Tanisha Singh, PhD

Research Scientist, University of Pittsburgh, School of Medicine

Research Expertise

Neurotoxicology
MicroRNAs
Neurodegenerative diseases
Stem Cells
Mitochondrial Biology

Publications

Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration

Journal of Clinical Investigation / May 11, 2020

Jauhari, A., Baranov, S. V., Suofu, Y., Kim, J., Singh, T., Yablonska, S., Li, F., Wang, X., Oberly, P., Minnigh, M. B., Poloyac, S. M., Carlisle, D. L., & Friedlander, R. M. (2020). Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration. Journal of Clinical Investigation, 130(6), 3124–3136. https://doi.org/10.1172/jci135026

Critical role of the miR‐200 family in regulating differentiation and proliferation of neurons

Journal of Neurochemistry / Apr 21, 2015

Pandey, A., Singh, P., Jauhari, A., Singh, T., Khan, F., Pant, A. B., Parmar, D., & Yadav, S. (2015). Critical role of the miR‐200 family in regulating differentiation and proliferation of neurons. Journal of Neurochemistry, 133(5), 640–652. Portico. https://doi.org/10.1111/jnc.13089

Regulation of miR-34 Family in Neuronal Development

Molecular Neurobiology / Jan 13, 2017

Jauhari, A., Singh, T., Singh, P., Parmar, D., & Yadav, S. (2017). Regulation of miR-34 Family in Neuronal Development. Molecular Neurobiology, 55(2), 936–945. https://doi.org/10.1007/s12035-016-0359-4

Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration

Journal of Clinical Investigation / May 03, 2021

Jauhari, A., Baranov, S. V., Suofu, Y., Kim, J., Singh, T., Yablonska, S., Li, F., Wang, X., Oberly, P., Minnigh, M. B., Poloyac, S. M., Carlisle, D. L., & Friedlander, R. M. (2021). Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration. Journal of Clinical Investigation, 131(9). https://doi.org/10.1172/jci150328

Ageing at Molecular Level: Role of MicroRNAs

Biochemistry and Cell Biology of Ageing: Part III Biomedical Science / Jan 01, 2023

Yadav, S., Sarkar, S., Pandey, A., & Singh, T. (2023). Ageing at Molecular Level: Role of MicroRNAs. In Subcellular Biochemistry (pp. 195–248). Springer International Publishing. https://doi.org/10.1007/978-3-031-21410-3_9

Role of Stem Cells and Derived Exosomes as Novel Therapeutic Agents against Neuroinflammation and Stroke

Applications of Stem Cells and derived Exosomes in Neurodegenerative Disorders / Jan 01, 2023

Mirza, R. S., Rawat, N., Thakur, D., Bhardwaj, A., Gairola, S., & Singh, T. (2023). Role of Stem Cells and Derived Exosomes as Novel Therapeutic Agents against Neuroinflammation and Stroke. In Applications of Stem Cells and derived Exosomes in Neurodegenerative Disorders (pp. 193–230). Springer Nature Singapore. https://doi.org/10.1007/978-981-99-3848-3_9

Neurodevelopmental disorders and neurotoxicity: MicroRNA in focus

Journal of Chemical Neuroanatomy / Mar 01, 2022

Jauhari, A., Singh, T., & Yadav, S. (2022). Neurodevelopmental disorders and neurotoxicity: MicroRNA in focus. Journal of Chemical Neuroanatomy, 120, 102072. https://doi.org/10.1016/j.jchemneu.2022.102072

Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral sclerosis is developmentally regulated

Scientific Reports / Sep 23, 2021

Singh, T., Jiao, Y., Ferrando, L. M., Yablonska, S., Li, F., Horoszko, E. C., Lacomis, D., Friedlander, R. M., & Carlisle, D. L. (2021). Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral sclerosis is developmentally regulated. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-97928-7

Coordinated Action of miR-146a and Parkin Gene Regulate Rotenone-induced Neurodegeneration

