Chandrakanth Emani

Research Scientist at MaxGene BioScience

Research Expertise

Plant Molecular Biology
Phytopharmaceuticals
Agrigenomics
Genetics
Agronomy and Crop Science
Plant Science
Biotechnology
Education
Orthopedics and Sports Medicine
Molecular Biology
Biochemistry
Structural Biology
Applied Mathematics
Computer Science Applications
Cell Biology
Developmental Biology

About

•I am a Research Scientist of Crop Transformation at MaxGene Bioscience. In a research career spanning 26 years, I was a Junior Research Fellow of the Rockefeller Foundation, a doctoral fellow of the Hindustan Ciba-Geigy (presently Syngenta), and a post-doctoral fellow of the Rockefeller Foundation. <br> •My current research expertise - Plant Genetic Engineering, plant-based pharmaceutical compounds as integrative treatment options for cancer, mammalian and plant tissue culture, agrigenomics, bioinformatics aimed at molecular evolution of cancer protein domains, and phytoremediation to reclaim cultivable land near oil fields. •My transferable research skills - molecular biology, cancer biology, phytopharmaceuticals, plant biotechnology, and bioinformatics On the personal side....I am a natural storyteller and more specifically a "Science Storyteller" and am passionate about promoting citizen science. I am also a bibliophile (I read books with any interesting subject...my favorites being THE DOUBLE HELIX (by James Watson), THE COMPLETE WORKS OF O. HENRY, ZEN AND THE ART OF MOTORCYCLE MAINTENANCE, THE HITCHHIKER'S GUIDE TO GALAXY, and THE FOUNTAINHEAD....in that order!!!). My free time is devoted to the three M's...MUSIC, MOLECULAR BIOLOGY, and MOVIES.

Publications

Enhanced fungal resistance in transgenic cotton expressing an endochitinase gene from Trichoderma virens

Plant Biotechnology Journal / Sep 01, 2003

Emani, C., Garcia, J. M., Lopata‐Finch, E., Pozo, M. J., Uribe, P., Kim, D., Sunilkumar, G., Cook, D. R., Kenerley, C. M., & Rathore, K. S. (2003). Enhanced fungal resistance in transgenic cotton expressing an endochitinase gene from Trichoderma virens. Plant Biotechnology Journal, 1(5), 321–336. Portico. https://doi.org/10.1046/j.1467-7652.2003.00029.x

Genome Editing in Plants: An Overview of Tools and Applications

International Journal of Agronomy / Jan 01, 2017

Kamburova, V. S., Nikitina, E. V., Shermatov, S. E., Buriev, Z. T., Kumpatla, S. P., Emani, C., & Abdurakhmonov, I. Y. (2017). Genome Editing in Plants: An Overview of Tools and Applications. International Journal of Agronomy, 2017, 1–15. https://doi.org/10.1155/2017/7315351

Transgene silencing and reactivation in sorghum

Plant Science / Feb 01, 2002

Emani, C., Sunilkumar, G., & Rathore, K. S. (2002). Transgene silencing and reactivation in sorghum. Plant Science, 162(2), 181–192. https://doi.org/10.1016/s0168-9452(01)00559-3

Sugarcane DIRIGENT and O-METHYLTRANSFERASE promoters confer stem-regulated gene expression in diverse monocots

Planta / Mar 30, 2010

Damaj, M. B., Kumpatla, S. P., Emani, C., Beremand, P. D., Reddy, A. S., Rathore, K. S., Buenrostro-Nava, M. T., Curtis, I. S., Thomas, T. L., & Mirkov, T. E. (2010). Sugarcane DIRIGENT and O-METHYLTRANSFERASE promoters confer stem-regulated gene expression in diverse monocots. Planta, 231(6), 1439–1458. https://doi.org/10.1007/s00425-010-1138-5

Role of MicroRNAs and small RNAs in regulation of developmental processes and agronomic traits in Gossypium species

Genomics / Sep 01, 2019

Ayubov, M. S., Mirzakhmedov, M. H., Sripathi, V. R., Buriev, Z. T., Ubaydullaeva, K. A., Usmonov, D. E., Norboboyeva, R. B., Emani, C., Kumpatla, S. P., & Abdurakhmonov, I. Y. (2019). Role of MicroRNAs and small RNAs in regulation of developmental processes and agronomic traits in Gossypium species. Genomics, 111(5), 1018–1025. https://doi.org/10.1016/j.ygeno.2018.07.012

Phaseolin: Structure and Evolution

The Open Evolution Journal / Jan 01, 2008

Emani, C., & Hall, T. C. (2008). Phaseolin: Structure and Evolution. The Open Evolution Journal, 1(1), 66–74. https://doi.org/10.2174/1874404400802010066

