Marie Mooney, PhD

Assistant Professor, University of North Florida specializing in Genetics, Neuroscience, and Bioinformatics

About

Marie Mooney, PhD is an Assistant Professor of Bioinformatics at the University of North Florida. She holds a PhD in Cell and Molecular Genetics from the Van Andel Research Institute, a MS in Biomedical Engineering from the University of Cincinnati, and a BS in Bioinformatics, from Michigan Technological University. Prior to her current role, she served as a Senior Postdoctoral Associate at Lurie Children's Hospital, A T32 Postdoctoral Scholar In Applied Genomics and Precision Medicine at Duke University, a Research Associate at Michigan State University. Her research focuses on integrative and translational approaches to repurpose therapeutics for use in rare congenital disorders. Her laboratory uses zebrafish as a genetic model organism to generate and test bioinformatics-driven hypotheses.

Education

Duke University

Postdoctoral Associate/Scholar, School of medicine / June, 2020

Durham , North Carolina, United States of America

Michigan State University

Postdoctoral Fellow, Pediatrics and Human Development / October, 2017

Grand Rapids, Michigan, United States of America

Van Andel Research Institute

Cell and Molecular Genetics, PhD, Graduate School / March, 2016

Grand Rapids, Michigan, United States of America

University of Cincinnati

Biomedical Engineering, MS, Biomedical Engineering / July, 2010

Cincinnati, Ohio, United States of America

Michigan Technological University

Bioinformatics, BS, suma cum laude, Biology / December, 2006

Houghton, Michigan, United States of America

Experience

University of North Florida

Assisstant Professor of Bioinformatics / August, 2021Present

Lurie Children's Hospital

Postdoctoral Associate / July, 2020June, 2021

Duke University

Postdoctoral Associate / February, 2018June, 2020

Michigan State University

Postdoctoral Fellow/Research Associate / April, 2016October, 2017

Publications

Acute exposure to a high-fat diet alters meal patterns and body composition

Physiology & Behavior / Jan 01, 2010

Melhorn, S. J., Krause, E. G., Scott, K. A., Mooney, M. R., Johnson, J. D., Woods, S. C., & Sakai, R. R. (2010). Acute exposure to a high-fat diet alters meal patterns and body composition. Physiology & Behavior, 99(1), 33–39. https://doi.org/10.1016/j.physbeh.2009.10.004

Comparative RNA-Seq and Microarray Analysis of Gene Expression Changes in B-Cell Lymphomas of Canis familiaris

PLoS ONE / Apr 04, 2013

Mooney, M., Bond, J., Monks, N., Eugster, E., Cherba, D., Berlinski, P., Kamerling, S., Marotti, K., Simpson, H., Rusk, T., Tembe, W., Legendre, C., Benson, H., Liang, W., & Webb, C. P. (2013). Comparative RNA-Seq and Microarray Analysis of Gene Expression Changes in B-Cell Lymphomas of Canis familiaris. PLoS ONE, 8(4), e61088. https://doi.org/10.1371/journal.pone.0061088

Meal patterns and hypothalamic NPY expression during chronic social stress and recovery

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology / Sep 01, 2010

Melhorn, S. J., Krause, E. G., Scott, K. A., Mooney, M. R., Johnson, J. D., Woods, S. C., & Sakai, R. R. (2010). Meal patterns and hypothalamic NPY expression during chronic social stress and recovery. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 299(3), R813–R822. https://doi.org/10.1152/ajpregu.00820.2009

Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations

American Journal of Medical Genetics Part A / Mar 21, 2015

Peacock, J. D., Dykema, K. J., Toriello, H. V., Mooney, M. R., Scholten, D. J., Winn, M. E., Borgman, A., Duesbery, N. S., Hiemenga, J. A., Liu, C., Campbell, S., Nickoloff, B. P., Williams, B. O., & Steensma, M. (2015). Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations. American Journal of Medical Genetics Part A, 167(7), 1429–1435. Portico. https://doi.org/10.1002/ajmg.a.37048

Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma

Biochemical Journal / Jan 31, 2018

Schultz, C. R., Geerts, D., Mooney, M., El-Khawaja, R., Koster, J., & Bachmann, A. S. (2018). Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma. Biochemical Journal, 475(2), 531–545. https://doi.org/10.1042/bcj20170597

Mutations in FAM50A suggest that Armfield XLID syndrome is a spliceosomopathy

Nature Communications / Jul 23, 2020

Lee, Y.-R., Khan, K., Armfield-Uhas, K., Srikanth, S., Thompson, N. A., Pardo, M., Yu, L., Norris, J. W., Peng, Y., Gripp, K. W., Aleck, K. A., Li, C., Spence, E., Choi, T.-I., Kwon, S. J., Park, H.-M., Yu, D., Heo, W. D., Mooney, M. R., … Schwartz, C. E. (2020). Mutations in FAM50A suggest that Armfield XLID syndrome is a spliceosomopathy. Nature Communications, 11(1). https://doi.org/10.1038/s41467-020-17452-6

