Vishal Kothari

Principal Scientist- Immuno-Oncology Pliant Therapeutics

Research Expertise

molecular biology
cancer
Cancer Research
Oncology
Urology
Pharmacology (medical)
Radiology, Nuclear Medicine and imaging
Endocrinology, Diabetes and Metabolism
Histology
Physiology
Surgery
Otorhinolaryngology
Radiation

About

Passionate team leader with a successful record of advancing therapeutic candidates from **discovery to FIH studies**. Extensive experience in **oncology,** **immune-oncology**, **discovery biology, drug discovery, assay development, biomarker discovery, translational research,** small molecule pharmacology, and functional genomics.

Legacy Map

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Publications

Faculty Opinions recommendation of Genomic hallmarks of localized, non-indolent prostate cancer.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
2018
Expressed Pseudogenes in the Transcriptional Landscape of Human Cancers
Cell
2012
The Long Non-Coding RNA PCAT-1 Promotes Prostate Cancer Cell Proliferation through cMyc
Neoplasia
2014
Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors
Cancer Discovery
2017
DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis
Cancer Cell
2015
Genomic Drivers of Poor Prognosis and Enzalutamide Resistance in Metastatic Castration-resistant Prostate Cancer
European Urology
2019
Maternal Embryonic Leucine Zipper Kinase (MELK) as a Novel Mediator and Biomarker of Radioresistance in Human Breast Cancer
Clinical Cancer Research
2016
MDM2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Ablation and Radiotherapy in a p53-Dependent Manner
Neoplasia
2016
Androgen receptor as a mediator and biomarker of radioresistance in triple-negative breast cancer
npj Breast Cancer
2017
The Landscape of Prognostic Outlier Genes in High-Risk Prostate Cancer
Clinical Cancer Research
2016
Patient-Level DNA Damage and Repair Pathway Profiles and Prognosis After Prostatectomy for High-Risk Prostate Cancer
JAMA Oncology
2016
Outlier Kinase Expression by RNA Sequencing as Targets for Precision Therapy
Cancer Discovery
2013
KRAS Engages AGO2 to Enhance Cellular Transformation
Cell Reports
2016
Cellular and molecular mechanisms of accelerated fracture healing by COX2 gene therapy
Bone
2013
Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies
Clinical Cancer Research
2019
HDAC inhibitor valproic acid enhances tumor cell kill in adenovirus‐HSVtk mediated suicide gene therapy in HNSCC xenograft mouse model
International Journal of Cancer
2009
Antisense Inhibition of Cyclin D1 in Human Head and Neck Squamous Cell Carcinoma
Archives of Otolaryngology–Head & Neck Surgery
2000
CDKN1B Deletions are Associated with Metastasis in African American Men with Clinically Localized, Surgically Treated Prostate Cancer
Clinical Cancer Research
2020
DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway
Clinical Cancer Research
2019
A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer
Clinical Cancer Research
2022
A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host
Oncotarget
2019
High-throughput transcriptomic analysis nominates proteasomal genes as age-specific biomarkers and therapeutic targets in prostate cancer
Prostate Cancer and Prostatic Diseases
2015
Driven to metastasize: Kinases as potential therapeutic targets in prostate cancer
Proceedings of the National Academy of Sciences
2016
DNA-Dependent Protein Kinase Promotes Metastatic Pathways in Triple-Negative Breast Cancer
International Journal of Radiation Oncology*Biology*Physics
2016
Abstract 1851: Novel roles of DNA-PK in metabolic regulation in prostate cancer
Cancer Research
2019
Abstract 2853: Investigating DNAPK as a biomarker and a novel therapeutic target in aggressive prostate cancer
Cancer Research
2015
Abstract LB-264: Preclinical evaluation of DNA-PK as a therapeutic target in prostate cancer
Cancer Research
2017
Abstract LB-008: KRAS engages AGO2 to enhance cellular transformation
Cancer Research
2016
Abstract LB-010: Maternal embryonic leucine zipper kinase (MELK): A novel target for radiosensitization that is independently prognostic in triple-negative breast cancers
Cancer Research
2016
Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer
Cell
2018
Mechanism-centric regulatory network identifies NME2 and MYC programs as markers of Enzalutamide resistance in CRPC
Nature Communications
2024

Experience

Northwestern University - Chicago

Research Assistant Professor / February, 2019Present

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