Pulmonary Arterial Hypertension
The Journal of Heart and Lung Transplantation
2020
Microbiota, Mucus, and Modulators: Cystic Fibrosis Infection Pathogenesis in the Cystic Fibrosis Transmembrane Conductance Regulator Modulator Era
The Journal of Infectious Diseases
2025
The Canadian Bronchiectasis and Nontuberculous Mycobacteria Registry: a study protocol
ERJ Open Research
2024
Clinical epidemiology and impact of Haemophilus influenzae airway infections in adults with cystic fibrosis
BMC Infectious Diseases
2024
Combined medical-interventional approaches for the management of complex fungal balls: a case series as a viable alternative in non-surgical patients
Therapeutic Advances in Respiratory Disease
2024
The language of health.
BMJ
1993
Effect of transient versus persistent Aspergillus colonisation on clinical outcomes in bronchiectasis
ERJ Open Research
2025
Economic impact of elexacaftor/tezacaftor/ivacaftor on healthcare expenditure in Canada
Journal of Cystic Fibrosis
2025
Daily variability of Pseudomonas aeruginosa density in cystic fibrosis sputum
Journal of Cystic Fibrosis
2025
Prevalence and impact of human papillomavirus (HPV) in adults with cystic fibrosis: A self-reported cross-sectional Canadian survey
Journal of Cystic Fibrosis
2024
A case of hypercalcemia from Pneumocystis jirovecii in an immunosuppressed non-HIV patient
BMC Pulmonary Medicine
2024
The Thorax
Unknown Venue
2023
The European Respiratory Journal : the ERS flagship heads for the next frontier
European Respiratory Journal
2023
Home sleep apnea testing for chronic heart failure: time to break the Cheyne?
Journal of Clinical Sleep Medicine
2021
Scientific overview: CSCI-CITAC Annual General Meeting and Young Investigator’s Forum 2013
Clinical and Investigative Medicine
2014
Spore Wars
CHEST
2026
Necessity of patient registries: Insights from the Canadian Bronchiectasis and Nontuberculous Mycobacteria Registry
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
2025
Regulatory delays in approval of CFTR modulating agents in Canada
Journal of Cystic Fibrosis
2025
Pulmonary pseudallescherioma in a 48-year-old woman with bronchiectasis
Canadian Medical Association Journal
2024
Bronchoscopic Removal of Recurrent, Bilateral Aspergillomas in a Person With Cystic Fibrosis (Pwcf) Who Underwent Double Lung Transplant With Polymicrobial Pulmonary Colonization and a Trial of Preprocedural Antibiotics
A49. RESEARCH STUDIES AND CASE REPORTS IN INTERVENTIONAL PULMONARY AND PLEURAL DISEASE
2024
Evaluating Sinus Microbiology by Transplant Status in Persons With Cystic Fibrosis: A Matched Cohort Study
OTO Open
2024
A 17-Year-Old Male With Hypoxemia After Long-Bone Fracture
CHEST
2023
Endoscopic aspergilloma management for non-surgical patients
Interventional pulmonology
2023
Quality over quantity: the next ACT in airway clearance in cystic fibrosis
European Respiratory Journal
2023
Thymoma
The Thorax
2023
510 Prevalence and clinical impact of respiratory viral infections in the Standardized Treatment of Pulmonary Exacerbations 2 Study
Journal of Cystic Fibrosis
2022
Body Mass Index and Clinical Outcomes in Persons Living With Cystic Fibrosis—Is Bigger Always Better?
JAMA Network Open
2022
Azithromycin and Tobramycin Therapy in Cystic Fibrosis Pulmonary Exacerbations: Less Is More?
Annals of the American Thoracic Society
2021
Heart Transplantation for End-Stage Heart Failure Due to Cardiac Sarcoidosis
Transplantation Proceedings
2015
Evidence Of Co-benefits Of Designing Communities For Active Living
Medicine & Science in Sports & Exercise
2015
Management of Adult Bronchiectasis: An American College of Chest Physicians Clinical Practice Guideline
CHEST
2026
Global, Regional, and National Burden of Tuberculosis and Multidrug-Resistant Tuberculosis in the Context of HIV/AIDS, 1990–2023: A Systematic Analysis for the Global Burden of Disease Study 2023
Unknown Venue
2026
Granules of truth: unpacking the eosinophilic endotype in bronchiectasis
Thorax
2026
