Liam D. Hendrikse, Ph.D.
Bioinformatician at the University Health Network in Toronto, CA, specializing in computational cancer research using various sequencing modalities.
Research Expertise
About
Publications
Childhood cerebellar tumours mirror conserved fetal transcriptional programs
Nature / May 01, 2019
Vladoiu, M. C., El-Hamamy, I., Donovan, L. K., Farooq, H., Holgado, B. L., Sundaravadanam, Y., Ramaswamy, V., Hendrikse, L. D., Kumar, S., Mack, S. C., Lee, J. J. Y., Fong, V., Juraschka, K., Przelicki, D., Michealraj, A., Skowron, P., Luu, B., Suzuki, H., Morrissy, A. S., … Taylor, M. D. (2019). Childhood cerebellar tumours mirror conserved fetal transcriptional programs. Nature, 572(7767), 67–73. https://doi.org/10.1038/s41586-019-1158-7
Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma
Nature Medicine / Apr 27, 2020
Donovan, L. K., Delaidelli, A., Joseph, S. K., Bielamowicz, K., Fousek, K., Holgado, B. L., Manno, A., Srikanthan, D., Gad, A. Z., Van Ommeren, R., Przelicki, D., Richman, C., Ramaswamy, V., Daniels, C., Pallota, J. G., Douglas, T., Joynt, A. C. M., Haapasalo, J., Nor, C., … Taylor, M. D. (2020). Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma. Nature Medicine, 26(5), 720–731. https://doi.org/10.1038/s41591-020-0827-2
H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Cancer Discovery / Dec 01, 2020
Khazaei, S., De Jay, N., Deshmukh, S., Hendrikse, L. D., Jawhar, W., Chen, C. C. L., Mikael, L. G., Faury, D., Marchione, D. M., Lanoix, J., Bonneil, É., Ishii, T., Jain, S. U., Rossokhata, K., Sihota, T. S., Eveleigh, R., Lisi, V., Harutyunyan, A. S., Jung, S., … Jabado, N. (2020). H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone. Cancer Discovery, 10(12), 1968–1987. https://doi.org/10.1158/2159-8290.cd-20-0461
Identification of a Novel Gammaherpesvirus in Canada lynx (Lynx canadensis)
Viruses / Apr 20, 2019
Hendrikse, L. D., Kambli, A., Kayko, C., Canuti, M., Rodrigues, B., Stevens, B., Vashon, J., Lang, A. S., Needle, D. B., & Troyer, R. M. (2019). Identification of a Novel Gammaherpesvirus in Canada lynx (Lynx canadensis). Viruses, 11(4), 363. https://doi.org/10.3390/v11040363
MDB-07. MYC AND TGFΒ PROMOTE GROUP 3 MEDULLOBLASTOMA TUMOR RESISTANCE THROUGH DEREGULATION OF KDM2B TARGETS
Neuro-Oncology / Jun 01, 2023
Qadeer, Z., Westelman, S., Johnson, M., Grele, S., Hou, E., Hendrikse, L., Wang, L., Husain, S., Beytagh, M. C., Schmidt, C., Huang, M., Taylor, M., & Weiss, W. (2023). MDB-07. MYC AND TGFΒ PROMOTE GROUP 3 MEDULLOBLASTOMA TUMOR RESISTANCE THROUGH DEREGULATION OF KDM2B TARGETS. Neuro-Oncology, 25(Supplement_1), i62–i63. https://doi.org/10.1093/neuonc/noad073.240
MDB-21. THE OTX2-REGULATED ALTERNATIVE SPLICING LANDSCAPE CONTROLS DIFFERENTIATION AND RECONSTITUTES THE DEVELOPMENTAL ORIGINS OF GROUP 3 MEDULLOBLASTOMA
Neuro-Oncology / Jun 01, 2023
Saulnier, O., Zagozewski, J., Liang, L., Hendrikse, L. D., Gordon, V., Aldinger, K. A., Haldipur, P., Borlase, S., Coudiere-Morrison, L., Layug, P., Cai, T., Porter, C. J., Richard, S., Doble, B. W., Millen, K. J., Taylor, M. D., & Werbowetski-Ogilvie, T. E. (2023). MDB-21. THE OTX2-REGULATED ALTERNATIVE SPLICING LANDSCAPE CONTROLS DIFFERENTIATION AND RECONSTITUTES THE DEVELOPMENTAL ORIGINS OF GROUP 3 MEDULLOBLASTOMA. Neuro-Oncology, 25(Supplement_1), i66–i67. https://doi.org/10.1093/neuonc/noad073.254
DDDR-33. TARGETING TGFΒ PATHWAY DEPENDENCIES IN GROUP 3 MEDULLOBLASTOMA
Neuro-Oncology / Nov 01, 2022
Qadeer, Z., Westelman, S., Johnson, M., Grele, S., Hendrikse, L., Taylor, M., & Weiss, W. (2022). DDDR-33. TARGETING TGFΒ PATHWAY DEPENDENCIES IN GROUP 3 MEDULLOBLASTOMA. Neuro-Oncology, 24(Supplement_7), vii106–vii106. https://doi.org/10.1093/neuonc/noac209.398
Enhancement of mitochondrial function fosters B cell immune memory
Jun 22, 2022
Shukla, A., Tiwari, A., Saulnier, O., Hendrikse, L., Hall, B., Rickert, R., Taylor, M. D., Shukla, V., & Bagchi, A. (2022). Enhancement of mitochondrial function fosters B cell immune memory. https://doi.org/10.1101/2022.06.21.497040
Failure of human rhombic lip differentiation underlies medulloblastoma formation
Nature / Sep 21, 2022
Hendrikse, L. D., Haldipur, P., Saulnier, O., Millman, J., Sjoboen, A. H., Erickson, A. W., Ong, W., Gordon, V., Coudière-Morrison, L., Mercier, A. L., Shokouhian, M., Suárez, R. A., Ly, M., Borlase, S., Scott, D. S., Vladoiu, M. C., Farooq, H., Sirbu, O., Nakashima, T., … Taylor, M. D. (2022). Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature, 609(7929), 1021–1028. https://doi.org/10.1038/s41586-022-05215-w
The transcriptional landscape of Shh medulloblastoma
Nature Communications / Mar 19, 2021
Skowron, P., Farooq, H., Cavalli, F. M. G., Morrissy, A. S., Ly, M., Hendrikse, L. D., Wang, E. Y., Djambazian, H., Zhu, H., Mungall, K. L., Trinh, Q. M., Zheng, T., Dai, S., Stucklin, A. S. G., Vladoiu, M. C., Fong, V., Holgado, B. L., Nor, C., Wu, X., … Taylor, M. D. (2021). The transcriptional landscape of Shh medulloblastoma. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-21883-0
Education
University of Toronto
Ph.D., Bioinformatics / June, 2023 (anticipated)
Western University
BMSc, Biochemistry and Immunology / June, 2018
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