Aimee Eggler
Professor of Chemistry and Biochemistry at Villanova University
Research Expertise
About
Publications
Kinetic assessment of Michael addition reactions of alpha, beta-unsaturated carbonyl compounds to amino acid and protein thiols
Free Radical Biology and Medicine / Jun 01, 2021
Sauerland, M., Mertes, R., Morozzi, C., Eggler, A. L., Gamon, L. F., & Davies, M. J. (2021). Kinetic assessment of Michael addition reactions of alpha, beta-unsaturated carbonyl compounds to amino acid and protein thiols. Free Radical Biology and Medicine, 169, 1–11. https://doi.org/10.1016/j.freeradbiomed.2021.03.040
Dr. Jekyll and Mr. Hyde: Oxidizable phenol-generated reactive oxygen species enhance sulforaphane's antioxidant response element activation, even as they suppress Nrf2 protein accumulation
Free Radical Biology and Medicine / Aug 01, 2018
Bauman, B. M., Jeong, C., Savage, M., Briker, A. L., Janigian, N. G., Nguyen, L. L., Kemmerer, Z. A., & Eggler, A. L. (2018). Dr. Jekyll and Mr. Hyde: Oxidizable phenol-generated reactive oxygen species enhance sulforaphane’s antioxidant response element activation, even as they suppress Nrf2 protein accumulation. Free Radical Biology and Medicine, 124, 532–540. https://doi.org/10.1016/j.freeradbiomed.2018.06.039
Comparison of human Nrf2 antibodies: A tale of two proteins
Toxicology Letters / Oct 01, 2015
Kemmerer, Z. A., Ader, N. R., Mulroy, S. S., & Eggler, A. L. (2015). Comparison of human Nrf2 antibodies: A tale of two proteins. Toxicology Letters, 238(2), 83–89. https://doi.org/10.1016/j.toxlet.2015.07.004
Chemical and Biological Mechanisms of Phytochemical Activation of NRF2 and Importance in Disease Prevention
50 Years of Phytochemistry Research / Jan 01, 2013
Eggler, A. L., & Savinov, S. N. (2013). Chemical and Biological Mechanisms of Phytochemical Activation of NRF2 and Importance in Disease Prevention. 50 Years of Phytochemistry Research, 121–155. https://doi.org/10.1007/978-3-319-00581-2_7
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding
Bioorganic & Medicinal Chemistry Letters / Nov 01, 2013
Turlington, M., Chun, A., Tomar, S., Eggler, A., Grum-Tokars, V., Jacobs, J., Daniels, J. S., Dawson, E., Saldanha, A., Chase, P., Baez-Santos, Y. M., Lindsley, C. W., Hodder, P., Mesecar, A. D., & Stauffer, S. R. (2013). Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding. Bioorganic & Medicinal Chemistry Letters, 23(22), 6172–6177. https://doi.org/10.1016/j.bmcl.2013.08.112
Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease
Journal of Medicinal Chemistry / Jan 03, 2013
Jacobs, J., Grum-Tokars, V., Zhou, Y., Turlington, M., Saldanha, S. A., Chase, P., Eggler, A., Dawson, E. S., Baez-Santos, Y. M., Tomar, S., Mielech, A. M., Baker, S. C., Lindsley, C. W., Hodder, P., Mesecar, A., & Stauffer, S. R. (2013). Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease. Journal of Medicinal Chemistry, 56(2), 534–546. https://doi.org/10.1021/jm301580n
Screening for natural chemoprevention agents that modify human Keap1
Analytical Biochemistry / Feb 01, 2012
Hu, C., Nikolic, D., Eggler, A. L., Mesecar, A. D., & van Breemen, R. B. (2012). Screening for natural chemoprevention agents that modify human Keap1. Analytical Biochemistry, 421(1), 108–114. https://doi.org/10.1016/j.ab.2011.10.028
Modification of Keap1 Cysteine Residues by Sulforaphane
Chemical Research in Toxicology / Mar 10, 2011
Hu, C., Eggler, A. L., Mesecar, A. D., & van Breemen, R. B. (2011). Modification of Keap1 Cysteine Residues by Sulforaphane. Chemical Research in Toxicology, 24(4), 515–521. https://doi.org/10.1021/tx100389r
Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3–RINGBox1 protein complex and elucidation of its quaternary structure with Keap1
Biochemical and Biophysical Research Communications / Oct 01, 2010
Small, E., Eggler, A., & Mesecar, A. D. (2010). Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3–RINGBox1 protein complex and elucidation of its quaternary structure with Keap1. Biochemical and Biophysical Research Communications, 400(4), 471–475. https://doi.org/10.1016/j.bbrc.2010.08.062
Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1
Biochemical Journal / Jul 29, 2009
Eggler, A. L., Small, E., Hannink, M., & Mesecar, A. D. (2009). Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. Biochemical Journal, 422(1), 171–180. https://doi.org/10.1042/bj20090471
The structures of T87I phosphono-CheY and T87I/Y106W phosphono-CheY help to explain their binding affinities to the FliM and CheZ peptides
Archives of Biochemistry and Biophysics / Nov 01, 2008
McAdams, K., Casper, E. S., Matthew Haas, R., Santarsiero, B. D., Eggler, A. L., Mesecar, A., & Halkides, C. J. (2008). The structures of T87I phosphono-CheY and T87I/Y106W phosphono-CheY help to explain their binding affinities to the FliM and CheZ peptides. Archives of Biochemistry and Biophysics, 479(2), 105–113. https://doi.org/10.1016/j.abb.2008.08.019
Prospective Type 1 and Type 2 Disulfides of Keap1 Protein
Chemical Research in Toxicology / Aug 26, 2008
Holland, R., Hawkins, A. E., Eggler, A. L., Mesecar, A. D., Fabris, D., & Fishbein, J. C. (2008). Prospective Type 1 and Type 2 Disulfides of Keap1 Protein. Chemical Research in Toxicology, 21(10), 2051–2060. https://doi.org/10.1021/tx800226m
Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2
Molecular Nutrition & Food Research / Apr 24, 2008
Eggler, A. L., Gay, K. A., & Mesecar, A. D. (2008). Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2. Molecular Nutrition & Food Research. https://doi.org/10.1002/mnfr.200700249
Identification of the Highly Reactive Cysteine 151 in the Chemopreventive Agent-Sensor Keap1 Protein is Method-Dependent
Chemical Research in Toxicology / Feb 01, 2008
Eggler, A. L., Luo, Y., van Breemen, R. B., & Mesecar, A. D. (2008). Identification of the Highly Reactive Cysteine 151 in the Chemopreventive Agent-Sensor Keap1 Protein is Method-Dependent. Chemical Research in Toxicology, 21(2), 556–556. https://doi.org/10.1021/tx800015c
Identification of the Highly Reactive Cysteine 151 in the Chemopreventive Agent-Sensor Keap1 Protein is Method-Dependent
Chemical Research in Toxicology / Oct 13, 2007
Eggler, A. L., Luo, Y., van Breemen, R. B., & Mesecar, A. D. (2007). Identification of the Highly Reactive Cysteine 151 in the Chemopreventive Agent-Sensor Keap1 Protein is Method-Dependent. Chemical Research in Toxicology, 20(12), 1878–1884. https://doi.org/10.1021/tx700217c
Sites of alkylation of human Keap1 by natural chemoprevention agents
Journal of the American Society for Mass Spectrometry / Dec 01, 2007
Luo, Y., Eggler, A. L., Liu, D., Liu, G., Mesecar, A. D., & van Breemen, R. B. (2007). Sites of alkylation of human Keap1 by natural chemoprevention agents. Journal of the American Society for Mass Spectrometry, 18(12), 2226–2232. https://doi.org/10.1016/j.jasms.2007.09.015
Screening Method for the Discovery of Potential Cancer Chemoprevention Agents Based on Mass Spectrometric Detection of Alkylated Keap1
Analytical Chemistry / Sep 03, 2005
Liu, G., Eggler, A. L., Dietz, B. M., Mesecar, A. D., Bolton, J. L., Pezzuto, J. M., & van Breemen, R. B. (2005). Screening Method for the Discovery of Potential Cancer Chemoprevention Agents Based on Mass Spectrometric Detection of Alkylated Keap1. Analytical Chemistry, 77(19), 6407–6414. https://doi.org/10.1021/ac050892r
