Elham Shirvani-Dastgerdi

Enthusiastic scientist with 15+ years of research experience in Molecular biology and cell and gene therapy

Research Expertise

Virology
Biotechnology
Molecular Biology
Hepatology
Infectious Diseases
Microbiology (medical)
Management of Technology and Innovation
History and Philosophy of Science
Sociology and Political Science
Philosophy
Ecology, Evolution, Behavior and Systematics
Microbiology
Genetics
Gastroenterology

About

Enthusiastic scientist with 15+ years of research experience in Molecular biology, Virology and cell and gene therapy in industry and academic environments. Expert in developing strong working relationships with leading researchers and healthcare providers to address scientific needs. Possess in depth knowledge in infectious disease, immune responses, and vaccines; with excellent oral and written communication skills as demonstrated by research manuscripts published in high-impact journals and oral presentations in national and international conferences. Efficient, self-motivated, detail-oriented, team-worker with exceptional analytical problem-solving ability, and strong planning and organizational skills; experienced in working on fast-paced, challenging projects. Strong leadership in conducting multiple projects simultaneously and in a cross-functional team to complete scientific projects in a timely manner. <br>

Publications

Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy

Journal of Hepatology / Aug 01, 2017

Shirvani-Dastgerdi, E., Winer, B. Y., Celià-Terrassa, T., Kang, Y., Tabernero, D., Yagmur, E., Rodríguez-Frías, F., Gregori, J., Luedde, T., Trautwein, C., Ploss, A., & Tacke, F. (2017). Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy. Journal of Hepatology, 67(2), 246–254. https://doi.org/10.1016/j.jhep.2017.03.027

Hepatocarcinogenesis associated with hepatitis B, delta and C viruses

Current Opinion in Virology / Oct 01, 2016

Shirvani-Dastgerdi, E., Schwartz, R. E., & Ploss, A. (2016). Hepatocarcinogenesis associated with hepatitis B, delta and C viruses. Current Opinion in Virology, 20, 1–10. https://doi.org/10.1016/j.coviro.2016.07.009

Genotypic Prediction of Co-receptor Tropism of HIV-1 Subtypes A and C

Scientific Reports / Apr 29, 2016

Riemenschneider, M., Cashin, K. Y., Budeus, B., Sierra, S., Shirvani-Dastgerdi, E., Bayanolhagh, S., Kaiser, R., Gorry, P. R., & Heider, D. (2016). Genotypic Prediction of Co-receptor Tropism of HIV-1 Subtypes A and C. Scientific Reports, 6(1). https://doi.org/10.1038/srep24883

Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection

Science Translational Medicine / Jun 27, 2018

Winer, B. Y., Shirvani-Dastgerdi, E., Bram, Y., Sellau, J., Low, B. E., Johnson, H., Huang, T., Hrebikova, G., Heller, B., Sharon, Y., Giersch, K., Gerges, S., Seneca, K., Pais, M.-A., Frankel, A. S., Chiriboga, L., Cullen, J., Nahass, R. G., Lutgehetmann, M., … Ploss, A. (2018). Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Science Translational Medicine, 10(447). https://doi.org/10.1126/scitranslmed.aap9328

Molecular and clinical aspects of hepatitis D virus infections

World Journal of Virology / Jan 01, 2012

Dastgerdi, E. S. (2012). Molecular and clinical aspects of hepatitis D virus infections. World Journal of Virology, 1(3), 71. https://doi.org/10.5501/wjv.v1.i3.71

Molecular interactions between hepatitis B virus and delta virus

World Journal of Virology / Jan 01, 2015

Shirvani-Dastgerdi, E. (2015). Molecular interactions between hepatitis B virus and delta virus. World Journal of Virology, 4(2), 36. https://doi.org/10.5501/wjv.v4.i2.36

HBsAg mutations related to occult hepatitis B virus infection in HIV‐positive patients result in a reduced secretion and conformational changes of HBsAg

Journal of Medical Virology / Aug 01, 2016

Sadeghi, A., Shirvani‐Dastgerdi, E., Tacke, F., Yagmur, E., Poortahmasebi, V., Poorebrahim, M., Mohraz, M., Hajabdolbaghi, M., Rasoolinejad, M., Abbasian, L., Jafari, R., Fakhari, Z., Norouzi, M., Ebrahimian, A., Geravand, B., Alavian, S. M., & Jazayeri, S. M. (2016). HBsAg mutations related to occult hepatitis B virus infection in HIV‐positive patients result in a reduced secretion and conformational changes of HBsAg. Journal of Medical Virology, 89(2), 246–256. Portico. https://doi.org/10.1002/jmv.24623

Comprehensive analysis of mutations in the hepatitis delta virus genome based on full-length sequencing in a nationwide cohort study and evolutionary pattern during disease progression

Clinical Microbiology and Infection / May 01, 2015

Shirvani-Dastgerdi, E., Amini-Bavil-Olyaee, S., Alavian, S. M., Trautwein, C., & Tacke, F. (2015). Comprehensive analysis of mutations in the hepatitis delta virus genome based on full-length sequencing in a nationwide cohort study and evolutionary pattern during disease progression. Clinical Microbiology and Infection, 21(5), 510.e11-510.e23. https://doi.org/10.1016/j.cmi.2014.12.008

