Johannes Frasnelli, MD

Department of Anatomy, Université du Québec à Trois-Rivières

Trois-Rivières

Research Expertise

smell
taste
chemical senses
humans
Parkinson's Disease
Alzheimer's Disease

About

I am a physician‑scientist and principal investigator specializing in sensory neuroscience, human anatomy, and translational research. I direct a university research laboratory and collaborate with clinical research centers, bringing more than two decades of experience in experimental design, neurophysiology, and scientific strategy. My consulting work focuses on strengthening research plans, evaluating evidence, and providing clear, high‑level guidance for teams working at the intersection of neuroscience, medicine, and human biology. I offer precise, actionable expertise grounded in both academic and clinical training.

Publications

Olfactory exposure to males, including men, causes stress and related analgesia in rodents
Nature Methods
2014
Position paper on olfactory dysfunction
Rhinology journal
2017
COVID-19, smell and taste – how is COVID-19 different from other respiratory diseases?
Unknown Venue
2020
Machine Learning for the Diagnosis of Parkinson's Disease: A Review of Literature
Frontiers in Aging Neuroscience
2021
Olfactory dysfunction and daily life
European Archives of Oto-Rhino-Laryngology
2004
Detection of presymptomatic Parkinson's disease: Combining smell tests, transcranial sonography, and SPECT
Movement Disorders
2004
The effect of Alzheimer's disease and Parkinson's disease on olfaction: A meta-analysis
Behavioural Brain Research
2012
Recovery of Olfactory Function Following Closed Head Injury or Infections of the Upper Respiratory Tract
Archives of Otolaryngology–Head & Neck Surgery
2006
Effects of olfactory function, age, and gender on trigeminally mediated sensations: a study based on the lateralization of chemosensory stimuli
Toxicology Letters
2003
Position paper on olfactory dysfunction: 2023
Rhinology Journal
2023
Post-viral effects of COVID-19 in the olfactory system and their implications
The Lancet Neurology
2021
Brain activations during pain
Pain
2016
The best COVID-19 predictor is recent smell loss: a cross-sectional study
Unknown Venue
Interactions between Olfaction and the Trigeminal System: What Can Be Learned from Olfactory Loss
Cerebral Cortex
2006
Crossmodal plasticity in sensory loss
Progress in Brain Research
2011
Orbitofrontal Cortex and Olfactory Bulb Volume Predict Distinct Aspects of Olfactory Performance in Healthy Subjects
Cerebral Cortex
2012
Odor Localization and Sniffing
Chemical Senses
2008
The neuronal correlates of intranasal trigeminal function—an ALE meta-analysis of human functional brain imaging data
Brain Research Reviews
2010
The fish is bad: Negative food odors elicit faster and more accurate reactions than other odors
Biological Psychology
2010
Differences Between Orthonasal and Retronasal Olfactory Functions in Patients With Loss of the Sense of Smell
Archives of Otolaryngology–Head & Neck Surgery
2005
Clinical presentation of qualitative olfactory dysfunction
European Archives of Oto-Rhino-Laryngology
2003
Neuroanatomical correlates of olfactory performance
Experimental Brain Research
2009
Clinical Olfactory Working Group consensus statement on the treatment of postinfectious olfactory dysfunction
Journal of Allergy and Clinical Immunology
2021
Cerebral Activation to Intranasal Chemosensory Trigeminal Stimulation
Chemical Senses
2007
Smell training improves olfactory function and alters brain structure
NeuroImage
2019
Intranasal trigeminal function in subjects with and without an intact sense of smell
Brain Research
2007
Gustatory Function in Chronic Inflammatory Middle Ear Diseases
The Laryngoscope
2005
Maternal status regulates cortical responses to the body odor of newborns
Frontiers in Psychology
2013