Xanthohumol Isolated from Humulus lupulus Inhibits Menadione-Induced DNA Damage through Induction of Quinone Reductase
Chemical Research in Toxicology / Jul 12, 2005
Dietz, B. M., Kang, Y.-H., Liu, G., Eggler, A. L., Yao, P., Chadwick, L. R., Pauli, G. F., Farnsworth, N. R., Mesecar, A. D., van Breemen, R. B., & Bolton, J. L. (2005). Xanthohumol Isolated from Humulus lupulus Inhibits Menadione-Induced DNA Damage through Induction of Quinone Reductase. Chemical Research in Toxicology, 18(8), 1296–1305. https://doi.org/10.1021/tx050058x
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
Proceedings of the National Academy of Sciences / Jul 08, 2005
Eggler, A. L., Liu, G., Pezzuto, J. M., van Breemen, R. B., & Mesecar, A. D. (2005). Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proceedings of the National Academy of Sciences, 102(29), 10070–10075. https://doi.org/10.1073/pnas.0502402102
The C Terminus of the Escherichia coli RecA Protein Modulates the DNA Binding Competition with Single-stranded DNA-binding Protein
Journal of Biological Chemistry / May 01, 2003
Eggler, A. L., Lusetti, S. L., & Cox, M. M. (2003). The C Terminus of the Escherichia coli RecA Protein Modulates the DNA Binding Competition with Single-stranded DNA-binding Protein. Journal of Biological Chemistry, 278(18), 16389–16396. https://doi.org/10.1074/jbc.m212920200
The Rad51-dependent Pairing of Long DNA Substrates Is Stabilized by Replication Protein A
Journal of Biological Chemistry / Oct 01, 2002
Eggler, A. L., Inman, R. B., & Cox, M. M. (2002). The Rad51-dependent Pairing of Long DNA Substrates Is Stabilized by Replication Protein A. Journal of Biological Chemistry, 277(42), 39280–39288. https://doi.org/10.1074/jbc.m204328200
DNA Pairing and Strand Exchange by the Escherichia coli RecA and Yeast Rad51 Proteins without ATP Hydrolysis
Journal of Biological Chemistry / Oct 01, 2001
Rice, K. P., Eggler, A. L., Sung, P., & Cox, M. M. (2001). DNA Pairing and Strand Exchange by the Escherichia coli RecA and Yeast Rad51 Proteins without ATP Hydrolysis. Journal of Biological Chemistry, 276(42), 38570–38581. https://doi.org/10.1074/jbc.m105678200
Single-Stranded DNA-Binding Proteins (SSBs)
Encyclopedia of Genetics / Jan 01, 2001
Eggler, A. L. (2001). Single-Stranded DNA-Binding Proteins (SSBs). Encyclopedia of Genetics, 1839–1842. https://doi.org/10.1006/rwgn.2001.1233
Insecticidal Activity of Cyanohydrin and Monoterpenoid Compounds
Molecules / Apr 03, 2000
Peterson, C., Tsao, R., Eggler, A., & Coats, J. (2000). Insecticidal Activity of Cyanohydrin and Monoterpenoid Compounds. Molecules, 5(12), 648–654. https://doi.org/10.3390/50400648
Solving the Problem of Assessing Synergy and Antagonism for Non-Traditional Dosing Curve Compounds Using the DE/ZI Method: Application to Nrf2 Activators
Frontiers in Pharmacology / Jun 07, 2021
Repash, E. M., Pensabene, K. M., Palenchar, P. M., & Eggler, A. L. (2021). Solving the Problem of Assessing Synergy and Antagonism for Non-Traditional Dosing Curve Compounds Using the DE/ZI Method: Application to Nrf2 Activators. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.686201
Education
University of California, Santa Cruz
BS, Chemistry / May, 1996
University of Wisconsin–Madison
Ph.D., Biochemistry / May, 2002
Experience
Villanova University
Associate Professor of Chemistry / 2019 — Present
Villanova University
Assistant Professor / 2012 — 2019
Purdue University
Research Assistant Professor / 2010 — 2012
University of Illinois at Chicago
Research Assistant Professor / 2006 — 2010
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