Toxicological Sciences / May 11, 2020

Jauhari, A., Singh, T., Mishra, S., Shankar, J., & Yadav, S. (2020). Coordinated Action of miR-146a and Parkin Gene Regulate Rotenone-induced Neurodegeneration. Toxicological Sciences, 176(2), 433–445. https://doi.org/10.1093/toxsci/kfaa066

Role of microRNAs in neurodegeneration induced by environmental neurotoxicants and aging

Ageing Research Reviews / Jul 01, 2020

Singh, T., & Yadav, S. (2020). Role of microRNAs in neurodegeneration induced by environmental neurotoxicants and aging. Ageing Research Reviews, 60, 101068. https://doi.org/10.1016/j.arr.2020.101068

Correction to: Expression of miR-145 and Its Target Proteins Are Regulated by miR-29b in Differentiated Neurons

Molecular Neurobiology / Jul 03, 2019

Jauhari, A., Singh, T., & Yadav, S. (2019). Correction to: Expression of miR-145 and Its Target Proteins Are Regulated by miR-29b in Differentiated Neurons. Molecular Neurobiology, 56(9), 6664–6665. https://doi.org/10.1007/s12035-019-01686-7

Expression of miR-145 and Its Target Proteins Are Regulated by miR-29b in Differentiated Neurons

Molecular Neurobiology / Apr 04, 2018

Jauhari, A., Singh, T., & Yadav, S. (2018). Expression of miR-145 and Its Target Proteins Are Regulated by miR-29b in Differentiated Neurons. Molecular Neurobiology, 55(12), 8978–8990. https://doi.org/10.1007/s12035-018-1009-9

Differentiation Induces Dramatic Changes in miRNA Profile, Where Loss of Dicer Diverts Differentiating SH-SY5Y Cells Toward Senescence

Molecular Neurobiology / Aug 15, 2016

Jauhari, A., Singh, T., Pandey, A., Singh, P., Singh, N., Srivastava, A. K., Pant, A. B., Parmar, D., & Yadav, S. (2016). Differentiation Induces Dramatic Changes in miRNA Profile, Where Loss of Dicer Diverts Differentiating SH-SY5Y Cells Toward Senescence. Molecular Neurobiology, 54(7), 4986–4995. https://doi.org/10.1007/s12035-016-0042-9

MicroRNAs are Emerging as Most Potential Molecular Biomarkers

Biochemistry & Analytical Biochemistry / Jan 01, 2015

Abhishek, S. Y. (2015). MicroRNAs are Emerging as Most Potential Molecular Biomarkers. Biochemistry & Analytical Biochemistry, 04(03). https://doi.org/10.4172/2161-1009.1000191

Transactivation of P53 by cypermethrin induced miR-200 and apoptosis in neuronal cells

Toxicology Research / Jan 01, 2015

Pandey, A., Jauhari, A., Singh, T., Singh, P., Singh, N., Srivastava, A. K., Khan, F., Pant, A. B., Parmar, D., & Yadav, S. (2015). Transactivation of P53 by cypermethrin induced miR-200 and apoptosis in neuronal cells. Toxicology Research, 4(6), 1578–1586. https://doi.org/10.1039/c5tx00200a

Regulatory Triangle of Neurodegeneration, Adult Neurogenesis and MicroRNAs

CNS & Neurological Disorders - Drug Targets / Feb 01, 2014

Singh, T., Jauhari, A., Pandey, A., Singh, P., Pant, A., Parmar, D., & Yadav, S. (2014). Regulatory Triangle of Neurodegeneration, Adult Neurogenesis and MicroRNAs. CNS & Neurological Disorders - Drug Targets, 13(1), 96–103. https://doi.org/10.2174/18715273113126660190

Education

Babu Banarasi Das University

PhD , Registered at BBDU

Lucknow

Experience

University of Pittsburgh

Research Scientist / September, 2023Present

Postdoctoral Research Associate / October, 2017August, 2023

CSIR-Indian Institute of Toxicology Research

Women Scientist A / February, 2016September, 2017

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