Esteban Terzo

Principal Scientist, Eloxx Pharmaceuticals

Research Expertise

Cell Biology
Oncology
Cancer Research
Pulmonary and Respiratory Medicine
Genetics
Genetics (clinical)
Immunology and Allergy
Immunology
Molecular Biology
Drug Discovery
Molecular Medicine

About

Strategic thinker and cross-functional communicator showcasing nearly 6 years of biotech industry experience leading projects as a specialist in early drug discovery, platform development, and oncology. Proven track record of establishing research laboratories, conceiving and executing cell-based assays, leading external projects in collaboration with CROs and academic partners. Passionate about mentoring and enabling opportunities for the next generation of scientists. Committed to finding solutions to complex challenges and seeking new ways to push the boundaries of discovery.

Legacy Map

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Publications

A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Cancer Research Communications
2023
Data from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
Data from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
FIGURE 1 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
FIGURE 1 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
FIGURE 2 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
FIGURE 2 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
FIGURE 3 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
FIGURE 3 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
FIGURE 4 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
FIGURE 4 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
FIGURE 5 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
FIGURE 5 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
Figure S1 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
Figure S1 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
Figure S2 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
Figure S2 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
Figure S3 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
Figure S3 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
Supplementary Data 1 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
Supplementary Data 1 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
Supplementary Methods 1 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
Supplementary Methods 1 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
Supplementary Table 1 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
Supplementary Table 1 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
TABLE 1 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
TABLE 1 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Unknown Venue
2023
Data from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Unknown Venue
2023
Figure S1 from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Unknown Venue
2023
Figure S1 from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Unknown Venue
2023
Figure S2 from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Unknown Venue
2023
Figure S2 from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Unknown Venue
2023
Figure S3 from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Unknown Venue
2023
Figure S3 from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Unknown Venue
2023
Supplementary Data 1 from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Unknown Venue
2023
Supplementary Data 1 from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Unknown Venue
2023
Supplementary Methods 1 from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Unknown Venue
2023
Supplementary Methods 1 from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Unknown Venue
2023
Supplementary Table 1 from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Unknown Venue
2023
Supplementary Table 1 from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Unknown Venue
2023
Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis
Journal of Cell Biology
2016
SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma
Cancer Research
2018
KLF6-SV1 Is a Novel Antiapoptotic Protein That Targets the BH3-Only Protein NOXA for Degradation and Whose Inhibition Extends Survival in an Ovarian Cancer Model
Cancer Research
2009
Targeted reduction of KLF6-SV1 restores chemotherapy sensitivity in resistant lung adenocarcinoma
Lung Cancer
2009
Primate Genome Gain and Loss: A Bone Dysplasia, Muscular Dystrophy, and Bone Cancer Syndrome Resulting from Mutated Retroviral-Derived MTAP Transcripts
The American Journal of Human Genetics
2012
Distinct self-interaction domains promote Multi Sex Combs accumulation in and formation of theDrosophilahistone locus body
Molecular Biology of the Cell
2015
Methylated α-tubulin antibodies recognize a new microtubule modification on mitotic microtubules
mAbs
2016
SETD2 loss sensitizes cells to PI3Kβ and AKT inhibition
Oncotarget
2019
Molecular cloning of multiple forms of the ovine B7-2 (CD86) costimulatory molecule
Veterinary Immunology and Immunopathology
2006
Molecular cloning and mRNA tissue-expression of two isoforms of the ovine costimulatory molecule CD80 (B7-1)
Veterinary Immunology and Immunopathology
2005
CREBBP/EP300 acetyltransferase inhibition disrupts FOXA1-bound enhancers to inhibit the proliferation of ER+ breast cancer cells
PLOS ONE
2022
Abstract 4722: Efficacy of a novel EP300/CBP histone acetyltransferase inhibitor in hormone responsive breast cancer
Cancer Research
2019
Novel read through agent: ZKN-0013 demonstrates efficacy in APCmin model of familial adenomatous polyposis
Journal of Molecular Medicine
2023
A novel class of Ribosome Modulating Agents (RMAs) target MYC driven SCLC and synergize with DNA intercalating agents
European Journal of Cancer
2022
A novel class of Ribosome Modulating Agents (RMAs) targets ribosome heterogeneity in a subset of colorectal cancers
European Journal of Cancer
2022
Correction: SETD2 loss sensitizes cells to PI3Kβ and AKT inhibition
Oncotarget
2019
Abstract 1942: Synthetic lethal interaction between SETD2 loss and inhibition of PI3Kβ in clear cell renal cell carcinoma (ccRCC)
Cancer Research
2018
Abstract B059: SETD2-PI3Kβ synthetic lethality
Molecular Cancer Therapeutics
2018
Abstract 3071: Exploring the molecular mechanism underlying SETD2-PI3Kβ synthetic-lethal interaction in renal cell carcinoma (RCC)
Cancer Research
2017
Abstract LB-89: Discovery and characterization of novel MTAP splice variants resulting in a hereditary form of osteosarcoma and demonstration of their dysregulation in sporadic forms of this cancer
Cancer Research
2012
Data from KLF6-SV1 Is a Novel Antiapoptotic Protein That Targets the BH3-Only Protein NOXA for Degradation and Whose Inhibition Extends Survival in an Ovarian Cancer Model
Unknown Venue
2023

Education

University of North Carolina at Chapel Hill

Ph.D., Genetics and Molecular Biology / December, 2015

Chapel Hill, North Carolina, United States of America

Experience

Eloxx Pharmaceuticals

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