Mohamad Hadla
Senior Research Fellow, Mayo Clinic
Research Expertise
Publications
Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models
Nanomedicine / Sep 01, 2016
Hadla, M., Palazzolo, S., Corona, G., Caligiuri, I., Canzonieri, V., Toffoli, G., & Rizzolio, F. (2016). Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models. Nanomedicine, 11(18), 2431–2441. https://doi.org/10.2217/nnm-2016-0154
Inorganic Nanoparticles for Cancer Therapy: A Transition from Lab to Clinic
Current Medicinal Chemistry / Dec 03, 2018
Bayda, S., Hadla, M., Palazzolo, S., Riello, P., Corona, G., Toffoli, G., & Rizzolio, F. (2018). Inorganic Nanoparticles for Cancer Therapy: A Transition from Lab to Clinic. Current Medicinal Chemistry, 25(34), 4269–4303. https://doi.org/10.2174/0929867325666171229141156
The Clinical Translation of Organic Nanomaterials for Cancer Therapy: A Focus on Polymeric Nanoparticles, Micelles, Liposomes and Exosomes
Current Medicinal Chemistry / Dec 03, 2018
Palazzolo, S., Bayda, S., Hadla, M., Caligiuri, I., Corona, G., Toffoli, G., & Rizzolio, F. (2018). The Clinical Translation of Organic Nanomaterials for Cancer Therapy: A Focus on Polymeric Nanoparticles, Micelles, Liposomes and Exosomes. Current Medicinal Chemistry, 25(34), 4224–4268. https://doi.org/10.2174/0929867324666170830113755
Exosomal doxorubicin reduces the cardiac toxicity of doxorubicin
Nanomedicine / Oct 01, 2015
Toffoli, G., Hadla, M., Corona, G., Caligiuri, I., Palazzolo, S., Semeraro, S., Gamini, A., Canzonieri, V., & Rizzolio, F. (2015). Exosomal doxorubicin reduces the cardiac toxicity of doxorubicin. Nanomedicine, 10(19), 2963–2971. https://doi.org/10.2217/nnm.15.118
Bottom-up synthesis of carbon nanoparticles with higher doxorubicin efficacy
Journal of Controlled Release / Feb 01, 2017
Bayda, S., Hadla, M., Palazzolo, S., Kumar, V., Caligiuri, I., Ambrosi, E., Pontoglio, E., Agostini, M., Tuccinardi, T., Benedetti, A., Riello, P., Canzonieri, V., Corona, G., Toffoli, G., & Rizzolio, F. (2017). Bottom-up synthesis of carbon nanoparticles with higher doxorubicin efficacy. Journal of Controlled Release, 248, 144–152. https://doi.org/10.1016/j.jconrel.2017.01.022
An Effective Multi-Stage Liposomal DNA Origami Nanosystem for In Vivo Cancer Therapy
Cancers / Dec 12, 2019
Palazzolo, S., Hadla, M., Russo Spena, C., Caligiuri, I., Rotondo, R., Adeel, M., Kumar, V., Corona, G., Canzonieri, V., Toffoli, G., & Rizzolio, F. (2019). An Effective Multi-Stage Liposomal DNA Origami Nanosystem for In Vivo Cancer Therapy. Cancers, 11(12), 1997. https://doi.org/10.3390/cancers11121997
Proof-of-Concept Multistage Biomimetic Liposomal DNA Origami Nanosystem for the Remote Loading of Doxorubicin
ACS Medicinal Chemistry Letters / Jan 31, 2019
Palazzolo, S., Hadla, M., Spena, C. R., Bayda, S., Kumar, V., Lo Re, F., Adeel, M., Caligiuri, I., Romano, F., Corona, G., Canzonieri, V., Toffoli, G., & Rizzolio, F. (2019). Proof-of-Concept Multistage Biomimetic Liposomal DNA Origami Nanosystem for the Remote Loading of Doxorubicin. ACS Medicinal Chemistry Letters, 10(4), 517–521. https://doi.org/10.1021/acsmedchemlett.8b00557
Enhanced Chemotherapeutic Behavior of Open‐Caged DNA@Doxorubicin Nanostructures for Cancer Cells
Journal of Cellular Physiology / Sep 28, 2015
Kumar, V., Bayda, S., Hadla, M., Caligiuri, I., Russo Spena, C., Palazzolo, S., Kempter, S., Corona, G., Toffoli, G., & Rizzolio, F. (2015). Enhanced Chemotherapeutic Behavior of Open‐Caged DNA@Doxorubicin Nanostructures for Cancer Cells. Journal of Cellular Physiology, 231(1), 106–110. Portico. https://doi.org/10.1002/jcp.25057
Biocompatible tailored zirconia mesoporous nanoparticles with high surface area for theranostic applications
J. Mater. Chem. B / Jan 01, 2015
Sponchia, G., Ambrosi, E., Rizzolio, F., Hadla, M., Tedesco, A. D., Spena, C. R., Toffoli, G., Riello, P., & Benedetti, A. (2015). Biocompatible tailored zirconia mesoporous nanoparticles with high surface area for theranostic applications. J. Mater. Chem. B, 3(36), 7300–7306. https://doi.org/10.1039/c5tb01424g
Cancer Extracellular Vesicles: Next-Generation Diagnostic and Drug Delivery Nanotools
Cancers / Oct 28, 2020
Palazzolo, S., Memeo, L., Hadla, M., Duzagac, F., Steffan, A., Perin, T., Canzonieri, V., Tuccinardi, T., Caligiuri, I., & Rizzolio, F. (2020). Cancer Extracellular Vesicles: Next-Generation Diagnostic and Drug Delivery Nanotools. Cancers, 12(11), 3165. https://doi.org/10.3390/cancers12113165
Association between SARS-CoV-2 RNAemia and dysregulated immune response in acutely ill hospitalized COVID-19 patients
