Work with Dr. David Siderovski, Ph.D. | NotedSource
Dr. David Siderovski is a renowned scientist and academic,
with a career spanning over two decades. He received his
Ph.D. in Medical Biophysics from the University of Toronto
in 1997, where he specialized in signal transduction and
cellular signaling pathways. After completing his
doctorate, Dr. Siderovski held various faculty positions
at prestigious universities, including the University of
North Carolina at Chapel Hill, West Virginia University
School of Medicine, and the University of North Texas
Health Science Center. At these institutions, Dr.
Siderovski has made significant contributions to the field
of pharmacology through his research on G protein-coupled
receptors (GPCRs) and RGS proteins, which are key
regulators of GPCR cellular signaling. His work has helped
to advance the understanding of RGS proteins and their
roles in various diseases, including cancer,
cardiovascular disorders, and neurological disorders. In
addition to his research, Dr. Siderovski is also a
dedicated educator and mentor. He has taught and mentored
numerous undergraduate, graduate, and medical students,
and has served as a mentor for postdoctoral fellows and
junior faculty members. He is known for his passion and
enthusiasm for science and his ability to inspire and
guide the next generation of scientists. Dr. Siderovski
has received numerous awards and honors for his
contributions to the scientific community. He was the
recipient of the Abel Award in 2004 from the American
Society of Pharmacology & Experimental Therapeutics
for his pioneering discoveries of the RGS proteins and the
GoLoco motif. He has also served on editorial boards of
several scientific journals (including a decade at
*J.Biol.Chem.*) and has been a member of various
scientific committees, NIH study section panels, and
pharma/biotech advisory boards, including for Inspire,
Wyeth, and BellBrook Labs. Overall, Dr. David Siderovski
is a highly accomplished and respected scientist and
educator, whose research has had a significant impact on
the field of pharmacology. His dedication and passion for
science continue to inspire and influence the next
generation of researchers in this field.
https://cv.notedsource.io/me/O4RYWQWJ
Dr. David Siderovski, Ph.D.
Professor of Computational Pharmacology; Chair of HSC SBS Dept. of Pharmacology & Neuroscience
Fort Worth
Research Expertise
Regulator of G protein Signaling (RGS) proteins
Pharmacology
Molecular Biology
Cellular and Molecular Neuroscience
Molecular Medicine
Cell Biology
Developmental Biology
Genetics
Drug Discovery
Applied Microbiology and Biotechnology
Structural Biology
Biochemistry
Immunology and Allergy
Immunology
Infectious Diseases
Virology
Biophysics
Psychiatry and Mental health
Microbiology
Clinical Biochemistry
Analytical Chemistry
Organic Chemistry
Computer Science Applications
Catalysis
Colloid and Surface Chemistry
Parasitology
About
Dr. David Siderovski is a renowned scientist
and academic, with a career spanning over two
decades. He received his Ph.D. in Medical
Biophysics from the University of Toronto in
1997, where he specialized in signal
transduction and cellular signaling pathways.
After completing his doctorate, Dr. Siderovski
held various faculty positions at prestigious
universities, including the University of
North Carolina at Chapel Hill, West Virginia
University School of Medicine, and the
University of North Texas Health Science
Center. At these institutions, Dr. Siderovski
has made significant contributions to the
field of pharmacology through his research on
G protein-coupled receptors (GPCRs) and RGS
proteins, which are key regulators of GPCR
cellular signaling. His work has helped to
advance the understanding of RGS proteins and
their roles in various diseases, including
cancer, cardiovascular disorders, and
neurological disorders. In addition to his
research, Dr. Siderovski is also a dedicated
educator and mentor. He has taught and
mentored numerous undergraduate, graduate, and
medical students, and has served as a mentor
for postdoctoral fellows and junior faculty
members. He is known for his passion and
enthusiasm for science and his ability to
inspire and guide the next generation of
scientists. Dr. Siderovski has received
numerous awards and honors for his
contributions to the scientific community. He
was the recipient of the Abel Award in 2004
from the American Society of Pharmacology
& Experimental Therapeutics for his
pioneering discoveries of the RGS proteins and
the GoLoco motif. He has also served on
editorial boards of several scientific
journals (including a decade at
*J.Biol.Chem.*) and has been a member of
various scientific committees, NIH study
section panels, and pharma/biotech advisory
boards, including for Inspire, Wyeth, and
BellBrook Labs. Overall, Dr. David Siderovski
is a highly accomplished and respected
scientist and educator, whose research has had
a significant impact on the field of
pharmacology. His dedication and passion for
science continue to inspire and influence the
next generation of researchers in this field.
