Claudia Colina Prisco Ph.D.

Scientist

Research Expertise

Neuroscience
G-protein coupled Receptors
ion channels and Lactate
Molecular Medicine
Drug Discovery
Biochemistry
Cellular and Molecular Neuroscience
Cell Biology
Molecular Biology
Biophysics
Structural Biology
Parasitology
Ecology, Evolution, Behavior and Systematics
Physiology (medical)
Physiology

About

Resourceful and results-oriented Senior Biologist with 20+ years of experience in conducting groundbreaking research and leading cross-functional teams in the field of cellular biology. Proven expertise in designing and executing complex experiments, analyzing data, and interpreting results to drive scientific advancements. Adept at utilizing cutting-edge technologies and methodologies to solve challenging biological problems. Strong publication record with contributions to renowned journals. Skilled in project management, budgeting, and fostering collaborative relationships with diverse stakeholders. Seeking to leverage extensive background in the field and leadership experience to contribute to a dynamic research team focused on innovation and scientific excellence. Additionally proficient in mentoring undergraduate, graduate, postbaccalaureate and Postdoctoral fellows in Venezuela, Puerto Rico and US. Committed to driving impactful results through a combination of technical proficiency and collaborative leadership.

Publications

Amiodarone Has Intrinsic Anti-Trypanosoma cruzi Activity and Acts Synergistically with Posaconazole

Journal of Medicinal Chemistry / Jan 05, 2006

Benaim, G., Sanders, J. M., Garcia-Marchán, Y., Colina, C., Lira, R., Caldera, A. R., Payares, G., Sanoja, C., Burgos, J. M., Leon-Rossell, A., Concepcion, J. L., Schijman, A. G., Levin, M., Oldfield, E., & Urbina, J. A. (2006). Amiodarone Has Intrinsic Anti-Trypanosoma cruzi Activity and Acts Synergistically with Posaconazole. Journal of Medicinal Chemistry, 49(3), 892–899. https://doi.org/10.1021/jm050691f

Na+ entry via glutamate transporter activates the reverse Na+/Ca2+ exchange and triggers ‐induced Ca2+ release in rat cerebellar Type‐1 astrocytes

Journal of Neurochemistry / Nov 06, 2006

Rojas, H., Colina, C., Ramos, M., Benaim, G., Jaffe, E. H., Caputo, C., & DiPolo, R. (2006). Na+ entry via glutamate transporter activates the reverse Na+/Ca2+ exchange and triggers ‐induced Ca2+ release in rat cerebellar Type‐1 astrocytes. Journal of Neurochemistry, 100(5), 1188–1202. Portico. https://doi.org/10.1111/j.1471-4159.2006.04303.x

Ceramide-1-P induces Ca2+ mobilization in Jurkat T-cells by elevation of Ins(1,4,5)-P3 and activation of a store-operated calcium channel

Biochemical and Biophysical Research Communications / Oct 01, 2005

Colina, C., Flores, A., Castillo, C., Rosario Garrido, M. del, Israel, A., DiPolo, R., & Benaim, G. (2005). Ceramide-1-P induces Ca2+ mobilization in Jurkat T-cells by elevation of Ins(1,4,5)-P3 and activation of a store-operated calcium channel. Biochemical and Biophysical Research Communications, 336(1), 54–60. https://doi.org/10.1016/j.bbrc.2005.08.039

Ceramide and sphingosine have an antagonistic effect on the plasma-membrane Ca2+-ATPase from human erythrocytes

Biochemical Journal / Feb 22, 2002

COLINA, C., CERVINO, V., & BENAIM, G. (2002). Ceramide and sphingosine have an antagonistic effect on the plasma-membrane Ca2+-ATPase from human erythrocytes. Biochemical Journal, 362(2), 247–251. https://doi.org/10.1042/bj3620247

Structural basis of Na+/K+-ATPase adaptation to marine environments

Nature Structural & Molecular Biology / Apr 29, 2007

Colina, C., Rosenthal, J. J. C., DeGiorgis, J. A., Srikumar, D., Iruku, N., & Holmgren, M. (2007). Structural basis of Na+/K+-ATPase adaptation to marine environments. Nature Structural & Molecular Biology, 14(5), 427–431. https://doi.org/10.1038/nsmb1237

