Matthew Laye, Ph.D.

Medical Physiology Teacher, Data Scientist, Endurance Coach, Wearable Technology Consultant, Writer About Research

Research Expertise

Physiology
Hepatology
Physiology (medical)
Gastroenterology
Public Health, Environmental and Occupational Health
Orthopedics and Sports Medicine
Advanced and Specialized Nursing
Endocrinology, Diabetes and Metabolism
Internal Medicine
Cell Biology
Aging
Biochemistry (medical)
Clinical Biochemistry
Endocrinology
Biochemistry
Cardiology and Cardiovascular Medicine
Genetics
Molecular Biology
Physical Therapy, Sports Therapy and Rehabilitation
Immunology
Education
Developmental Biology
Biotechnology

Legacy Map

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Publications

Lack of Exercise Is a Major Cause of Chronic Diseases
Comprehensive Physiology
2012
Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model
Journal of Hepatology
2010
Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle
The Journal of Physiology
2010
Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats
American Journal of Physiology-Gastrointestinal and Liver Physiology
2008
The miRNA Plasma Signature in Response to Acute Aerobic Exercise and Endurance Training
PLoS ONE
2014
Association Between Cardiorespiratory Fitness and the Determinants of Glycemic Control Across the Entire Glucose Tolerance Continuum
Diabetes Care
2015
The effects of age and dietary restriction on the tissue‐specific metabolome of D rosophila
Aging Cell
2015
Muscle specific miRNAs are induced by testosterone and independently upregulated by age
Frontiers in Physiology
2014
Skeletal Muscle to Pancreatic β-Cell Cross-talk: The Effect of Humoral Mediators Liberated by Muscle Contraction and Acute Exercise on β-Cell Apoptosis
The Journal of Clinical Endocrinology & Metabolism
2015
Immediate post-breakfast physical activity improves interstitial postprandial glycemia: a comparison of different activity-meal timings
Pflügers Archiv - European Journal of Physiology
2019
Targeting Postprandial Hyperglycemia With Physical Activity May Reduce Cardiovascular Disease Risk. But What Should We Do, and When Is the Right Time to Move?
Frontiers in Cardiovascular Medicine
2018
Physical Activity Enhances Metabolic Fitness Independently of Cardiorespiratory Fitness in Marathon Runners
Disease Markers
2015
Determining pancreatic β-cell compensation for changing insulin sensitivity using an oral glucose tolerance test
American Journal of Physiology-Endocrinology and Metabolism
2014
Daily Marathon Running for a Week—The Biochemical and Body Compositional Effects of Participation
Journal of Strength and Conditioning Research
2013
Book of Abstracts of the 57th Annual Meeting of the European Association for Animal Production
Unknown Venue
2006
Multi-Institutional Survey of Faculty Experiences Teaching Capstones
College Teaching
2020
Acute Exercise and Ca2+ Stimulation Regulate Enzymes Involved in DNA Methylation in Human Skeletal Muscle
Medicine & Science in Sports & Exercise
2010
Human visceral and subcutaneous adipose stem and progenitor cells retain depot-specific adipogenic properties during obesity
Frontiers in Cell and Developmental Biology
2022
Understanding Faculty Needs in Capstone Experiences
Cultivating Capstones
2023
Immediate Post-breakfast Physical Activity Improves Postprandial Glycemia To High And Low Glycemic Index Mixed Meals
Medicine & Science in Sports & Exercise
2022
The Effect Of Arm Versus Leg Dominant Physical Activity On Postprandial Blood Glucose Levels
Medicine & Science in Sports & Exercise
2020
729-P: Post-Breakfast Physical Activity Is Most Optimal for Improving Postprandial Glycemic Control in Healthy Adults
Diabetes
2019
Role of TLR4 in endoplasmic reticulum stress induced by physical exercise in skeletal muscle
Unknown Venue
Myomir Expression Pattern Across Gender And Age
Medicine & Science in Sports & Exercise
2010
The effects of physical activity on adipose tissue metabolism and DNA methylation
Unknown Venue
The Effects of Exercise and Obesity on Adipose Tissue Mitochondria
Medicine & Science in Sports & Exercise
2009
