Shariq Usmani, PhD

Massachusetts General Hospital, Harvard Medical School

Boston, Massachusetts, United States of America

Research Expertise

Microbiology
Virology
Immunology
Molecular Biology
Genetics
Biochemistry
Analytical Chemistry
Infectious Diseases
Physiology
Immunology and Allergy

About

Dr. Shariq Usmani is scientific director at Cabaletta bio, a leader in cell therapy for autoimmune diseases (https://www.cabalettabio.com). He leads a research team in preclinical R&D organization at Cabaletta bio. He directly manage a talented group of Senior Scientists, Scientists and Research Associates to spearhead and drive innovation in cell therapies and biologics in autoimmune disease indications. <br> He is also serves as consultant at Zohdan Bio, where he provides strategic support for preclinical R&D programs focused on gene therapy, genome editing, and virology. With a deep foundation in oncology and biologics, Dr. Usmani has led groundbreaking work in both academia and industry, including his tenures at Sana Biotechnology, Harvard Medical School and Massachusetts General Hospital. He's led and spearheaded the development of innovative in vivo genome editing platforms, optimized viral vectors, and engineered cutting-edge reporter assays.

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Publications

Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy
Nature
2019
Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses
Nature Nanotechnology
2013
Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen
Nature Communications
2014
Nef Proteins of Epidemic HIV-1 Group O Strains Antagonize Human Tetherin
Cell Host & Microbe
2014
Human Tetherin Exerts Strong Selection Pressure on the HIV-1 Group N Vpu Protein
PLoS Pathogens
2012
A molecular tweezer antagonizes seminal amyloids and HIV infection
eLife
2015
Semen amyloids participate in spermatozoa selection and clearance
eLife
2017
Liquefaction of Semen Generates and Later Degrades a Conserved Semenogelin Peptide That Enhances HIV Infection
Journal of Virology
2014
Bone degradation machinery of osteoclasts: An HIV-1 target that contributes to bone loss
Proceedings of the National Academy of Sciences
2018
Efficient Nef-Mediated Downmodulation of TCR-CD3 and CD28 Is Associated with High CD4 + T Cell Counts in Viremic HIV-2 Infection
Journal of Virology
2012
Reacquisition of Nef-Mediated Tetherin Antagonism in a Single In Vivo Passage of HIV-1 through Its Original Chimpanzee Host
Cell Host & Microbe
2012
DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs
JCI Insight
2017
Atomic force microscopy of microvillous cell surface dynamics at fixed and living alveolar type II cells
Analytical and Bioanalytical Chemistry
2010
HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission
Cell Host & Microbe
2019
The efficiency of Vpx-mediated SAMHD1 antagonism does not correlate with the potency of viral control in HIV-2-infected individuals
Retrovirology
2013
Molecular basis of early epithelial response to streptococcal exotoxin: role of STIM1 and Orai1 proteins
Cellular Microbiology
2011
2-APB and Capsazepine-induced Ca<sup>2+</sup> Influx Stimulates Clathrin-dependent Endocytosis in Alveolar Epithelial Cells
Cellular Physiology and Biochemistry
2010
Lentiviral Nef Proteins Manipulate T Cells in a Subset-Specific Manner
Journal of Virology
2015
Plasma Membrane Trafficking in Alveolar Type II Cells
Cellular Physiology and Biochemistry
2010
Cancer cells relax and resist cytotoxic attack
Immunity
2021
HIV-enhancing Amyloids Are Prevalent in Fresh Semen and Are a Determinant for Semen's Ability to Enhance HIV Infection: Relevance for HIV Transmission
AIDS Research and Human Retroviruses
2014
Intravital Microscopy
Molecular Imaging
2021

Education

University of Konstanz

PhD, Molecular and Cell Biology / May, 2011

Konstanz

Harvard University

Postdoctoral fellow, Virology/Immunology / 2019

Cambridge, Massachusetts, United States of America

Experience

Cabaletta Bio

Scientific Director / 2024Present

I lead a research team in the preclinical R&D organization at Cabaletta bio. I directly manage a talented group of Senior Scientists, Scientists and Research Associates to spearhead and drive innovation in cell therapies and biologics in autoimmune disease indications.

Sana Biotechnology

Principal Scientist / 20222023

As a team lead, I led efforts to establish in vivo genome editing platform, vector design/engineering and optimization, with a broader goal to develop innovative and effective genomic medicine for unmet medical needs.

Zohdan Bio

Consultant / 2024Present

Providing strategic support for all aspects of preclinical, R&D programs in gene therapy, genome editing and virology and immunology space.

Massachusetts General Hospital

Senior Staff Scientist / 20192022

Principal Investigator on an NIH funded grant award to study virus-immune interaction and immune evasion mechanisms. I directed all project aspects including planning, writing, finance/budgeting, and supervision and mentoring of direct reports. Developed a novel multiphoton intravital imaging platform to study virus-immune cell interactions in vivo in lymphoid and mucosal tissues during acute stages of HIV infection.

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