Evaluating the clinical usefulness of structured questions in parosmia assessment
The Laryngoscope
2010
Cross-modal integration of intranasal stimuli: A functional magnetic resonance imaging study
Neuroscience
2007
Interactions between the chemical senses: Trigeminal function in patients with olfactory loss
International Journal of Psychophysiology
2007
Intranasal Localizability of Odorants: Influence of Stimulus Volume
Chemical Senses
2011
The intranasal trigeminal system
Handbook of Clinical Neurology
2019
Olfactory Function in Chronic Renal Failure
American Journal of Rhinology
2002
Olfaction in the Autism Spectrum
Perception
2013
Responsiveness of human nasal mucosa to trigeminal stimuli depends on the site of stimulation
Neuroscience Letters
2004
Perceptual differences between chemical stimuli presented through the ortho- or retronasal route
Flavour and Fragrance Journal
2005
Age-related decline of intranasal trigeminal sensitivity: is it a peripheral event?
Brain Research
2003
Central Processing of Trigeminal Activation in Humans
Annals of the New York Academy of Sciences
2009
Grey matter changes of the pain matrix in patients with burning mouth syndrome
European Journal of Neuroscience
2016
Perception of specific trigeminal chemosensory agonists
Neuroscience
2011
Olfactory and Trigeminal Systems Interact in the Periphery
Chemical Senses
2018
The vomeronasal organ is not involved in the perception of endogenous odors
Human Brain Mapping
2011
Olfactory dysfunction affects thresholds to trigeminal chemosensory sensations
Neuroscience Letters
2010
Subjects with Congenital Anosmia Have Larger Peripheral but Similar Central Trigeminal Responses
Cerebral Cortex
2006
Brain structure is changed in congenital anosmia
NeuroImage
2013
Chemosensory specific reduction of trigeminal sensitivity in subjects with olfactory dysfunction
Neuroscience
2006
Systemic corticosteroids in coronavirus disease 2019 (COVID‐19)‐related smell dysfunction: an international view
International Forum of Allergy & Rhinology
2021
Chemosensory decrease in different forms of olfactory dysfunction
Journal of Neurology
2019
Ghrelin Enhances Food Odor Conditioning in Healthy Humans: An fMRI Study
Cell Reports
2018
Cross-Modality of Texture and Aroma Perception Is Independent of Orthonasal or Retronasal Stimulation
Journal of Agricultural and Food Chemistry
2006
Mechanical Obstruction of the Olfactory Cleft Reveals Differences Between Orthonasal and Retronasal Olfactory Functions
Chemical Senses
2005
Sex differentiated responses to intranasal trigeminal stimuli
International Journal of Psychophysiology
2005
The role of trigeminal function in the sensation of nasal obstruction in chronic rhinosinusitis
The Laryngoscope
2016
Dual processing streams in chemosensory perception
Frontiers in Human Neuroscience
2012
Cerebral processing of gustatory stimuli in patients with taste loss
Behavioural Brain Research
2007
Now You Like Me, Now You Don't: Impact of Labels on Odor Perception
Chemical Senses
2013
Olfactory Identification in Subjective Cognitive Decline: A Meta-Analysis
Journal of Alzheimer’s Disease
2021
Trigeminal system in Parkinson's disease: A potential avenue to detect Parkinson-specific olfactory dysfunction
Parkinsonism & Related Disorders
2017
Same Same but Different. Different Trigeminal Chemoreceptors Share the Same Central Pathway
PLOS ONE
2015
The neural representation of odor is modulated by the presence of a trigeminal stimulus during odor encoding
Clinical Neurophysiology
2007
Intranasal Concentrations of Orally Administered Flavors
Chemical Senses
2005
Volumetry of Olfactory Structures in Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review and a Meta-Analysis
Brain Sciences
2021
Chemosensory Dysfunctions Induced by COVID-19 Can Persist up to 7 Months: A Study of Over 700 Healthcare Workers
Chemical Senses
2021