Legacy Map
Full ViewPublications
Molecular characterization of
mitochondrial apoptosis-inducing factor
Nature
1999
Negative Regulation of PKB/Akt-Dependent
Cell Survival by the Tumor Suppressor PTEN
Cell
1998
G-protein signaling: back to the future
Cellular and Molecular Life
Sciences
2005
5′-Capping enzymes are targeted to
pre-mRNA by binding to the phosphorylated
carboxy-terminal domain of RNA
polymerase II
Genes & Development
1997
The GAPs, GEFs, and GDIs of heterotrimeric
G-protein alpha subunits
International Journal of Biological
Sciences
2005
Regulators of G-Protein signalling as new
central nervous system drug targets
Nature Reviews Drug Discovery
2002
Regulator of G-protein signaling-2
mediates vascular smooth muscle relaxation
and blood pressure
Nature Medicine
2003
Tiam1 mediates Ras activation of Rac by a
PI(3)K-independent mechanism
Nature Cell Biology
2002
A Seven-Transmembrane RGS Protein That
Modulates Plant Cell Proliferation
Science
2003
Translation of Polarity Cues into
Asymmetric Spindle Positioning in
Caenorhabditis elegans
Embryos
Science
2003
Dynamic Regulation of RGS2 Suggests a
Novel Mechanism in G-Protein Signaling and
Neuronal Plasticity
The Journal of Neuroscience
1998
Regulation of T cell activation, anxiety,
and male aggression by RGS2
Proceedings of the National Academy of
Sciences
2000
A G protein γ subunit-like domain shared
between RGS11 and other RGS proteins
specifies binding to G
β5
subunits
Proceedings of the National Academy of
Sciences
1998
Structural and Evolutionary Division of
Phosphotyrosine Binding (PTB) Domains
Journal of Molecular Biology
2005
Regulators of G-Protein Signaling and
Their Gα Substrates: Promises and
Challenges in Their Use as Drug Discovery
Targets
Pharmacological Reviews
2011
A crystallographic view of interactions
between Dbs and Cdc42: PH domain-assisted
guanine nucleotide exchange
The EMBO Journal
2002
Structural determinants for GoLoco-induced
inhibition of nucleotide release by Gα
subunits
Nature
2002
The telomerase reverse transcriptase is
limiting and necessary for telomerase
function in vivo
Current Biology
2000
A new family of regulators of
G-protein-coupled receptors?
Current Biology
1996
Structural basis for the selective
activation of Rho GTPases by Dbl exchange
factors
Nature Structural Biology
2002
Molecular cloning ofLSIRF, a
lymphoid-specific member of the interferon
regulatory factor family that binds the
interferon-stimulated response element
(ISRE)
Nucleic Acids Research
1995
The Mitochondrial Proteins NLRX1 and TUFM
Form a Complex that Regulates Type I
Interferon and Autophagy
Immunity
2012
RGS12 and RGS14 GoLoco Motifs Are
GαiInteraction Sites with Guanine
Nucleotide Dissociation Inhibitor Activity
Journal of Biological Chemistry
2001
GTPase Activating Specificity of RGS12 and
Binding Specificity of an Alternatively
Spliced PDZ (PSD-95/Dlg/ZO-1) Domain
Journal of Biological Chemistry
1998
GTPase acceleration as the rate-limiting
step in
Arabidopsis
G protein-coupled sugar signaling
Proceedings of the National Academy of
Sciences
2007
Return of the GDI: The GoLoco Motif in
Cell Division
Annual Review of Biochemistry
2004
Regulator of G protein signaling 2
mediates cardiac compensation to pressure
overload and antihypertrophic effects of
PDE5 inhibition in mice
Journal of Clinical Investigation
2009
RIC-8 Is Required for GPR-1/2-Dependent Gα
Function during Asymmetric Division of C.