Anti-tumor effect of sulfasalazine in neuroblastoma

Biochemical Pharmacology / Apr 01, 2019

Mooney, M. R., Geerts, D., Kort, E. J., & Bachmann, A. S. (2019). Anti-tumor effect of sulfasalazine in neuroblastoma. Biochemical Pharmacology, 162, 237–249. https://doi.org/10.1016/j.bcp.2019.01.007

Recessive variants in ZNF142 cause a complex neurodevelopmental disorder with intellectual disability, speech impairment, seizures, and dystonia

Genetics in Medicine / Nov 01, 2019

Khan, K., Zech, M., Morgan, A. T., Amor, D. J., Skorvanek, M., Khan, T. N., Hildebrand, M. S., Jackson, V. E., Scerri, T. S., Coleman, M., Rigbye, K. A., Scheffer, I. E., Bahlo, M., Wagner, M., Lam, D. D., Berutti, R., Havránková, P., Fečíková, A., Strom, T. M., … Winkelmann, J. (2019). Recessive variants in ZNF142 cause a complex neurodevelopmental disorder with intellectual disability, speech impairment, seizures, and dystonia. Genetics in Medicine, 21(11), 2532–2542. https://doi.org/10.1038/s41436-019-0523-0

A multi-site feasibility study for personalized medicine in canines with Osteosarcoma

Journal of Translational Medicine / Jul 01, 2013

Monks, N. R., Cherba, D. M., Kamerling, S. G., Simpson, H., Rusk, A. W., Carter, D., Eugster, E., Mooney, M., Sigler, R., Steensma, M., Grabinski, T., Marotti, K. R., & Webb, C. P. (2013). A multi-site feasibility study for personalized medicine in canines with Osteosarcoma. Journal of Translational Medicine, 11(1). https://doi.org/10.1186/1479-5876-11-158

Analysis of Single Nucleotide Variants in CRISPR-Cas9 Edited Zebrafish Exomes Shows No Evidence of Off-Target Inflation

Frontiers in Genetics / Oct 11, 2019

Mooney, M. R., Davis, E. E., & Katsanis, N. (2019). Analysis of Single Nucleotide Variants in CRISPR-Cas9 Edited Zebrafish Exomes Shows No Evidence of Off-Target Inflation. Frontiers in Genetics, 10. https://doi.org/10.3389/fgene.2019.00949

Analysis of single nucleotide variants in CRISPR-Cas9 edited zebrafish embryos shows no evidence of off-target inflation

Mar 05, 2019

Mooney, M. R., Davis, E. E., & Katsanis, N. (2019). Analysis of single nucleotide variants in CRISPR-Cas9 edited zebrafish embryos shows no evidence of off-target inflation. https://doi.org/10.1101/568642

Abstract 4027: Regulation of p16INK4A and TGF-beta by DNA hydroxymethylation in glioblastoma multiforme

Cancer Research / Apr 01, 2012

Popkie, A. P., deCarvalho, A. C., Scott, S. B., Eugster, E. E., Monsma, D., Davidson, P. J., Dawna, D., Mooney, M. R., Monks, N. R., Mikkelsen, T., & Webb, C. P. (2012). Abstract 4027: Regulation of p16INK4A and TGF-beta by DNA hydroxymethylation in glioblastoma multiforme. Cancer Research, 72(8_Supplement), 4027–4027. https://doi.org/10.1158/1538-7445.am2012-4027

Elucidating Metastatic Behavior Through Nanopatterned Membranes

Sep 01, 2010

Groves, J. (2010). Elucidating Metastatic Behavior Through Nanopatterned Membranes. https://doi.org/10.21236/ada545004

The CIMS (Cyanobacterial ITS motif slicer) for molecular systematics

Fottea / Feb 20, 2023

Labrada, N. A., McGovern, C. A., Thomas, A. L., Hurley, A. C., Mooney, M. R., & Casamatta, D. A. (2023). The CIMS (Cyanobacterial ITS motif slicer) for molecular systematics. Fottea. https://doi.org/10.5507/fot.2023.008

Links & Social Media

Research Interests

translational medicine
bioinformatics
neuro-oncology
oncology
neurodevelopmental disorders
Behavioral Neuroscience
Experimental and Cognitive Psychology
Multidisciplinary
Physiology (medical)
Physiology
Genetics (clinical)
Genetics
Cell Biology
Molecular Biology
Biochemistry
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
General Chemistry
Pharmacology
General Medicine
Molecular Medicine
Cancer Research
Plant Science
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