Mohamad Hadla

Senior Research Fellow, Mayo Clinic

Research Expertise

Molecular Biology
Cancer Biology
Nanomedicine
Drug Delivery Systems
Biomedical Engineering
Bioengineering
Development
Molecular Medicine
Organic Chemistry
Biochemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Oncology
Cancer Research
Cell Biology
Clinical Biochemistry
Physiology
Transplantation
Nephrology
Polymers and Plastics

Publications

Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models

Nanomedicine / Sep 01, 2016

Hadla, M., Palazzolo, S., Corona, G., Caligiuri, I., Canzonieri, V., Toffoli, G., & Rizzolio, F. (2016). Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models. Nanomedicine, 11(18), 2431–2441. https://doi.org/10.2217/nnm-2016-0154

Inorganic Nanoparticles for Cancer Therapy: A Transition from Lab to Clinic

Current Medicinal Chemistry / Dec 03, 2018

Bayda, S., Hadla, M., Palazzolo, S., Riello, P., Corona, G., Toffoli, G., & Rizzolio, F. (2018). Inorganic Nanoparticles for Cancer Therapy: A Transition from Lab to Clinic. Current Medicinal Chemistry, 25(34), 4269–4303. https://doi.org/10.2174/0929867325666171229141156

The Clinical Translation of Organic Nanomaterials for Cancer Therapy: A Focus on Polymeric Nanoparticles, Micelles, Liposomes and Exosomes

Current Medicinal Chemistry / Dec 03, 2018

Palazzolo, S., Bayda, S., Hadla, M., Caligiuri, I., Corona, G., Toffoli, G., & Rizzolio, F. (2018). The Clinical Translation of Organic Nanomaterials for Cancer Therapy: A Focus on Polymeric Nanoparticles, Micelles, Liposomes and Exosomes. Current Medicinal Chemistry, 25(34), 4224–4268. https://doi.org/10.2174/0929867324666170830113755

Exosomal doxorubicin reduces the cardiac toxicity of doxorubicin

Nanomedicine / Oct 01, 2015

Toffoli, G., Hadla, M., Corona, G., Caligiuri, I., Palazzolo, S., Semeraro, S., Gamini, A., Canzonieri, V., & Rizzolio, F. (2015). Exosomal doxorubicin reduces the cardiac toxicity of doxorubicin. Nanomedicine, 10(19), 2963–2971. https://doi.org/10.2217/nnm.15.118

Bottom-up synthesis of carbon nanoparticles with higher doxorubicin efficacy

Journal of Controlled Release / Feb 01, 2017

Bayda, S., Hadla, M., Palazzolo, S., Kumar, V., Caligiuri, I., Ambrosi, E., Pontoglio, E., Agostini, M., Tuccinardi, T., Benedetti, A., Riello, P., Canzonieri, V., Corona, G., Toffoli, G., & Rizzolio, F. (2017). Bottom-up synthesis of carbon nanoparticles with higher doxorubicin efficacy. Journal of Controlled Release, 248, 144–152. https://doi.org/10.1016/j.jconrel.2017.01.022

An Effective Multi-Stage Liposomal DNA Origami Nanosystem for In Vivo Cancer Therapy

Cancers / Dec 12, 2019

Palazzolo, S., Hadla, M., Russo Spena, C., Caligiuri, I., Rotondo, R., Adeel, M., Kumar, V., Corona, G., Canzonieri, V., Toffoli, G., & Rizzolio, F. (2019). An Effective Multi-Stage Liposomal DNA Origami Nanosystem for In Vivo Cancer Therapy. Cancers, 11(12), 1997. https://doi.org/10.3390/cancers11121997

Proof-of-Concept Multistage Biomimetic Liposomal DNA Origami Nanosystem for the Remote Loading of Doxorubicin

ACS Medicinal Chemistry Letters / Jan 31, 2019

Palazzolo, S., Hadla, M., Spena, C. R., Bayda, S., Kumar, V., Lo Re, F., Adeel, M., Caligiuri, I., Romano, F., Corona, G., Canzonieri, V., Toffoli, G., & Rizzolio, F. (2019). Proof-of-Concept Multistage Biomimetic Liposomal DNA Origami Nanosystem for the Remote Loading of Doxorubicin. ACS Medicinal Chemistry Letters, 10(4), 517–521. https://doi.org/10.1021/acsmedchemlett.8b00557

Enhanced Chemotherapeutic Behavior of Open‐Caged DNA@Doxorubicin Nanostructures for Cancer Cells

Journal of Cellular Physiology / Sep 28, 2015

Kumar, V., Bayda, S., Hadla, M., Caligiuri, I., Russo Spena, C., Palazzolo, S., Kempter, S., Corona, G., Toffoli, G., & Rizzolio, F. (2015). Enhanced Chemotherapeutic Behavior of Open‐Caged DNA@Doxorubicin Nanostructures for Cancer Cells. Journal of Cellular Physiology, 231(1), 106–110. Portico. https://doi.org/10.1002/jcp.25057

Biocompatible tailored zirconia mesoporous nanoparticles with high surface area for theranostic applications

J. Mater. Chem. B / Jan 01, 2015

Sponchia, G., Ambrosi, E., Rizzolio, F., Hadla, M., Tedesco, A. D., Spena, C. R., Toffoli, G., Riello, P., & Benedetti, A. (2015). Biocompatible tailored zirconia mesoporous nanoparticles with high surface area for theranostic applications. J. Mater. Chem. B, 3(36), 7300–7306. https://doi.org/10.1039/c5tb01424g

