Elham Shirvani-Dastgerdi
Enthusiastic scientist with 15+ years of research experience in Molecular biology and cell and gene therapy
Research Expertise
About
Publications
Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy
Journal of Hepatology / Aug 01, 2017
Shirvani-Dastgerdi, E., Winer, B. Y., Celià-Terrassa, T., Kang, Y., Tabernero, D., Yagmur, E., Rodríguez-Frías, F., Gregori, J., Luedde, T., Trautwein, C., Ploss, A., & Tacke, F. (2017). Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy. Journal of Hepatology, 67(2), 246–254. https://doi.org/10.1016/j.jhep.2017.03.027
Hepatocarcinogenesis associated with hepatitis B, delta and C viruses
Current Opinion in Virology / Oct 01, 2016
Shirvani-Dastgerdi, E., Schwartz, R. E., & Ploss, A. (2016). Hepatocarcinogenesis associated with hepatitis B, delta and C viruses. Current Opinion in Virology, 20, 1–10. https://doi.org/10.1016/j.coviro.2016.07.009
Genotypic Prediction of Co-receptor Tropism of HIV-1 Subtypes A and C
Scientific Reports / Apr 29, 2016
Riemenschneider, M., Cashin, K. Y., Budeus, B., Sierra, S., Shirvani-Dastgerdi, E., Bayanolhagh, S., Kaiser, R., Gorry, P. R., & Heider, D. (2016). Genotypic Prediction of Co-receptor Tropism of HIV-1 Subtypes A and C. Scientific Reports, 6(1). https://doi.org/10.1038/srep24883
Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection
Science Translational Medicine / Jun 27, 2018
Winer, B. Y., Shirvani-Dastgerdi, E., Bram, Y., Sellau, J., Low, B. E., Johnson, H., Huang, T., Hrebikova, G., Heller, B., Sharon, Y., Giersch, K., Gerges, S., Seneca, K., Pais, M.-A., Frankel, A. S., Chiriboga, L., Cullen, J., Nahass, R. G., Lutgehetmann, M., … Ploss, A. (2018). Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Science Translational Medicine, 10(447). https://doi.org/10.1126/scitranslmed.aap9328
Molecular and clinical aspects of hepatitis D virus infections
World Journal of Virology / Jan 01, 2012
Dastgerdi, E. S. (2012). Molecular and clinical aspects of hepatitis D virus infections. World Journal of Virology, 1(3), 71. https://doi.org/10.5501/wjv.v1.i3.71
Molecular interactions between hepatitis B virus and delta virus
World Journal of Virology / Jan 01, 2015
Shirvani-Dastgerdi, E. (2015). Molecular interactions between hepatitis B virus and delta virus. World Journal of Virology, 4(2), 36. https://doi.org/10.5501/wjv.v4.i2.36
HBsAg mutations related to occult hepatitis B virus infection in HIV‐positive patients result in a reduced secretion and conformational changes of HBsAg
Journal of Medical Virology / Aug 01, 2016
Sadeghi, A., Shirvani‐Dastgerdi, E., Tacke, F., Yagmur, E., Poortahmasebi, V., Poorebrahim, M., Mohraz, M., Hajabdolbaghi, M., Rasoolinejad, M., Abbasian, L., Jafari, R., Fakhari, Z., Norouzi, M., Ebrahimian, A., Geravand, B., Alavian, S. M., & Jazayeri, S. M. (2016). HBsAg mutations related to occult hepatitis B virus infection in HIV‐positive patients result in a reduced secretion and conformational changes of HBsAg. Journal of Medical Virology, 89(2), 246–256. Portico. https://doi.org/10.1002/jmv.24623
Comprehensive analysis of mutations in the hepatitis delta virus genome based on full-length sequencing in a nationwide cohort study and evolutionary pattern during disease progression
Clinical Microbiology and Infection / May 01, 2015
Shirvani-Dastgerdi, E., Amini-Bavil-Olyaee, S., Alavian, S. M., Trautwein, C., & Tacke, F. (2015). Comprehensive analysis of mutations in the hepatitis delta virus genome based on full-length sequencing in a nationwide cohort study and evolutionary pattern during disease progression. Clinical Microbiology and Infection, 21(5), 510.e11-510.e23. https://doi.org/10.1016/j.cmi.2014.12.008
The Main Causes of Mortality in Pediatric Intensive Care Unit in South West of Iran
Zahedan Journal of Research in Medical Sciences / Apr 30, 2018