elegans Embryos
Cell
2004
Structural diversity in the RGS domain and
its interaction with heterotrimeric G
protein α-subunits
Proceedings of the National Academy of
Sciences
2008
LGN regulates mitotic spindle orientation
during epithelial morphogenesis
Journal of Cell Biology
2010
The GoLoco motif: a Gαi/o binding motif
and potential guanine-nucleotide exchange
factor
Trends in Biochemical Sciences
1999
Activator of G protein signaling 3 is a
guanine dissociation inhibitor for Gα
i
subunits
Proceedings of the National Academy of
Sciences
2000
HIV-1 Tat Directly Interacts with the
Interferon-Induced, Double-Stranded
RNA-Dependent Kinase, PKR
Virology
1995
Receptor-Mediated Activation of
Heterotrimeric G-Proteins: Current
Structural Insights
Molecular Pharmacology
2007
Rgs1 regulates multiple Gα subunits in
Magnaporthe pathogenesis, asexual growth
and thigmotropism
The EMBO Journal
2007
A Human Gene Encoding a Putative Basic
Helix–Loop–Helix Phosphoprotein Whose mRNA
Increases Rapidly in Cycloheximide-Treated
Blood Mononuclear Cells
DNA and Cell Biology
1994
Activation of Phospholipase C-ε by
Heterotrimeric G Protein βγ-Subunits
Journal of Biological Chemistry
2001
Whither Goest the RGS Proteins?
Critical Reviews in Biochemistry and
Molecular Biology
1999
Mammalian Inscuteable Regulates Spindle
Orientation and Cell Fate in the
Developing Retina
Neuron
2005
Ric-8 controls Drosophila neural
progenitor asymmetric division by
regulating heterotrimeric G proteins
Nature Cell Biology
2005
Receptor-selective Effects of Endogenous
RGS3 and RGS5 to Regulate
Mitogen-activated Protein Kinase
Activation in Rat Vascular Smooth Muscle
Cells
Journal of Biological Chemistry
2002
Fidelity of G protein β-subunit
association by the G protein
γ-subunit-like domains of RGS6, RGS7, and
RGS11
Proceedings of the National Academy of
Sciences
1999
PB1 Domain Interaction of p62/Sequestosome
1 and MEKK3 Regulates NF-κB Activation
Journal of Biological Chemistry
2010
Comment on "A G Protein–Coupled Receptor
Is a Plasma Membrane Receptor for the
Plant Hormone Abscisic Acid"
Science
2007
Molecular Cloning and Expression Analysis
of RatRgs12andRgs14
Biochemical and Biophysical Research
Communications
1997
Clathrin Adaptor AP2 Regulates Thrombin
Receptor Constitutive Internalization and
Endothelial Cell Resensitization
Molecular and Cellular Biology
2006
Quantitative Analysis of the Effect of
Phosphoinositide Interactions on the
Function of Dbl Family Proteins
Journal of Biological Chemistry
2001
Telomerase-Associated Protein TEP1 Is Not
Essential for Telomerase Activity or
Telomere Length Maintenance In Vivo
Molecular and Cellular Biology
2000
Crystal structure of the multifunctional
Gβ5–RGS9 complex
Nature Structural & Molecular
Biology
2008
Structure-based Protocol for Identifying
Mutations that Enhance Protein–Protein
Binding Affinities
Journal of Molecular Biology
2007
Chronic Olanzapine Treatment Causes
Differential Expression of Genes in
Frontal Cortex of Rats as Revealed by DNA
Microarray Technique
Neuropsychopharmacology
2006
Cortical localization of the Gα protein
GPA-16 requires RIC-8 function duringC. elegansasymmetric cell division
Development
2005
Structure of Gαi1 Bound to a GDP-Selective
