Ace Santiago, Ph.D.

Scientist at 10x Genomics with chemistry and biology training at Cornell and Harvard

Research Expertise

biochemistry
proteins
biophysics
single-molecule imaging
genomics
Cell Biology
Applied Microbiology and Biotechnology
Microbiology (medical)
Genetics
Microbiology
Immunology
Molecular Biology
Physical and Theoretical Chemistry
Materials Chemistry
Surfaces, Coatings and Films

About

Experienced Biochemist and Biophysicist with 13+ years in protein and nucleic acid research, specializing in genomics assay development, multi-omics, biomolecule analytics, microbiology, and cellular imaging. Multi-disciplinary Scientist with outstanding academic training and 4 years of industrial research experience, adept at studying biomolecular interactions and gene expression to understand protein function and cellular physiology.

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Publications

Concentration- and chromosome-organization-dependent regulator unbinding from DNA for transcription regulation in living cells
Nature Communications
2015
Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan
Nature Microbiology
2020
The Length of Lipoteichoic Acid Polymers Controls Staphylococcus aureus Cell Size and Envelope Integrity
Journal of Bacteriology
2020
Metalloregulator CueR biases RNA polymerase’s kinetic sampling of dead-end or open complex to repress or activate transcription
Proceedings of the National Academy of Sciences
2015
Adaptor protein mediates dynamic pump assembly for bacterial metal efflux
Proceedings of the National Academy of Sciences
2017
Mechanical stress compromises multicomponent efflux complexes in bacteria
Proceedings of the National Academy of Sciences
2019
Quantifying Multistate Cytoplasmic Molecular Diffusion in Bacterial Cells via Inverse Transform of Confined Displacement Distribution
The Journal of Physical Chemistry B
2015
Metal-induced sensor mobilization turns on affinity to activate regulator for metal detoxification in live bacteria
Proceedings of the National Academy of Sciences
2020
Single-Molecule Dynamics and Mechanisms of Metalloregulators and Metallochaperones
Biochemistry
2013
Single‐molecule dynamics of the molecular chaperone trigger factor in living cells
Molecular Microbiology
2016
The cell cycle in Staphylococcus aureus is regulated by an amidase that controls peptidoglycan synthesis
Unknown Venue
2019
Single-Molecule Specific Mislocalization of Red Fluorescent Proteins in Live Escherichia coli
Biophysical Journal
2016

Education

University of the Philippines Diliman

Bachelor of Science, Chemistry

Quezon City

Cornell University

Doctor of Philosophy, Chemistry and Chemical Biology

Ithaca, New York, United States of America

Experience

Harvard Medical School

Postdoctoral Fellow / June, 2017Present

Cornell University

Postdoctoral Associate / August, 2016April, 2017

10x Genomics

Scientist II / August, 2021Present

Development of single cell and spatial multi-omics technologies

Siemens Healthineers

Senior Biochemist / March, 2020August, 2021

Analytical development of clinical diagnostics assays

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