The Effects of Transgenic Crops on Non-target Organisms

Sustainable Development and Biodiversity / Jan 01, 2014

Emani, C. (2014). The Effects of Transgenic Crops on Non-target Organisms. In Biotechnology and Biodiversity (pp. 59–66). Springer International Publishing. https://doi.org/10.1007/978-3-319-09381-9_4

Insect Resistance

Genomics and Breeding for Climate-Resilient Crops / Jan 01, 2013

Emani, C., & Hunter, W. (2013). Insect Resistance. In Genomics and Breeding for Climate-Resilient Crops (pp. 315–332). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-37048-9_9

Transgenic Cotton for Agronomical Useful Traits

Sustainable Development and Biodiversity / Jan 01, 2016

Emani, C. (2016). Transgenic Cotton for Agronomical Useful Traits. In Fiber Plants (pp. 201–216). Springer International Publishing. https://doi.org/10.1007/978-3-319-44570-0_10

Using the “DNA Story” to Inculcate a Scientific Thought Process in the Classroom

The American Biology Teacher / Sep 01, 2010

Emani, C. (2010). Using the “DNA Story” to Inculcate a Scientific Thought Process in the Classroom. The American Biology Teacher, 72(7), 410–413. https://doi.org/10.1525/abt.2010.72.7.4

Identification of Traits, Genes, and Crops of the Future

Genomics and Breeding for Climate-Resilient Crops / Jan 01, 2013

De Pace, C., Ricciardi, L., Kumar, A., Pavan, S., Lotti, C., Dixit, S., & Emani, C. (2013). Identification of Traits, Genes, and Crops of the Future. In Genomics and Breeding for Climate-Resilient Crops (pp. 27–177). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-37045-8_3

The Biology of Plant-Insect Interactions

Mar 05, 2018

Emani, C. (Ed.). (2018, March 5). The Biology of Plant-Insect Interactions: A Compendium for the Plant Biotechnologist. CRC Press. https://doi.org/10.1201/9781315119571

Prolotherapy agent P2G is associated with upregulation of fibroblast growth factor-2 genetic expression in vitro

Journal of Experimental Orthopaedics / Dec 01, 2020

Johnston, E., Emani, C., Kochan, A., Ghebrehawariat, K., Tyburski, J., Johnston, M., & Rabago, D. (2020). Prolotherapy agent P2G is associated with upregulation of fibroblast growth factor-2 genetic expression in vitro. Journal of Experimental Orthopaedics, 7(1). https://doi.org/10.1186/s40634-020-00312-z

Gossypium

Wild Crop Relatives: Genomic and Breeding Resources / Jan 01, 2011

Emani, C. (2011). Gossypium. In Wild Crop Relatives: Genomic and Breeding Resources (pp. 109–122). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-21102-7_6

The Coevolution of the Plant-Insect Interaction Networks

The Biology of Plant-Insect Interactions / Mar 05, 2018

Corneal, K., Campbell, J., Evans, N., & Emani, C. (2018). The Coevolution of the Plant-Insect Interaction Networks. In The Biology of Plant-Insect Interactions (pp. 74–92). CRC Press. https://doi.org/10.1201/9781315119571-4

Metabolic Engineering of Pathways and Gene Discovery

Transgenic Crop Plants / Jan 01, 2010

Juříček, M., Emani, C., Kertbundit, S., & Hall, T. C. (2010). Metabolic Engineering of Pathways and Gene Discovery. In Transgenic Crop Plants (pp. 275–306). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-04809-8_10

Figure 1. Comparison of protein coding genes in the genomes of JCVI-syn3A (NCBI GenBank: https://www.ncbi.nlm.nih.gov/nuccore/CP016816.2 (Glass, 2017)), M. pneumoniae (NCBI GenBank: https://www.ncbi.nlm.nih.gov/nuccore/U00089.2 (Himmelreich et al., 2014)), and E. coli (NCBI GenBank: https://www.ncbi.nlm.nih.gov/nuccore/NC_012967.1 (Jeong et al., 2017)) with 452, 688, and 4637 coding genes, respectively.

Figure 1. Comparison of protein coding genes in the genomes of JCVI-syn3A (NCBI GenBank: https://www.ncbi.nlm.nih.gov/nuccore/CP016816.2 (Glass, 2017)), M. pneumoniae (NCBI GenBank: https://www.ncbi.nlm.nih.gov/nuccore/U00089.2 (Himmelreich et al., 2014)), and E. coli (NCBI GenBank: https://www.ncbi.nlm.nih.gov/nuccore/NC_012967.1 (Jeong et al., 2017)) with 452, 688, and 4637 coding genes, respectively.: Each color represents a primary functional class, each contiguous shaded region corresponds to a secondary functional class, within each of the shaded regions the bold lines separate tertiary functional classes, finally each polygonal cell represents a single gene. The functional class hierarchy is presented in Supplementary file 1A. The ratio of metabolic to genetic information processing genes—0.67, 0.79, and 2.23 respectively—is smallest for JCVI-syn3A. The JCVI-syn3A genome contains both the smallest absolute number of genes of unclear function and the smallest percentage, 91 (20 %), compared to M. pneumoniae with 311 (45 %) and E. coli with 1780 (38 %). (n.d.). eLife Sciences Publications, Ltd. https://doi.org/10.7554/elife.36842.003