Peptide Provides Insight into Guanine
Nucleotide Exchange
Structure
2005
Cloning of Human Lymphocyte-Specific
Interferon Regulatory Factor
(hLSIRF/hIRF4) and Mapping of the Gene to
6p23–p25
Genomics
1996
Regulators of G-protein Signaling
accelerate GPCR signaling kinetics and
govern sensitivity solely by accelerating
GTPase activity
Proceedings of the National Academy of
Sciences
2010
Gβγ Isoforms Selectively Rescue Plasma
Membrane Localization and Palmitoylation
of Mutant Gαs and Gαq
Journal of Biological Chemistry
2001
β
2
-Adrenoceptor agonist-induced RGS2
expression is a genomic mechanism of
bronchoprotection that is enhanced by
glucocorticoids
Proceedings of the National Academy of
Sciences
2011
A Set of Human Putative Lymphocyte
G0/G1Switch Genes
Includes Genes Homologous to Rodent
Cytokine and Zinc Finger Protein-Encoding
Genes
DNA and Cell Biology
1990
Selective role for RGS12 as a Ras/Raf/MEK
scaffold in nerve growth factor-mediated
differentiation
The EMBO Journal
2007
Gα12/13- and Rho-Dependent
Activation of Phospholipase C-ϵ by
Lysophosphatidic Acid and Thrombin
Receptors
Molecular Pharmacology
2006
Exome Sequencing in 53 Sporadic Cases of
Schizophrenia Identifies 18 Putative
Candidate Genes
PLoS ONE
2014
Structural Determinants of G-protein α
Subunit Selectivity by Regulator of
G-protein Signaling 2 (RGS2)
Journal of Biological Chemistry
2009
Genome-Scale Analysis Reveals Sst2 as the
Principal Regulator of Mating Pheromone
Signaling in the Yeast
Saccharomyces cerevisiae
Eukaryotic Cell
2006
High-Affinity Immobilization of Proteins
Using Biotin- and GST-Based Coupling
Strategies
Methods in Molecular Biology
2010
Selective Regulation of N-Type Ca Channels
by Different Combinations of G-Protein β/γ
Subunits and RGS Proteins
The Journal of Neuroscience
2000
Functional relevance of the
disulfide-linked complex of the N-terminal
PDZ domain of InaD with NorpA
The EMBO Journal
2001
Guanine nucleotide dissociation inhibitor
activity of the triple GoLoco motif
protein G18: alanine-to-aspartate mutation
restores function to an inactive second
GoLoco motif
Biochemical Journal
2004
The G DIMER as a NOVEL SOURCE
of SELECTIVITY in G-Protein Signaling:
GGL-ing AT CONVENTION
Molecular Interventions
2004
Dynamic Regulation of Mammalian Numb by G
Protein-coupled Receptors and Protein
Kinase C Activation: Structural
Determinants of Numb Association with the
Cortical Membrane
Molecular Biology of the Cell
2006
D2 dopamine receptor activation of
potassium channels is selectively
decoupled by Gαi‐specific
GoLoco motif peptides
Journal of Neurochemistry
2005
G protein signaling in the parasite
Entamoeba histolytica
Experimental & Molecular
Medicine
2013
Gβ Association and Effector Interaction
Selectivities of the Divergent Gγ Subunit
Gγ13
Journal of Biological Chemistry
2001
The RGS protein inhibitor CCG-4986 is a
covalent modifier of the RGS4
Gα-interaction face
Biochimica et Biophysica Acta (BBA) -
Proteins and Proteomics
2007
Established and Emerging
Fluorescence-Based Assays for G-Protein
Function: Ras-Superfamily GTPases
Combinatorial Chemistry & High
Throughput Screening
2003
A Capture Coupling Method for the Covalent
Immobilization of Hexahistidine Tagged