Cancer Extracellular Vesicles: Next-Generation Diagnostic and Drug Delivery Nanotools

Cancers / Oct 28, 2020

Palazzolo, S., Memeo, L., Hadla, M., Duzagac, F., Steffan, A., Perin, T., Canzonieri, V., Tuccinardi, T., Caligiuri, I., & Rizzolio, F. (2020). Cancer Extracellular Vesicles: Next-Generation Diagnostic and Drug Delivery Nanotools. Cancers, 12(11), 3165. https://doi.org/10.3390/cancers12113165

Association between SARS-CoV-2 RNAemia and dysregulated immune response in acutely ill hospitalized COVID-19 patients

Scientific Reports / Nov 16, 2022

Rovito, R., Bono, V., Augello, M., Tincati, C., Mainoldi, F., Beaudoin-Bussières, G., Tauzin, A., Bianchi, S., Hadla, M., Yellenki, V., d’Arminio Monforte, A., Casola, S., Borghi, E., Finzi, A., & Marchetti, G. (2022). Association between SARS-CoV-2 RNAemia and dysregulated immune response in acutely ill hospitalized COVID-19 patients. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-23923-1

Effect of Quorum Sensing

Fundamentals of Quorum Sensing, Analytical Methods and Applications in Membrane Bioreactors / Jan 01, 2018

Hadla, M., & Halabi, M. A. (2018). Effect of Quorum Sensing. In Comprehensive Analytical Chemistry (pp. 95–116). Elsevier. https://doi.org/10.1016/bs.coac.2018.02.004

Abstract 2205: Exosomal encapsulation of doxorubicin reduces the cardiac toxicity of mice

Cancer Research / Jul 15, 2016

Rizzolio, F., Hadla, M., Corona, G., Caligiuri, I., Palazzolo, S., Semeraro, S., Gamini, A., Canzonieri, V., & Toffoli, G. (2016). Abstract 2205: Exosomal encapsulation of doxorubicin reduces the cardiac toxicity of mice. Cancer Research, 76(14_Supplement), 2205–2205. https://doi.org/10.1158/1538-7445.am2016-2205

ANTIBACTERIAL ACTIVITY OF SOAP MADE FROM ESSENTIAL OILS AND COMMERCIAL SOAP SOLD IN THE LEBANESE MARKET

Bacterial Empire / Jun 29, 2021

GERGES, C., HADLA, M., ELIALI, M., RICHA, M., Mammari, N., & HALABI, M. A. (2021). ANTIBACTERIAL ACTIVITY OF SOAP MADE FROM ESSENTIAL OILS AND COMMERCIAL SOAP SOLD IN THE LEBANESE MARKET. Bacterial Empire, e304. https://doi.org/10.36547/be.304

Humic substances (HS) as plant biostimulants in agriculture

Biostimulants for sustainable crop production / Jul 28, 2020

Ertani, A., Schiavon, M., & Nardi, S. (2020). Humic substances (HS) as plant biostimulants in agriculture. In Burleigh Dodds Series in Agricultural Science (pp. 55–76). Burleigh Dodds Science Publishing. https://doi.org/10.19103/as.2020.0068.04

Growth Differentiation Factor 15 (GDF-15) Levels Associate with Lower Survival in Chronic Kidney Disease Patients with COVID-19

Biomedicines / Dec 14, 2022

Galassi, A., Ciceri, P., Bono, V., Magagnoli, L., Sala, M., Artioli, L., Rovito, R., Hadla, M., Yellenki, V., D’Arminio Monforte, A., Tincati, C., Cozzolino, M., & Marchetti, G. (2022). Growth Differentiation Factor 15 (GDF-15) Levels Associate with Lower Survival in Chronic Kidney Disease Patients with COVID-19. Biomedicines, 10(12), 3251. https://doi.org/10.3390/biomedicines10123251

MO409: GDF-15 is a Predictor of Mortality in Chronic Kidney Disease Patients With Covid-19 Infection

Nephrology Dialysis Transplantation / May 01, 2022

Ciceri, P., Bono, V., Magagnoli, L., Sala, M., Artioli, L., Rovito, R., Hadla, M., Yellenki, V., D’arminio Monforte, A., Galassi, A., Tincati, C., Marchetti, G., & Gennaro Cozzolino, M. (2022). MO409: GDF-15 is a Predictor of Mortality in Chronic Kidney Disease Patients With Covid-19 Infection. Nephrology Dialysis Transplantation, 37(Supplement_3). https://doi.org/10.1093/ndt/gfac070.023

Education

Università degli Studi di Padova

Ph.D., Molecular and Cellular Pharmacology / March, 2017

Padova

Università degli Studi di Pavia

M.Sc., Molecular Biology and Genetics / July, 2012

Pavia

Experience

Mayo Clinic

Senior Research Fellow / July, 2022Present

Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo

Senior Research Scientist / March, 2021June, 2022

Centro di Riferimento Oncologico IRCCS

Postdoctoral Researcher / January, 2017December, 2020

Centro di Riferimento Oncologico

Research fellow / April, 2013December, 2016

Doctoral School for the Biotechnology studies

Research fellow / 20092013

Links & Social Media

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