Rebecca Baillie

Unknown affiliation

California

Research Expertise

Metabolomics, Drug development, biomarkers, mathematical modeling
science and mathematical modeling

About

Scientist with more than 20 years of experience in the pharmaceutical industry and owner of a profitable scientific research consulting business with academic and pharmaceutical clients. Project Lead and Principal Scientist responsible for project management and designing and developing more than 50 quantitative systems pharmacology (QSP) models for decision-making in drug and device development. Research supporting drug programs across many therapeutic areas (oncology, immunology, neurology, dermatology, respiratory, gastroenterology, nephrology, cardiovascular, metabolic, rheumatology, rare diseases), modalities (small molecules, nanocages, nanobodies, antibodies, engineered proteins, and cell therapies), through discovery, development, and post-approval phases. Proven ability to work with diverse teams to understand client needs and implement solutions to impact decision-making.

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Publications

Circulating lipid profiles are associated with cross-sectional and longitudinal changes of central biomarkers for Alzheimer’s disease
Unknown Venue
2023
APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies
Alzheimer's & Dementia
2022
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease
Communications Biology
2022
Brief Report: Higher Fentanyl Exposures Require Higher Doses of Naloxone for Successful Reversals in a Quantitative Systems Pharmacology Model
Unknown Venue
2021
Integrative metabolomics‐genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease
Alzheimer's & Dementia
2021
Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression
Translational Psychiatry
2021
Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature
Scientific Reports
2021
Multi-Omic Analyses Characterize the Ceramide/Sphingomyelin Pathway as a Therapeutic Target in Alzheimer’s Disease
Unknown Venue
2021
Serum metabolites associated with brain amyloid beta deposition, cognition and dementia progression
Brain Communications
2021
Serum Metabolites Associated with Brain Amyloid Beta Deposition, Cognitive Dysfunction, and Alzheimer’s Disease Progression
Unknown Venue
2020
Peripheral serum metabolomic profiles inform central cognitive impairment
Scientific Reports
2020
Circulating ethanolamine plasmalogen indices in Alzheimer's disease: Relation to diagnosis, cognition, and CSF tau
Alzheimer's & Dementia
2020
Higher naloxone dosing in a quantitative systems pharmacology model that predicts naloxone-fentanyl competition at the opioid mu receptor level
PLOS ONE
2020
Serum triglycerides in Alzheimer disease
Neurology
2020
Combining two large clinical cohorts (AIBL and ADNI) to identify multiple lipid metabolic pathways in prevalent and incident Alzheimer’s disease
Unknown Venue
2020
Alterations in Acylcarnitines, Amines, and Lipids Inform about Mechanism of Action of Citalopram/Escitalopram in Major Depression
Unknown Venue
2020
Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
Nature Communications
2020
Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer’s Disease
Cell Reports Medicine
2020
Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome
Nature Communications
2020
Peripheral Serum Metabolomic Profiles Inform Antecedent Central Cognitive Impairment in Older Adults
Unknown Venue
2019
Bile acids targeted metabolomics and medication classification data in the ADNI1 and ADNIGO/2 cohorts
Scientific Data
2019
Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers
JAMA Network Open
2019
The Alzheimer’s Disease Metabolome: Effects of Sex andAPOEε4 genotype
Unknown Venue
2019
A blood-based signature of cerebrospinal fluid Aβ1–42 status
Scientific Reports
2019
Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer’s Disease – An Emerging Role for Gut Microbiome
Unknown Venue
2018
Altered Bile Acid Profile in Mild Cognitive Impairment and Alzheimer’s Disease: Relationship to Neuroimaging and CSF Biomarkers
Unknown Venue
2018
Considerations for Adapting Pre-existing Mechanistic Quantitative Systems Pharmacology Models for New Research Contexts
Frontiers in Pharmacology
2019
Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
2019
F3‐02‐04: SERUM INDICES OF ETHANOLAMINE PLASMALOGENS AND PHOSPHATIDE METABOLISM IN THE COMBINED ADNI‐1/GO/2 COHORT: DOES THE LIVER CONTRIBUTE TO AD RISK BY FAILING TO SUPPLY KEY LIPIDS TO THE BRAIN?
