Aimee Eggler

Professor of Chemistry and Biochemistry at Villanova University

Villanova, Pennsylvania, United States of America

Research Expertise

Biochemistry
Physiology (medical)
Toxicology
Organic Chemistry
Clinical Biochemistry
Drug Discovery
Pharmaceutical Science
Molecular Biology
Molecular Medicine
Cell Biology
Biophysics
Food Science
Biotechnology
Spectroscopy
Structural Biology
Analytical Chemistry
Physical and Theoretical Chemistry
Pharmacology (medical)
Pharmacology

About

Dr. Eggler has 20 years of experience in the field of redox biology, with a focus on the Nrf2 transcription factor, a master regulator of antioxidant, detoxification and anti-inflammatory genes. She is also an award-winning educator and the recipient of the Villanova University Junior Faculty Excellence in Teaching award. Her interests in education include innovation in teaching metabolism from a logic-based perspective.

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Publications

Kinetic assessment of Michael addition reactions of alpha, beta-unsaturated carbonyl compounds to amino acid and protein thiols
Free Radical Biology and Medicine
2021
Dr. Jekyll and Mr. Hyde: Oxidizable phenol-generated reactive oxygen species enhance sulforaphane's antioxidant response element activation, even as they suppress Nrf2 protein accumulation
Free Radical Biology and Medicine
2018
Comparison of human Nrf2 antibodies: A tale of two proteins
Toxicology Letters
2015
Chemical and Biological Mechanisms of Phytochemical Activation of NRF2 and Importance in Disease Prevention
50 Years of Phytochemistry Research
2013
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding
Bioorganic & Medicinal Chemistry Letters
2013
Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease
Journal of Medicinal Chemistry
2013
Screening for natural chemoprevention agents that modify human Keap1
Analytical Biochemistry
2012
Modification of Keap1 Cysteine Residues by Sulforaphane
Chemical Research in Toxicology
2011
Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3–RINGBox1 protein complex and elucidation of its quaternary structure with Keap1
Biochemical and Biophysical Research Communications
2010
Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1
Biochemical Journal
2009
The structures of T87I phosphono-CheY and T87I/Y106W phosphono-CheY help to explain their binding affinities to the FliM and CheZ peptides
Archives of Biochemistry and Biophysics
2008
Prospective Type 1 and Type 2 Disulfides of Keap1 Protein
Chemical Research in Toxicology
2008
Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2
Molecular Nutrition & Food Research
2008
Identification of the Highly Reactive Cysteine 151 in the Chemopreventive Agent-Sensor Keap1 Protein is Method-Dependent
Chemical Research in Toxicology
2008
Identification of the Highly Reactive Cysteine 151 in the Chemopreventive Agent-Sensor Keap1 Protein is Method-Dependent
Chemical Research in Toxicology
2007
Sites of alkylation of human Keap1 by natural chemoprevention agents
Journal of the American Society for Mass Spectrometry
2007
Screening Method for the Discovery of Potential Cancer Chemoprevention Agents Based on Mass Spectrometric Detection of Alkylated Keap1
Analytical Chemistry
2005
Xanthohumol Isolated from Humulus lupulus Inhibits Menadione-Induced DNA Damage through Induction of Quinone Reductase
Chemical Research in Toxicology
2005
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
Proceedings of the National Academy of Sciences
2005
The C Terminus of the Escherichia coli RecA Protein Modulates the DNA Binding Competition with Single-stranded DNA-binding Protein
Journal of Biological Chemistry
2003
The Rad51-dependent Pairing of Long DNA Substrates Is Stabilized by Replication Protein A
Journal of Biological Chemistry
2002
DNA Pairing and Strand Exchange by the Escherichia coli RecA and Yeast Rad51 Proteins without ATP Hydrolysis
Journal of Biological Chemistry
2001
Single-Stranded DNA-Binding Proteins (SSBs)
Encyclopedia of Genetics
2001
Insecticidal Activity of Cyanohydrin and Monoterpenoid Compounds
Molecules
2000
Solving the Problem of Assessing Synergy and Antagonism for Non-Traditional Dosing Curve Compounds Using the DE/ZI Method: Application to Nrf2 Activators
Frontiers in Pharmacology
2021

Education

University of California, Santa Cruz

BS, Chemistry / May, 1996

Santa Cruz, California, United States of America

University of Wisconsin–Madison

Ph.D., Biochemistry / May, 2002

Madison, Wisconsin, United States of America

Experience

Villanova University

Associate Professor of Chemistry / 2019Present

Villanova University

Assistant Professor / 20122019

Purdue University

Research Assistant Professor / 20102012

University of Illinois at Chicago

Research Assistant Professor / 20062010

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