Vasundhara Kain

Cardiovascular scientist expertise inflammation-resolution signaling

Research Expertise

Heart Failure
Resolution and inflammation
leukocyte biology
lipid mediators

About

I am a devoted cardiovascular research scientist with a keen focus on unraveling the intricate connections between inflammation, immune response, and metabolic dysregulation in both ischemic and non-ischemic heart failure. My passion lies in conceiving innovative hypotheses within cardiovascular medicine and translating them into feasible and actionable solutions, particularly in addressing inflammation through the exploration of Specialized Pro-Resolving Mediators (SPMs) and Pro-Inflammatory Mediators (PIMs) amid risk factors like obesity, diabetes, aging, and cardiotoxic co-medications (oncological drugs). My research delves deeply into four primary areas: comprehensively studying heart failure etiology by integrating insights from splenic leukocytes and cardiac function; quantifying inflammatory mediators hindering cardiac repair while identifying lipid mediators facilitating post-heart attack recovery; elucidating the roles of resolution receptors in inflammation-resolution dynamics within heart failure; and translating our findings into potential human therapies, thoughtfully considering associated risk factors. With over a decade of experience in cardiovascular research, I possess a versatile skill set encompassing mouse models, imaging, flow cytometry, primary cell cultures, histology, molecular biology, and microscopy. Presently, I'm actively engaged in projects exploring the developmental trajectories of Heart Failure with Preserved Ejection Fraction (HFpEF) and investigating the impact of lipoxygenases, specifically 12/15LOX and 5LOX, on acute heart failure across various age groups