Regulation of Na+/K+ ATPase Transport Velocity by RNA Editing

PLoS Biology / Nov 23, 2010

Colina, C., Palavicini, J. P., Srikumar, D., Holmgren, M., & Rosenthal, J. J. C. (2010). Regulation of Na+/K+ ATPase Transport Velocity by RNA Editing. PLoS Biology, 8(11), e1000540. https://doi.org/10.1371/journal.pbio.1000540

Ceramide increase cytoplasmic Ca2+ concentration in Jurkat T cells by liberation of calcium from intracellular stores and activation of a store-operated calcium channel

Archives of Biochemistry and Biophysics / Apr 01, 2005

Colina, C., Flores, A., Rojas, H., Acosta, A., Castillo, C., Rosario Garrido, M. del, Israel, A., DiPolo, R., & Benaim, G. (2005). Ceramide increase cytoplasmic Ca2+ concentration in Jurkat T cells by liberation of calcium from intracellular stores and activation of a store-operated calcium channel. Archives of Biochemistry and Biophysics, 436(2), 333–345. https://doi.org/10.1016/j.abb.2005.02.014

Evaluation of the Presence of a Thapsigargin-Sensitive Calcium Store in Trypanosomatids Using Trypanosoma evansi as a Model

Journal of Parasitology / Oct 01, 2004

Mendoza, M., Mijares, A., Rojas, H., Colina, C., Cervino, V., DiPolo, R., & Benaim, G. (2004). Evaluation of the Presence of a Thapsigargin-Sensitive Calcium Store in Trypanosomatids Using Trypanosoma evansi as a Model. Journal of Parasitology, 90(5), 1181–1183. https://doi.org/10.1645/ge-263r

Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons

Scientific Reports / Nov 26, 2018

Colina, C., Puhl, H. L., & Ikeda, S. R. (2018). Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-35690-z

Sodium-Calcium Exchanger Modulates the L-Glutamate Cai 2+ Signalling in Type-1 Cerebellar Astrocytes

Advances in Experimental Medicine and Biology / Oct 25, 2012

Rojas, H., Colina, C., Ramos, M., Benaim, G., Jaffe, E., Caputo, C., & Di Polo, R. (2012). Sodium-Calcium Exchanger Modulates the L-Glutamate Cai 2+ Signalling in Type-1 Cerebellar Astrocytes. In Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications (pp. 267–274). Springer US. https://doi.org/10.1007/978-1-4614-4756-6_22

A systematic review of the biological mediators of fat taste and smell

Physiological Reviews / Jan 01, 2023

Jaime-Lara, R. B., Brooks, B. E., Vizioli, C., Chiles, M., Nawal, N., Ortiz-Figueroa, R. S. E., Livinski, A. A., Agarwal, K., Colina-Prisco, C., Iannarino, N., Hilmi, A., Tejeda, H. A., & Joseph, P. V. (2023). A systematic review of the biological mediators of fat taste and smell. Physiological Reviews, 103(1), 855–918. https://doi.org/10.1152/physrev.00061.2021

Retrograde signaling in injured nerve – the axon reaction revisited

Journal of Neurochemistry / Aug 08, 2006

Hanz, S., & Fainzilber, M. (2006). Retrograde signaling in injured nerve – the axon reaction revisited. Journal of Neurochemistry, 99(1), 13–19. Portico. https://doi.org/10.1111/j.1471-4159.2006.04089.x

Ceramide and sphingosine have an antagonistic effect on the plasma-membrane Ca2+-ATPase from human erythrocytes

Biochemical Journal / Feb 15, 2002

COLINA, C., CERVINO, V., & BENAIM, G. (2002). Ceramide and sphingosine have an antagonistic effect on the plasma-membrane Ca2+-ATPase from human erythrocytes. Biochemical Journal, 362(1), 247. https://doi.org/10.1042/0264-6021:3620247

Education

Universidad Central de Venezuela

Ph.D., Cell Biologist

Caracas

Experience

Kelly Services Inc

Research Clinical Assistant / July, 2021Present

Scientist / October, 2020Present

Kelly Services

Scientist / July, 2019October, 2020

Kelly Services (United States)

Scientist / February, 2014June, 2019

National Institutes of Health

Visiting Fellow / January, 2009August, 2010

University of Puerto Rico System

Visiting Fellow / August, 2005December, 2008

Universidad Central de Venezuela: Caracas, Distrito Capital, VE

Teaching Assistance / September, 1994July, 1996

Links & Social Media

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