Elvira Forte

Scientific strategist • Senior Scientist • Senior Scientific Editor

New York, New York, United States of America

Research Expertise

fibrosis
inflammation
cardiomyopathies
Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)
Developmental Biology
Molecular Biology
Biomaterials
Bioengineering
Cancer Research
Cell Biology
Molecular Medicine
Hematology
Pharmacology
Genetics
Genetics (clinical)
Pharmaceutical Science
Medical Laboratory Technology
Endocrinology, Diabetes and Metabolism
Biochemistry
Immunology and Allergy
Immunology
Computer Science Applications
Organic Chemistry
Inorganic Chemistry
single cell omics

About

Motivated and growth-driven biomedical scientist with over 15 years of experience in the cardiovascular field. Strong background in cell and molecular biology, data analysis, and interpretation. Seeking #newopportunities to deliver value as a Senior Scientist, Associate Principal Scientist, Scientific Liaison, or Scientific Consultant within a company that combines new technologies such as single-cell omics and AI for drug discovery and personalized medicine. <br> Throughout my career, I've used various in vivo and in vitro models to investigate the molecular and cellular mechanisms of fibrosis and inflammation in the heart, and how these mechanisms are affected in mice with different genetic backgrounds. My experience includes project management and mentoring. I completed three projects involving international collaborations, supervised two junior researchers, and taught cellular and molecular techniques to at least six professionals. As one of the launching editors and senior editor at Nature Cardiovascular Research, I oversaw the quality of the content published in the journal and the editorial process. I collaborated with authors, reviewers, and editors to ensure the highest standards of scientific rigor, relevance, and innovation. I also contributed to the journal's vision, strategy, and outreach, promoting the latest advances and discoveries in the cardiovascular and hematology fields. This experience has sharpened my analytical and communication skills and broadened my understanding of the field, covering a wide range of studies, from basic research to clinical, epidemiological, and public health research. My mission is to advance the knowledge and practice of cardiovascular medicine and to bridge the gap between research and clinical applications. Keywords: cardiovascular, #fibrosis, inflammation, cardioimmunology, RNA, single-cell biology, #transcriptomics, imaging, animal models, small animal surgery, and scientific writing.

Publications

Fibroblasts: Origins, definitions, and functions in health and disease

Cell / Jul 01, 2021

Plikus, M. V., Wang, X., Sinha, S., Forte, E., Thompson, S. M., Herzog, E. L., Driskell, R. R., Rosenthal, N., Biernaskie, J., & Horsley, V. (2021). Fibroblasts: Origins, definitions, and functions in health and disease. Cell, 184(15), 3852–3872. https://doi.org/10.1016/j.cell.2021.06.024

Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields

Cardiovascular Research / Feb 19, 2009

Gaetani, R., Ledda, M., Barile, L., Chimenti, I., De Carlo, F., Forte, E., Ionta, V., Giuliani, L., D’Emilia, E., Frati, G., Miraldi, F., Pozzi, D., Messina, E., Grimaldi, S., Giacomello, A., & Lisi, A. (2009). Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields. Cardiovascular Research, 82(3), 411–420. https://doi.org/10.1093/cvr/cvp067

Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction

Nature Communications / Jan 29, 2021

Tombor, L. S., John, D., Glaser, S. F., Luxán, G., Forte, E., Furtado, M., Rosenthal, N., Baumgarten, N., Schulz, M. H., Wittig, J., Rogg, E.-M., Manavski, Y., Fischer, A., Muhly-Reinholz, M., Klee, K., Looso, M., Selignow, C., Acker, T., Bibli, S.-I., … Dimmeler, S. (2021). Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-20905-1

Cardiac stem cells: isolation, expansion and experimental use for myocardial regeneration

Nature Clinical Practice Cardiovascular Medicine / Feb 01, 2007

Barile, L., Chimenti, I., Gaetani, R., Forte, E., Miraldi, F., Frati, G., Messina, E., & Giacomello, A. (2007). Cardiac stem cells: isolation, expansion and experimental use for myocardial regeneration. Nature Clinical Practice Cardiovascular Medicine, 4(S1), S9–S14. https://doi.org/10.1038/ncpcardio0738

Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice

Cell Reports / Mar 01, 2020

Forte, E., Skelly, D. A., Chen, M., Daigle, S., Morelli, K. A., Hon, O., Philip, V. M., Costa, M. W., Rosenthal, N. A., & Furtado, M. B. (2020). Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice. Cell Reports, 30(9), 3149-3163.e6. https://doi.org/10.1016/j.celrep.2020.02.008

The interstitium in cardiac repair: role of the immune–stromal cell interplay

Nature Reviews Cardiology / Sep 04, 2018

Forte, E., Furtado, M. B., & Rosenthal, N. (2018). The interstitium in cardiac repair: role of the immune–stromal cell interplay. Nature Reviews Cardiology, 15(10), 601–616. https://doi.org/10.1038/s41569-018-0077-x

Developmental origin and lineage plasticity of endogenous cardiac stem cells

Development / Apr 15, 2016

Santini, M. P., Forte, E., Harvey, R. P., & Kovacic, J. C. (2016). Developmental origin and lineage plasticity of endogenous cardiac stem cells. Development, 143(8), 1242–1258. https://doi.org/10.1242/dev.111591

Human cardiosphere-seeded gelatin and collagen scaffolds as cardiogenic engineered bioconstructs

Biomaterials / Dec 01, 2011

Chimenti, I., Rizzitelli, G., Gaetani, R., Angelini, F., Ionta, V., Forte, E., Frati, G., Schussler, O., Barbetta, A., Messina, E., Dentini, M., & Giacomello, A. (2011). Human cardiosphere-seeded gelatin and collagen scaffolds as cardiogenic engineered bioconstructs. Biomaterials, 32(35), 9271–9281. https://doi.org/10.1016/j.biomaterials.2011.08.049

EMT/MET at the Crossroad of Stemness, Regeneration and Oncogenesis: The Ying-Yang Equilibrium Recapitulated in Cell Spheroids

Cancers / Jul 29, 2017

Forte, E., Chimenti, I., Rosa, P., Angelini, F., Pagano, F., Calogero, A., Giacomello, A., & Messina, E. (2017). EMT/MET at the Crossroad of Stemness, Regeneration and Oncogenesis: The Ying-Yang Equilibrium Recapitulated in Cell Spheroids. Cancers, 9(12), 98. https://doi.org/10.3390/cancers9080098

Isolation and Expansion of Adult Cardiac Stem/Progenitor Cells in the Form of Cardiospheres from Human Cardiac Biopsies and Murine Hearts

Somatic Stem Cells / Jan 01, 2012

Chimenti, I., Gaetani, R., Barile, L., Forte, E., Ionta, V., Angelini, F., Frati, G., Messina, E., & Giacomello, A. (2012). Isolation and Expansion of Adult Cardiac Stem/Progenitor Cells in the Form of Cardiospheres from Human Cardiac Biopsies and Murine Hearts. In Methods in Molecular Biology (pp. 327–338). Humana Press. https://doi.org/10.1007/978-1-61779-815-3_19

Developmental origins and lineage descendants of endogenous adult cardiac progenitor cells

Stem Cell Research / Nov 01, 2014

Chong, J. J. H., Forte, E., & Harvey, R. P. (2014). Developmental origins and lineage descendants of endogenous adult cardiac progenitor cells. Stem Cell Research, 13(3), 592–614. https://doi.org/10.1016/j.scr.2014.09.008

Serum and supplement optimization for EU GMP‐compliance in cardiospheres cell culture

Journal of Cellular and Molecular Medicine / Jan 20, 2014

Chimenti, I., Gaetani, R., Forte, E., Angelini, F., De Falco, E., Zoccai, G. B., Messina, E., Frati, G., & Giacomello, A. (2014). Serum and supplement optimization for <scp>EU GMP</scp>‐compliance in cardiospheres cell culture. Journal of Cellular and Molecular Medicine, 18(4), 624–634. Portico. https://doi.org/10.1111/jcmm.12210

Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart

Circulation / Feb 23, 2021

Forte, E., Perkins, B., Sintou, A., Kalkat, H. S., Papanikolaou, A., Jenkins, C., Alsubaie, M., Chowdhury, R. A., Duffy, T. M., Skelly, D. A., Branca, J., Bellahcene, M., Schneider, M. D., Harding, S. E., Furtado, M. B., Ng, F. S., Hasham, M. G., Rosenthal, N., & Sattler, S. (2021). Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart. Circulation, 143(8), 821–836. https://doi.org/10.1161/circulationaha.120.044581

Cardiospheres and tissue engineering for myocardial regeneration: potential for clinical application

Journal of Cellular and Molecular Medicine / May 01, 2010

Gaetani, R., Rizzitelli, G., Chimenti, I., Barile, L., Forte, E., Ionta, V., Angelini, F., Sluijter, J. P. G., Barbetta, A., Messina, E., & Frati, G. (2010). Cardiospheres and tissue engineering for myocardial regeneration: potential for clinical application. Journal of Cellular and Molecular Medicine, no-no. https://doi.org/10.1111/j.1582-4934.2010.01078.x

TGFβ-Dependent Epithelial-to-Mesenchymal Transition Is Required to Generate Cardiospheres from Human Adult Heart Biopsies

Stem Cells and Development / Nov 20, 2012

Forte, E., Miraldi, F., Chimenti, I., Angelini, F., Zeuner, A., Giacomello, A., Mercola, M., & Messina, E. (2012). TGFβ-Dependent Epithelial-to-Mesenchymal Transition Is Required to Generate Cardiospheres from Human Adult Heart Biopsies. Stem Cells and Development, 21(17), 3081–3090. https://doi.org/10.1089/scd.2012.0277

Different types of cultured human adult Cardiac Progenitor Cells have a high degree of transcriptome similarity

Journal of Cellular and Molecular Medicine / Oct 14, 2014

Gaetani, R., Feyen, D. A. M., Doevendans, P. A., Gremmels, H., Forte, E., Fledderus, J. O., Ramjankhan, F. Z., Messina, E., Sussman, M. A., Giacomello, A., & Sluijter, J. P. G. (2014). Different types of cultured human adult Cardiac Progenitor Cells have a high degree of transcriptome similarity. Journal of Cellular and Molecular Medicine, 18(11), 2147–2151. Portico. https://doi.org/10.1111/jcmm.12458

Cardiac Cell Therapy: The Next (Re)Generation

Stem Cell Reviews and Reports / Mar 25, 2011

Forte, E., Chimenti, I., Barile, L., Gaetani, R., Angelini, F., Ionta, V., Messina, E., & Giacomello, A. (2011). Cardiac Cell Therapy: The Next (Re)Generation. Stem Cell Reviews and Reports, 7(4), 1018–1030. https://doi.org/10.1007/s12015-011-9252-8

Bone marrow‐derived cells can acquire cardiac stem cells properties in damaged heart

Journal of Cellular and Molecular Medicine / Jan 01, 2011

Barile, L., Cerisoli, F., Frati, G., Gaetani, R., Chimenti, I., Forte, E., Cassinelli, L., Spinardi, L., Altomare, C., Kizana, E., Giacomello, A., Messina, E., Ottolenghi, S., & Magli, M. C. (2011). Bone marrow‐derived cells can acquire cardiac stem cells properties in damaged heart. Journal of Cellular and Molecular Medicine, 15(1), 63–71. Portico. https://doi.org/10.1111/j.1582-4934.2009.00968.x

New Perspectives to Repair a Broken Heart

Cardiovascular & Hematological Agents in Medicinal Chemistry / Apr 01, 2009

Gaetani, R., Barile, L., Forte, E., Chimenti, I., Ionta, V., Di Consiglio, A., Miraldi, F., Frati, G., Messina, E., & Giacomello, A. (2009). New Perspectives to Repair a Broken Heart. Cardiovascular &amp; Hematological Agents in Medicinal Chemistry, 7(2), 91–107. https://doi.org/10.2174/187152509787847128