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Publications

Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function
Journal of Molecular and Cellular Cardiology
2015
Inflammation revisited: inflammation versus resolution of inflammation following myocardial infarction
Basic Research in Cardiology
2014
High glucose-induced Ca2+ overload and oxidative stress contribute to apoptosis of cardiac cells through mitochondrial dependent and independent pathways
Biochimica et Biophysica Acta (BBA) - General Subjects
2012
Splenic leukocytes define the resolution of inflammation in heart failure
Science Signaling
2018
Cardiomyocyte-specific Bmal1 deletion in mice triggers diastolic dysfunction, extracellular matrix response, and impaired resolution of inflammation
American Journal of Physiology-Heart and Circulatory Physiology
2015
Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarction
American Journal of Physiology-Heart and Circulatory Physiology
2015
Aging dysregulates D- and E-series resolvins to modulate cardiosplenic and cardiorenal network following myocardial infarction
Aging
2016
Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism
Scientific Reports
2015
Doxorubicin triggers splenic contraction and irreversible dysregulation of COX and LOX that alters the inflammation-resolution program in the myocardium
American Journal of Physiology-Heart and Circulatory Physiology
2018
Immune responsive resolvin D1 programs myocardial infarction‐induced cardiorenal syndrome in heart failure
The FASEB Journal
2018
Resolution Agonist 15-epi-Lipoxin A4 Programs Early Activation of Resolving Phase in Post-Myocardial Infarction Healing
Scientific Reports
2017
Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation
American Journal of Physiology-Heart and Circulatory Physiology
2018
Molecular and Cellular Differences in Cardiac Repair of Male and Female Mice
Journal of the American Heart Association
2020
Obesity and Cardiometabolic Defects in Heart Failure Pathology
Comprehensive Physiology
2017
Obesogenic diet in aging mice disrupts gut microbe composition and alters neutrophi:lymphocyte ratio, leading to inflamed milieu in acute heart failure
The FASEB Journal
2019
Heart functional and structural compendium of cardiosplenic and cardiorenal networks in acute and chronic heart failure pathology
American Journal of Physiology-Heart and Circulatory Physiology
2018
Azelnidipine prevents cardiac dysfunction in streptozotocin-diabetic rats by reducing intracellular calcium accumulation, oxidative stress and apoptosis
Cardiovascular Diabetology
2011
Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarction
Journal of Molecular and Cellular Cardiology
2018
Role of neutrophils in ischemic heart failure
Pharmacology & Therapeutics
2020
Race, Natriuretic Peptides, and High-Carbohydrate Challenge
Circulation Research
2019
Interaction of 12/15-lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved postmyocardial infarction healing
American Journal of Physiology-Heart and Circulatory Physiology
2017
Azelnidipine protects myocardium in hyperglycemia-induced cardiac damage
Cardiovascular Diabetology
2010
Lipoxygenase drives lipidomic and metabolic reprogramming in ischemic heart failure
Metabolism
2019
Inhibition of FPR2 impaired leukocytes recruitment and elicited non-resolving inflammation in acute heart failure
Pharmacological Research
2019
Cardiotoxicity of calmidazolium chloride is attributed to calcium aggravation, oxidative and nitrosative stress, and apoptosis
Free Radical Biology and Medicine
2009
Co-activator binding protein PIMT mediates TNF-α induced insulin resistance in skeletal muscle via the transcriptional down-regulation of MEF2A and GLUT4
Scientific Reports
2015
Race‐based and sex‐based differences in bioactive lipid mediators after myocardial infarction
ESC Heart Failure
2020
Immune responsive resolvin D1 programs peritoneal macrophages and cardiac fibroblast phenotypes in diversified metabolic microenvironment
Journal of Cellular Physiology
2018
Subacute treatment of carprofen facilitate splenocardiac resolution deficit in cardiac injury
Journal of Leukocyte Biology
2018
ERK1/2 activated PHLPP1 induces skeletal muscle ER stress through the inhibition of a novel substrate AMPK
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
2018
MicroRNA-16 modulates macrophage polarization leading to improved insulin sensitivity in myoblasts
Biochimie
2015
Comprehensive targeted and non-targeted lipidomics analyses in failing and non-failing heart
Analytical and Bioanalytical Chemistry
2018
Sphingosine-1-phosphate interactions in the spleen and heart reflect extent of cardiac repair in mice and failing human hearts
American Journal of Physiology-Heart and Circulatory Physiology
2021
ERK2-Mediated Phosphorylation of Transcriptional Coactivator Binding Protein PIMT/NCoA6IP at Ser298 Augments Hepatic Gluconeogenesis
PLoS ONE
2013
Metabolic and Biochemical Stressors in Diabetic Cardiomyopathy
Frontiers in Cardiovascular Medicine
2017
Arachidonate 5-lipoxygenase is essential for biosynthesis of specialized pro-resolving mediators and cardiac repair in heart failure
American Journal of Physiology-Heart and Circulatory Physiology
2022
Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity
The FASEB Journal
2020
Big eater macrophages dominate inflammation resolution following myocardial infarction
Journal of Molecular and Cellular Cardiology
2015