Bridging the airway microbiome and targeted therapy in bronchiectasis: multi-omics insights, endotypes and emerging therapies
European Respiratory Journal
2026
The Guild Model of CF Airway Microbial Ecology
mBio
2026
Incomplete use of global data for aetiological attribution of diarrhoeal disease in the Global Burden of Disease study
The Lancet Infectious Diseases
2019
Impact of long-term elexacaftor/tezacaftor/ivacaftor therapy on fungal pathogens and the wider mycobiome in adults with cystic fibrosis
Journal of Cystic Fibrosis
2026
Remodelling of cystic fibrosis respiratory microbiota in response to extended elexacaftor–tezacaftor–ivacaftor therapy
Microbiome
2026
A 67-year-old woman with bronchiectasis and acute worsening respiratory symptoms
Canadian Medical Association Journal
2026
Cardiovascular Risk Assessment in Patients with Bronchiectasis: Insights from the Canadian Bronchiectasis and NTM (CanBE-NTM) Registry
ERJ Open Research
2026
Density fluctuations of Burkholderia and Achromobacter in cystic fibrosis sputum
Journal of Cystic Fibrosis
2026
Rates and Characteristics of Bronchiectasis-Related Hospitalizations in the United States in 2022: A Population-Based Cohort Study
Annals of the American Thoracic Society
2026
A case of lung nodular aspergilloma mimicking tumor metastasis accompanied by pulmonary embolism in a gastric cancer patient in remission
Sage Open Medical Case Reports
2026
Multimorbidity in patients with bronchiectasis: results from the US Bronchiectasis and NTM Research Registry (US BRR)
Epidemiology
2024
Are postal sputum samples a valid tool for clinical and research applications in bronchiectasis?
Respiratory infections and bronchiectasis
2025
The Mammalian Gut Microbiome, Immune Responses and Disease: From Observational to Causal Relationships
Journal of Cellular Immunology
2020
AIoptamer: Artificial Intelligence-Driven Aptamer Optimization Pipeline for Targeted Therapeutics in Healthcare
Unknown Venue
Murine autoimmune arthritis is exaggerated by infection with the rat tapeworm, Hymenolepis diminuta
International Journal for Parasitology
2013
538 Monoclonal antibodies targeting Psl and PcrV potentiate bacterial clearance of Pseudomonas aeruginosa from cystic fibrosis children who failed eradication therapy
Journal of Cystic Fibrosis
2022
Expansion of anaerobic bacteria in the lung microbiome of critically ill patients is associated with altered immune landscape and worsened outcomes.
Acute critical care
2023
B45-26 Osteoporosis and Fragility Fracture Risk in Patients With Non-cystic Fibrosis Bronchiectasis: A Large Propensity-matched Population Analysis
American Journal of Respiratory and Critical Care Medicine
2026
Trigger Criteria for Advance Care Planning in Adults With Congenital Heart Disease: A Systematic Review
CJC Pediatric and Congenital Heart Disease
2026
Development and external validation of the ‘Global Surgical-Site Infection’ (GloSSI) predictive model in adult patients undergoing gastrointestinal surgery
British Journal of Surgery
2024
P186 Prospective study of antimicrobial RESIstance in chronic lung DIsease (PRESIDE) – a new global registry. Protocol and pilot phase results
Respiratory infections: pathogens to patients
2025
Taking a wider view: The Lancet Respiratory Medicine Commission on bronchiectasis
The Lancet Respiratory Medicine
2026
Cooling the flames, clearing the airways: systemic inflammation in the era of elexacaftor/tezacaftor/ivacaftor
European Respiratory Journal
2025
Hepatitis E virus seroprevalence is increased amongst pancreatic insufficient adults with cystic fibrosis – A single centre study
Journal of Cystic Fibrosis
2025
Trends in Medicare versus Medicaid spending on CFTR modulator therapy – an economic evaluation
Journal of Cystic Fibrosis
2025
Genomic analysis of the liverpool epidemic strain of pseudomonas aeruginosa infecting persons with cystic fibrosis reveals likely Canadian origins
Journal of Cystic Fibrosis
2025
Unveiling hidden culprits: new perspectives on bronchiectasis pathogens in Taiwan
ERJ Open Research
2025
senek, n.
Oxford English Dictionary
2023