Alzheimer's & Dementia
2018
F3‐02‐03: ASSOCIATION OF SERUM LIPIDS WITH ALZHEIMER'S DISEASE IN THE ADNI COHORT: AN UNTARGETED LIPIDOMICS STUDY
Alzheimer's & Dementia
2018
Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study
PLOS Medicine
2018
Generation and quality control of lipidomics data for the alzheimer’s disease neuroimaging initiative cohort
Scientific Data
2018
Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate
CPT: Pharmacometrics & Systems Pharmacology
2018
Serum triglycerides in Alzheimer’s disease: Relation to neuroimaging and CSF biomarkers
Unknown Venue
2018
Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics
Journal of the American Heart Association
2018
[F2–01–03]: GUT DERIVED BILE ACID METABOLITES CORRELATE WITH STRUCTURAL AND FUNCTIONAL NEUROIMAGING MEASURES IN ALZHEIMER's DISEASE
Alzheimer's & Dementia
2017
Metabolic network failures in Alzheimer's disease: A biochemical road map
Alzheimer's & Dementia
2017
Pharmacometabolomic signature links simvastatin therapy and insulin resistance
Metabolomics
2016
Targeted metabolomics and medication classification data from participants in the ADNI1 cohort
Scientific Data
2017
P3‐157: Indices of Plasmalogen Biosynthesis in ADNI‐1 Baseline Serum Samples: Association with Progression to Dementia in Subjects with Mild Cognitive Impairment
Alzheimer's & Dementia
2016
F1‐02‐02: Genetic Influence on Levels of Targeted Metabolites Associated with Alzheimer’s Disease
Alzheimer's & Dementia
2016
Is a Diabetes Mellitus–Linked Amino Acid Signature Associated With β-Blocker–Induced Impaired Fasting Glucose?
Circulation: Cardiovascular Genetics
2014
Pharmacokinetic analysis of 14C‐ursodiol in newborn infants using accelerator mass spectrometry
The Journal of Clinical Pharmacology
2014
Virtual Systems Pharmacology (ViSP) software for simulation from mechanistic systems-level models
Frontiers in Pharmacology
2014
Lipidomics Reveals Early Metabolic Changes in Subjects with Schizophrenia: Effects of Atypical Antipsychotics
PLoS ONE
2013
Correction: Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment
PLoS ONE
2013
Abstracts Accepted for American Conference on Pharmacometrics 2013
Journal of Pharmacokinetics and Pharmacodynamics
2013
Impaired plasmalogens in patients with schizophrenia
Psychiatry Research
2012
Metabolomics Reveals Amino Acids Contribute to Variation in Response to Simvastatin Treatment
PLoS ONE
2012
Plasma Omega-3 Polyunsaturated Fatty Acids and Survival in Patients with Chronic Heart Failure and Major Depressive Disorder
Journal of Cardiovascular Translational Research
2011
Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment
PLoS ONE
2011
Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study
Metabolomics
2010
A lipidomic analysis of nonalcoholic fatty liver disease
Hepatology
2007
Metabolomic mapping of atypical antipsychotic effects in schizophrenia
Molecular Psychiatry
2007
Targeted Deletion of FATP5 Reveals Multiple Functions in Liver Metabolism: Alterations in Hepatic Lipid Homeostasis
Gastroenterology
2006
Copper Deficiency Induces Hepatic Fatty Acid Synthase Gene Transcription in Rats by Increasing the Nuclear Content of Mature Sterol Regulatory Element Binding Protein 1
The Journal of Nutrition
2000
Peroxisome proliferator-activated receptors: a family of lipid-activated transcription factors
The American Journal of Clinical Nutrition
1999
Coordinate induction of peroxisomal acyl-CoA oxidase and UCP-3 by dietary fish oil: a mechanism for decreased body fat deposition
Prostaglandins, Leukotrienes and Essential Fatty Acids
1999
Regulation of the Action of Steroid/Thyroid Hormone Receptors by Medium-chain Fatty Acids
Journal of Biological Chemistry
1998
Fatty Acid Regulation of Gene Expression Its Role in Fuel Partitioning and Insulin Resistancea
Annals of the New York Academy of Sciences
1997
Hepatic fatty acid synthase gene transcription is induced by a dietary copper deficiency
American Journal of Physiology-Endocrinology and Metabolism
1997
Specific effects of polyunsaturated fatty acids on gene expression
Current Opinion in Lipidology
1996
Nutritional and Hormonal Regulation of Expression of the Gene for Malic Enzyme
Progress in Nucleic Acid Research and Molecular Biology
1996
Transient transfection of chick-embryo hepatocytes
The Journal of Nutritional Biochemistry
1993
Characterization of an Acrosomal Matrix Protein in Hamster and Bovine Spermatids and Spermatozoa1
Biology of Reproduction
1990