The Main Causes of Mortality in Pediatric Intensive Care Unit in South West of Iran

Zahedan Journal of Research in Medical Sciences / Apr 30, 2018

Valavi, E., Aminzadeh, M., Shirvani, E., Jaafari, L., & Madhooshi, S. (2018). The Main Causes of Mortality in Pediatric Intensive Care Unit in South West of Iran. Zahedan Journal of Research in Medical Sciences, 20(4). https://doi.org/10.5812/zjrms.63006

Public Perceptions of Nanotechnology: A Survey in the Mega Cities of Iran

NanoEthics / Aug 02, 2012

Rahimpour, M., Rahimpour, M., Gomari, H., Shirvani, E., Niroumanesh, A., Saremi, K., & Sardari, S. (2012). Public Perceptions of Nanotechnology: A Survey in the Mega Cities of Iran. NanoEthics, 6(2), 119–126. https://doi.org/10.1007/s11569-012-0147-1

15 year fulminant hepatitis B follow-up in Belgium: Viral evolution and signature of demographic change

Infection, Genetics and Evolution / Apr 01, 2017

Mina, T., Amini-Bavil-Olyaee, S., Shirvani-Dastgerdi, E., Trovão, N. S., Van Ranst, M., & Pourkarim, M. R. (2017). 15 year fulminant hepatitis B follow-up in Belgium: Viral evolution and signature of demographic change. Infection, Genetics and Evolution, 49, 221–225. https://doi.org/10.1016/j.meegid.2017.01.020

Hepatitis delta virus facilitates the selection of hepatitis B virus mutants in vivo and functionally impacts on their replicative capacity in vitro

Clinical Microbiology and Infection / Jan 01, 2016

Shirvani-Dastgerdi, E., Pourkarim, M. R., Herbers, U., Amini-Bavil-Olyaee, S., Yagmur, E., Alavian, S. M., Trautwein, C., & Tacke, F. (2016). Hepatitis delta virus facilitates the selection of hepatitis B virus mutants in vivo and functionally impacts on their replicative capacity in vitro. Clinical Microbiology and Infection, 22(1), 98.e1-98.e6. https://doi.org/10.1016/j.cmi.2015.09.020

Impact of Drug-Resistance Polymerase Mutations on the Replication of HBeAg-Positive and HBeAg-Negative Hepatitis B Virus Strains in Vitro

Hepatitis Monthly / Jun 01, 2012

Tacke, F., & Shirvani-Dastgerdi, E. (2012). Impact of Drug-Resistance Polymerase Mutations on the Replication of HBeAg-Positive and HBeAg-Negative Hepatitis B Virus Strains in Vitro. Hepatitis Monthly, 12(6), 357–360. https://doi.org/10.5812/hepatmon.6131

Hepatitis E Virus Infection in Macaca Mulatta

Hepatitis Monthly / Sep 30, 2011

Dastgerdi, E. S., & Amini-Bavil-Olyaee, S. (2011). Hepatitis E Virus Infection in Macaca Mulatta. Hepatitis Monthly, 11(10), 852–853. https://doi.org/10.5812/kowsar.1735143x.783

Hepatitis delta virus RNA decline post-inoculation in human NTCP transgenic mice is biphasic

mBio / Jul 12, 2023

Maya, S., Hershkovich, L., Cardozo-Ojeda, E. F., Shirvani-Dastgerdi, E., Srinivas, J., Shekhtman, L., Uprichard, S. L., Berneshawi, A. R., Cafiero, T. R., Dahari, H., & Ploss, A. (2023). Hepatitis delta virus RNA decline post-inoculation in human NTCP transgenic mice is biphasic. MBio. https://doi.org/10.1128/mbio.01008-23

Hepatitis delta virus RNA decline post inoculation in human NTCP transgenic mice is biphasic

Feb 17, 2023

Maya, S., Hershkovich, L., Cardozo-Ojeda, E. F., Shirvani-Dastgerdi, E., Srinivas, J., Shekhtman, L., Uprichard, S. L., Berneshawi, A. R., Cafiero, T. R., Dahari, H., & Ploss, A. (2023). Hepatitis delta virus RNA decline post inoculation in human NTCP transgenic mice is biphasic. https://doi.org/10.1101/2023.02.17.528964

Hepatitis Delta Virus

Hepatitis Delta Virus / Jan 01, 2006

Sureau, C. (2006). Hepatitis Delta Virus: HDV-HBV Interactions. In Hepatitis Delta Virus (pp. 10–19). Springer US. https://doi.org/10.1007/0-387-35103-5_2

BMC Gastroenterology reviewer acknowledgement 2014

BMC Gastroenterology / Feb 05, 2015

Morawska, M. (2015). BMC Gastroenterology reviewer acknowledgement 2014. BMC Gastroenterology, 15(1). https://doi.org/10.1186/s12876-015-0238-x

Education

Princeton University

postdoc, Molecular Biology / June, 2019

Princeton, New Jersey, United States of America

Experience

Regeneron Pharmaceutical

Precision Medicine Strategy lead / March, 2023Present

Castle Creek Biosciences

Principal scientist / July, 2021March, 2023

Johnson & Johnson

Scientist / June, 2019June, 2021

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