Ganapathy Sriram, Ph.D.

Scientist with expertise in cancer biology, immunology, cell signaling, protein biochemistry and drug discovery

Waltham, Massachusetts, United States of America

Research Expertise

Cell Injury, dendritic cell activation, antigen cross-presentation, tumor cell signaling and immune evasion

Publications

Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade
Molecular & Cellular Oncology
2022
The injury response to DNA damage in live tumor cells promotes antitumor immunity
Science Signaling
2021
MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer
Frontiers in Immunology
2021
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints
Nature Communications
2020
Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti–PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer
Cancer Research
2019
Tranexamic acid mediates proinflammatory and anti-inflammatory signaling via complement C5a regulation in a plasminogen activator–dependent manner
Journal of Trauma and Acute Care Surgery
2019
MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis
Proceedings of the National Academy of Sciences
2018
Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression
Molecular Cancer Research
2017
Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway
Nature Chemical Biology
2015
Iterative tyrosine phosphorylation controls non-canonical domain utilization in Crk
Oncogene
2014
Crk at the Quarter Century Mark: Perspectives in Signaling and Cancer
Journal of Cellular Biochemistry
2014
Commentary: The carboxyl‐terminal Crk SH3 domain: Regulatory strategies and new perspectives
FEBS Letters
2012
Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII
Nature Chemical Biology
2012
Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation
Oncogene
2011
Expression of Type II Chorionic Gonadotropin Genes Supports a Role in the Male Reproductive System
Molecular and Cellular Biology
2011
Emerging Roles for Crk in Human Cancer
Genes & Cancer
2010
Contribution of Defective PS Recognition and Efferocytosis to Chronic Inflammation and Autoimmunity
Frontiers in Immunology
2014

Education

Rutgers University

PhD, Biochemistry / May, 2014

Newark, New Jersey, United States of America

PES University

B.E, Biotechnology / June, 2007

Bengaluru

Experience

Massachusetts Institute of Technology

Postdoctoral Fellow / March, 2015September, 2020

Leveraging DNA damage and cell injury to enhance responses to immune checkpoint blockade for cancer

Montai Health Inc

Research Scientist / October, 2020July, 2021

Discovery and development of small molecules for cancer therapy and inflammatory disorders

EMD Serono Research and Development Institute Inc.

Senior Scientist / August, 2021March, 2024

Target Discovery for cancer immunotherapy, development of small molecules and antibodies for cancer immunotherapy

Tufts University

Lecturer (part-time) / September, 2024December, 2024

Teaching a Masters level course on Cancer Biology and Therapeutics

Cell Communication and Signaling (Springer Nature)

Editor / January, 2022Present

Links & Social Media

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