A Chemical Biology Approach to Myocardial Regeneration

Journal of Cardiovascular Translational Research / Mar 22, 2011

Willems, E., Lanier, M., Forte, E., Lo, F., Cashman, J., & Mercola, M. (2011). A Chemical Biology Approach to Myocardial Regeneration. Journal of Cardiovascular Translational Research, 4(3), 340–350. https://doi.org/10.1007/s12265-011-9270-6

Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart

Journal of Cellular and Molecular Medicine / Nov 29, 2020

Forte, E., Panahi, M., Baxan, N., Ng, F. S., Boyle, J. J., Branca, J., Bedard, O., Hasham, M. G., Benson, L., Harding, S. E., Rosenthal, N., & Sattler, S. (2020). Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart. Journal of Cellular and Molecular Medicine, 25(1), 229–243. Portico. https://doi.org/10.1111/jcmm.15937

From Ontogenesis to Regeneration

Progress in Molecular Biology and Translational Science / Jan 01, 2012

Chimenti, I., Forte, E., Angelini, F., Giacomello, A., & Messina, E. (2012). From Ontogenesis to Regeneration. In Genetics of Stem Cells, Part A (pp. 109–137). Elsevier. https://doi.org/10.1016/b978-0-12-398459-3.00005-8

PDGFRα signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair

Nov 28, 2017

Asli, N. S., Xaymardan, M., Patrick, R., Farbehi, N., Cornwell, J., Forte, E., Waardenberg, A. J., Janbandhu, V., Kesteven, S., Chandrakanthan, V., Malinowska, H., Reinhard, H., Schofield, P., Christ, D., Ahmed, I., Bouveret, R., Srivastava, S., Mishra, R. K., Dhawan, J., … Harvey, R. P. (2017). PDGFRα signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair. https://doi.org/10.1101/225979

Adult mouse fibroblasts retain organ-specific transcriptomic identity

eLife / Mar 16, 2022

Forte, E., Ramialison, M., Nim, H. T., Mara, M., Li, J. Y., Cohn, R., Daigle, S. L., Boyd, S., Stanley, E. G., Elefanty, A. G., Hinson, J. T., Costa, M. W., Rosenthal, N. A., & Furtado, M. B. (2022). Adult mouse fibroblasts retain organ-specific transcriptomic identity. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.71008

Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease

Molecular Metabolism / Feb 01, 2019

Wilmanns, J. C., Pandey, R., Hon, O., Chandran, A., Schilling, J. M., Forte, E., Wu, Q., Cagnone, G., Bais, P., Philip, V., Coleman, D., Kocalis, H., Archer, S. K., Pearson, J. T., Ramialison, M., Heineke, J., Patel, H. H., Rosenthal, N. A., Furtado, M. B., & Costa, M. W. (2019). Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease. Molecular Metabolism, 20, 102–114. https://doi.org/10.1016/j.molmet.2018.11.002

Continuous Subcutaneous Insulin Infusion in Italy: Third National Survey

Diabetes Technology & Therapeutics / Feb 01, 2015

Bruttomesso, D., Laviola, L., Lepore, G., Bonfanti, R., Bozzetto, L., Corsi, A., Di Blasi, V., Girelli, A., Grassi, G., Iafusco, D., Rabbone, I., & Schiaffini, R. (2015). Continuous Subcutaneous Insulin Infusion in Italy: Third National Survey. Diabetes Technology &amp; Therapeutics, 17(2), 96–104. https://doi.org/10.1089/dia.2014.0242

Biochemistry and biology: Heart-to-heart to investigate cardiac progenitor cells

Biochimica et Biophysica Acta (BBA) - General Subjects / Feb 01, 2013

Chimenti, I., Forte, E., Angelini, F., Messina, E., & Giacomello, A. (2013). Biochemistry and biology: Heart-to-heart to investigate cardiac progenitor cells. Biochimica et Biophysica Acta (BBA) - General Subjects, 1830(2), 2459–2469. https://doi.org/10.1016/j.bbagen.2012.08.004