Education

The University of Calgary

Doctor of Medicine (MD) / December, 2016

The University of Calgary

Doctor of Philosophy (PhD), Microbiology and Infectious Diseases / December, 2013

University of Calgary

Bachelor of Science (BSc), Cellular, Molecular and Microbial Biology / December, 2009

University of Michigan

Postdoctoral Fellow, Medical Research / 2022

University of Calgary, Faculty of Medicine

Respirology Fellow, Respirology / 2021

University of Calgary, Faculty of Medicine

Internal Medicine Resident, Internal Medicine / 2019

University of Calgary, Faculty of Medicine Leaders in Medicine Program (MDPhD)

Doctor of Medicine (MD), Medicine / 2016

University of Calgary, Faculty of Medicine Leaders in Medicine Program (MDPhD)

Doctor of Philosophy (PhD), Microbiology and Infectious Diseases / 2013

University of Calgary, Faculty of Science

Bachelor of Science (BSc), Cellular Molecular and Microbial Biology, Psychology Minor / 2009

University of Michigan

Postdoctoral Fellow, Medical Research / 2022

University of Calgary, Faculty of Medicine

Respirology Fellow, Respirology / 2021

University of Calgary, Faculty of Medicine

Internal Medicine Resident, Internal Medicine / 2019

University of Calgary, Faculty of Medicine Leaders in Medicine Program (MDPhD)

Doctor of Medicine (MD), Medicine / 2016

University of Calgary, Faculty of Medicine Leaders in Medicine Program (MDPhD)

Doctor of Philosophy (PhD), Microbiology and Infectious Diseases / 2013

University of Calgary, Faculty of Science

Bachelor of Science (BSc), Cellular Molecular and Microbial Biology, Psychology Minor / 2009

Experience

University of Calgary

Assistant Professor / August, 2022Present

Departments of Medicine and Microbiology, Immunology and Infectious Diseases

MD/PhD Student / September, 2009May, 2016

MD/PhD student in Microbiology & Infectious Diseases. I am interested in the polymicrobial infections within cystic fibrosis (CF). Specifically, my PhD work was focused on detailed characterization of Streptococcus (genotypic and phenotypic), assessment of antibiotic resistance and molecular mechanisms of resistance acquisition, as well as the virulence associated with these organisms towards principal pathogens such as Pseudomonas aeruginosa.

Teaching Assistant / September, 2010April, 2013

I was a teaching assistant for a third year undergraduate laboratory course.

Honours Thesis Project Student / September, 2008May, 2009

My honours thesis project was focused on detailed genotypic and phenotypic characterization of the Streptococcus genus isolated from adult cystic fibrosis patients.

Summer Student / May, 2008September, 2008

I studied the genotypic and phenotypic properties of Streptococcus bacteria isolated from cystic fibrosis patients.

Assistant Professor / August, 2022March, 2026

Assistant Professor in the Division of Respirology, Department of Medicine with a cross-appointment in the Department of Microbiology, Immunology and Infectious Diseases.

Assistant Professor / August, 2022March, 2026

Assistant Professor in the Division of Respirology, Department of Medicine with a cross-appointment in the Department of Microbiology, Immunology and Infectious Diseases.

University of Michigan

Postdoctoral Research Fellow / July, 2021July, 2022

Postdoctoral Fellow / July, 2021July, 2022

Postdoctoral Fellow / July, 2021July, 2022

Alberta Health Services

Respirology Fellow / July, 2019June, 2021

Internal Medicine Resident / July, 2016June, 2019

The Princeton Review

MCAT Biology Instructor / November, 2009May, 2011

I taught the general biology section of the MCAT.

Let's Talk Science

Volunteer Co-ordinator / September, 2008September, 2010

University of Calgary, Faculty of Medicine

Respirology Fellow / July, 2019June, 2021

Internal Medicine Resident / July, 2016June, 2019

Respirology Fellow / July, 2019June, 2021

Internal Medicine Resident / July, 2016June, 2019

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