Valavi, E., Aminzadeh, M., Shirvani, E., Jaafari, L., & Madhooshi, S. (2018). The Main Causes of Mortality in Pediatric Intensive Care Unit in South West of Iran. Zahedan Journal of Research in Medical Sciences, 20(4). https://doi.org/10.5812/zjrms.63006
Public Perceptions of Nanotechnology: A Survey in the Mega Cities of Iran
NanoEthics / Aug 02, 2012
Rahimpour, M., Rahimpour, M., Gomari, H., Shirvani, E., Niroumanesh, A., Saremi, K., & Sardari, S. (2012). Public Perceptions of Nanotechnology: A Survey in the Mega Cities of Iran. NanoEthics, 6(2), 119–126. https://doi.org/10.1007/s11569-012-0147-1
15 year fulminant hepatitis B follow-up in Belgium: Viral evolution and signature of demographic change
Infection, Genetics and Evolution / Apr 01, 2017
Mina, T., Amini-Bavil-Olyaee, S., Shirvani-Dastgerdi, E., Trovão, N. S., Van Ranst, M., & Pourkarim, M. R. (2017). 15 year fulminant hepatitis B follow-up in Belgium: Viral evolution and signature of demographic change. Infection, Genetics and Evolution, 49, 221–225. https://doi.org/10.1016/j.meegid.2017.01.020
Hepatitis delta virus facilitates the selection of hepatitis B virus mutants in vivo and functionally impacts on their replicative capacity in vitro
Clinical Microbiology and Infection / Jan 01, 2016
Shirvani-Dastgerdi, E., Pourkarim, M. R., Herbers, U., Amini-Bavil-Olyaee, S., Yagmur, E., Alavian, S. M., Trautwein, C., & Tacke, F. (2016). Hepatitis delta virus facilitates the selection of hepatitis B virus mutants in vivo and functionally impacts on their replicative capacity in vitro. Clinical Microbiology and Infection, 22(1), 98.e1-98.e6. https://doi.org/10.1016/j.cmi.2015.09.020
Impact of Drug-Resistance Polymerase Mutations on the Replication of HBeAg-Positive and HBeAg-Negative Hepatitis B Virus Strains in Vitro
Hepatitis Monthly / Jun 01, 2012
Tacke, F., & Shirvani-Dastgerdi, E. (2012). Impact of Drug-Resistance Polymerase Mutations on the Replication of HBeAg-Positive and HBeAg-Negative Hepatitis B Virus Strains in Vitro. Hepatitis Monthly, 12(6), 357–360. https://doi.org/10.5812/hepatmon.6131
Hepatitis E Virus Infection in Macaca Mulatta
Hepatitis Monthly / Sep 30, 2011
Dastgerdi, E. S., & Amini-Bavil-Olyaee, S. (2011). Hepatitis E Virus Infection in Macaca Mulatta. Hepatitis Monthly, 11(10), 852–853. https://doi.org/10.5812/kowsar.1735143x.783
Hepatitis delta virus RNA decline post-inoculation in human NTCP transgenic mice is biphasic
mBio / Jul 12, 2023
Maya, S., Hershkovich, L., Cardozo-Ojeda, E. F., Shirvani-Dastgerdi, E., Srinivas, J., Shekhtman, L., Uprichard, S. L., Berneshawi, A. R., Cafiero, T. R., Dahari, H., & Ploss, A. (2023). Hepatitis delta virus RNA decline post-inoculation in human NTCP transgenic mice is biphasic. MBio. https://doi.org/10.1128/mbio.01008-23
Hepatitis delta virus RNA decline post inoculation in human NTCP transgenic mice is biphasic
Feb 17, 2023
Maya, S., Hershkovich, L., Cardozo-Ojeda, E. F., Shirvani-Dastgerdi, E., Srinivas, J., Shekhtman, L., Uprichard, S. L., Berneshawi, A. R., Cafiero, T. R., Dahari, H., & Ploss, A. (2023). Hepatitis delta virus RNA decline post inoculation in human NTCP transgenic mice is biphasic. https://doi.org/10.1101/2023.02.17.528964
Hepatitis Delta Virus
Hepatitis Delta Virus / Jan 01, 2006
Sureau, C. (2006). Hepatitis Delta Virus: HDV-HBV Interactions. In Hepatitis Delta Virus (pp. 10–19). Springer US. https://doi.org/10.1007/0-387-35103-5_2
BMC Gastroenterology reviewer acknowledgement 2014
BMC Gastroenterology / Feb 05, 2015
Morawska, M. (2015). BMC Gastroenterology reviewer acknowledgement 2014. BMC Gastroenterology, 15(1). https://doi.org/10.1186/s12876-015-0238-x
Education
Princeton University
postdoc, Molecular Biology / June, 2019
Experience
Regeneron Pharmaceutical
Precision Medicine Strategy lead / March, 2023 — Present
Castle Creek Biosciences
Principal scientist / July, 2021 — March, 2023
Johnson & Johnson
Scientist / June, 2019 — June, 2021
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