Editorial: Fibrosis and Inflammation in Tissue Pathophysiology

Frontiers in Physiology / Jan 21, 2022

Chimenti, I., Sattler, S., del Monte-Nieto, G., & Forte, E. (2022). Editorial: Fibrosis and Inflammation in Tissue Pathophysiology. Frontiers in Physiology, 12. https://doi.org/10.3389/fphys.2021.830683

Evidence for the Existence of Resident Cardiac Stem Cells

Regenerating the Heart / Jan 01, 2011

Chimenti, I., Gaetani, R., Barile, L., Forte, E., Ionta, V., Angelini, F., Messina, E., & Giacomello, A. (2011). Evidence for the Existence of Resident Cardiac Stem Cells. In Regenerating the Heart (pp. 131–147). Humana Press. https://doi.org/10.1007/978-1-61779-021-8_9

Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction

European Heart Journal / Nov 01, 2020

Tombor, L., John, D., Glaser, S. F., Luxan, G., Forte, E., Furtado, M., Rosenthal, N., Manavski, Y., Fischer, A., Muhly-Reinholz, M., Looso, M., Acker, T., Harvey, R., Abplanalp, A., & Dimmeler, S. (2020). Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. European Heart Journal, 41(Supplement_2). https://doi.org/10.1093/ehjci/ehaa946.3736

Protocol for Isolation of Cardiac Interstitial Cells from Adult Murine Hearts for Unbiased Single Cell Profiling

STAR Protocols / Sep 01, 2020

Forte, E., Daigle, S., & Rosenthal, N. A. (2020). Protocol for Isolation of Cardiac Interstitial Cells from Adult Murine Hearts for Unbiased Single Cell Profiling. STAR Protocols, 1(2), 100077. https://doi.org/10.1016/j.xpro.2020.100077

Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19

Nature Communications / Jul 25, 2023

Robertson, S. J., Bedard, O., McNally, K. L., Shaia, C., Clancy, C. S., Lewis, M., Broeckel, R. M., Chiramel, A. I., Shannon, J. G., Sturdevant, G. L., Rosenke, R., Anzick, S. L., Forte, E., Preuss, C., Baker, C. N., Harder, J. M., Brunton, C., Munger, S., Bruno, D. P., … Best, S. M. (2023). Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-40076-5

Circulating spike protein may contribute to myocarditis after COVID-19 vaccination

Nature Cardiovascular Research / Feb 08, 2023

Forte, E. (2023). Circulating spike protein may contribute to myocarditis after COVID-19 vaccination. Nature Cardiovascular Research, 2(2), 100–100. https://doi.org/10.1038/s44161-023-00222-0

Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19

Sep 18, 2021

Robertson, S. J., Bedard, O., McNally, K. L., Shaia, C., Clancy, C., Lewis, M., Broeckel, R. M., Chiramel, A. I., Shannon, J. G., Sturdevant, G. L., Rosenke, R., Anzick, S. L., Forte, E., Preuss, C., Baker, C. N., Harder, J., Brunton, C., Munger, S., Bruno, D. P., … Best, S. M. (2021). Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19. https://doi.org/10.1101/2021.09.17.460664

Adult fibroblasts retain organ-specific transcriptomic identity

Jun 04, 2021

Forte, E., Ramialison, M., Nim, H. T., Mara, M., Cohn, R., Daigle, S. L., Boyd, S., Hinson, J. T., Costa, M. W., Rosenthal, N. A., & Furtado, M. B. (2021). Adult fibroblasts retain organ-specific transcriptomic identity. https://doi.org/10.1101/2021.06.03.446915

Myocardial damage induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart

Feb 27, 2020

Forte, E., Panahi, M., Ng, F. S., Boyle, J. J., Branca, J., Bedard, O., Hasham, M. G., Benson, L., Harding, S. E., Rosenthal, N., & Sattler, S. (2020). Myocardial damage induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart. https://doi.org/10.1101/2020.02.27.962696

HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic Mice

The Journal of Immunology / Dec 15, 2023

Racine, J. J., Misherghi, A., Dwyer, J. R., Maser, R., Forte, E., Bedard, O., Sattler, S., Pugliese, A., Landry, L., Elso, C., Nakayama, M., Mannering, S., Rosenthal, N., & Serreze, D. V. (2023). HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic Mice. The Journal of Immunology, 211(12), 1792–1805. https://doi.org/10.4049/jimmunol.2300303

Recruited macrophages are a potential therapeutic target in atrial fibrillation

Nature Cardiovascular Research / Aug 07, 2023

Forte, E. (2023). Recruited macrophages are a potential therapeutic target in atrial fibrillation. Nature Cardiovascular Research, 2(8), 715–715. https://doi.org/10.1038/s44161-023-00321-y

A cell-intrinsic regulator of emergency hematopoiesis

Nature Cardiovascular Research / Jan 10, 2023

Forte, E. (2023). A cell-intrinsic regulator of emergency hematopoiesis. Nature Cardiovascular Research, 2(1), 8–8. https://doi.org/10.1038/s44161-022-00207-5

The multifaceted effect of efferocytosis on cardiac repair after infarction

Nature Cardiovascular Research / Apr 04, 2022

Forte, E. (2022). The multifaceted effect of efferocytosis on cardiac repair after infarction. Nature Cardiovascular Research, 1(4), 283–283. https://doi.org/10.1038/s44161-022-00054-4

Ex uno, plures–From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology

International Journal of Molecular Sciences / Feb 19, 2021

Forte, E., McLellan, M. A., Skelly, D. A., & Rosenthal, N. A. (2021). Ex uno, plures–From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology. International Journal of Molecular Sciences, 22(4), 2071. https://doi.org/10.3390/ijms22042071

Cardiac stem cells can be generated in damaged heart from bone marrow-derived cells

Journal of Molecular and Cellular Cardiology / Jun 01, 2007

Barile, L., Cerisoli, F., Gaetani, R., Forte, E., Ottolenghi, S., Magli, M. C., & Messina, E. (2007). Cardiac stem cells can be generated in damaged heart from bone marrow-derived cells. Journal of Molecular and Cellular Cardiology, 42(6), S100. https://doi.org/10.1016/j.yjmcc.2007.03.220

Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti–PD-1 Immune Checkpoint Inhibitor Cancer Therapy

The Journal of Immunology / Mar 01, 2024

Racine, J. J., Bachman, J. F., Zhang, J.-G., Misherghi, A., Khadour, R., Kaisar, S., Bedard, O., Jenkins, C., Abbott, A., Forte, E., Rainer, P., Rosenthal, N., Sattler, S., & Serreze, D. V. (2024). Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti–PD-1 Immune Checkpoint Inhibitor Cancer Therapy. The Journal of Immunology, 212(8), 1287–1306. https://doi.org/10.4049/jimmunol.2300841

Abnormal complement activation is a sign of long COVID

Nature Cardiovascular Research / Feb 07, 2024

Forte, E. (2024). Abnormal complement activation is a sign of long COVID. Nature Cardiovascular Research, 3(2), 95–95. https://doi.org/10.1038/s44161-024-00434-y

The leading example of the Leducq Foundation

Nature Cardiovascular Research / Jan 17, 2024

Forte, E. (2024). The leading example of the Leducq Foundation. Nature Cardiovascular Research, 3(1), 4–7. https://doi.org/10.1038/s44161-023-00406-8

Patisiran improves quality of life in patients with ATTR cardiac amyloidosis

Nature Cardiovascular Research / Nov 29, 2023

Forte, E. (2023). Patisiran improves quality of life in patients with ATTR cardiac amyloidosis. Nature Cardiovascular Research, 2(12), 1101–1101. https://doi.org/10.1038/s44161-023-00399-4

Scar fibroblasts affect cardiac excitability

Nature Cardiovascular Research / Oct 23, 2023

Forte, E. (2023). Scar fibroblasts affect cardiac excitability. Nature Cardiovascular Research, 2(11), 959–959. https://doi.org/10.1038/s44161-023-00366-z