Physical activity prevents endothelial dysfunction induced by sedentary life style and high fat diet in murine coronary microcirculation
The FASEB Journal
2009
T1620 Loss of Mitochondrial Content and Function Contribute to the Natural History of Nonalcoholic Fatty Liver Disease in a Hyperphagic Obese Rodent Model
Gastroenterology
2009
S1894 Physical Activity and Short-Term Inactivity Modulate Hepatic Fatty Acid Oxidation and Lipogenesis Proteins in Otsuka Long-Evans Tokushima Fatty (Oletf) Rats
Gastroenterology
2008
Effect of moderate fat/high sucrose diet on glycogen synthesis rates in rat skeletal muscle upon the cessation of voluntary wheel running
The FASEB Journal
2007
Adipose tissue compensates to maintain whole body insulin sensitivity 173 hours following the cessation of voluntary running in rats
The FASEB Journal
2007
Increased Fat Mass Occurs Independently of Caloric Intake During Inactivity
Medicine & Science in Sports & Exercise
2006
Different Immunological Phenotypes Associated with Preserved CD4+ T Cell Counts in HIV-Infected Controllers and Viremic Long Term Non-Progressors
PLoS ONE
2013
Impaired Thymic Output in Patients with Chronic Hepatitis C Virus Infection
Scandinavian Journal of Immunology
2013
Increased shelterin mRNA expression in peripheral blood mononuclear cells and skeletal muscle following an ultra-long-distance running event
Journal of Applied Physiology
2012
Physical activity opposes coronary vascular dysfunction induced during high fat feeding in mice
The Journal of Physiology
2012
LIF is a contraction-induced myokine stimulating human myocyte proliferation
Journal of Applied Physiology
2011
Lifetime sedentary living accelerates some aspects of secondary aging
Journal of Applied Physiology
2011
Changes in skeletal muscle mitochondria in response to the development of type 2 diabetes or prevention by daily wheel running in hyperphagic OLETF rats
American Journal of Physiology-Endocrinology and Metabolism
2010
Gold standards for scientists who are conducting animal-based exercise studies
Journal of Applied Physiology
2010
Last Word on Viewpoint: Gold standards for scientists who are conducting animal-based exercise studies
Journal of Applied Physiology
2010
The future: genes, physical activity and health
Acta Physiologica
2010
Cessation of daily wheel running differentially alters fat oxidation capacity in liver, muscle, and adipose tissue
Journal of Applied Physiology
2009
Changes in visceral adipose tissue mitochondrial content with type 2 diabetes and daily voluntary wheel running in OLETF rats
The Journal of Physiology
2009
Lack of adequate appreciation of physical exercise's complexities can pre-empt appropriate design and interpretation in scientific discovery
The Journal of Physiology
2009
Novel epigenetic regulation of skeletal muscle myosin heavy chain genes. Focus on “Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading”
American Journal of Physiology-Cell Physiology
2009
Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury
The Journal of Physiology
2009
Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats
The Journal of Physiology
2008
Exercise-induced attenuation of obesity, hyperinsulinemia, and skeletal muscle lipid peroxidation in the OLETF rat
Journal of Applied Physiology
2008
Reduced physical activity and risk of chronic disease: the biology behind the consequences
European Journal of Applied Physiology
2007
Inactivity induces increases in abdominal fat
Journal of Applied Physiology
2007
Increased mitochondrial glycerol-3-phosphate acyltransferase protein and enzyme activity in rat epididymal fat upon cessation of wheel running
American Journal of Physiology-Endocrinology and Metabolism
2006

Education

University of Missouri

Ph.D, Medical Physiology / June, 2009

Columbia, Missouri, United States of America

University of California, Davis

BS, Exercise Biology / December, 2004

Davis, California, United States of America

Experience

Idaho College of Osteopathic Medicine

Associate Professor Physiology / March, 2022Present

The College of Idaho

Assistant/Associate/Chair / September, 2015March, 2022

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