Proteins for Surface Plasmon Resonance
Methods in Molecular Biology
2010
Induction of Regulator of G-Protein
Signaling 2 Expression by Long-Acting
β2-Adrenoceptor Agonists
and Glucocorticoids in Human Airway
Epithelial Cells
Journal of Pharmacology and
Experimental Therapeutics
2013
Computational Design of the Sequence and
Structure of a Protein-Binding Peptide
Journal of the American Chemical
Society
2011
Regulator of G-Protein Signaling 14
(RGS14) Is a Selective H-Ras Effector
PLoS ONE
2009
A direct fluorescence-based assay for RGS
domain GTPase accelerating activity
Analytical Biochemistry
2005
Integrating energy calculations with
functional assays to decipher the
specificity of G protein–RGS protein
interactions
Nature Structural & Molecular
Biology
2011
A Point Mutation to Gαi Selectively Blocks
GoLoco Motif Binding
Journal of Biological Chemistry
2008
The GoLoco Motif: Heralding a New Tango
Between G Protein Signaling and Cell
Division
Molecular Interventions
2002
Gα selectivity and inhibitor function of
the multiple GoLoco motif protein
GPSM2/LGN
Biochimica et Biophysica Acta (BBA) -
Molecular Cell Research
2005
Minimal Determinants for Binding Activated
Gα from the Structure of a
Gαi1−Peptide Dimer,
Biochemistry
2006
Cloning of a retinally abundant regulator
of G-protein signaling (RGS-r/RGS16):
genomic structure and chromosomal
localization of the human gene
Gene
1998
Inhibition of Dopamine Transporter
Activity by G Protein βγ Subunits
PLoS ONE
2013
The effect of RGS12 on PDGFβ receptor
signalling to p42/p44 mitogen activated
protein kinase in mammalian cells
Cellular Signalling
2006
Cooperative interaction between the
DNA-binding domains of PU.1 and IRF4
Journal of Molecular Biology
1998
Purification and In Vitro Functional
Analysis of the Arabidopsis thaliana
Regulator of G-Protein Signaling-1
Regulators of G-Protein Signaling, Part
A
2004
Covalent immobilization of
histidine-tagged proteins for surface
plasmon resonance
Analytical Biochemistry
2006
Established and Emerging
Fluorescence-Based Assays for G-Protein
Function: Heterotrimeric G-Protein Alpha
Subunits and Regulator of G-Protein
Signaling (RGS) Proteins
Combinatorial Chemistry & High
Throughput Screening
2003
A P-loop Mutation in Gα Subunits Prevents
Transition to the Active State:
Implications for G-protein Signaling in
Fungal Pathogenesis
PLoS Pathogens
2012
A High Throughput Fluorescence
Polarization Assay for Inhibitors of the
GoLoco Motif/G-alpha Interaction
Combinatorial Chemistry & High
Throughput Screening
2008
Regulator of G-protein Signaling-21
(RGS21) Is an Inhibitor of Bitter
Gustatory Signaling Found in Lingual and
Airway Epithelia
Journal of Biological Chemistry
2012
Education
University of Toronto
Ph.D., Medical Biophysics / November, 1997
Toronto, Ontario, Canada
Experience
University of North Carolina at Chapel Hill
Professor / January, 1999 — June, 2012
West Virginia University School of Medicine
E.J. Van Liere Endowed Medicine Professor and Chairman / July, 2012 — February, 2020
Chair of the Dept. of Physiology and Pharmacology
University of North Texas Health Science Center
Professor & Chair / March, 2020 — Present
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