Erratum to “Altered bile acid profile associates with cognitive impairment in Alzheimer’s disease—An emerging role for gut microbiome” [Alzheimer’s & Dementia 2019;15:76‐92.]
Alzheimer's & Dementia
2019
Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers
Alzheimer's & Dementia
2018
Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Cholesterol Metabolism in Alzheimer’s Disease
SSRN Electronic Journal
2020
Cytosolic and nuclear distribution of PPARγ2 in differentiating 3T3-L1 preadipocytes
Journal of Lipid Research
1998
Non-Alcoholic Steatohepatitis (NASH)/Non-Alcoholic Fatty Liver Disease (NAFLD)
Gastroenterology Nursing
2006
Chapter 27. Biosimulation: Dynamic modeling of biological systems
Annual Reports in Medicinal Chemistry
2002
Functional Annotation of Genomic Data with Metabolic Inference
Poultry Science
2007
Nanotube technology gains US patent
Reinforced Plastics
2004
Conference report
World Patent Information
2006
7088 A lipidomic analysis of non-alcoholic fatty liver disease (NAFLD)
Journal of Hepatology
2006
A novel 3T3-L1 preadipocyte variant that expresses PPARγ2 and RXRα but does not undergo differentiation
Journal of Lipid Research
1998
Onwueme, Tess Osonye
African American Studies Center
2011
Gold Standard Animal Models
Pharmaceutical Sciences Encyclopedia
2011
Effect of citrate on zinc bioavailability from milk, milk fractions and infant formulas
Nutrition Research
1993
Transcriptomics, metabolomics, lipidomics, metabolic flux and mGWAS analyses of sphingolipid pathway highlights novel drugs for Alzheimer’s disease
Alzheimer's & Dementia
2021
Genome‐wide study of the human lipidome and links to Alzheimer’s disease risk
Alzheimer's & Dementia
2020
Integrative metabolomics‐genomics approach reveals that pathways related to the metabolism of acylcarnitines and amines are new potential targets of Alzheimer’s disease
Alzheimer's & Dementia
2020
Airway Inflammation and Remodeling in Asthma: Current Concepts
Human Airway Inflammation
Étude bactériologique des sinusites sphénoïdales nosocomiales
Médecine et Maladies Infectieuses
2000
Zinc, vanadate and selenate inhibit the tri-iodothyronine-induced expression of fatty acid synthase and malic enzyme in chick-embryo hepatocytes in culture
Biochemical Journal
1994
The Metabolome-Wide Signature of Major Depressive Disorder
Unknown Venue
2023
Novel circling SWAT for deep learning based diagnostic classification of Alzheimer’s disease: Application to metabolome data
Alzheimer's & Dementia
2022
Thanks to our Reviewers of 2022!
Journal of Pharmacokinetics and Pharmacodynamics
2023
Lipidomic signatures for APOE genotypes provides new insights about mechanisms of resilience in Alzheimer’s disease
Alzheimer's & Dementia
2021
Modeling shows the NK3R antagonist, ACER-801, reduces treatment-induced vasomotor symptoms.
Journal of Clinical Oncology
2021
Identification of concordant plasma lipid signatures in Alzheimer’s disease: Validation between two independent studies of Alzheimer’s disease
Alzheimer's & Dementia
2020
Serum metabolome informs neuroimaging biomarkers for Alzheimer’s disease
Alzheimer's & Dementia
2020
Combining two large clinical cohorts (AIBL and ADNI) to identify multiple lipid metabolic pathways in prevalent and incident Alzheimer
Unknown Venue
Assessing association of cumulative fluid balance with acute kidney injury after orthotopic liver transplantation
Nephrology
2020
P4‐116: SERUM TRIGLYCERIDES IN ALZHEIMER'S DISEASE: RELATION TO NEUROIMAGING, CSF, AND GENETIC VARIATION
Alzheimer's & Dementia
2019
P1‐386: ASSOCIATION OF SERUM‐BASED PLASMALOGENS WITH NEUROIMAGING AND GENETIC VARIATION IN ALZHEIMER'S DISEASE
Alzheimer's & Dementia
2019
LB1573 Evaluation of a novel therapy and identification of uncertainties critical to efficacy and competitive differentiation in a Psoriasis PhysioPD™ Platform
Journal of Investigative Dermatology
2018
F3‐02‐01: ALTERED BILE ACID METABOLITES IN MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE: RELATION TO NEUROIMAGING AND CSF BIOMARKERS
Alzheimer's & Dementia
2018

Education

California State University East Bay

Certificate, Business Management

Hayward, California, United States of America

University of Iowa

PhD

Iowa City, Iowa, United States of America

Experience

Rosa and Co LLC

Principal Scientist / 2007Present

Chief of Staff / 20072022

RABaillie Consulting

Owner / June, 2005Present

Lipomics Inc

Senior Research Biologist / 20022007

Entelos Inc

Sr. Scientist / 19982002

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