Metabolic transformation of fat in obesity determines the inflammation resolving capacity of splenocardiac and cardiorenal networks in heart failure
American Journal of Physiology-Heart and Circulatory Physiology
2022
Lipoxygenase inhibitor ML351 dysregulated an innate inflammatory response leading to impaired cardiac repair in acute heart failure
Biomedicine & Pharmacotherapy
2021
Pretreatment of carprofen impaired initiation of inflammatory- and overlapping resolution response and promoted cardiorenal syndrome in heart failure
Life Sciences
2019
MicroRNA-712 restrains macrophage pro-inflammatory responses by targeting LRRK2 leading to restoration of insulin stimulated glucose uptake by myoblasts
Molecular Immunology
2017
Activation of EP4 receptor limits transition of acute to chronic heart failure in lipoxygenase deficient mice
Theranostics
2021
A novel SOD mimic with a redox-modulating mn (II) complex, ML1 attenuates high glucose-induced abnormalities in intracellular Ca 2+ transients and prevents cardiac cell death through restoration of mitochondrial function
Biochemistry and Biophysics Reports
2016
Sleep deprivation in obesogenic setting alters lipidome and microbiome toward suboptimal inflammation in acute heart failure
The FASEB Journal
2023
Abstract 14092: Arachidonate 5 Lipoxygenase Deficiency Drives Age-Related Obesity, Macrophage Dysfunction in Cardiac Repair, and Omnipresence of Inflammation
Circulation
2021
Abstract 12648: Deletion of 12/15 Lipoxygenase Improves Left Ventricle Function and Survival by Resolving Inflammation Post Myocardial Infarction
Circulation
2014
Resolution Agonist 15‐epi‐Lipoxin A4 Directs FPR2 to Expedite Healing Phase Post‐Myocardial Infarction
The FASEB Journal
2016
Abstract 13975: Macrophage Specific Lipoxygenase Deletion Amplify Cardiac Repair Activating Treg in Chronic Heart Failure
Circulation
2021
Gravin gravitates atherogenesis to atheroprogression in the obesogenic setting
American Journal of Physiology-Heart and Circulatory Physiology
2019
Resolvin D1 Programs Myocardial Infarction‐induced Cardiorenal Syndrome in Heart Failure Pathology
The FASEB Journal
2017
Cardiomyocyte Specific Bmal1 Deletion Triggers Extracellular Matrix Response Associated with Markers of Impaired Inflammation Resolution and Diastolic Dysfunction
The FASEB Journal
2015
Novel Mn-SOD Mimetics Offer Superior Protection Against Oxidative Damages in Hek293 Kidney Cells
Journal of Pharmaceutical Sciences and Pharmacology
2014
Exercise reduces pro-inflammatory lipids and preserves resolution mediators that calibrate macrophage-centric immune metabolism in spleen and heart following obesogenic diet in aging mice
Journal of Molecular and Cellular Cardiology
2024
Genetic deletion of 12/15 lipoxygenase delays vascular remodeling and limits cardiorenal dysfunction after pressure overload
Journal of Molecular and Cellular Cardiology Plus
2023
Interaction of aging with lipoxygenase deficiency initiates hypersplenism, cardiac dysfunction, and profound leukocyte directed non-resolving inflammation
GeroScience
2021
Abstract 14038: Deficiency of Arachidonate 5-Lipoxygenase Intensifies Sepsis-Induced Cardiac Dysfunction in Aging
Circulation
2021
Abstract 17240: A Pilot Clinical Trial to Study Racial Differences in Natriuretic Peptide Response to a High-Carbohydrate Challenge
Circulation
2018
Inhibition of FPR2 Impaired Leukocyte Get‐in Signal and Triggers Non‐Resolving Inflammation in Heart Failure
The FASEB Journal
2018
Maresin‐1 Activates Resolution Sensor and Improves Left Ventricle Function In Acute Heart Failure
The FASEB Journal
2018
Abstract 323: Metabolic Transformation of Fatty Acids Defines Resolving Versus Non-Resolving Inflammation in Obesity-Associated Heart Failure
Circulation Research
2017
Abstract 12625: Splenic Leukocytes Defines the Resolution of Inflammation and Left Ventricle Healing in Heart Failure Pathology
Circulation
2016
Non‐Resolving Chemokine Response Dysregulates Cardiosplenic And Cardiorenal Network Following Myocardial Infarction In Aging
The FASEB Journal
2016
Abstract 213: Deletion of 12/15 Lipoxygenase and Fatty Acids Interaction Alters Leukocyte Kinetics Leading to Improved Healing Following Myocardial Infarction
Circulation Research
2015
RvD1 Activates Resolution of Inflammation Following Myocardial Infarction Leading To Improved Ventricular Function
The FASEB Journal
2015
Abstract 13276: DHA but not Etanercept Expedites Resolution of Inflammation leading to Improved Survival Following Myocardial Infarction in Aging Mice
Circulation
2014
Role of Oxidative/Nitrosative Stress in Diarrhea and Constipation
Novel Prospects in Oxidative and Nitrosative Stress
2018
Extrinsic and intrinsic modulators of inflammation-resolution signaling in heart failure
American Journal of Physiology-Heart and Circulatory Physiology
2023
Dysfunction of resolution receptor triggers cardiomyopathy of obesity and signs of non-resolving inflammation in heart failure
Molecular and Cellular Endocrinology
2022
Lack of resolution sensor drives age-related cardiometabolic and cardiorenal defects and impedes inflammation-resolution in heart failure
Molecular Metabolism
2020

Education

National Centre For Cell Science

Phd, biotechnology / January, 2011

Pune

Experience

Universty of South Florida

Lab Faculty / February, 2020Present

University of Alabama at Birmingham

Postodctoral Trainee / December, 2013February, 2020

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