Particulate matter pollution and cardiovascular health

Nature Cardiovascular Research / Oct 09, 2023

Forte, E. (2023). Particulate matter pollution and cardiovascular health. Nature Cardiovascular Research, 2(10), 855–857. https://doi.org/10.1038/s44161-023-00342-7

A cardiac dyad component controls cardiomyocytes maturation in regenerative hearts

Nature Cardiovascular Research / Jun 07, 2023

Forte, E. (2023). A cardiac dyad component controls cardiomyocytes maturation in regenerative hearts. Nature Cardiovascular Research, 2(6), 491–491. https://doi.org/10.1038/s44161-023-00292-0

Gene-edited cardiomyocytes to prevent engraftment arrhythmias

Nature Cardiovascular Research / May 03, 2023

Forte, E. (2023). Gene-edited cardiomyocytes to prevent engraftment arrhythmias. Nature Cardiovascular Research, 2(5), 417–417. https://doi.org/10.1038/s44161-023-00273-3

BeNeDuctus trial supports expectant management of PDA

Nature Cardiovascular Research / Apr 06, 2023

Forte, E. (2023). BeNeDuctus trial supports expectant management of PDA. Nature Cardiovascular Research, 2(4), 337–337. https://doi.org/10.1038/s44161-023-00263-5

A liver-secreted coagulation factor protects against heart dysfunction

Nature Cardiovascular Research / Oct 26, 2022

Forte, E. (2022). A liver-secreted coagulation factor protects against heart dysfunction. Nature Cardiovascular Research, 1(11), 971–971. https://doi.org/10.1038/s44161-022-00167-w

CD69 as a potential prognostic marker for heart failure

Nature Cardiovascular Research / Oct 03, 2022

Forte, E. (2022). CD69 as a potential prognostic marker for heart failure. Nature Cardiovascular Research, 1(10), 869–869. https://doi.org/10.1038/s44161-022-00149-y

Visualization and targeting of the cardiac conduction system

Nature Cardiovascular Research / Sep 13, 2022

Forte, E. (2022). Visualization and targeting of the cardiac conduction system. Nature Cardiovascular Research, 1(9), 792–792. https://doi.org/10.1038/s44161-022-00135-4

Missing the Y in cardiac fibrosis

Nature Cardiovascular Research / Aug 11, 2022

Forte, E. (2022). Missing the Y in cardiac fibrosis. Nature Cardiovascular Research, 1(8), 696–696. https://doi.org/10.1038/s44161-022-00122-9

Tracing the source of blood cells

Nature Cardiovascular Research / Jul 07, 2022

Forte, E. (2022). Tracing the source of blood cells. Nature Cardiovascular Research, 1(7), 605–605. https://doi.org/10.1038/s44161-022-00106-9

The single-cell footprints of coronary artery disease progression

Nature Cardiovascular Research / Jun 08, 2022

Forte, E. (2022). The single-cell footprints of coronary artery disease progression. Nature Cardiovascular Research, 1(6), 545–545. https://doi.org/10.1038/s44161-022-00089-7

Rilzabrutinib for immune thrombocytopenia

Nature Cardiovascular Research / May 11, 2022

Forte, E. (2022). Rilzabrutinib for immune thrombocytopenia. Nature Cardiovascular Research, 1(5), 416–416. https://doi.org/10.1038/s44161-022-00076-y

Net fishing for de novo variants in congenital heart disease

Nature Cardiovascular Research / Mar 07, 2022

Forte, E. (2022). Net fishing for de novo variants in congenital heart disease. Nature Cardiovascular Research, 1(3), 195–195. https://doi.org/10.1038/s44161-022-00040-w

How sex matters to aortic valves

Nature Cardiovascular Research / Feb 11, 2022

Forte, E. (2022). How sex matters to aortic valves. Nature Cardiovascular Research, 1(2), 107–107. https://doi.org/10.1038/s44161-022-00024-w

Response by Forte and Sattler to Letter Regarding Article, “Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart”

