Dr. Nathan D. Palmer, Ph.D.

Ph.D. Scientist in molecular and computational biology with expertise in gene therapy and systems immunology.

Research Expertise

gene therapy

immunology

bioengineering

Biomedical Engineering

Biotechnology

Computer Science Applications

Genetics

Pathology and Forensic Medicine

Histology

Cell Biology

Oncology

Hematology

Molecular Biology

Legacy Map

Publications

Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy

Nature Biomedical Engineering

Long-lasting analgesia via targeted in situ repression of Na _V 1.7 in mice

Science Translational Medicine

Destabilizing mutations encode nongenetic variation that drives evolutionary innovation

Translating CRISPR-Cas Therapeutics: Approaches and Challenges

The CRISPR Journal

Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity

Peptide-tiling screens of cancer drivers reveal oncogenic protein domains and associated peptide inhibitors

Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA base-editing activity, functionality and specificity

Strong Episodic Selection for Natural Competence for Transformation Due to Host-Pathogen Dynamics

Reprogramming Adeno-Associated Virus Tropism Via Displayed Peptides Tiling Receptor-Ligands

Extensive in vitro and in vivo protein translation via in situ circularized RNAs

UC San Diego Holding ISBN 978-83-67405-11-9

Long-lasting Analgesia via Targetedin vivoEpigenetic Repression of Nav1.7

Education

University of California, San Diego

Ph.D., Biology / May, 2022

La Jolla, California, United States of America

Arizona State University

B.S., Molecular Bioscience & Biotechnology / June, 2016

Tempe, Arizona, United States of America

Experience

Sangamo Therapeutics

Scientist - AAV Engineering / November, 2022 — January, 2024

Developed and implemented high throughput screening methods to engineering AAV delivery across the blood-brain barrier.

University of California, San Diego

Doctoral Candidate / April, 2017 — May, 2022

Prashant Mali Lab -- Developed and implemented a novel protein engineering strategy based on high-throughput screening and nanopore sequencing to systematically de-immunize Cas9 multiple epitopes at a time. -- Characterized immune barriers to AAV-delivered CRISPR-Cas gene therapies in mouse models, and demonstrated proof-of-concept immune orthogonal re-dosing method which improved gene editing via avoidance of induced AAV and Cas9 immunity.

Doctoral Researcher

Justin Meyer Lab -- Created mathematical models to understand the evolution of receptor switching in λ phage.

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