Scientific Reports / Nov 16, 2022
Rovito, R., Bono, V., Augello, M., Tincati, C., Mainoldi, F., Beaudoin-Bussières, G., Tauzin, A., Bianchi, S., Hadla, M., Yellenki, V., d’Arminio Monforte, A., Casola, S., Borghi, E., Finzi, A., & Marchetti, G. (2022). Association between SARS-CoV-2 RNAemia and dysregulated immune response in acutely ill hospitalized COVID-19 patients. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-23923-1
Effect of Quorum Sensing
Fundamentals of Quorum Sensing, Analytical Methods and Applications in Membrane Bioreactors / Jan 01, 2018
Hadla, M., & Halabi, M. A. (2018). Effect of Quorum Sensing. In Comprehensive Analytical Chemistry (pp. 95–116). Elsevier. https://doi.org/10.1016/bs.coac.2018.02.004
Abstract 2205: Exosomal encapsulation of doxorubicin reduces the cardiac toxicity of mice
Cancer Research / Jul 15, 2016
Rizzolio, F., Hadla, M., Corona, G., Caligiuri, I., Palazzolo, S., Semeraro, S., Gamini, A., Canzonieri, V., & Toffoli, G. (2016). Abstract 2205: Exosomal encapsulation of doxorubicin reduces the cardiac toxicity of mice. Cancer Research, 76(14_Supplement), 2205–2205. https://doi.org/10.1158/1538-7445.am2016-2205
ANTIBACTERIAL ACTIVITY OF SOAP MADE FROM ESSENTIAL OILS AND COMMERCIAL SOAP SOLD IN THE LEBANESE MARKET
Bacterial Empire / Jun 29, 2021
GERGES, C., HADLA, M., ELIALI, M., RICHA, M., Mammari, N., & HALABI, M. A. (2021). ANTIBACTERIAL ACTIVITY OF SOAP MADE FROM ESSENTIAL OILS AND COMMERCIAL SOAP SOLD IN THE LEBANESE MARKET. Bacterial Empire, e304. https://doi.org/10.36547/be.304
Humic substances (HS) as plant biostimulants in agriculture
Biostimulants for sustainable crop production / Jul 28, 2020
Ertani, A., Schiavon, M., & Nardi, S. (2020). Humic substances (HS) as plant biostimulants in agriculture. In Burleigh Dodds Series in Agricultural Science (pp. 55–76). Burleigh Dodds Science Publishing. https://doi.org/10.19103/as.2020.0068.04
Growth Differentiation Factor 15 (GDF-15) Levels Associate with Lower Survival in Chronic Kidney Disease Patients with COVID-19
Biomedicines / Dec 14, 2022
Galassi, A., Ciceri, P., Bono, V., Magagnoli, L., Sala, M., Artioli, L., Rovito, R., Hadla, M., Yellenki, V., D’Arminio Monforte, A., Tincati, C., Cozzolino, M., & Marchetti, G. (2022). Growth Differentiation Factor 15 (GDF-15) Levels Associate with Lower Survival in Chronic Kidney Disease Patients with COVID-19. Biomedicines, 10(12), 3251. https://doi.org/10.3390/biomedicines10123251
MO409: GDF-15 is a Predictor of Mortality in Chronic Kidney Disease Patients With Covid-19 Infection
Nephrology Dialysis Transplantation / May 01, 2022
Ciceri, P., Bono, V., Magagnoli, L., Sala, M., Artioli, L., Rovito, R., Hadla, M., Yellenki, V., D’arminio Monforte, A., Galassi, A., Tincati, C., Marchetti, G., & Gennaro Cozzolino, M. (2022). MO409: GDF-15 is a Predictor of Mortality in Chronic Kidney Disease Patients With Covid-19 Infection. Nephrology Dialysis Transplantation, 37(Supplement_3). https://doi.org/10.1093/ndt/gfac070.023
Education
Università degli Studi di Padova
Ph.D., Molecular and Cellular Pharmacology / March, 2017
Università degli Studi di Pavia
M.Sc., Molecular Biology and Genetics / July, 2012
Experience
Mayo Clinic
Senior Research Fellow / July, 2022 — Present
Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo
Senior Research Scientist / March, 2021 — June, 2022
Centro di Riferimento Oncologico IRCCS
Postdoctoral Researcher / January, 2017 — December, 2020
Centro di Riferimento Oncologico
Research fellow / April, 2013 — December, 2016
Doctoral School for the Biotechnology studies
Research fellow / 2009 — 2013
Join Mohamad on NotedSource!
Join Now
At NotedSource, we believe that professors, post-docs, scientists and other researchers have deep, untapped knowledge and expertise that can be leveraged to drive innovation within companies. NotedSource is committed to bridging the gap between academia and industry by providing a platform for collaboration with industry and networking with other researchers.
For industry, NotedSource identifies the right academic experts in 24 hours to help organizations build and grow. With a platform of thousands of knowledgeable PhDs, scientists, and industry experts, NotedSource makes connecting and collaborating easy.
For academic researchers such as professors, post-docs, and Ph.D.s, NotedSource provides tools to discover and connect to your colleagues with messaging and news feeds, in addition to the opportunity to be paid for your collaboration with vetted partners.
Expert Institutions




Proudly trusted by