Circulation / Aug 03, 2021

Forte, E., & Sattler, S. (2021). Response by Forte and Sattler to Letter Regarding Article, “Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart.” Circulation, 144(5). https://doi.org/10.1161/circulationaha.121.055584

Abstract 704: Profiling Differential Response to Myocardial Infarction by Single Cell Analysis of the Cardiac Interstitium

Circulation Research / Aug 02, 2019

Forte, E. (2019). Abstract 704: Profiling Differential Response to Myocardial Infarction by Single Cell Analysis of the Cardiac Interstitium. Circulation Research, 125(Suppl_1). https://doi.org/10.1161/res.125.suppl_1.704

Abstract 12: Physiological Role of Endogenous Adult Cardiac Colony-forming Unit Fibroblasts

Circulation Research / Jul 17, 2015

Forte, E., Janbandhu, V., Asli, N. S., Cornwell, J., Abeygunawardena, D., Xaymardan, M., & Harvey, R. P. (2015). Abstract 12: Physiological Role of Endogenous Adult Cardiac Colony-forming Unit Fibroblasts. Circulation Research, 117(suppl_1). https://doi.org/10.1161/res.117.suppl_1.12

Education

Sapienza University of Rome

PhD, Pasteurian Sciences / January, 2011

Rome

Sapienza University of Rome

Master, Medical, Molecular and Cellular Biotechnology / October, 2006

Rome

Sapienza University of Rome

Bachelor, Biotechnology / October, 2004

Rome

Experience

Springer Nature

Associate/Senior Editor / June, 2021February, 2024

Helped shape and launch a new journal, Nature Cardiovascular Research, which publishes exceptional advances in the fields of cardiac, vascular, and blood biology, covering fundamental, translational, clinical, and public health research. • Assessed the novelty and impact of manuscripts within all the topics covered by the journal and chaperoned the whole revision process until acceptance for over 40% of all the content published by the journal since its start, with optimal processing times and excellent feedback from the authors. • Interfaced with scientists around the World, provided scientific guidance on how to improve manuscripts, or recommended more appropriate journals to publish with. Commissioned Comments, Reviews, News and Views on current topics, and summarized novel scientific findings in meaningful snippets and Research Highlights. • Contributed to the training and supervision of 2 Associate Editors; covered the Chief Editor's functions when needed.

Research Fellow/Associate Research Scientist / January, 2017June, 2021

• Analyzed the dynamic cellular changes during the fibrotic repair post-myocardial infarction, using cutting-edge techniques such as single-cell RNAseq with 10xChromium. Learned how to perform myocardial infarction in mice and assess the cardiac function via echography; analyze scRNAseq data using the Seurat package on R studio. • Completed a project aimed to characterize similarities and differences among fibroblasts from different organs cultured in the same conditions. Through cytometric, transcriptomic analysis, functional assays, shRNA and CRISPR-Cas9-mediated in vitro gene knockdowns we showed that fibroblasts isolated from different organs retain the expression of key transcription factors reflecting their embryological origin. • Collaborated with other laboratories in the Institute to design new mice models that could possibly recapitulate the symptoms of COVID-19; to analyze the response of mice with diverse genetic backgrounds to stressors.

Post-doctoral fellow/ Co-joint lecturer / May, 2013November, 2016

Developed projects aimed at understanding the embryological origin and function of a population of putative progenitor cells, cardiac colony forming unit fibroblasts cCFU-F, identified 2 years before in the lab (PMID: 22136928). • Performed cell lineage tracing and designed in vitro and in vivo cellular assays to assess the functional and immunomodulatory properties of PDGFRa+ fibroblasts in homeostasis and post-myocardial infarction with or without treatment with the PDGF-AB ligands. The data, presented in 3 international conferences and included in a preprint manuscript, have supported the use of a short-term treatment with PDGF-AB in a preclinical model of acute myocardial infarction in pigs. • Co-supervised 2 Ph.D. students at University of New South Wales

Scientific Editor / March, 2024Present

Consultant freelancer position within a team of former journal editors and grants specialists • Helped scientists increase the impact of their science by providing advice, in-depth editing, and feedback on manuscripts.

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