Structural and Functional MRI Differences in Master Sommeliers: A Pilot Study on Expertise in the Brain
Frontiers in Human Neuroscience
2016
Intranasal trigeminal thresholds in healthy subjects
Environmental Toxicology and Pharmacology
2005
Ortho- and Retronasal Presentation of Olfactory Stimuli Modulates Odor Percepts
Chemosensory Perception
2007
Event-related Potentials to Intranasal Trigeminal Stimuli Change in Relation to Stimulus Concentration and Stimulus Duration
Journal of Clinical Neurophysiology
2003
Olfactory function in acute traumatic brain injury
Clinical Neurology and Neurosurgery
2016
Perception of Trigeminal Mixtures
Chemical Senses
2014
Increased Odor Detection Speed in Highly Anxious Healthy Adults
Chemical Senses
2013
Taste Disorders
Management of Smell and Taste Disorders
2014
Anxiety and Depression Assessments in a Mouse Model of Congenital Blindness
Frontiers in Neuroscience
2022
Severe Chemotherapy-Induced Parosmia
American Journal of Rhinology
2006
Localisation of unilateral nasal stimuli across sensory systems
Neuroscience Letters
2010
Olfactory Training Impacts Olfactory Dysfunction Induced by COVID-19: A Pilot Study
ORL
2022
Olfactory bulb surroundings can help to distinguish Parkinson’s disease from non-parkinsonian olfactory dysfunction
NeuroImage: Clinical
2020
Olfactory, cognitive and affective dysfunction assessed 24 hours and one year after a mild Traumatic Brain Injury (mTBI)
Brain Injury
2019
Individual Differences in the Chemical Senses: Is There a Common Sensitivity?
Chemical Senses
2012
Euosmia: A rare form of parosmia
Acta Oto-Laryngologica
2006
The influence of stimulus duration on odor perception
International Journal of Psychophysiology
2006
Brain responses to odor mixtures with sub-threshold components
Frontiers in Psychology
2013
Loss of Trigeminal Sensitivity Reduces Olfactory Function
The Laryngoscope
2006
Increased olfactory sensitivity in euthymic patients with bipolar disorder with event-related episodes compared with patients with bipolar disorder without such episodes
Journal of Psychiatry and Neuroscience
2006
Olfaction and declarative memory in aging: a meta-analysis
Chemical Senses
2023
The Intranasal Trigeminal System
Springer Handbook of Odor
2017
Olfactory and executive dysfunctions following orbito-basal lesions in traumatic brain injury
Brain Injury
2015
Characterization of an olfactometer by proton-transfer-reaction mass spectrometry
Measurement Science and Technology
2010
Food-Related Odors and the Reward Circuit: Functional MRI
Chemosensory Perception
2015
Olfactory bulb volume and cortical thickness evolve during sommelier training
Human Brain Mapping
2022
Olfactory priming leads to faster sound localization
Neuroscience Letters
2012
Volatile flavour retention in food technology and during consumption: Juice and custard examples
Food Chemistry
2008
Insula and Olfaction: A Literature Review and Case Report
Brain Sciences
2021
Persisting chemosensory impairments in 366 healthcare workers following COVID-19: an 11-month follow-up
Chemical Senses
2022
Olfaction in Athletes with Concussion
American Journal of Rhinology & Allergy
2012
Cortical network and connectivity underlying hedonic olfactory perception
Journal of Neural Engineering
2021

Education

University of Vienna

MD / January, 2001

Vienna

TU Dresden

PD, Experimental ENT Medicine / September, 2009

Dresden

Experience

McGill University

Academic Trainee / January, 2006December, 2007

CHU Ste.-Justine, University of Montréal

Postdoctoral Fellow / January, 2008December, 2009

Monell Chemical Senses Center

Visiting Scientist / January, 20102010

University of Montreal

Postdoctoral Fellow / April, 20102013

Sacré-Coeur Hospital Montreal

Regular Researcher / 2013Present

Université du Québec à Trois-Rivières

Full Professor / 2014Present

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