Prolotherapy upregulates Fibroblast Growth Factor‐2 (FGF‐2) and Insulin‐like Growth Factor‐1 (IGF‐1) mRNA which may increase chondrocyte proliferation and mediates osteoarthritic inflammation

The FASEB Journal / Apr 01, 2020

Johnston, E. D., & Emani, C. (2020). Prolotherapy upregulates Fibroblast Growth Factor‐2 (FGF‐2) and Insulin‐like Growth Factor‐1 (IGF‐1) mRNA which may increase chondrocyte proliferation and mediates osteoarthritic inflammation. The FASEB Journal, 34(S1), 1–1. Portico. https://doi.org/10.1096/fasebj.2020.34.s1.09039

Transgenic approaches to combatting insect pests in the field

The Biology of Plant-Insect Interactions / Mar 05, 2018

Campbell, J., Veizaj, J., Evans, N., Taylor, S., & Emani, C. (2018). Transgenic approaches to combatting insect pests in the field. In The Biology of Plant-Insect Interactions (pp. 113–128). CRC Press. https://doi.org/10.1201/9781315119571-6

Genetic, Biochemical and Molecular Networks of Plant-Insect Interactions–Model Platforms for Integrative Biological Research

The Biology of Plant-Insect Interactions / Mar 05, 2018

Lasher, J., Speer, A., Taylor, S., & Emani, C. (2018). Genetic, Biochemical and Molecular Networks of Plant-Insect Interactions–Model Platforms for Integrative Biological Research. In The Biology of Plant-Insect Interactions (pp. 48–61). CRC Press. https://doi.org/10.1201/9781315119571-2

MEvoLib v1.0: the first molecular evolution library for Python

BMC Bioinformatics / Oct 28, 2016

Álvarez-Jarreta, J., & Ruiz-Pesini, E. (2016). MEvoLib v1.0: the first molecular evolution library for Python. BMC Bioinformatics, 17(1). https://doi.org/10.1186/s12859-016-1303-3

Identification of recurrent focal copy number variations and their putative targeted driver genes in ovarian cancer

BMC Bioinformatics / May 26, 2016

Zhang, L., Yuan, Y., Lu, K. H., & Zhang, L. (2016). Identification of recurrent focal copy number variations and their putative targeted driver genes in ovarian cancer. BMC Bioinformatics, 17(1). https://doi.org/10.1186/s12859-016-1085-7

Proceedings of the Fourteenth Annual UT- KBRIN Bioinformatics Summit 2015

BMC Bioinformatics / Oct 23, 2015

Rouchka, E. C., Chariker, J. H., & Harrison, B. J. (2015). Proceedings of the Fourteenth Annual UT- KBRIN Bioinformatics Summit 2015. BMC Bioinformatics, 16(S15). https://doi.org/10.1186/1471-2105-16-s15-i1

Transgenic Crops to Preserve Biodiversity

Sustainable Development and Biodiversity / Jan 01, 2014

Emani, C. (2014). Transgenic Crops to Preserve Biodiversity. In Biotechnology and Biodiversity (pp. 3–15). Springer International Publishing. https://doi.org/10.1007/978-3-319-09381-9_1

Education Posters

In Vitro Cellular & Developmental Biology - Animal / May 18, 2013

Education Posters. (2013). In Vitro Cellular &amp; Developmental Biology - Animal, 49(S1), 47–49. https://doi.org/10.1007/s11626-013-9606-4

Focused Plant Biotechnological Research to Preserve Biodiversity

Journal of Biodiversity Management & Forestry / Jan 01, 2013

Emani, C. (2013). Focused Plant Biotechnological Research to Preserve Biodiversity. Journal of Biodiversity Management &amp; Forestry, 01(01). https://doi.org/10.4172/2327-4417.1000e102

Education

Osmania University

Ph D, Genetics and Plant Molecular Biology, Center for Plant Molecular Biology, Department of Genetics / March, 1997

Hyderabad

University of Pune

M.Sc., Biochemistry, Biochemistry / May, 1991

Pune

Nizam College

B.Sc. Genetics, Zoology, Chemistry, Genetics / May, 1989

Hyderabad

Experience

Western Kentucky University

Associate Professor / January, 2010September, 2023

Teaching and research in plant molecular biology, biotechnology, genetics, biochemistry and bioinformatics

Research Scientist - MaxGene BioScience / October, 2023Present

R&D - CRISPR editing and genetic engineering

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